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Celiac.com 04/17/2024 - Maintaining optimal health involves ensuring that our bodies receive essential nutrients, including magnesium, a vital mineral crucial for various bodily functions. Magnesium deficiency can arise from various factors, including medical conditions like celiac disease, poor absorption, increased need, or excessive elimination. Understanding the signs, causes, and remedies for magnesium deficiency is essential for overall well-being. Identifying Magnesium Deficiency Symptoms Magnesium deficiency symptoms may initially manifest subtly, including muscle spasms, fatigue, decreased appetite, and nausea. However, if left unaddressed, more severe effects such as abnormal heart rhythm, seizures, anxiety, and personality changes may occur. As these symptoms overlap with those of other health conditions, a blood test from a medical provider is crucial to confirm magnesium deficiency accurately. Causes of Magnesium Deficiency Malabsorption due to gastrointestinal conditions like celiac disease or inflammatory bowel disease can hinder magnesium absorption. Additionally, certain medications and increased magnesium needs, such as during pregnancy or in athletes, can contribute to deficiency. Factors that affect magnesium elimination, like alcohol consumption or medical conditions such as kidney disease, also play a role. The Role of Magnesium in the Body Magnesium plays a vital role in numerous bodily processes, including muscle and nerve function, heart rhythm maintenance, blood sugar control, bone health, and blood pressure regulation. Furthermore, magnesium influences hormone balance related to sleep, circadian rhythm, and mood regulation, and can alleviate conditions like migraine headaches. Sources of Magnesium To address magnesium deficiency, both oral supplements and magnesium-rich foods can be beneficial. Supplements, such as magnesium glycinate or magnesium citrate, offer an easily accessible solution, although they may cause mild gastrointestinal side effects. Alternatively, incorporating magnesium-rich foods like pumpkin seeds, almonds, spinach, soy, and black beans into one's diet can help meet daily magnesium requirements. Frequently Asked Questions About Magnesium What is the best magnesium supplement? Magnesium glycinate and magnesium citrate are generally well-tolerated forms of magnesium supplements. Are there supplements best avoided when taking magnesium? Calcium supplements should be taken separately from magnesium to prevent competition for absorption. What medications interfere with magnesium: Certain medications, including proton pump inhibitors, antibiotics, diuretics, and chemotherapy drugs, can hinder magnesium absorption and should be managed accordingly. In conclusion, recognizing the signs of magnesium deficiency, understanding its causes, and knowing how to address it through supplementation or dietary adjustments are essential for maintaining optimal health. Consulting healthcare providers for accurate diagnosis and personalized treatment plans is vital in managing magnesium deficiency effectively. This article is not intended to offer medical advice, and is for informational purposes only. Please consult a medical professional for personal advice on celiac disease, magnesium deficiency, and/or any other medical concern.
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Vitamins for Anxiety, Depression and Mental Health
knitty kitty posted a blog entry in Thiamine Thiamine Thiamine
Below are links to studies showing that vitamins in the B Complex help relieve anxiety and depression. References: Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey https://pubmed.ncbi.nlm.nih.gov/33848753/ The Role of Vitamins and Minerals in Psychiatry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/ Thiamine and benfotiamine: Focus on their therapeutic potential https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682628/ Hiding in Plain Sight: Modern Thiamine Deficiency https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/ Vitamin B6: A new approach to lowering anxiety, and depression? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577631/ High‐dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787829/ Higher vitamin B6 intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study https://pubmed.ncbi.nlm.nih.gov/31188081/ Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060244/ Dietary niacin intake in relation to depression among adults: a population-based study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506255/ A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770181/ Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake https://pubmed.ncbi.nlm.nih.gov/34959947/ Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688056/ The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/ Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post‐hoc analysis of a randomised controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292249/ The Role of Vitamins and Minerals in Psychiatry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/ Additionally... Factors associated with villus atrophy in symptomatic coeliac disease patients on a gluten-free diet https://pubmed.ncbi.nlm.nih.gov/28220520/ Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728667/ The Effects of Dietary Tryptophan on Affective Disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393508/ Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574116/ Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level https://pubmed.ncbi.nlm.nih.gov/34737364/ Effect of Tryptophan, Vitamin B6, and Nicotinamide-Containing Supplement Loading between Meals on Mood and Autonomic Nervous System Activity in Young Adults with Subclinical Depression: A Randomized, Double-Blind, and Placebo-Controlled Study https://pubmed.ncbi.nlm.nih.gov/31902864/ Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959081/ Nutrition as Metabolic Treatment for Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907178/ Sharing Pathological Mechanisms of Insomnia and Osteoporosis, and a New Perspective on Safe Drug Choice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336562/ Passiflora incarnata in Neuropsychiatric Disorders—A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766837/ Effects of L-tryptophan on sleepiness and on sleep https://pubmed.ncbi.nlm.nih.gov/6764927/ The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression https://pubmed.ncbi.nlm.nih.gov/33942088/ Is tryptophan a natural hypnotic? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161739/ The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555967/-
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To All, A few years ago Celiac.com featured an article on Cytokines (aka different Interleukins) that are produced in response to a gluten challenge and it got me thinking? Here is the article as summarized by Jefferson Adams if you would like to scan the summary... Here is the length to the full study if somebody wants to read through/scan and explain to me and other on the Celiac.com forum. https://www.science.org/doi/10.1126/sciadv.aaw7756 A recent discussion lead me do some more research on this topic? Could poor nutrition be a trigger for Cytokine reslease and I found YES it could be! Here is the research that I wanted to lead with.....their is other research that can be included but this is just to get the ball rolling/started you might say... Here is looking at you Blue-Sky @Blue-Sky 30+ years old and the medical community has forgotten how Cytokine/Interlukin production is triggerd/controlled by poor nutrition! See this research on Zinc Entitled "Role of zinc in interleukin 2 (IL-2)-mediated T-cell activation" https://pubmed.ncbi.nlm.nih.gov/2345864/#:~:text=In a serum-free culture containing no zinc%2C zinc,was completely inhibited by anti-IL-2 receptor (CD25) antibodies. This one is also worth your time explains B-Vitamins role in Cytokine production in the body as sign of Inflammation. Entitled "The effects of vitamin B on the immune/cytokine network and their involvement in depression" https://www.maturitas.org/article/S0378-5122(16)30299-7/fulltext What do other's think......which came first (the poor nutrition) or the inflammation (IE triggering) the Immune response? I wish us all good health soon! STRESS Kills us.....but it MAIMS us first! I hope this is helpful but it is not medical advice. Also in tribute to Blue-Sky it is worth noting Blue-Sky's great blog post on a Zinc deficiency as a possible trigger for IBS......which is the best article on Celiac.com IMO on the topic of Zinc!!! as it relates to GI problems like IBS etc. Posterboy by the grace of God,
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To All, I told Scott months ago I would start this resource page of sources and now I am finally making good on my promise(s). I am combining this page into a resource for Vitamin B-3 and Vitamin B-2 because they are related and do not happen in an uncomplicated way. I will start with some Niaicin and/or Niacinamide resources but it is ok to post both B-2 and B-3 resources on this page. There is a similar resource page started by Knitty Kitty on Thiamine.....callled Thiamine, Thiamine, Thiamine. And one on Magnesium, Magnesium, Magnesium etc. This one on Niacin and Riboflavin in a way you might say completes the Triology etc. So here goes nothing as they say... This came up in a different thread and deserves its own thread talking about the role Niacin plays in a healhty GI system. Entitled "Niacin ameliorates ulcerative colitis (aka UC) via prostaglandin D2-mediated D prostanoid receptor 1 activation" https://www.embopress.org/doi/full/10.15252/emmm.201606987 And this one entitled "Two Cases of Dermatitis Herpetiformis (aka DH) Successfully Treated with Tetracycline and Niacinamide" https://pubmed.ncbi.nlm.nih.gov/30390734/ I will try and add more later but that is about all the time I have for tonight. I hope this is helpful but it is not medical advice. Posterboy,
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To All, This research was quoted by RMJ and I thought it was worth sharing! And I wanted to start a conversation about it considering how and what role B-Vitamins have in Cytokine production and/or the management of our Immune System(s) since we know B-Vitamins are involved in controlling Cytokine production we know they play a role in activating and controlling our immune responses. I will start with this research. Entitled "Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund’s adjuvant" https://www.sciencedirect.com/science/article/abs/pii/S1734114016302729 I hope this is helpful but it is not medical advice. Posterboy,
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To All, I came across this research on Magnesium and Intestinal health recently and I thought it was worth sharing! Let me know what you think! Is a Magnesium deficiency a trigger for an impaired immune system in the GI tract in Mammals? Quoting from the article abstract "These changes were accompanied by modifications in the expression of several genes involved in cell growth and stress response. From this present work, it may be concluded that short periods of Mg deprivation can affect the intestinal mucosa and local immune response of the intestine." Research is new ever day......so it is often hard to keep up.....surprisingly this research 20 years old this year and no one even mention's it.....because there is so much new research being published every day......it is literally almost impossible to read it and digest it all!!! Ecclesiastes 12:12 And further, by these, my son, be admonished: of making many books there is no end; and much study is a weariness of the flesh. I hope this is helpful but it is not medical advice. Posterboy by the grace of God,
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To All, I just wanted to start a thread so these research articles on B-Complex and Magnesium for support care in COVID-19 patients is in one thread and easier to find if some one wanted to research them some more. See this entitled "Be well: A potential role for vitamin B in COVID-19" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428453/ And two on Magnesium for supportive care for COVID-109 patients. Entitled "The COVID-19 pandemic: is there a role for magnesium? Hypotheses and perspectives" https://pubmed.ncbi.nlm.nih.gov/32554340/ And the second one Magnesium Entitled "Possibility of Magnesium supplementation for supportive treatment in patients with COVID-19" https://pubmed.ncbi.nlm.nih.gov/32931782/ I hope this is helpful but it is not medical advice. Posterboy,
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To All. Is Refeeding Syndrome being misdiagnosed as Celiac Disease today? Refeeding Syndrome happens among the severely malnourished and having Celiac disease is a risk for a Refeeding Syndrome leading to a Celiac Crisis aka Celiac diagnosis. See this research entitled “Celiac Crisis: an unusual presentation of gluten-sensitive enteropathy” where the Symptoms of Refeeding Syndrome (Electrolyte Imbalances) is being diagnosed as “Celiac Crisis” instead…. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066267/ Refeeding Syndrome is missed in 50 percent of patients and there have been many studies showing Refeeding Syndrome (RFS) being diagnosed as Celiac Crisis instead…. Quoting from the above study about this phenomenon in Celiacs... “PubMed articles published between September 1990 and April 2018, were searched using the uniterm “celiac crisis” in patients older than 18 years; 31 reported cases were gathered (Table 1). The mean age was 52 years ranging from 23 to 83 years and a gender predominance was found among females (1.81:1). Interestingly, amid the 31 cases, only 3 had the diagnosis of Celiac Disease before the crisis. ” So in these studies these Electrolyte Anomalies aka Refeeding Syndrome where ultimately diagnosed as Celiac disease instead of RFS….of which there is a readily medically treatable regimen with good clinical/patient outcomes. See this Medical New Today article to see if you are experiencing what is known as Refeeding Syndrome many times diagnosed as a Celiac Crisis instead... https://www.medicalnewstoday.com/articles/322120 I only know it happened in my case.....and your case might be similar....low Potassium is often an early sign of Refeeding Syndrome.... IN these cases the Electrolyte abnormalities showed up before the Celiac diagnosis as it did in my case too! It is not as a rare as people/doctor's believe it is .....in only two years time the case studies on the this topic for Refeeding Syndrome (Connection/Association) as a a trigger for Celiac disease has gone up 50+ Percent because doctors are now more aware and are looking for it more! See this very recent 2020 Case Study article that bears this out...entitled "Life-threatening onset of celiac disease: a case report and literature review" https://pubmed.ncbi.nlm.nih.gov/32381744/ where they note: "The present case highlights that celiac disease may manifest quite abruptly with a severe malabsorption syndrome, that is, electrolyte abnormalities".. .IE Refeeding Syndrome....commonly known/diagnosed as a "Celiac Crisis" instead today I believe... Comparing the number of studies of Refeeding Syndrome in Celiac's went from only 31 to almost 50 studies in under two years time... It is time doctor's became more aware of these connections so Celiac's can be helped sooner in those who have developed a Thiamine deficiency (commonly found in Refeeding Syndrome) as the triggering cause of a Celiac Crisis! You will probably also have a Magnesium deficiency presenting as Low Potassium and Chronic Fatigue.....I know I did in my case! Because as the Medical News Today article pointed out.....Low Potassium is a symptom of Low Magnesium levels...quoting from the above Medical News Today article... Refeeding syndrome can also lead to a lack of magnesium. Hypomagnesemia is the name for dangerously low levels of magnesium. Signs and symptoms of hypomagnesemia include: low potassium levels, or hypokalemia ......weakness.... and fatigue. And in my case terrible "Charlie Horses" aka Muscle Spasms that got better after taking Magnesium Citrate with meals. I hope this helps at least one other person....I share because I have suffered these same symptom's going undiagnosed in/with my Celiac diagnosis and if I am right being the Posterboy for Celiac disease and this research is right being Misdiagnosed as a Celiac Crisis instead today! I hope it helps the next person....I only know it helped me! I hope this is helpful but it is not medical advise. 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God,
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I’m looking for a good gluten-free magnesium supplement that isn’t the oxide form and the Natural Calm products say gluten free on them, but when I contacted them they said that it is a shared facility/equipment that gets “thoroughly sanitised” before gluten-free products are made. I’m not sure if I want to try it or not so I was just wondering if any of you have tried it before and what your experience was!
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Magnesium Helps Rebuild Bones in Celiac Disease
Dr. Ron Hoggan, Ed.D. posted an article in Autumn 2002 Issue
Five years ago I became concerned about weakness in my bones after a couple of surprising fractures. At one point, I broke a rib while shingling a storage-shed roof. I leaned across the peak of the roofs ridge to pick up a shingle. I never expected such light pressure to cause a problem, however, I felt a sudden, sharp pain, and heard an odd sound. This, along with a couple of less dramatic, but similar injuries, caused me enough concern to begin looking into the question of celiac disease and bone strength. My explorations taught me that calcium absorption probably is not our main problem. People with celiac disease seem to be able to absorb adequate calcium1, but the primary problem appears to come from excreting too much of it, thus causing us to lose more calcium than we are absorbing. I also learned that research shows little or no benefit from calcium supplementation for celiac patients, while magnesium supplementation alone results in significant improvements2. The explanation for this may be that some of the antibodies caused by active celiac disease attack the parathyroid gland3. This organ is an important player in regulating calcium metabolism. Magnesium is necessary for the body to repair the parathyroid and to maintain its continued good function. Being convinced by this research, I began to take magnesium supplements without any calcium. I found that I had to be careful. Too much had me visiting the washroom frequently, and I was afraid that too little would fail to provide me the benefits I was seeking. At the same time, I also requested a bone density test. I wanted objective information that would allow me to evaluate the progress I hoped to make. The first test was conducted in March of 1997. The results (called "T scores") are reported based on comparison with the density of bones found in young adults. For instance, a score of 0 indicates that the bone density is about the same as would be found in an average young adult. A score in the minus range indicates a bone that has less mineral and more pores than is found in the same young adult. Thus, a score of –1.0 to –2.5 indicates mild mineral losses, while a score of –2.5 or lower indicates osteoporosis. My test results were not as bad as I had feared. The mineral density in my lower back was normal for my age, at –0.23. However, my upper leg, where it fits into my hip, was reported as –2.02, and my forearm was slightly stronger than that of a normal young adult at +0.19. As I saw it, there were only two causes for concern. First, at the tender age of 50, my hips were very close to osteoporotic, and certainly at a substantially increased risk of fracture. Such fractures can be very serious. Secondly, since only three skeletal areas had been tested for mineral density—and since there was such a wide range of density reported for each of these areas, it seemed impossible to estimate the density of the rest of the bones in my body. About three years after my first bone density test, some Calgary-based research made me suspect that the amount of vitamin D supplements I was taking might be too low4. I increased my intake to 1,000 IU daily. By the fall of 2001, I began to wonder if I was being foolish by avoiding calcium supplements based on the reports I had read. I therefore began to supplement 350 mg of calcium each day. In July of 2002, I underwent a second bone scan. They did not test my forearm, but the other two areas appear to have improved substantially. The T score for my lower back was now at + 0.06, and the T score for my hip had improved to –0.72. I realize that what I am reporting is just one persons experience. It is what the medical professionals call "anecdotal," and does not usually carry much weight. However, my experience does support the only published research of the impact of mineral supplements on bone density in celiac patients that I can find. Based on my own experience, and the relevant research, I am now convinced that magnesium is the most important supplement to consider in the context of celiac disease. I was thrilled to read my latest bone density report. Vitamin D may also be an important factor, but limitations of time and space force me to leave this topic for another day. References: Marsh MN. Bone disease and gluten sensitivity: time to act, to treat, and to prevent. Am J Gastroenterol. 1994 Dec;89(12):2105-7. Rude RK, Olerich M. Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int. 1996;6(6):453-61. Kumar V, Valeski JE, Wortsman J. Celiac disease and hypoparathyroidism: cross-reaction of endomysial antibodies with parathyroid tissue. Clin Diagn Lab Immunol. 1996 Mar;3(2):143-6. Embry AF, Snowdon LR, Vieth R. Vitamin D and seasonal fluctuations of gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol. 2000 Aug;48(2):271-2.
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