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I found these neat articles. B cells defined by immunoglobulin isotypes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985177/ And... Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1 https://pubmed.ncbi.nlm.nih.gov/26411688/ And... Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478888/ And... TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448773/ Immune cells called B cells need thiamine to become antibody producing cells. If there's a thiamine deficiency, the B cells cannot become antibody producing cells and there's less of an immune reaction. Different types of B cells produce different types of antibodies. B cells that can produce IgG antibodies are in the bloodstream, so they are the first line of defense. They can use different methods of making energy, so are not dependent on Thiamine to be able to change into IgG antibody producing cells. IgA antibodies are produced mainly in the intestines after B cells which produce IgA antibodies are changed into IgA antibody producing cells. This change is dependent upon Thiamine. If there's not sufficient thiamine, fewer B cells can change and fewer IgA antibodies are produced. The IgA antibodies stay in the intestines until there's sufficient numbers of them they get into the bloodstream from the intestines. Some of us are seronegative. Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/ Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/ Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/
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Hello! I was hoping someone would be able to explain a little more to me about the recent blood results I have received. Long story short, I am a female in my mid twenties, I lost 30 pounds in the span of three months with no explanation (5'6" 128lbs in February of 2020, down to 98lbs in April of 2020). I have since gained a few pounds over the last year, but not much, I now rest around 101/102lbs. I was tiny before, and now I am extremely underweight. I am eating normally and have been, no changes in exercise, no explanation. I noticed I started having typical GI issues related to Celiac, went to four different doctors who kept telling me I had an eating disorder (which I am eating the exact same as I always have and have not changed any exercise patterns) which was very frustrating because I knew something was wrong, but no one was taking me seriously. Finally one doctor decided to test me for Celiac and we got a positive result back on one of the tests and I now have to get an EGD and colonoscopy done (they want to look for multiple things at the same time for a biopsy from what I understand). However, no one has really explained anything to me so I have been trying to do my own research. (They tested me for other things such as diabetes, thyroid, etc. and nothing was positive except the celiac panel). These were the tests run and the results (picture of test and result numbers listed below): Antigliadin Abs, IgA; Antigliadin Abs, IgG; t-Transglutaminase (tTG) IgA; t-Transglutaminase (tTG) IgG; Immunoglobulin A, Qn, Serum The only thing that came back positive was the t-Transglutaminase (tTG) IgG at a score of (7) which is scored as a weak positive. What does this mean? Is this also affected also by the amount of gluten that is consumed (I do not eat much to begin with because I picked up that it was gluten that was giving me issues and I have been reading that you have to eat a good amount of gluten to be able to get a solid positive test). What does it mean that the TTG-IGG came back positive, but the TTG-IGA came back negative? And that none of the other ones came back positive? I've also been reading about sensitivities and specificities of the blood tests, but don't entirely understand what that means if someone can help explain that as well. Thank you all so much ahead of time, I really appreciate your help to help me understand the beginning of this journey!
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Celiac.com 09/14/2020 - Researchers understand that celiac disease is marked by robust B cell and antibody responses to gluten, and to the transglutaminase 2 (TG2) autoantigen. In contrast, non-celiac gluten sensitivity (NCGS) is marked by the absence of the physical or testable features of celiac disease. Beyond that, researchers don't know much about NCGS. There are no established biomarkers yet for NCGS, but research shows a state of systemic immune activation together with a compromised intestinal epithelium. Researchers have been homing in on IgG antibody response to gluten as a means of distinguishing non-celiac gluten sensitivity (NCGS ) from celiac disease. A team of researchers recently set out to observed differences in the IgG subclass distribution and relationship with FABP2 release in NCGS versus celiac disease. The team's recent paper describes a contrast in the IgG subclass distribution and relationship with FABP2 release in NCGS versus celiac disease, which, they say, demonstrates differences in the evolution and disease relevance of B cell immune responses in each condition. Pathways involved in this process may make tempting targets for molecular therapy focused on disrupting or blocking the pathway. The team demonstrated that the anti-gluten IgG antibody in NCGS differs substantially from celiac disease in subclass distribution, and in terms of intestinal cell damage. The data suggests a sustained primary B cell response to gluten in celiac patients, despite the condition’s chronicity, and a more advanced and less intense immune response to gluten in NCGS. Based on their data, the team is calling for further study of the evolution of gluten-reactive B cell response and subclass switching in celiac disease and NCGS. In addition, they expect information on other aspects of B cell and antibody variability, including affinity, glycosylation profile, and epitope specificity, to improve the understanding of differences in the immune response to gluten, and its relationship with disease pathophysiology, in the two conditions. Coupled with markers described earlier, these aspects of immune response to gluten will likely offer more biomarkers that may help to clarify potential disease subsets with varying mechanisms, prognoses, and therapeutic efficacy. Researchers are making critical progress in distinguishing celiac disease from NCGS. Their efforts could drive breakthroughs in the diagnosis and treatment of both conditions, so their ongoing study is important. Read more in Gastroenterology The research team included Melanie Uhde, PhD, Giacomo Caio, MD, Roberto De Giorgio, MD, Peter H. Green, MD, Umberto Volta, MD, and Armin Alaedini, PhD. They are variously affiliated with the Department of Medicine, Columbia University Medical Center, New York, NY, USA; the Institute of Human Nutrition, Columbia University Medical Center, New York, NY, USA; the Celiac Disease Center, Columbia University Medical Center, New York, NY, USA; the Department of Medical Sciences, University of Ferrara, Arcispedale St. Anna, Ferrara, Italy; the Celiac Disease Center and Mucosal Immunology and Biology Research Center, Massachusetts General Hospital – Harvard Medical School, Boston, MA, USA; the Department of Medical and Surgical Sciences, University of Bologna, Italy; the Department of Medicine, New York Medical College, Valhalla, NY, USA.
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Iron: 17 mcg/dL (Low) November 11, 2016 Ferritin: 1.8 ng/mL (Low) November 11, 2016 RBC: 4.05x10^6/uL (Low) November 11, 2016 Hemoglobin: 8.5 gm/dL (Low) November 11, 2016 Vitamin D: 25.7 ng/mL (Low) February 22, 2017 ANA Profile : February 27, 2017 FANA: Positive FANA Titer: 1:640 FANA Pattern: Homogenous Gliadin IgA: 2 units June 29, 2017 Gliadin IgG: 3 units June 29,2017 TTG Ab IgA: <1 units/mL June 29, 2017 TTG Ab IgG: <1 units/mL June 29, 2017 Immunoglobulin A: 59.1 mg/Dl (Low) July 10, 2017 Immunoglobulin M: 44.2 mg/Dl (Low) July 10,2017 Immunoglobulin G: 1010.0 mg/Dl (Normal?) July 10, 2017 Immunoglobulin E: 5 KU/L July 10,2017 My RBC and Hemoglobin have come up and are normal. My iron levels will get high (too high) when I take 65 mg elemental iron twice a day for several weeks but my ferritin has never gotten over 42 ng/mL. When I stop taking my iron supplement my iron and ferritin plummet in just a matter of weeks. My hair is falling out, I get rapid heartbeat when I get too low on iron and if I get my iron too high. My whole body hurts especially my finger joints, back , knees and really all of my joints. Going to the bathroom at least 2 times day and sometimes up to 5 times a day. Extreme fatigue, Brain fog, extremely emotional and irritable. I just went gluten free July 1, 2017 and am starting to feel better. Joints feel better, I can sleep better, my mood is better. Celiac or maybe just gluten sensitive? Any thoughts? What do my labs say about me?
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Hi everyone, This is my first post so bear with me. I have been lurking and reading many helpful posts but was hoping to share my current situation and ask for advice. Around 2 months ago I got what I thought was the flu. I had a fever, aches, diarrhoea and an odd fast heart rate with a bounding pulse. I also developed high blood pressure for the first time in my life and it was usually around 150/100 when high. Most of the symptoms cleared up in a couple days but the diarrhoea and heart complications remained. I have seen a cardiologist and they ran me through tests like ECG and 24 hrs halter. The diagnosis was that my heart was structurally normal and he thought my heart was reacting to the virus as I recovered. In the first month I lost about 10-15lbs and became pretty weak. My stomach would normally feel fine through the day but would cause a lot of bloating pain overnight. I eventually saw a GI doc and he ran a series of blood tests for me. My thyroid, liver and full blood counts were good but the celiac screen showed a positive value. Below were my results. anti-gliadin peptides iga 13, normal range 0-25 anti-gliadin peptides igg under 2, normal range 0-25 TTG IGA 3, normal range 0-20 TTG IGG 31, normal range 0-10 So it would appear my TTG IGG was the only positive which seems a bit unusual. The GI doc would like to do the biopsy but I have concerns about getting put to sleep when my heart is abnormal. I am hoping I can consider the elevated TTG IGG as a diagnosis and forego the biopsy if possible. I have 2 young kids and am 32 right now so I am hoping to look at Long term recovery. In terms of background I had GBS when I was 18 so I have a history with autoimmune. My Sister has autoimmune arthritis and my Mother has autoimmune psoriasis. My grandpas sister and my cousin have celiac disease. I started taking some vitamin supplements and feel better but the worst symptoms remaining are the heart complications, achey joints and poorly digested food. Thanks for your time.
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Celiac.com 01/08/2020 - Researchers currently don't have much good information on the frequency of hypogammaglobulinemia (Ig deficiency) in people with multiple sclerosis. A team of researchers recently set out to assess the frequency of reduced immunoglobulin (Ig) concentrations and its association with immunotherapy and disease course in two independent multiple sclerosis study groups. The research team included Greta Zoehner, Andrei Miclea, Anke Salmen, Nicole Kamber, Lara Diem, Christoph Friedli, Maud Bagnoud, Farhad Ahmadi, Myriam Briner, Nazanin Sédille-Mostafaie, Constantinos Kilidireas, Leonidas Stefanis, Andrew Chan, Robert Hoepner, and Maria Eleftheria Evangelopoulos. The team's retrospective cross-sectional study included multiple sclerosis patients and control patients with head or neck pain from Bern University Hospital in Bern, and Eginition University Hospital in Athens. The lower limits of normal (LLN) for serum Ig concentration were IgG < 700 mg/dl, IgM < 40 mg/dl, and IgA < 70 mg/dl. The team analyzed the results using the Mann–Whitney U test, analysis of variance test, and multiple linear regression. The study shows that multiple sclerosis patients have high rates of reduced serum IgG concentrations, both with and without disease-modifying treatments. Interestingly, in patients with other autoimmune diseases, Ig deficiency is also more prevalent, and 1.7% of patients with celiac disease and 5.2% of patients with systemic lupus erythematosus also have IgA deficiency. Given that infections or interference with antibody production usually happen at much lower IgG levels, around 400 mg/dl, and below, the importance of lower IgG concentrations at the levels noted remains unknown. The team suggests using the information to monitor IgG levels, particularly with anti-B-cell therapies, and considering IgG substitution at levels below 400 mg/dl. Read more in Therapeutic Advances in Neurological Disorders The researchers are variously affiliated with the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; the University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; the Center of Laboratory Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; the Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; and the Department of Neurology, Eginition University Hospital at the National and Kapodistrian University of Athens, Athens, Greece.
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Hi everyone, I had my TTG IGG test done recently by Quest Diagnostics and it came back as "10" (6 and higher is positive)... My TTG IGA test only came back as a "1" ( 4 and higher is positive)... First question, is 10 considered pretty high/noteworthy on the IGG or kinda not really? --They also tested for Gliadin (deamidated) IGA and it came back "5". Gliadin (deamidated) IGG came back as "2". For both 20 or higher is considered positive. Whatever all that is. The Dr. was basically like, this means you're really allergic to gluten (the high IGG score) and should just act like you have celiacs, which you (likely) don't.. I'm reading a lot though about positive IGG scores and negative IGA scores and not so reassured. Curious if any gurus can interpret my results better than I can. She didn't ever suggest an endoscopy etc just said cut out gluten. Thanks, Cal
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When all Else Fails: These Solved My Health Problems!
1desperateladysaved posted a blog entry in 1desperateladysaved's Blog
Sometimes the celiac diagnosis isn't the whole answer. I don't want to confuse new people; it does take some months to recover, but if recovery takes more than a year, although you sense movement; I would most certainly start looking for other possible problems contributing to your symptoms. I have been there and believe I have conquered. Here is my list of great helps: IGG/IgA sensitivity test: This essentially helped me to be on the diet I use now as I stopped eating everything that I had antibodies to. As I added foods back under the advice of my physician, I didn't feel the fatigue I expected that would indicate to me a problem. I kept eating those foods until I realized I swelled more and more and gained 45 lbs! The diet didn’t include sweets or gluten! It was then I realized I needed to go back to my strictest diet. About that time I discovered the work of Izabella Wentz (thyroid pharmacist). I took her course and discovered that viruses can trip celiac. Finally, I realized I needed to address the Epstein-Barr virus that took up residence in me and likely tripped my celiac many decades before. I tried many treatments to build up and nourish my body, but I hadn’t ever done things to kill old viruses that are stubborn and elusive for the immune system. I felt really sick when I tried to take supplements for that, so I looked for further help. I watched Izabella Wentz's "Thyroid Secret" and there I discovered that a person with similar symptoms (swelling, bloating, fatigue) that received helped from nutritionist Teri Cochrane in Reston, Virginia. Teri became instrumental in helping me to feel better and I hope now I know what I need to know to stay there. I highly recommend visiting with Teri if you are in difficulty or to maximize your health. Teri Cochrane: Teri accessed my genetics and informed me of my difficulties in breaking down protein, fats, sulfur foods (someone told me that here years back) and my own hormones! Knowing this helped tremendously, no longer did my problems seem so mysterious. Teri has a Wildetarian quiz online that may help you to access if you have any of these difficulties. IF you are having trouble this quiz is free and helpful. Teri Cochrane also wrote a book: The Wildetarian Diet I highly recommend it if you wish to try using the diet. She has recipes and gets very practical. In my visit with her Teri also confirmed that Epstein-Barr virus triggered celiac and still wreaked havoc in me. Also, she discovered another virus (C virus) I don't know how to spell it. Wild Diet: The diet Teri put me on came from information derived using my 23andme test. My diet contains proteins such as bison, duck eggs, elk, wild caught fish and duck. My vegetables include lettuce, sweet potatoes, olives, seaweed and peppers. My fruits are mostly cherries and berries. I also eat sunflower and pumpkin seeds, pecans and hazelnuts. I use Wild rice. I had tried a similar diet with the food sensitivity tests, so I am reasonably confident the diet is helpful Energy treatments: I used NAET and Biofeedback to help get rid of my Epstein-Barr and also had treatments for tick-borne diseases and food allergies. I used this concurrently with diet and supplements, so it is difficult to always say just what worked. At this point, I don’t care as long as I have energy. I feel the energy treatments caused extreme and long detox responses followed by great improvements in my health and energy levels. Chiropractic: I did regular back adjustments that seemed to be more and more helpful with other improvements. Recently, we discovered my vagus nerve had been attacked by the virus and my chiropractor had an effective treatment to help it. This further improved my digestion and general health. Not to mention that my chiropractor first mentioned my gluten problem and kept me alive with her supplements when I was at my worse. After living most of 35+ years in foggy fatigue, my energy is back up and I feel like a whole person. My diet is satisfying and nourishing. My weight is down to a normal level. After all this work, I need to say that with the Creator, Jesus's miracle in my health. I would not be here today. Teri Cochrane said that my body was designed to heal; I believe it!- 2 comments
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Hello, What does my results mean? Am I allergic to gluten? tTg-IgG 8.62 tTg-IgA 3.02 Anti Gliadin IgA 93.24 And what’s the normal range for each? Thank you!
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Last week I got my ceilac penal results Although in my biopsy doctor confirm me as ceilac patient I am on gluten free diet since 3 month. Still some problems are there.. endomysial anti body IGA negative.. tissue transglutmanise Ab ,iga 5 u/ml. Immune globulin A is 213 . Thanks and any good vitamins.
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If anyone could clear this up for me it would be really helpful. My primary care doctor wasn’t able to get me in for months and my insurance isn’t very good so I found a lab online to do blood work. i only did the gluten allergy IGg blood test. I got my results online today and I don’t understand them fully. From what it says I’m ‘in range’ but my range is exactly what the range number is. Therefor is it higher than average just not high enough to be out of range? This is the results I have. In range <2.0 Reference range <2.0 mcg/mL so technically I’m not over the range but there’s nothing to reference, as in do most people that aren’t gluten sensitive have a 0? Because I feel awful most days with serious brain fog, anxiety and depression and massive headaches that never go away and stomach cramps and I can’t see what else could be causing this. I already had an ultrasound from my gynecologist and I don’t have anything visably wrong on the ultra sound causing the stomach cramping. Any insight would be helpful since I can’t get a doctor to fully interpret this. Thank you!!
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Hi Everyone, I am sure that this question has been asked multiple times but I am new to this forum as well as the Celiac world. I haven't been feeling like myself health-wise for a couple years now, with my stomach always being bloated, crampy, irritated, and just plain old not feeling well. I am a 20 year old nursing student so I had not had the time to focus on what the issue may be but I finally decided that I wanted to figure it out. I love pasta, but every time I ate it my stomach would expand to the size of a 5 month old pregnant woman and become rock solid I got tested for gluten sensitivity and the test came back as having high allergen gluten IgG levels. It says that the normal amount is less than 2.0 mcg/mL and my results read 6.4 mcg/mL. The doctor at my school said the only way to determine if this is Celiac is to get a biopsy and see a GI doctor. It's not easy for me to do that as I am a busy student, out of state. I was wondering if anyone knew if this was a good indication of Celiac or non-celiac gluten sensitivity. I know it is hard to determine from that one test but I'm looking for all the help I can get. Thank you! - Naomi Moore
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Hello, I've been having a lot of stomach problems recently, so I thought to get tested for a few things including celiac disease. My results are interesting though. If anyone could give me insight on what this could mean please let me know! Picture attached with the blood test in question with doctor notes. Thanks
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