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Celiac.com 05/16/2025 - For people with celiac disease, avoiding gluten is just one piece of the puzzle. Research shows that celiac disease often coexists with other autoimmune disorders, such as Hashimoto’s thyroiditis, Type 1 diabetes, and rheumatoid arthritis. This overlap raises important questions: Why do these conditions cluster together? What does this mean for diagnosis and management? And most importantly, how can individuals with celiac disease reduce their risk of developing additional autoimmune conditions? This article explores the science behind these connections, the shared mechanisms that trigger multiple autoimmune diseases, and practical steps for safeguarding long-term health. 1. The Autoimmune Link: Why Celiac Disease Often Comes with Company Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. Celiac disease—an immune reaction to gluten that damages the small intestine—is just one of over 100 recognized autoimmune disorders. Studies suggest that up to 30% of people with celiac disease develop at least one other autoimmune condition, compared to just 3-5% of the general population. Common Autoimmune Conditions Linked to Celiac Disease Hashimoto’s thyroiditis (underactive thyroid) Type 1 diabetes (pancreatic beta-cell destruction) Rheumatoid arthritis (joint inflammation) Sjögren’s syndrome (dry eyes/mouth) Lupus (systemic inflammation) Why does this happen? Shared genetic risk (e.g., HLA-DQ2/DQ8 variants) Leaky gut and molecular mimicry (gluten triggers immune cross-reactivity) Chronic inflammation perpetuating further autoimmunity 2. The Role of Genetics: Why Some Bodies Attack Themselves Genetics play a major role in autoimmune clustering. The HLA-DQ2 and HLA-DQ8 genes are present in nearly all celiac patients and are also linked to: Type 1 diabetes (50% genetic overlap with celiac disease) Hashimoto’s (higher prevalence in those with HLA-DQ2) However, genes alone aren’t enough—environmental triggers (like gluten, infections, or stress) "turn on" these conditions in susceptible individuals. 3. The Gut-Immune System Connection Celiac disease damages the intestinal lining, leading to "leaky gut"—where undigested food particles and bacteria escape into the bloodstream. This can: Trigger immune responses against other tissues (e.g., thyroid, joints). Worsen inflammation, creating a cycle that promotes additional autoimmune diseases. Key Fact: Early diagnosis and strict gluten-free diets may reduce the risk of developing other autoimmune conditions. 4. Common Autoimmune Partners of Celiac Disease A. Hashimoto’s Thyroiditis Prevalence: Up to 15% of celiac patients develop Hashimoto’s. Symptoms: Fatigue, weight gain, depression. Action Step: Request thyroid antibody tests (TPO, TgAb) if symptoms arise. B. Type 1 Diabetes Prevalence: 6-10% of Type 1 diabetics also have celiac disease. Symptoms: Unexplained blood sugar swings, nutrient deficiencies. Action Step: Screen for celiac disease at Type 1 diagnosis (and vice versa). C. Rheumatoid Arthritis (RA) Prevalence: 2-5x higher RA risk in celiac patients. Symptoms: Joint pain, morning stiffness. Action Step: Anti-inflammatory diets (e.g., gluten-free + omega-3s) may help both conditions. 5. Reducing the Risk: Can You Prevent a Second Autoimmune Disease? While genetics can’t be changed, these strategies may lower risks: Strict Gluten-Free Diet Reduces intestinal damage and systemic inflammation. Gut Healing Supplements Probiotics, L-glutamine, and vitamin D support immune balance. Regular Screening Annual thyroid, blood sugar, and nutrient level checks. Stress & Lifestyle Management Chronic stress worsens autoimmunity; mindfulness and sleep are key. 6. Conclusion: Empowerment Through Awareness For those with celiac disease, the connection to other autoimmune conditions can feel overwhelming—but knowledge is power. By understanding shared risks, staying vigilant with screenings, and adopting a proactive health approach, it’s possible to manage or even mitigate additional autoimmune diagnoses. Key Takeaways: Autoimmune clustering is common—celiac rarely travels alone. Genetics + environment = trigger—but diet and lifestyle matter. Early action helps—strict gluten-free eating may protect against further autoimmunity. If you have celiac disease, work closely with a healthcare provider to monitor for other conditions. With the right care, living well with autoimmunity is absolutely possible. Watch the video version of this article:

Celiac.com 07/29/2024 - Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder characterized by inflammation and impaired function of the thyroid gland, leading to hypothyroidism. The disease involves a complex interplay of genetic, environmental, and epigenetic factors, particularly affecting the regulation of T regulatory (Treg) cells, including CD4+ foxp3+ T cells. The FoxP3 transcription factor is crucial for the development and differentiation of Treg cells, which are essential for maintaining immune tolerance. Disruptions in this regulation can lead to immune dysregulation and proinflammatory responses. This study investigates the impact of dietary patterns, specifically the elimination of gluten and casein proteins, on the epigenetic changes in the FoxP3 gene in patients with HT. The primary aim is to evaluate how such dietary changes might influence the methylation levels of the FoxP3 gene, considering the potential link between these dietary components and the triggering of autoimmune diseases. Methods The study involved analyzing the methylation levels of the FoxP3 gene in two groups: patients with Hashimoto's thyroiditis following a strict casein-free and gluten-free diet, and a control group following a regular diet. The analysis was done before and after the dietary intervention to see if eliminating these proteins had any effect on the methylation levels of the FoxP3 gene. Results The results showed a significant reduction in the methylation levels of the FoxP3 gene in patients with Hashimoto's thyroiditis who adhered to the casein-free and gluten-free diet. This reduction was not observed in the control group, which continued with their regular diet. This suggests that the dietary intervention specifically influenced the epigenetic regulation of the FoxP3 gene in the patients with Hashimoto's thyroiditis. Discussion The reduction in methylation levels of the FoxP3 gene could potentially enhance its expression. Increased expression of FoxP3 would improve the function of regulatory T cells, which are vital for maintaining immune tolerance. This improvement could help prevent the immune system from attacking the body's own tissues, thereby reducing the autoimmune response in patients with Hashimoto's thyroiditis. The findings highlight the significant role of environmental factors, such as diet, in influencing epigenetic changes that regulate immune function. The study supports the idea that dietary interventions could be a viable strategy for managing autoimmune diseases through epigenetic mechanisms. Conclusion This study underscores the potential benefits of a casein-free and gluten-free diet in managing Hashimoto's thyroiditis through epigenetic changes. By reducing the methylation levels of the FoxP3 gene, such a diet may enhance the function of regulatory T cells, improving immune regulation and reducing autoimmune responses. These findings are particularly meaningful for individuals with celiac disease, as they highlight the broader implications of dietary changes on autoimmune health. Further research with larger and more diverse groups is needed to validate these findings and develop personalized dietary interventions for managing autoimmune diseases. Read more at: cureus.com

Celiac.com 03/11/2022 - As many of you already know, celiac disease can be associated with quite a few other autoimmune diseases such as lupus, fibromyalgia, Crohn’s, Sjogren’s, multiple sclerosis, diabetes, etc. In addition, celiac disease can also be connected with a few hormonal issues such as thyroid disease (specifically Hashimoto’s), adrenal fatigue, and high/low levels of estrogen. For those with celiac disease and hormonal issues, some of the symptoms you can experience include hot flashes, insomnia, headaches, weight gain or loss, fatigue, muscle spasms, heavy menstrual cycles, heart rate changes, and much more. There are many ways you can treat hormone imbalances, but many people prefer to first try more natural methods, in the hope of avoiding pharmaceutical medications. For those in this group, nutrition can be an excellent way to help stabilize your body’s estrogen levels and feel better fast. Foods to eat include pistachios, artichokes, cruciferous vegetables (broccoli, Brussels sprouts, kale, and cauliflower), chia and hemp seeds. Simply by incorporating these nuts, seeds, and vegetables into your daily lifestyle, you’ll begin to feel more energetic and have less pain. Even if you don’t happen to be living an allergen-friendly life, these foods can definitely be beneficial for hormonal regulation. For those with celiac disease, eating gluten-free foods can help reduce the intensity of your thyroid and adrenal fatigue symptoms. There are even certain herbs that can be beneficial for your hormone levels, and picking the right once, of course, will depend on your body’s individual needs. From maca, yarrow, red raspberry, ashwaganda, chase tree, black cohosh, mother wart, mugwort, shepherd’s purse, stinging nettle, to burdock. Choosing the right one may help decrease fatigue, lessen menstrual pain, reduce hot flashes, and ease headaches. Be sure to read up on the known side-effects of any of these herbs before taking them, as they may interfere with other conditions you may have, for example ashwaganda can increase your blood pressure. Lastly, there are certain types of exercises that can help to alleviate chronic pain and adrenal fatigue. Yoga can be a fantastic way to become flexible, strengthen muscles, and balance estrogen levels. Try working out three times per week doing yoga or light dancing. In summary, many people with hormone imbalances can often find relief with basic approaches, such as exercise, nutritional changes, and adding herbal supplements which can often make a big difference. References: Reuters.com Glutenfreesociety.org

Celiac.com 08/10/2019 - The Real Housewives of Beverly Hills star, Denise Richards, says her health is improving after she switched to a gluten-free diet in response to an enlarged thyroid. The 48-year old year star is also sending out big thanks to fans who spotted the abnormal growth on her neck during the show’s reunion episodes. “A few of you pointed out after the #RHOBH reunion that my thyroid was enlarged,” Richards wrote on Instagram. “You were right, it was something I ignored until pointed out.” Richards said that she is doing better after going gluten-free. “It’s amazing to me in a short time eliminating gluten from my diet how much my thyroid has changed,” she said. “… I had no idea how much our diet really can affect our body and for me how toxic gluten really is…I thank all of you who sent me messages.” Also known as a goiter, an enlarged thyroid is not harmful in itself, though it can cause some discomfort, and pain when swallowing or coughing. However, while generally harmless, goiters can be an indication of a more serious health issue, such as thyroid, Graves’ or Hashimoto’s disease, or even thyroid cancer. Many of these conditions are associated with celiac disease. Goiters are more common in women, especially women over 40. Goiters are usually treated with hormone-regulate drugs, surgery. Some mild cases may heal independently. Though commonly advocated in various online health and medical forums, a gluten-free diet has not been clinically shown to work, according to Scientific American. There is some recent evidence to support a gluten-free diet treatment for goiters. A clinical study published in July 2018 found that switching to a gluten-free diet did help women with autoimmune thyroid disease. Read more at People.com