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Showing results for tags 'immunologic'.
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Jefferson Adams posted an article in Celiac Disease & Gluten Intolerance ResearchCeliac.com 02/16/2010 - A team of German clinicians recently noted a case that indicates that tumors may influence immunologic reactions. The team included F. Mühr-Wilkenshoffa, M. Friedricha, H.-D. Fossb, M. Hummelb, M. Zeitza, and S. Dauma. They are associated with the Medical Clinic I, Gastroenterology, Rheumatology and Infectious Diseases, and with the Department of Pathology, Charité at University Medicine Berlin. They recently reported on the case of a 72-year-old patient who suffered from celiac disease that had been diagnosed in his early fifties. The patient had not followed a gluten-free diet. Rather, he had eaten a normal diet. However, he showed no evidence of enteropathy or celiac-associated antibodies. Still, the patient developed a jejunal T-cell lymphoma. Due to perforation, the team performed a resection, and added four courses of IMVP-16. The patient switched to a strict gluten-free diet. After two years, he presented with weight loss and a clonally divergent refractory sprue type II with loss of antigen (CD8; T-cell receptor-Î²) expression in intraepithelial lymphocytes. At that point, even though he remained on a strict gluten-free diet, he showed elevated blood levels of celiac-associated antibodies. The team notes several interesting facets to the case. First, the lack of enteropathy under a gluten-containing diet supports the notion that malignant diseases, especially non-Hodgkin lymphoma, trigger immune suppression. Secondly, the fact that, while still on a strict gluten-free diet, the patient developed an early form of a second independent T-cell lymphoma (refractory sprue type II), coupled with the celiac-associated antibodies, raises the question whether the clonal intraepithelial lymphocytes might be stimulating antibody production. Thus, taken alone, the detection of celiac-associated antibodies in patients with celiac disease is not sufficient to prove noncompliance with gluten-free diet. Source: Digestion 2010;81:231-234 (DOI: 10.1159/000269810)
Scott Adams posted an article in Oats and Celiac Disease: Are They Gluten-Free?Gut 2000;46:327-331. March 10, 2000 Celiac.com 03/17/2000 - Finish researchers report that people with celiac disease who eat oats show no adverse autoantibody or intraepithelial lymphocyte level effects. According to Dr. M. I. J. Uusitupa (University of Kuopio), and colleagues: Wheat, rye, and barley have harmful effects on the small intestinal mucosa of patients with coeliac disease, whereas maize and rice are harmless...(H)owever, the place of oats in the coeliac diet has been debated. The researchers studied two groups: 40 adults with newly diagnosed celiac disease and 52 adults whose celiac disease was in remission. The people in both groups were randomized to either a conventional gluten-free diet, or a gluten-free diet that also included oats. Both groups were monitored for autoantibodies and intraepithelial lymphocytes over a 6- or 12-month period. In the patients with newly diagnosed celiac disease the disappearance rates of antireticulin antibodies, antigliadin antibodies, and intraepithelial lymphocytes were the same, regardless of their diet. Likewise the people with celiac disease that was in remission had similar antibody and intraepithelial lymphocyte levels between both dietary groups. According to the researchers: These results strengthen the view that adult patients with coeliac disease can consume moderate amounts of oats without adverse immunological effects. The researchers also note that: more clinical studies are needed to ensure the safety of oats when consumed permanently in a coeliac diet as well as to determine the effect of larger amounts of oats.