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Celiac.com 03/08/2018 - A team of researchers recently set out to study delays in diagnosing patients who have biopsy-proven celiac disease with gastrointestinal complaints, compared to those without non-gastrointestinal complaints. The research team included Marco A. Paez, MD, Anna Maria Gramelspacher, MD, James Sinacore, PhD, Laura Winterfield, MD, and Mukund Venu, MD. They are variously affiliated with the Division of Gastroenterology, Department of Medicine, Howard College of Medicine, Washington, DC; the Department of Medicine, the Department of Public Health Sciences, the Division of Gastroenterology, and the Department of Medicine at Loyola University Medical Center in Maywood, Illinois. The research team first conducted a medical chart review of 687 adult patients diagnosed with celiac disease. All patients they studied had biopsy-proven celiac disease and were grouped according to presence or absence of gastrointestinal symptoms before diagnosis. The team found 101 biopsy-proven celiac patients that met their study criteria. The groups were roughly equal in size, with 52 patients showing gastrointestinal symptoms before diagnosis, and 49 with no gastrointestinal symptoms. The results for the groups were starkly different. Statistical analysis revealed an average diagnosis delay of 2.3 months for the group with gastrointestinal symptoms, while the group that showed no symptoms showed an average delay of 42 months. That’s a difference of nearly 3½ years. Nearly half of the patients with non-gastrointestinal symptoms had abnormal thyroid-stimulating hormone, as opposed to 15.5% in the gastrointestinal symptom group (P = .004). Nearly 70% of patients without gastrointestinal symptoms had anemia, compared with just 11.5% of the group with gastrointestinal symptoms. Also, nearly 70% of patients in the non-gastrointestinal symptom group showed abnormal bone density scans, compared with 41% in the gastrointestinal symptom group. The team saw no sex differences on chi-squared analysis between the 2 groups. Although there is growing awareness of celiac disease, the delay in diagnosis for patients without gastrointestinal symptoms remains prolonged, with an average delay of 3.5 years for celiac diagnosis, compared with just over two months for those with symptoms. Clearly, more needs to be done with regard to diagnosing celiac disease in patients who show no symptoms. On the upside, researchers are currently working on ways to better diagnose celiac disease via faster, more accurate tests, even in patients who have already gone gluten-free. Source: PlumX Metrics
Celiac.com 07/27/2012 - In my work as a celiac advocate and researcher, I've promoted taking daily vitamin supplements for better health for quite some time, but now with a study published in the American Journal of Clinical Nutrition confirming this I am pushing it even more. Telomeres are considered to be the "key" to anti-aging. As you age, your telomeres get shorter and shorter. Lengthening your telomeres will lead to a longer, healthier life. The study in the Journal of Clinical Nutrition shows that multivitamin use can lengthen one's telomeres. This can be accomplished by specific vitamins such as B12, C and E due to the fact that they are antioxidants. This means they fight damaging effects of oxidant (radicals) and even can repair damage which already has been received by the cells. It's important for one to take B12, C and E regularly and to also get these in your daily diet. Grass-fed beef, salmon, tuna and milk all contain B12. You can get your vitamin C from foods such as strawberries, grapefruit, green bell peppers, etc. Vitamin E is found in broccoli, almonds and many other sources. It's probably easier to just take a multivitamin, but be careful of ones containing iron. Iron has been shown to have a shortening effect on telomeres. Just adding something as simple as a multivitamin can boost your life span and make you feel great! Resources: Xu et al. “Multivitamin use and telomere length in women,” Am J Clin Nutr (March 11, 2009). L.A. Times: Can taking a multivitamin extend life? http://latimesblogs.latimes.com/booster_shots/2009/05/can-taking-a-multivitamin-extend-life.html Life Extension: Longer telomeres associated with multivitamin use http://www.lef.org/newsletter/2009/0317_Longer-Telomeres-Associated-with-Multivitamin-Use.htm
Am J Clin Nutr 2002;75:914-921. Celiac.com 06/06/2002 - Results of a recent study conducted by Anneli Ivarsson and colleagues at Umea University in Sweden suggest that continuing to breast-feed infants while they are being introduced to new foods may reduce their risk of getting celiac disease. Dr. Ivarssons study suggests that the cause of celiac disease may include environmental factors, and not just be limited to genetic factors. Their study evaluated the breast-feeding habits of 627 children with celiac disease and 1,254 healthy children, and specifically looked at their responses to newly introduced foods. The results, published in the May issue of the American Journal of Clinical Nutrition, indicate that dietary patterns of infants may have a strong influence on the bodys immune responses, and certain dietary patterns could lead to lifelong food intolerances. Children under 2 years of age who were still being breast-fed when they were introduced to dietary gluten had a 40% lower incidence of celiac disease. Another important factor was the overall amount of gluten in an infants diet, and a direct correlation was found between increased gluten consumption and an increased incidence of celiac disease. According to the researchers, the protective effect of breast feeding was even more pronounced in infants who were breast-fed beyond the introduction of gluten. Ultimately the teams findings indicate that breast feeding infants through the period of gluten introduction can significantly lower their risk of getting celiac disease. More research needs to be done to determine if this protective effect will extend over a lifetime.