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Showing results for tags 'mast cells'.
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To All, I came across this article and research and haven't been able to post it till now and I thought it deserved it's on thread topic. I will probably post in the Magnesium, Magnesium, Magnesium thread at a later date. Maybe it will help some one else. https://blog.organicolivia.com/magnesium-deficiency-associated-high-histamine-levels-allergies/ And this research they quoted entitled "Blood and mast cell histamine levels in magnesium-deficient rats" https://pubmed.ncbi.nlm.nih.gov/6445415/ Where they note Histamine Levels are elevated to 6 to 7X compared to a healthy person with normal Magnesium levels. There seems to be an direct relationship (IMHO) between a Magnesium deficiency and a disordered immune systems IE a Magnesium deficiency could be the trigger for a Histamine Intolerance leading to a Histamine Storm... This would explain well this research as well entitled "Effects of magnesium deficiency on dermal mast cells in rats]" https://pubmed.ncbi.nlm.nih.gov/2438197/ I hope this is helpful but it is not medical advice. Posterboy,
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To All, This research was quoted by RMJ and I thought it was worth sharing! And I wanted to start a conversation about it considering how and what role B-Vitamins have in Cytokine production and/or the management of our Immune System(s) since we know B-Vitamins are involved in controlling Cytokine production we know they play a role in activating and controlling our immune responses. I will start with this research. Entitled "Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund’s adjuvant" https://www.sciencedirect.com/science/article/abs/pii/S1734114016302729 I hope this is helpful but it is not medical advice. Posterboy,
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To All, Knitty Kitty started a thread on Thiamine, Thiamine, Thiamine, once upon a time, so now is the time to start a thread on Magnesium as a resource for others who don't have the time to do the research and wonder if taking Magnesium might help them! Maybe it will be helpful to others as Knitty Kitty's thread on Thiamine deficiency. I will start with one on IBS and Magnesium Deficiency. Entitled "Magnesium and inflammatory bowel disease" aka IBS quoting there entire abstract because it is instructive. Abstract "Mg deficiency is a frequent complication of inflammatory bowel disease (IBD) demonstrated in 13-88% of patients. Decreased oral intake, malabsorption and increased intestinal losses are the major causes of Mg deficiency. The complications of Mg deficiency include: cramps, bone pain, delirium, acute crises of tetany, fatigue, depression, cardiac abnormalities, urolithiasis, impaired healing and colonic motility disorders. Serum Mg is an insensitive index of Mg status in IBD. Twenty-four-hour urinary excretion of Mg is a sensitive index and should be monitored periodically. Parenteral Mg requirements in patients with IBD are at least 120 mg/day or more depending upon fecal or stomal losses. Oral requirements may be as great as 700 mg/day depending on the severity of malabsorption." Or simply stated up to almost 90% of IBS patients are or could be low in Magnesium. This youtube webinar that summarizes a lot of Magnesium links to allergies in about a 30 minute video. https://www.youtube.com/watch?v=NYeuSw86bzk This one for anyone who has asthma entitled "Role of magnesium in regulation of lung function" https://pubmed.ncbi.nlm.nih.gov/8509592/ This one entitled "Magnesium (Deficiency) in Infectious Diseases in Older People" https://pubmed.ncbi.nlm.nih.gov/33435521/ This one entitled "Possible roles of magnesium on the immune system" https://www.nature.com/articles/1601689 This is enough to get this thread started I/you/we can always add more research latter. I always said the Lord being my help......I was lucky I found Magnesium early and I still believe that! I hope this is helpful but it is not medical advice. Posterboy by the grace of God,
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Celiac.com 05/20/2021 - Celiac disease is the result of complex interactions of environmental, genetic, and immunological factors. Celiac disease is now considered a prototype of T-cell-mediated disease marked by gluten intolerance, and the targeted destruction of enterocytes by T-cell receptor αβ intraepithelial lymphocytes. However, the latest research indicates that innate immune system activation is necessary to trigger a gluten-specific T helper-1 response. Mast cells play a key role in innate immune response, and contribute to the pathogenesis of numerous diseases. A team of researchers recently set out to examine the role of mast cells in celiac disease. The research team included Barbara Frossi, Marco De Carli, and Antonino Calabrò. They are variously affiliated with the Department of Medical and Biological Science, University of Udine, in Udine, Italy; the Second Unit of Internal Medicine, University Hospital of Udine, in Udine, Italy; the Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University Hospital of Florence, Florence, Italy; and the Tuscany Referral Center for Adult Coeliac Disease, AOU Careggi in Florence, Italy. They reviewed the results of studies on the role of mast cells in the development and trajectory of celiac disease, demonstrating that these cells increase in number as the disease progresses, and promote inflammation, and the researchers conclude: "Considering that mast cells are at the forefront in the interaction with the environment due to their privileged position within the mucosal tissue, the ability of mast cells to respond to gliadin peptides accounts firstly for a direct role of mast cells in the onset of celiac disease." Read their full report in the International Journal of Molecular Science.
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Mast Cells Tied to Onset and Progression of Celiac Disease
Jefferson Adams posted an article in Latest Research
Celiac.com 05/18/2017 - Researchers understand pretty well that celiac disease is driven in part by an accumulation of immune cells in the duodenal mucosa as a consequence of both adaptive and innate immune responses to undigested gliadin peptides. Mast cells are innate immune cells that produce a majority of co-stimulatory signals and inflammatory mediators in the intestinal mucosa. A team of researchers recently set out to evaluate the role of mast cells in the development of celiac disease. The research team included Barbara Frossi, PhD, Claudio Tripodo, MD, Carla Guarnotta, PhD, Antonio Carroccio, MD, Marco De Carli, MD, Stefano De Carli, MD, Marco Marino, MD, Antonino Calabrò, MD, and Carlo E. Pucillo, MD. They are variously affiliated with the Department of Gastroenterology and Digestive Endoscopy at the University Hospital of Udine in Udine, Italy; the Department of Medical and Biological Sciences, University of Udine, Udine, Italy; the Second Unit of Internal Medicine, University of Udine, Udine, Italy; the Department of Experimental and Clinical Biomedical Sciences “Mario Serio,” University Hospital of Florence, Florence, Italy; the Tuscany Referral Center for Adult Coeliac Disease, AOU Careggi, Florence, Italy; the Department of Health Science, University Hospital of Palermo in Palermo, Italy; and the Department of Internal Medicine and Specialist at the University Hospital of Palermo in Palermo, Italy. For their study, the research team scored intestinal biopsy results from celiac patients according to Marsh classification, and characterized those results for leukocyte infiltration and MC distribution. They also characterized mast cell reactivity to gliadin and its peptides via in vitro assays. The team found that infiltrating mast cells reflected the severity of mucosal damage, and their numbers were increased in patients with higher Marsh scores. They noted that mast cells responded directly to non-immunodominant gliadin fragments by releasing pro-inflammatory mediators. Their immunohistochemical analysis of infiltrating mast cells, along with the effects of gliadin peptides on intestinal mast cells, indicates that patients in with advanced celiac disease face an increase in pro-inflammatory mast cell function. This result was also tied to increased neutrophil accumulation, the prevalence of M1 macrophages, and the severity of tissue damage. This study clearly describes the progressive stages of celiac disease, and shows that mast cells are a prominent feature of the inflammatory process. These results show that mast cells are associated with the onset and progression of celiac disease, and that the view of celiac disease should be revised to account for the contribution of mast cells in the onset and progression of the disease; and in the development any new celiac treatments. Source: Journal of Allergy, & Clinical Immunology. DOI: http://dx.doi.org/10.1016/j.jaci.2016.08.011- 2 comments
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