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Celiac Disease & Gluten-Free Diet Forums

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Celiac Disease & Gluten-Free Diet Blogs

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  • Research on South African Celiac Tours
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  • Keating's Not-so-Glutenfree life
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  • Searchin for a Primary Care Dr. In Redlands That is Knowledgeable about Celiac disease
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  • Living in Japan with Ceoliac Disease
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  • MJ
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  • HONG KONG GLUTEN, WHEAT FREE PRODUCTS
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  • Healthy Food Healthy You
  • SydneyT1D - Diabetic and Celiac YouTuber!
  • GFGF's Blog
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  • SMAS: www.celiac.com
  • gardener1's Blog
  • Naezer's Blog
  • JordanBattenSymons' Blog
  • JillianC
  • Sugar's Blog
  • Blanche22's Blog
  • Jason's Blog
  • Gluten-Free Sisters :)
  • Eab12's Celiac Blog
  • ohiodad's Blog
  • Newly Self Diagnosed?
  • misscorpiothing's Blog
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  • Petroguy
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  • Soap Opera Central
  • nurcan's Blog
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  • Mr J's Blog
  • Rachel Keating's Blog
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  • krisb's Blog
  • deetee's Blog
  • CAC's Blog
  • EmilyLinn7's Blog
  • Teri Kiefer's Blog
  • happyasabeewithceliac's Blog
  • quietmorning01's Blog
  • jaimekochan's Blog
  • Cheryl
  • Seosamh's Blog
  • donna mae's Blog
  • Colleen's blog
  • DawnJ's Blog
  • Gluten Challenge
  • twins2's Blog
  • just trying to feel better's Blog
  • Celiac Teen
  • MNBelle blog
  • Gabe351's Blog
  • moosemalibu's Blog
  • Coeliac Disease or Coeliac Sprue or Non Tropical Sprue
  • karalto's Blog
  • deacon11's Blog
  • Nyxie's Blog
  • Swpocket's Blog
  • threeringfilly's Blog
  • Madison Papers: Living Gluten-Free in a Gluten-Full World
  • babinsky's Blog
  • prettycat's Blog
  • Celiac Diagnosis at Age 24 months in 1939
  • Sandy R's Blog
  • mary m's Blog
  • Jkrupp's Blog
  • Oreo1964's Blog
  • keyboard
  • Louisa's Blog
  • Guts & Brains
  • Gluten Free Betty
  • Jesse'sGirl's Blog
  • NewMom's Blog
  • Connie C.'s Blog
  • garden girl's Blog
  • april anne's Blog
  • 4xmom's Blog
  • benalexander60's Blog
  • missmyrtle's Blog
  • Jersey Shore wheat no more's Blog
  • swezzan's Blog
  • aheartsj's Blog
  • MeltheBrit's Blog
  • glutenfreecosmeticcounter
  • Reasons Why Tummy tuck is considered best to remove unwanted belly fat?
  • alfgarrie's Blog
  • SmidginMama's Blog
  • lws' Blog
  • KMBC2014's Blog
  • Musings and Lessons Learned
  • txwildflower65's Blog
  • Uncertain
  • jess4736's Blog
  • deedo's Blog
  • persistent~Tami's Blog
  • Posterboy's Blog
  • jferguson
  • tiffjake's Blog
  • KCG91's Blog
  • Yolo's Herbs & Other Healing Strategies
  • scrockwell's Blog
  • Sandra45's Blog
  • Theresa Marie's Blog
  • Skylark's Blog
  • JessicaB's Blog
  • Anna'sMommy's Blog
  • Skylark's Oops
  • Jehovah witnesses
  • Celiac in Seattle's Blog
  • March On
  • honeybeez's Blog
  • The Liberated Kitchen, redux
  • onceandagain's Blog
  • JoyfulM's Blog
  • keepingmybabysafe's Blog
  • To beer, with love...
  • nana b's Blog
  • kookooto's Blog
  • SunnyJ's Blog
  • Mia'smommy's Blog
  • Amanda's Blog
  • jldurrani's Blog
  • Why choosing Medical bracelets for women online is the true possible?
  • Carriefaith's Blog
  • acook's Blog
  • REAGS' Blog
  • gfreegirl0125's Blog
  • Gluten Free Recipes - Blog
  • avlocken's Blog
  • Thiamine Thiamine Thiamine
  • wilbragirl's Blog
  • Gluten and Maize-Free (gluten-free-MF)
  • Elimination Diet Challenge
  • DJ 14150
  • mnsny's Blog
  • Linda03's Blog
  • GFinDC's Blog
  • Kim UPST NY's Blog
  • cmc's Blog
  • blog comppergastta1986
  • JesikaBeth's Blog
  • Melissa
  • G-Free's Blog
  • miloandotis' Blog
  • Confessions of a Celiac
  • Know the significance of clean engine oil
  • bobhayes1's Blog
  • Robinbird's Blog
  • skurtz's Blog
  • Olivia's Blog
  • Jazzdncr222's Blog
  • Lemonade's Blog
  • k8k's Blog
  • celiaccoach&triathlete's Blog
  • Gluten Free Goodies
  • cherbourgbakes.blogspot.com
  • snow dogs' Blog
  • Rikki Tikki's Blog
  • lthurman1979's Blog
  • Sprue that :)'s Blog
  • twinkletoes' Blog
  • Ranking the best gluten free pizzas
  • Gluten Free Product
  • Wildcat Golfer's Blog
  • Becci's Blog
  • sillyker0nian's Blog
  • txplowgirl's Blog
  • Gluten Free Bread Blog
  • babygoose78's Blog
  • G-freegal12's Blog
  • kelcat's Blog
  • Heavy duty 0verhead crane
  • beckyk's Blog
  • pchick's Blog
  • NOT-IN-2gluten's Blog
  • PeachPie's Blog
  • Johny
  • Breezy32600's Blog
  • Edgymama's Gluten Free Journey
  • Geoff
  • audra's Blog
  • mfrklr's Blog
  • 2 chicks
  • I Need Help With Bread
  • the strong one has returned!
  • sabrina_B_Celiac's Blog
  • Gluten Free Pioneer's Blog
  • Theanine.
  • The Search of Hay
  • Vanessa
  • racecar16's Blog
  • JCH13's Blog
  • b&kmom's Blog
  • Gluten Free Foodies
  • NanaRobin's Blog
  • mdrumr8030's Blog
  • Sharon LaCouture's Blog
  • Zinc, Magnesium, and Selenium
  • sao155's Blog
  • Tabasco's Blog
  • Amanda Smith
  • mmc's Blog
  • xphile1121's Blog
  • golden exch
  • kerrih's Blog
  • jleb's Blog
  • RUGR8FUL's Blog
  • Brynja's Grain Free Kitchen
  • schneides123's Blog
  • Greenville, SC Gluten-Free Blog
  • ramiaha's Blog
  • Kathy P's Blogs
  • rock on!'s Blog
  • Carri Ninja's Blog
  • jerseygirl221's Blog
  • Pkhaselton's Blog
  • Hyperceliac Blog
  • abbiekir's Blog
  • Lasister's Thoughts
  • bashalove's Blog
  • Steph1's Blog
  • Etboces
  • Rantings of Tiffany
  • GlutenWrangler's Blog
  • kalie's Blog
  • Mommy Of A Gluten Free Child
  • ready2go's Blog
  • Maureen
  • Floridian's Blog
  • Bobbie41972's Blog
  • Everyday Victories
  • Intolerance issue? Helpppp!
  • Feisty
  • In the Beginning...
  • Cheri46's Blog
  • Acne after going gluten free
  • sissSTL's Blog
  • Elizabeth19's Blog
  • LindseyR's Blog
  • sue wiesbrook's Blog
  • I'm Hungry's Blog
  • badcasper's Blog
  • M L Graham's Blog
  • Wolicki's Blog
  • katiesalmons' Blog
  • CBC and celiac
  • Kaycee's Blog
  • wheatisbad's Blog
  • beamishmom's Blog
  • Celiac Ninja's Blog
  • scarlett54's Blog
  • GloriaZ's Blog
  • Holly F's Blog
  • Jackie's Blog
  • lbradley's Blog
  • TheSandWitch's Blog
  • Ginger Sturm's Blog
  • The Struggle is Real
  • whataboutmary's Blog
  • JABBER's Blog
  • morningstar38's Blog
  • Musings of a Celiac
  • Celiacchef's Blog
  • healthygirl's Blog
  • allybaby's Blog
  • MGrinter's Blog
  • LookingforAnswers15's Blog
  • Lis
  • Alilbratty's Blog
  • 3sisters' Blog
  • MGrinter's Blog
  • Amanda
  • felise's Blog
  • rochesterlynn's Blog
  • mle_ii's Blog
  • GlamourGetaways' Blog
  • greendog's Blog
  • Tabz's Blog
  • Smiller's Blog
  • my vent
  • newby to celiac?'s Blog
  • siren's Blog
  • myraljo's Blog
  • Relieved and confused
  • carb bingeing
  • scottish's Blog
  • maggiemay832's Blog
  • Cristina Barbara
  • ~~~AnnaBelle~~~'s Blog
  • nikky's Blog
  • Suzy-Q's Blog
  • mfarrell's Blog
  • Kat-Kat's Blog
  • Kelcie's Blog
  • cyoshimit's Blog
  • pasqualeb's Blog
  • My girlfriend has celiacs and she refuses to see a doctor
  • Ki-Ki29's Blog
  • mailmanrol's Blog
  • Sal Gal
  • WildBillCODY's Blog
  • Ann Messenger
  • aprilz's Blog
  • the gluten-free guy
  • gluten-free-wifey's Blog
  • Lynda MEADOWS's Blog
  • mellajane's Blog
  • Jaded's Celiac adventures in a non-celiac world.
  • booboobelly18's Blog
  • Dope show
  • Classic Celiac Blog
  • Keishalei's Blog
  • Bada
  • Sherry's blurbs
  • addict697's Blog
  • MIchael530btr's Blog
  • Shawn C
  • antono's Blog
  • Undiagnosed
  • little_d's Blog
  • Gluten, dairy, pineapple
  • The Fat (Celiac) Lady Sings
  • Periomike
  • Sue Mc's Blog
  • BloatusMaximus' Blog
  • It's just one cookie!
  • Kimmy
  • jacobsmom44's Blog
  • mjhere's Blog
  • tlipasek's Blog
  • You're Prescribing Me WHAT!?!
  • Kimmy
  • nybbles's Blog
  • Karla T.'s Blog
  • Young and dealing with celiacs
  • Celiac.com Podcast Edition
  • LCcrisp's Blog
  • ghfphd's allergy blog
  • https://www.bendglutenfree.com/
  • Costume's and GF Life
  • mjhere69's Blog
  • dedeadge's Blog
  • CeliacChoplin
  • Ravenworks' Blog
  • ahubbard83's Blog
  • celiac<3'sme!'s Blog
  • William Parsons
  • Gluten Free Breeze (formerly Brendygirl) Blog
  • Ivanna44's Blog
  • Daily Life and Compromising
  • Vonnie Mostat
  • Aly'smom's Blog
  • ar8's Blog
  • farid's Blog
  • Sandra Lee's Blog
  • Demertitis hepaformis no Celac
  • Vonnie Mostat, R.N.
  • beetle's Blog
  • Sandra Lee's Blog
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  • Kim
  • Vhips
  • twinsmom's Blog
  • Newbyliz's Blog
  • collgwg's Blog
  • Living in the Gluten Free World
  • lisajs38's Blog
  • Mary07's Blog
  • Treg immune celsl, short chain fatty acids, gut bacteria etc.
  • questions
  • A Blog by Yvonne (Vonnie) Mostat, RN
  • ROBIN
  • covsooze's Blog
  • HeartMagic's Blog
  • electromobileplace's Blog
  • Adventures of a Gluten Free Mom
  • Fiona S
  • bluff wallace's Blog
  • sweetbroadway's Blog
  • happybingf's Blog
  • Carla
  • jaru24's Blog
  • AngelaMH's Blog
  • collgwg's Blog
  • blueangel68's Blog
  • SimplyGF Blog
  • Jim L Christie
  • Debbie65's Blog
  • Alcohol, jaundice, and celiac
  • kmh6leh's Blog
  • Gluten Free Mastery
  • james
  • danandbetty1's Blog
  • Feline's Blog
  • Linda Atkinson
  • Auntie Lur: The Blog of a Young Girl
  • KathyNapoleone's Blog
  • Gluten Free and Specialty Diet Recipes
  • Why are people ignoring Celiac Disease, and not understanding how serious it actually is?
  • miasuziegirl's Blog
  • KikiUSA's Blog
  • Amyy's Blog
  • Pete Dixon
  • abigail's Blog
  • CHA's Blog
  • Eczema or Celiac Mom?'s Blog
  • Thoughts
  • International Conference on Gastroenterology
  • Deedle's Blog
  • krackers' Blog
  • cliniclfortin's Blog
  • Mike Menkes' Blog
  • Juanita's Blog
  • BARB OTTUM
  • holman's Blog
  • It's EVERYWHERE!
  • life's Blog
  • writer ann's Blog
  • Ally7's Blog
  • Gluten Busters: Gluten-Free Product Alerts by Celiac.com
  • K Espinoza
  • klc's Blog
  • Pizza&beer's Blog
  • CDiseaseMom's Blog
  • sidinator's Blog
  • Dr Rodney Ford's Blog
  • How and where is it safe to buy cryptocurrency?
  • lucedith's Blog
  • Random Thoughts
  • Kate
  • twin#1's Blog
  • myadrienne's Blog
  • Nampa-Boise Idaho
  • Ursa Major's Blog
  • bakingbarb's Blog
  • Does Celiac Cause Sensitivites To Rx's?
  • delana6303's Blog
  • psychologygrl25's Blog
  • Alcohol and Celiac Disease
  • How do we get it???
  • cooliactic_BOOM's Blog
  • GREAT GF eating in Toronto
  • Gluten-free Food Recommendations!
  • YAY! READ THIS!!
  • BROW-FREE DIET BLOG
  • carib168's Blog
  • A Healing Kitchen
  • Shawn s
  • AZ Gal's Blog
  • mom1's Blog
  • The Beginning - The Diagnosis
  • PeweeValleyKY's Blog
  • solange's Blog
  • Cate K's Blog
  • Layered Vegetable Baked Pasta (gluten-free Vegetarian Lasagna)
  • Gluten Free Teen by Ava
  • mtdawber's Blog
  • sweeet_pea's Blog
  • DCE's Blog
  • Infertility and Celiac Disease
  • What to do in the Mekong Delta in 1 Day?
  • glutenfreenew's Blog
  • Living in the Garden of Eden
  • toddzgrrl02's Blog
  • redface's Blog
  • Gluten Free High Protein
  • Ari
  • Great Harvest Chattanooga's Blog
  • CeliBelli's Blog
  • Aboluk's Blog
  • redface's Blog
  • Being in Control of Your Gluten-Free Diet on a Cruise Ship
  • jayshunee's Blog
  • lilactorgirl's Blog
  • Yummy or Yucky Gluten-Free Foods
  • Electra's Blog
  • Cocerned husband's Blog
  • lilactorgirl's Blog
  • A Little History - My Celiac Disease Diagnosis
  • How to line my stomach
  • sewfunky's Blog
  • Oscar's Blog
  • Chey's Blog
  • The Fun of Gluten-free Breastfeeding
  • Dawnie's Blog
  • Sneaky gluten free goodness!
  • Chicago cubs shirts- A perfect way of showing love towards the baseball team!
  • Granny Garbonzo's Blog
  • GFzinks09's Blog
  • How do I get the Celiac.com podcast on my mp3 player?
  • quantumsugar's Blog
  • Littlebit's Blog
  • Kimberly's Blog
  • Dayz's Blog
  • Swimming Breadcrumbs and Other Issues
  • Helen Burdass
  • celiacsupportnancy's Blog
  • Life of an Aggie Celiac
  • kyleandjra.jacobson's Blog
  • Hey! I'm Not "Allergic" to Wheat!
  • FoOdFaNaTic's Blog
  • Wendy Cohan, RN's Gluten-Free and Dairy-Free Cooking Classes
  • Lora Derry
  • Dr. Joel Goldman's Blog
  • The Ultimate Irony
  • Lora Derry
  • ACK514's Blog
  • katinagj's Blog
  • What Goes On, Goes In (Gluten in Skin Care Products)
  • What’s new in hydraulic fittings?
  • cannona3's Blog
  • citykatmm's Blog
  • Adventures in Gluten-Free Toddling
  • tahenderson67's Blog
  • The Dinner Party Drama—Two Guidelines to Assure a Pleasant Gluten-Free Experience
  • What’s new in hydraulic fittings?
  • sparkybear's Blog
  • justbikeit77's Blog
  • To "App" or Not to "App": The Use of Gluten Free Product List Computer Applications
  • Onangwatgo
  • Raine's Blog
  • lalla's Blog
  • To die for Cookie Crumb Gluten-Free Pie Crust
  • DeeTee33's Blog
  • http://glutenfreegroove.com/blog/
  • David2055's Blog
  • Gluten-Free at the Fancy Food Show in San Francisco
  • Kup wysokiej jakości paszporty, prawa jazdy, dowody osobiste
  • Janie's Blog
  • Managing Hives & Gluten Allergies
  • Bogaert's Blog
  • Janie's Blog
  • RaeD's Blog
  • Dizzying Disclaimers!
  • Dream Catcher's Blog
  • PinkZebra's Blog
  • Hibachi Food and Hidden Gluten Hazards (How to Celebrate Gluten-Free)
  • jktenner's Blog
  • OhSoTired's Blog
  • PinkZebra's Blog
  • gluten-free Lover's Blog
  • Gluen Free Health Australia
  • Melissamb21's Blog
  • Andy C's Blog
  • halabackgirl9129's Blog
  • Liam Edwards' Blog
  • Celiac Disease in Africa?
  • Suz's Blog
  • Gluten-Free Fast Food
  • Eldene Goosen
  • mis_chiff's Blog
  • gatakat's Blog
  • macocha's Blog
  • Newly Diagnosed Celiacs Needed for Study in Chicago
  • Elaine Anne
  • Poor Baby's Blog
  • the loonie celiac's Blog
  • jenlex's Blog
  • Sex Drive/Testosterone can be Depleted by Certain Foods
  • Sharon
  • samantha79's Blog
  • 21 Months into the Gluten-free Diet
  • WashingtonLady's Blog-a-log
  • James S. Reid's Blog
  • Living with a Gluten-Free Husband
  • Diane King
  • runner girl's Blog
  • kp3972's Blog
  • ellie_lynn's Blog
  • trayne91's Blog
  • Gluten-free Lipstick!
  • Debado
  • Nonna2's Blog
  • Schar Chocolate Hazelnut Bar (Gluten-Free)
  • Diane
  • pnltbox27's Blog
  • Live2BWell's Blog
  • melissajohnson's Blog
  • nvsmom's Blog
  • Diagnosed with Celiac Disease and Still Sick
  • Coming out having gluten intolerance and celiac disease
  • snowcoveredheart's Blog
  • Gluten Free Nurse
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  1. Celiac.com 11/19/2021 - The association between celiac disease and a range of respiratory diseases has long been recognized(1). An exploration of the literature on this point brought me several new insights. For instance, I learned that gluten sensitivity is also an important risk factor for certain lung disorders. Although celiac disease was only slightly more frequent (one of 29 subjects had celiac disease) a whopping 40% (12 of 29) of patients with sarcoidosis showed gluten sensitivity(2). I also learned that some researchers are even pointing to celiac disease as an underlying cause of some cases of lymphocytic bronchoalveolitis(3) which is an inflammation that narrows the airways in the lungs. Perhaps the most startling new insight I gained was that despite compliance with a gluten-free diet, patients with celiac disease continue to show signs of a mucosal defect in the lungs(4). From a personal standpoint, although I experienced asthma and many breathing problems as a child, I have blamed my 25 years of smoking cigarettes for the bulk of my lung problems. While I remain confident that this is a large factor in the lung disease I have today, I am also realizing that my celiac disease is a contributing factor. I have made some important strides in improving my lung function as a result of my studies, and it is these that I would like to share with you here. Although my memory is vague on this point, I’m sure I experienced improvement from the celiac diagnosis and subsequent gluten-free diet. I’m also sure that food allergy testing, and subsequent avoidance of problem foods, helped stabilize my breathing to the point where I have rarely experienced breathing crises in the last six years. Nonetheless, I have been limited by a very small capacity for exercise and the predictable losses in conditioning. In the process of researching ketogenic and low carb dieting for a video I am working on, I chanced upon a reference(5) to a study of healthy women that claimed a 5% increase in peak flow and a 10% improvement in pulmonary function after one week on a low carbohydrate diet(6). I have now been following a low carbohydrate diet for more than a month. My average peak flow has increased by about 15%. Far more importantly, my tolerance for exercise has increased quite dramatically. Although I still become breathless after vigorous exercise, I can engage in mild to moderate exercise for considerable periods without any breathing difficulty. This constitutes a considerable improvement in my breathing and provides an important increase in the quality of my life. I realize that smoking is a foolish habit to start. Despite many warnings I continued this habit for many years, until six months prior to my celiac diagnosis. I know I am fortunate in not having contracted any of the deadly diseases caused by smoking. Thus, I take solace in the research that shows that tobacco smoking is a way of self-treating the symptoms of celiac disease(7,8,9,10). These publications have helped me deal with the self-recrimination that accompanies the knowledge that I created my own breathing problems. It has also led me to a deeper understanding of the powerful addiction I experienced, the illness I felt after I did finally quit, and the recognition that celiac disease has shaped a great deal of my life. References: Stevens FM, Connolly CE, Murray JP, McCarthy CF. Lung cavities in patients with coeliac disease. Digestion. 1990;46(2):72-80. Papadopoulos KI, Sjoberg K, Lindgren S, Hallengren B. Evidence of gastrointestinal immune reactivity in patients with sarcoidosis. J Intern Med. 1999 May;245(5):525-31. Brightling CE, Symon FA, Birring SS, Wardlaw AJ, Robinson R, Pavord ID. A case of cough, lymphocytic bronchoalveolitis and coeliac disease with improvement following a gluten free diet. Thorax. 2002 Jan;57(1):91-2. Robertson DA, Taylor N, Sidhu H, Britten A, Smith CL, Holdstock G. Pulmonary permeability in coeliac disease and inflammatory bowel disease. Digestion. 1989;42(2):98-103. The Ketogenic Diet: A Complete Guide for the Dieter and Practitioner by Lyle McDonald. 1998. Kwan RM, Thomas S, Mir MA. Effects of a low carbohydrate isoenergetic diet on sleep behavior and pulmonary functions in healthy female adult humans. J Nutr. 1986 Dec;116(12):2393-402. Suman S, Williams EJ, Thomas PW, Surgenor SL, Snook JA. Is the risk of adult coeliac disease causally related to cigarette exposure? Eur J Gastroenterol Hepatol. 2003 Sep;15(9):995-1000. Austin AS, Logan RF, Thomason K, Holmes GK. Cigarette smoking and adult coeliac disease. Scand J Gastroenterol. 2002 Aug;37(8):978-82. Vazquez H, Smecuol E, Flores D, Mazure R, Pedreira S, Niveloni S, Maurino E, Bai JC. Relation between cigarette smoking and celiac disease: evidence from a case-control study. Am J Gastroenterol. 2001 Mar;96(3):798-802. Snook JA, Dwyer L, Lee-Elliott C, Khan S, Wheeler DW, Nicholas DS. Adult coeliac disease and cigarette smoking. Gut. 1996 Jul;39(1):60-2.

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  3. Celiac.com 09/04/2021 - I was recently chided by Melissa Jones. She is a reader who wrote to say that I had missed an important element of the topic when I discussed the discovery of zonulin and the therapeutic promise offered by this discovery. Melissa’s complaint was that I should have included a discussion of the connection with lung disease. I agree. After some reflection, I think that there is a good deal more that should be said about this recently discovered protein, including its connection with lung disease. Excessive amounts of zonulin are produced by those who have intestinal diseases. These particularly include celiac disease and type 1 diabetes. Zonulin is a likely factor in autoimmune thyroiditis, systemic lupus erythematosus, Sjogren’s syndrome, scleroderma, and at least sub-groups of multiple sclerosis patients and many rheumatoid arthritis patients. Zonulin may also be a major factor in the development and maintenance of many learning disorders and psychiatric illnesses. Current research has shown that zonulin weakens protective barriers throughout the body, in the intestines, lungs, blood vessels, skin, and perhaps, the brain. Research has also connected increased zonulin production to gluten consumption, but there may be additional factors that can trigger production and the resulting compromise to the various protective barriers this protein regulates. Lung disease is only one facet of this complex issue. The range and rate of lung diseases among celiac patients is broad and elevated, so Melissa’s concerns are well grounded. Some researchers report a greater frequency of many lung diseases including bird fancier’s lung, farmer’s lung, Idiopathic pulmonary hemosiderosis, lymphocytic bronchoalveolitis, pulmonary sarcoidosis, cavities in the lung walls, fibrosing alveolitis, and while there is some disagreement in the literature, there may also be higher rates and greater severity of asthma among celiac patients. Nonetheless, it should not be surprising that we experience an increased risk of lung disease since there is considerable similarity between the barrier functions of the mucosa of the lungs and that of the intestines. Thus, the search for a drug that can help us maintain the integrity of this barrier could protect against lung disease and provide important benefits for gluten sensitive individuals who are at greater risk of developing breathing problems along with the host of other ailments that involve compromised protective barrier function. For instance, investigations of zonulin have the potential to help people with autoimmune diseases. This research may even offer a new, proactive therapy for workers in the baking and milling industries, for severe burn victims who will predictably develop intestinal distress, and for cancer patients who are undergoing radiation treatments. Even patients with skin diseases may be helped. The therapeutic promise of the gluten-free diet for improving various psychiatric diseases, learning disabilities, and behavior problems might also be realized, at long last. The potential therapeutic implications of zonulin research, for a wide range of patients, are startlingly broad. I attended Blake Patterson’s presentation at the 12th International Celiac Disease Symposium on Saturday, November 11th in New York City. Alba Therapeutics, with Blake Patterson at the helm, is currently developing a drug that is aimed at delivering AT-1001 with meals. This substance blocks zonulin action by cloning the receptors which bind to zonulin but do not relax the tight junctions and are subsequently wasted in feces. This would decrease the compromising impact of zonulin by reducing permeability at tight junctions between cells of the protective tissues of the intestine, lungs, blood vessels, and perhaps, the blood barrier. This blockage, if it is achieved, may provide a means of regulating the tight epithelial junctions that create the various protective barriers mentioned earlier. Although he was extremely conservative when discussing the potential benefits of the drug Alba is developing, there can be little doubt that he has considered many more potential applications than I can think to list. The short-range objective, and the intended market of this drug, is to provide a more rapid and complete disease remission. Although it may ultimately allow a celiac patient to eat a normal diet, this is not the only objective of their development work. I have little personal interest in eating gluten again, but it would be nice not to have to worry about accidental and trace sources of gluten if that is part of what the drug offers. Research has already shown that a gluten-free diet can prevent type I diabetes from developing in two genetically susceptible people. One was at high risk of developing diabetes while the other already had it. This confirms the many animal studies that have shown, among the genetically susceptible, a dose-dependent relationship between gluten ingestion and the development of type 1 diabetes. It is a small leap to infer that if AT-1001 restores the barrier function in the intestinal wall of diabetic patients, as a gluten-free diet does, it should also stop the autoimmune attack on islet cells which make insulin in the pancreas. The current belief is that when gluten is leaking into the bloodstream and genetically susceptible people mount an immune response against that gluten, the antibodies identify certain sequences of amino acids in the protein structure. These sequences are similar to those found in islet cells, so the antibodies will also attack and destroy these insulin producing cells of the pancreas. By tightening the junctions of the protective barrier in the intestinal wall, thus stopping the leakage of gluten into the bloodstream of genetically susceptible individuals, AT-1001 should also stop the autoimmune result of this process frequently referred to as molecular mimicry. AT-1001 could be used not only to protect surviving islet cells in the type 1 diabetic who still has some production capacity, it can also aid the long-term survival of transplanted islet cells. These transplants are somewhat limited, in current circumstances, because the transplanted cells are destined to be destroyed by the same autoimmune process that destroyed the individual’s original islet cells. Thus, the therapeutic implications for this drug go far beyond Alba’s short term objectives. Many celiac patients, myself included, experience significant lung disease. I am well aware that my history of smoking cigarettes, now fifteen years in the past, contributed to my lung disease. On the other hand, I’m also aware that when I visit rural locations where there is little air pollution, my lung function improves dramatically. My own lung problem results, in part, from extensive scarring on the walls of my lungs. This scar tissue impedes the normal exchange of oxygen and carbon-dioxide across the lung wall, to and from the blood. This component of the problem probably won’t get much better. There is also an allergy-driven asthma component to my difficulties. This facet of my lung problems, as shown by my improved lung function, when away from urban air pollution, could be helped dramatically by a drug that tightens the barriers in the lining of my lungs and protects me from the absorption of these airborne particles of pollution. Zonulin research is so new that it is difficult to predict where it might go, or the medicinal purposes it might serve. Those of us who have been frustrated by watching the medical community overlook the scope and severity of gluten-induced illness may well be vindicated by this work. I had the privilege of speaking to a support group at the University of Arizona Medical School in Tucson last year. At that time I stated that the discovery of zonulin should lead to the Nobel Prize for Fasano et. al. because of the enormous implications of their discovery. The more important outgrowth of this research is that many millions of sick and/or vulnerable people may benefit enormously from AT-1001 if it can be formulated to successfully and effectively regulate the impact of zonulin in humans. It will save and enhance the quality of many lives.
  4. To All, I came across this research recently on COVID-19 and the gut-long axis and how COVID-19 might start as a Leaky Gut problem and wanted to share and see what other's thought. The previous article I read on this topic.....indicated COVID-19 might start in the GUT and why many patients don't have respiratory problems until the 2nd week. Here is the early article I read on it in early 2020 Entitled "Coronavirus can infect intestine as well as lungs, says study" https://finance.yahoo.com/news/coronavirus-infect-intestine-well-lungs-093000721.html IF the first week it finds into to the body through the ACE2 receptor then it makes sense that the GI tract would be infected first. Here is the research entitled "Severe COVID-19 Is Fueled by Disrupted Gut Barrier Integrity" https://www.medrxiv.org/content/10.1101/2020.11.13.20231209v1.full And this recent research that bears out the Saliva in the mouth might harbor the Corona Virus and be a means for transmission. See this research entitled "Scientists reveal salivary gland cells as sites of COVID-19 infection" https://www.news-medical.net/news/20210325/Scientists-reveal-salivary-gland-cells-as-sites-of-COVID-19-infection.aspx quoting from the News Medical article. "They looked for individual cells that expressed two key entry proteins - ACE2 and the TMPRSS2 protease - which SARS-CoV-2 uses to infect human cells, and discovered that salivary gland ductal cells and some gingival, or gum, cells expressed both proteins. This showed that these cells were vulnerable to infection." They also noted quoting again. "Of the 27 people who experienced symptoms, those with virus in their saliva were more likely to report loss of taste and smell, suggesting that oral infection might underlie oral symptoms of COVID-19." I quoted them together because they are related research. I don't know what all it means....but it is interesting research anyway. Here are the other recent articles on Celiac.com for others to read about Celiac disease and COVID-19 if you have not read them already. Just so you won't have to go look them up.....I am including them here for those who have not read them yet.... Maybe you can make more sense of it than me.....but I think COVID-19 might just start as a "Leaky Gut" issue first then spread to the lungs??? What do others think? I hope this is helpful but it is not medical advise. Posterboy,
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