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Celiac.com 05/16/2025 - For people with celiac disease, avoiding gluten is just one piece of the puzzle. Research shows that celiac disease often coexists with other autoimmune disorders, such as Hashimoto’s thyroiditis, Type 1 diabetes, and rheumatoid arthritis. This overlap raises important questions: Why do these conditions cluster together? What does this mean for diagnosis and management? And most importantly, how can individuals with celiac disease reduce their risk of developing additional autoimmune conditions? This article explores the science behind these connections, the shared mechanisms that trigger multiple autoimmune diseases, and practical steps for safeguarding long-term health. 1. The Autoimmune Link: Why Celiac Disease Often Comes with Company Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. Celiac disease—an immune reaction to gluten that damages the small intestine—is just one of over 100 recognized autoimmune disorders. Studies suggest that up to 30% of people with celiac disease develop at least one other autoimmune condition, compared to just 3-5% of the general population. Common Autoimmune Conditions Linked to Celiac Disease Hashimoto’s thyroiditis (underactive thyroid) Type 1 diabetes (pancreatic beta-cell destruction) Rheumatoid arthritis (joint inflammation) Sjögren’s syndrome (dry eyes/mouth) Lupus (systemic inflammation) Why does this happen? Shared genetic risk (e.g., HLA-DQ2/DQ8 variants) Leaky gut and molecular mimicry (gluten triggers immune cross-reactivity) Chronic inflammation perpetuating further autoimmunity 2. The Role of Genetics: Why Some Bodies Attack Themselves Genetics play a major role in autoimmune clustering. The HLA-DQ2 and HLA-DQ8 genes are present in nearly all celiac patients and are also linked to: Type 1 diabetes (50% genetic overlap with celiac disease) Hashimoto’s (higher prevalence in those with HLA-DQ2) However, genes alone aren’t enough—environmental triggers (like gluten, infections, or stress) "turn on" these conditions in susceptible individuals. 3. The Gut-Immune System Connection Celiac disease damages the intestinal lining, leading to "leaky gut"—where undigested food particles and bacteria escape into the bloodstream. This can: Trigger immune responses against other tissues (e.g., thyroid, joints). Worsen inflammation, creating a cycle that promotes additional autoimmune diseases. Key Fact: Early diagnosis and strict gluten-free diets may reduce the risk of developing other autoimmune conditions. 4. Common Autoimmune Partners of Celiac Disease A. Hashimoto’s Thyroiditis Prevalence: Up to 15% of celiac patients develop Hashimoto’s. Symptoms: Fatigue, weight gain, depression. Action Step: Request thyroid antibody tests (TPO, TgAb) if symptoms arise. B. Type 1 Diabetes Prevalence: 6-10% of Type 1 diabetics also have celiac disease. Symptoms: Unexplained blood sugar swings, nutrient deficiencies. Action Step: Screen for celiac disease at Type 1 diagnosis (and vice versa). C. Rheumatoid Arthritis (RA) Prevalence: 2-5x higher RA risk in celiac patients. Symptoms: Joint pain, morning stiffness. Action Step: Anti-inflammatory diets (e.g., gluten-free + omega-3s) may help both conditions. 5. Reducing the Risk: Can You Prevent a Second Autoimmune Disease? While genetics can’t be changed, these strategies may lower risks: Strict Gluten-Free Diet Reduces intestinal damage and systemic inflammation. Gut Healing Supplements Probiotics, L-glutamine, and vitamin D support immune balance. Regular Screening Annual thyroid, blood sugar, and nutrient level checks. Stress & Lifestyle Management Chronic stress worsens autoimmunity; mindfulness and sleep are key. 6. Conclusion: Empowerment Through Awareness For those with celiac disease, the connection to other autoimmune conditions can feel overwhelming—but knowledge is power. By understanding shared risks, staying vigilant with screenings, and adopting a proactive health approach, it’s possible to manage or even mitigate additional autoimmune diagnoses. Key Takeaways: Autoimmune clustering is common—celiac rarely travels alone. Genetics + environment = trigger—but diet and lifestyle matter. Early action helps—strict gluten-free eating may protect against further autoimmunity. If you have celiac disease, work closely with a healthcare provider to monitor for other conditions. With the right care, living well with autoimmunity is absolutely possible. Watch the video version of this article:
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Celiac.com 07/29/2024 - Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder characterized by inflammation and impaired function of the thyroid gland, leading to hypothyroidism. The disease involves a complex interplay of genetic, environmental, and epigenetic factors, particularly affecting the regulation of T regulatory (Treg) cells, including CD4+ foxp3+ T cells. The FoxP3 transcription factor is crucial for the development and differentiation of Treg cells, which are essential for maintaining immune tolerance. Disruptions in this regulation can lead to immune dysregulation and proinflammatory responses. This study investigates the impact of dietary patterns, specifically the elimination of gluten and casein proteins, on the epigenetic changes in the FoxP3 gene in patients with HT. The primary aim is to evaluate how such dietary changes might influence the methylation levels of the FoxP3 gene, considering the potential link between these dietary components and the triggering of autoimmune diseases. Methods The study involved analyzing the methylation levels of the FoxP3 gene in two groups: patients with Hashimoto's thyroiditis following a strict casein-free and gluten-free diet, and a control group following a regular diet. The analysis was done before and after the dietary intervention to see if eliminating these proteins had any effect on the methylation levels of the FoxP3 gene. Results The results showed a significant reduction in the methylation levels of the FoxP3 gene in patients with Hashimoto's thyroiditis who adhered to the casein-free and gluten-free diet. This reduction was not observed in the control group, which continued with their regular diet. This suggests that the dietary intervention specifically influenced the epigenetic regulation of the FoxP3 gene in the patients with Hashimoto's thyroiditis. Discussion The reduction in methylation levels of the FoxP3 gene could potentially enhance its expression. Increased expression of FoxP3 would improve the function of regulatory T cells, which are vital for maintaining immune tolerance. This improvement could help prevent the immune system from attacking the body's own tissues, thereby reducing the autoimmune response in patients with Hashimoto's thyroiditis. The findings highlight the significant role of environmental factors, such as diet, in influencing epigenetic changes that regulate immune function. The study supports the idea that dietary interventions could be a viable strategy for managing autoimmune diseases through epigenetic mechanisms. Conclusion This study underscores the potential benefits of a casein-free and gluten-free diet in managing Hashimoto's thyroiditis through epigenetic changes. By reducing the methylation levels of the FoxP3 gene, such a diet may enhance the function of regulatory T cells, improving immune regulation and reducing autoimmune responses. These findings are particularly meaningful for individuals with celiac disease, as they highlight the broader implications of dietary changes on autoimmune health. Further research with larger and more diverse groups is needed to validate these findings and develop personalized dietary interventions for managing autoimmune diseases. Read more at: cureus.com
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Celiac Disease, Hormone Imbalances, and Nutrition
Sarah Curcio posted an article in Winter 2022 Issue
Celiac.com 03/11/2022 - As many of you already know, celiac disease can be associated with quite a few other autoimmune diseases such as lupus, fibromyalgia, Crohn’s, Sjogren’s, multiple sclerosis, diabetes, etc. In addition, celiac disease can also be connected with a few hormonal issues such as thyroid disease (specifically Hashimoto’s), adrenal fatigue, and high/low levels of estrogen. For those with celiac disease and hormonal issues, some of the symptoms you can experience include hot flashes, insomnia, headaches, weight gain or loss, fatigue, muscle spasms, heavy menstrual cycles, heart rate changes, and much more. There are many ways you can treat hormone imbalances, but many people prefer to first try more natural methods, in the hope of avoiding pharmaceutical medications. For those in this group, nutrition can be an excellent way to help stabilize your body’s estrogen levels and feel better fast. Foods to eat include pistachios, artichokes, cruciferous vegetables (broccoli, Brussels sprouts, kale, and cauliflower), chia and hemp seeds. Simply by incorporating these nuts, seeds, and vegetables into your daily lifestyle, you’ll begin to feel more energetic and have less pain. Even if you don’t happen to be living an allergen-friendly life, these foods can definitely be beneficial for hormonal regulation. For those with celiac disease, eating gluten-free foods can help reduce the intensity of your thyroid and adrenal fatigue symptoms. There are even certain herbs that can be beneficial for your hormone levels, and picking the right once, of course, will depend on your body’s individual needs. From maca, yarrow, red raspberry, ashwaganda, chase tree, black cohosh, mother wart, mugwort, shepherd’s purse, stinging nettle, to burdock. Choosing the right one may help decrease fatigue, lessen menstrual pain, reduce hot flashes, and ease headaches. Be sure to read up on the known side-effects of any of these herbs before taking them, as they may interfere with other conditions you may have, for example ashwaganda can increase your blood pressure. Lastly, there are certain types of exercises that can help to alleviate chronic pain and adrenal fatigue. Yoga can be a fantastic way to become flexible, strengthen muscles, and balance estrogen levels. Try working out three times per week doing yoga or light dancing. In summary, many people with hormone imbalances can often find relief with basic approaches, such as exercise, nutritional changes, and adding herbal supplements which can often make a big difference. References: Reuters.com Glutenfreesociety.org-
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Celiac.com 08/10/2019 - The Real Housewives of Beverly Hills star, Denise Richards, says her health is improving after she switched to a gluten-free diet in response to an enlarged thyroid. The 48-year old year star is also sending out big thanks to fans who spotted the abnormal growth on her neck during the show’s reunion episodes. “A few of you pointed out after the #RHOBH reunion that my thyroid was enlarged,” Richards wrote on Instagram. “You were right, it was something I ignored until pointed out.” Richards said that she is doing better after going gluten-free. “It’s amazing to me in a short time eliminating gluten from my diet how much my thyroid has changed,” she said. “… I had no idea how much our diet really can affect our body and for me how toxic gluten really is…I thank all of you who sent me messages.” Also known as a goiter, an enlarged thyroid is not harmful in itself, though it can cause some discomfort, and pain when swallowing or coughing. However, while generally harmless, goiters can be an indication of a more serious health issue, such as thyroid, Graves’ or Hashimoto’s disease, or even thyroid cancer. Many of these conditions are associated with celiac disease. Goiters are more common in women, especially women over 40. Goiters are usually treated with hormone-regulate drugs, surgery. Some mild cases may heal independently. Though commonly advocated in various online health and medical forums, a gluten-free diet has not been clinically shown to work, according to Scientific American. There is some recent evidence to support a gluten-free diet treatment for goiters. A clinical study published in July 2018 found that switching to a gluten-free diet did help women with autoimmune thyroid disease. Read more at People.com
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I am currently searching for a Doctor that can help me monitor multiple health issues. I have Celiac Disease, Hashimoto Thyroid, Vitiligo, and Pernicious Anemia. I am looking for Tri Cities, WA, Walla Walla WA, or Spokane, WA. I need someone who understands the complications each of the diseases can have themselves as well as the potential combination of issues. Someone who will monitor my bloodworm etc. but can think in gray, not just black and white. I take Levothyroxine and have had monthly B12 injections for about 16. I take Vitamin D supplements to keep the level up. I take numerous other supplements and have been on a strict gluten-free diet for 41/2 years. I do have other food allergies too. I do not absorb Iron well at all and have had a Hematologist monitor my Ferritin etc. It began about 6 years ago. I was having trouble with a constant dry cough and was sent to a Pulmonologist, who determined I was not getting enough oxygen to my lungs. My PCP did a lot of blood work and found I had a Ferritin level of basically 0 and Hemoglobin of 5.5. Tried mega Iron supplements with no change in level. The doctor told me to throw them away and had me begin Iron Infusions She helped me get it leveled out after a few years and now I don't need them as often. The Hematologist was the one who suspected Celiac Disease and sent me to be tested. (Please note I had been scoped up and down numerous times, swallowed a camera and still the Gastro could not find anything wrong. Never did a biopsy. He attributed my issues to IBS....) About a year ago my most excellent Hematologist left the practice and moved far away. She was very intelligent, keen, and thought outside the box in many ways. I could count on her to test, evaluate and analyze my bloodwork. She was an excellent communicator and would research for additional information. It is difficult to explain how comfortable I was with her managing my care. I no longer feel that way and for the last year my Ferritin has been between 8 and 10.8 and the Saturation has been hovering around or below the low level. And I have not had any infusions. Thank you!
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have Hashimotos hypothyroidism. was whole foods vegan for 5 years. in January I went to get blood panel ( because I couldnt digest properly and was having depression come back and weakness) and ldl was high and omegas low, decided to start eating meat again. for the last 6 months I've been struggling with hemorrhoids and possibly anal fissures. went gluten free once again (prior to all of this I had started eating gluten again for about 3 months) and mostly AIP and hemorrhoid has improved but not gone and still bleeds. if I eat certain things my stomach from below my belly button feels swollen, I thought possibly sibo but last weekend I ate pizza (not gluten free) and ever since then my stomach has felt super swollen . is this possibly just a gluten issue? It's not gas but literally feels like my intestines are swollen, and it lasts for days after eating gluten or other foods that I suspect had gluten contamination. The swelling typically only happens the next day or several hours later that night and lasts 3-5 days.
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Hi all, This is my first post here. I'm a college student and I have to eat most meals on the go, I'm also a nanny and have no choice but to cook and eat in a mixed kitchen for work. I also live in a home with HEAVY gluten eaters. It is not financially viable at this point in my life for me to buy my own pots and pans, utensils, etc. I have two main parts to my problem: 1. It is so overwhelming to be gluten free when I eat most of my meals on a college campus where they don't pay any mind to if the food is being cross contaminated. I try to bring lunch and snacks, but I am out for 15-18 hours a day and forget or get hungry and need to buy additional food while I'm out. What are some meal prep tips y'all can give me? How can I ensure these meals stay gluten free when I'm stuck living in a home with a mixed kitchen? I don't have a dishwasher, so even washing the dishes makes me nervous. I'm trying to learn how to cook but my anxiety over gluten is at the point where I don't even want to be around the kitchen. 2. I've been gluten free for a year now, since my diagnosis with both celiac and hashimoto's disease. I'm VERY sensitive to cross contamination. I work at this so hard, I'm hyper vigilant, I annoy restaurant employees asking them to change utensils and wipe surfaces and change gloves, I annoy everyone in my home about cleaning up between prep, I obsessively read labels. I feel like being gluten free is a full time job, and I STILL get severely glutened regularly. It has happened twice just this week, and I get so sick every time. What else am I supposed to do? How much hidden gluten is there? On this one, I really could just use some support and maybe quick tips on how to keep this from feeling so difficult. Thank you so much in advance. This whole thing is so difficult. I'm young and want to be able to enjoy meals out with friends, cook for the kids I watch, eat on campus, enjoy my life, and just to not be sick half the time.
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So a couple years ago I was tested for celiac... Ttg IgG/IgA were all negative DGA IgG/IgA were all negative AGA IgG: Positive AGA IgA Negative HLADQB1*02 Negative HLADQB1*03:02 Negative HLADQA1*05 Positive Biopsies have all been negative. I suffer from Hashimoto's thyroiditis and I just feel miserable with all the body aches and brain fog. My son was born back in July and I'm just so tired of not feeling well and I really want to finally feel good and enjoy life to the fullest. I'm thinking of asking for my labs to be repeated again and see. I'm just wondering if it is possible for me to still have celiac or if I'm just looking for something that just isn't there because I'm desperate for answers... Appreciate any input!! Thank you
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Hello! I have read many forums on this site over the past few months and it has been incredibly helpful. I am here now because I am basically in a "resource desert" as far as services and doctors in my area and I desperately need advice. Question & Concern #1: I have been gluten free for about 6 months now due to problems that started about a year and a half ago including constipation, gas, bloating, anxiety & depression. After going gluten free my symptoms quickly resolved themselves and I have been happily gluten free ever since. However, my doctor (I have had no previous medical issues and so I trusted her opinion without doing my own research -believe me I learned my lesson) does not connect those symptoms with Celiacs disease so even though I thought that there was a connection and voiced my opinions, testing was not done. I was told that it "didn't matter" if I had the diagnosis since the treatment either way is eating gluten free. I have learned from this site that was 100% wrong. Although I may not have Celiacs, even if there is a 1% chance that I do, I feel that I deserve to know. I have a doctors appointment this week and I really need advice for what to fight for, so far I have heard of these options: 1. Eating gluten for 90 days and getting a blood test done (although I have heard this is not the most accurate way to diagnos Celiacs and I dread the thought of eating gluten for 90 days) 2. Eating gluten for 2 weeks and getting an endoscopy - am I allowed to request this?? 3. Genetic testing - sort of what I am leaning towards right now because if I do have the genetic disposition I would just live the rest of my life like I have Celiacs. Is there any reason that I NEED the actual diagnosis? If you were in my situation what would you recommend? Question & Concern #2: I was tested for hypothyrodisim because everyone in my maternal family has been diagnosed with that but they all were diagnosed later in life (early 40s, I believe my mother went through premature menopause becuase it was undiagnosed for so long). Nobody in my family has heard of Hashimotos but when talking with my friend who is a nurse who has Hashimotos she said that sometimes the TSH test that I was given won't pick up on that. My TSH result was a 2.6 which I believe is slightly higher than the ideal range although the normal range on that result was considered up to a 5. I am going to go in and request to make sure that I don't have hypothyroidism of any kind including Hashimotos. Does anybody have any relevant advice for what tests I should request? I have been googling it but I was wondering if anybody went through that and has personal experience for the tests. I also really need to know: - Can going gluten free help cure Hashimotos/Hypothyrodism symptoms? (I also am FREEZING cold all the time which is another indicator of that and most of the reasons I went gluten free could be indicators of Hashimotos as well - I do know there is a connection but I really didn't know if eating gluten free would help alievate the symptoms). -Will going gluten free affect getting a diagnosis for Hypothyroidsm/Hashimotos? To add on to it - My husband & I were planning on trying to start a family in March so I really pray that all this can be resolved quickly so we can start our family in the next year because I don't want to start trying until I have some answers. ANY advice/websites/articles/books would be incredibly helpful for me right now. If you know anybody on the site who has experience with Hashimotos and gluten sensitivity or Celiacs I would be super appreciative if you could reach out to them to get me some help. I am in the process of finding a new doctor but it is a slow process (no appointments in my area until February) so I am keeping my appointment with the doctor who doesn't want to do the Celiacs testing so I want to be as informed as possible so I can really stick to my guns and insist on what is best for me (and my future babies!!). I feel lost & not sure what information is reliable so I'm just looking for people who have more experience than I do to help! Thank you all so much ~Shannon
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Hi All - I was recently diagnosed with Hashimotos. My doctor said TPO AB 76 is above range. I initially went to the doctor because since graduating college 3 years ago I have gotten a significant number of gray hairs (25% of my hair I would say) and I just turned 25 and am an African American woman. She put me on OMP Thyrotain. Has anyone used this? She has also advised me to go gluten free. Has anyone seen any reversal in the grey hair? I don't consider myself a shallow person but at such a young age, without any family history of this, it's really impacting me negatively. Any advice or experiences would be so helpful.
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