-
Welcome to Celiac.com!
You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
-
Celiac.com Sponsor (A1):
Celiac.com Sponsor (A1-M):
-
Get Celiac.com Updates:Support Our Content
Search the Community
Showing results for tags 'niacin'.
-
Celiac.com 02/29/2020 - It has been a long and winding road, and around each curve something new has been discovered. I have learned more than I ever thought there was to know about celiac disease. I am forever grateful for having received a celiac diagnosis because it was on that day that I began my journey back to health. On my first day of diagnosis I set out to find out as much as possible about this seemingly rare, but obviously complicated disease. My diagnosis answered a lot of questions for me, yet I was also struck by how many new questions arose. What was the trigger for celiac disease, of course gluten played a part, but what in my past history put me over the edge? What had changed? Did the doctors know so little about the trigger for celiac disease that it was only now becoming clinically identifiable? My last article was an attempt to explain how genetics and environment intersect in celiac disease, but I may have gotten part of it wrong, in part because the International Journal of Celiac Disease (IJCD) got it wrong (at least in my case they did). After the IJCD cited Pellagra in celiacs at a 58% percent rate, I piled on the bandwagon. Quoting “The two diseases can be connected in two aspects. 58% of pellagra patients were shown to have malabsorption and many had intestinal pathology on biopsies.” But we were both wrong I now believe—hold onto that 58% thought, as it will come up later—and I think it's important in helping to confirm my new theory. So where did my pellagra position go wrong? I chose the capstone, pellagra, and not the cornerstone, which may actually be thiamine (B1), and this is easier to do than you might imagine. These diseases have diffuse symptom’s common in their pathogenesis, and only testing can confirm my high suspicion that I may have had undiagnosed, or misdiagnosed, beriberi. Beriberi is is caused by low thiamine (B1). I recently came across research that is 30+ years old that establishes, in mammal’s at least, a trigger for thinning villi titled “Effect of dietary thiamin deficiency on intestinal functions in rats.” To quote from the research “The activities of brush border sucrase, lactase, maltase, alkaline phosphatase, and leucine aminopeptidase were reduced by 42 to 66% in thiamine deficiency, compared to pair-fed controls. Kinetic studies with sucrase and alkaline phosphatase evinced that a decrease in Vmax (61 and 64%, respectively) with no change in Km (33.8 and 4.3 mM, respectively) was responsible for observed impairment in the enzyme activities in thiamine deficiency.” This research leads me to believe that the lactose intolerance so common in those with celiac disease may actually be triggered by thiamine deficiency. I had many of the symptom’s of beriberi, but since I was not in a concentration camp or was not an alcoholic the clinical suspicion was not high enough to have me tested for a thiamine deficiency, despite thiamine and other B vitamins deficiencies that are common in celiac disease. Unfortunately even going on a gluten-free diet does not always correct B vitamin deficiencies, and thiamine, niacin and riboflavin deficiencies have been excluded from most celiac disease studies. One study entitled “Evidence of poor vitamin status in Celiac patients on a gluten-free diet for 10 years" shows that such deficiencies can continue long after diagnosis. Another study entitled “Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients” says: “Almost all celiac disease-patients (87%) had at least one value below the lower limit of reference.” Testing for certain vitamin deficiencies is standard care following a celiac disease diagnosis, however levels of thiamine (B1), niacin (B3) and riboflavin (B2) are not usually part of a standard screening. It is my hope from reading this that you are alerted to possible B vitamin deficiencies so that you can ask your doctor to have your levels checked, especially if you have been recently diagnosed, or are still struggling with diffuse symptoms years later, for example fatigue, muscle cramps, tingling in your feet and hands, burning feet syndrome, worse at night, etc. You may still be low in thiamine, riboflavin and/or niacin, and doctors often overlook screening for these deficiencies in celiac disease. Celiac Disease is a Genetic Disease with an Environmental Trigger This is where B vitamins come in, as they help us make energy and regulate our environment at the cellular level. It is a 50/50 equation of stress vs. environment combined with genetics, and this can be a hard concept to understand because many people believe that it's all due to DNA. Research from December 2019 entitled “DNA Has Relatively Little Say in Disease Risk (Usually)” says: “In fact, for such (most) diseases, the genetic contribution to disease risk is just 5–10%. There are diseases, however, for which the genetic contribution is about 40–50%. These diseases include Crohn’s disease, celiac disease, and macular degeneration.” B Vitamins, Especially Thiamine (B1), Could be the Missing Pieces to the Puzzle Via the Parasympathetic Nervous System (PNS) the neurotransmitter "acetylcholine" regulates our organ functions throughout the body, and could be why both undiagnosed celiac disease and beriberi affect so many organs in the body. Without enough thiamine our body can’t synthesize enough acetylcholine to regulate it’s organs, which may cause the body to go into high alert mode and trigger a runaway auto-immune reaction like celiac disease. Another study shows a connection with the microvilli that line organs and how they can trigger auto-immune reactions throughout the body. What about that 58% I mentioned earlier? It happens to be the same rate that Japanese sailors developed beriberi, which is what you would expect to find when someone relies on too many carbs, including too much rice or wheat in their diets. It's possible that when the carb happens to be wheat this deficiency could trigger celiac disease, a disease that was discovered by Willem-Karel Dicke in the post WWII Netherlands, or present itself as beriberi when one only eats rice. It took 20 years and countless deaths before the Japanese army discovered what the Japanese navy had learned 20 years earlier, and this article on the “Barley Baron” supports why there is a strong need to enrich gluten-free bread with B vitamins, exactly as regular wheat bread is enriched. According to this article, "(w)e now know that beriberi stems from a lack of vitamin B1, which the body requires for metabolizing carbohydrates and maintaining neurological functions. Without it, a person succumbs to nerve damage and eventually death." So, perhaps a thiamine deficiency is one of the overall environmental triggers of celiac disease in those who have the genetic disposition? Could beriberi trigger celiac disease in susceptible individuals? Hopefully more research will be done to determine this, but in the meantime, get your thiamine levels checked! Additional Resources: https://www.ncbi.nlm.nih.gov/pubmed/23379830 https://www.ncbi.nlm.nih.gov/pubmed/29982183 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863043/
- 23 comments
-
- celiac disease
- niacin
-
(and 5 more)
Tagged with:
-
Vitamins for Anxiety, Depression and Mental Health
knitty kitty posted a blog entry in Thiamine Thiamine Thiamine
Below are links to studies showing that vitamins in the B Complex help relieve anxiety and depression. References: Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey https://pubmed.ncbi.nlm.nih.gov/33848753/ The Role of Vitamins and Minerals in Psychiatry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/ Thiamine and benfotiamine: Focus on their therapeutic potential https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682628/ Hiding in Plain Sight: Modern Thiamine Deficiency https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/ Vitamin B6: A new approach to lowering anxiety, and depression? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577631/ High‐dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787829/ Higher vitamin B6 intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study https://pubmed.ncbi.nlm.nih.gov/31188081/ Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060244/ Dietary niacin intake in relation to depression among adults: a population-based study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506255/ A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770181/ Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake https://pubmed.ncbi.nlm.nih.gov/34959947/ Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688056/ The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/ Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post‐hoc analysis of a randomised controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292249/ The Role of Vitamins and Minerals in Psychiatry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/ Additionally... Factors associated with villus atrophy in symptomatic coeliac disease patients on a gluten-free diet https://pubmed.ncbi.nlm.nih.gov/28220520/ Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728667/ The Effects of Dietary Tryptophan on Affective Disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393508/ Antidepressant-like Effects of Representative Types of Food and Their Possible Mechanisms https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10574116/ Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level https://pubmed.ncbi.nlm.nih.gov/34737364/ Effect of Tryptophan, Vitamin B6, and Nicotinamide-Containing Supplement Loading between Meals on Mood and Autonomic Nervous System Activity in Young Adults with Subclinical Depression: A Randomized, Double-Blind, and Placebo-Controlled Study https://pubmed.ncbi.nlm.nih.gov/31902864/ Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2959081/ Nutrition as Metabolic Treatment for Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907178/ Sharing Pathological Mechanisms of Insomnia and Osteoporosis, and a New Perspective on Safe Drug Choice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336562/ Passiflora incarnata in Neuropsychiatric Disorders—A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766837/ Effects of L-tryptophan on sleepiness and on sleep https://pubmed.ncbi.nlm.nih.gov/6764927/ The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression https://pubmed.ncbi.nlm.nih.gov/33942088/ Is tryptophan a natural hypnotic? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161739/ The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555967/-
- biotin
- cobalamine
-
(and 8 more)
Tagged with:
-
To All, I came across this Old Live Journal blog a few years ago doing research on Zonulin and/or Niacin to see if I could find a "Metabolic link" to Pellagra in Celiac disease and I never had a good opportunity or chance to use it......but thought it was research worth discussing so I thought I would start a thread about it to see what others thought about it? https://alobar.livejournal.com/2930798.html#%2F2930798.html Could Zonulin be the body's way to tell the body it needs more Niacin? This researcher seems to think so and the research seems to indicate.....and I tend to agree with it/them what do others think about this? quoting from the blog post... "For a number of years I have mentioned some articles talking about gluten and corn protein having the effect of opening up the permeability of the intestines WHEN (and only when) the animals were niacin deficient at the time of exposure." And also a little lower in the blog post see this quote... "Jon Pangborn and I have had conversations about a shift that may have occurred since he began looking at plasma amino acid profiles years ago and saw many with elevated tryptophan. I don't see elevated tryptophan that much, but I do see a lot of reports (20%) that don't have a figure for tryptophan. I think this is because it was not detected, although I WISH the labs were clearer about SAYING that instead of just leaving it blank. One reason for my suspicion that the blank field means "not detected" is that I've seen repeat tests from some children, and on other tests, they had measurable tryptophan but it was very, very low. Regardless, tryptophan was above the mean in only about 15% of my database, and below the mean in 81% of the ones where there was a number there. That is nothing like a normal distribution! So, maybe there is something about having low niacin that suddenly makes peptides from gluten (and to some extent corn zein) become signalling molecules, and the raised level of zonulin may just be a "reasonable" response to that signal. In other words, this (Zonulin) might be a "Plan B for niacin" signal. You will see, in the first article below, they did find low plasma tryptophan in people with celiac disease and an altered low neutral amino acid to tryptophan ratio." He was remarking about this study in Celiac children... Entitled "Plasma precursor amino acids of central nervous system monoamines in children with coeliac disease.....American spelling Celiac disease. https://pubmed.ncbi.nlm.nih.gov/1773952/#:~:text=A significantly lower ratio of plasma tryptophan to,children and was more pronounced in untreated children. Here is the full abstract for anyone who wants to read it. Abstract "Some children with coeliac disease show behavioural disorders such as depression and other signs which have been correlated with reduced central monoamine metabolism. We have therefore investigated the brain availability of the monoamine precursors tryptophan and tyrosine in 15 untreated children with coeliac disease and 12 treated children with coeliac disease as well as in 12 control children. Significantly decreased plasma concentrations of tryptophan were found in untreated children (mean (SD) 13 (4) mumols/l, p less than 0.001) compared with treated children (31 (13) mumols/l), and in both groups of coeliac children when compared with control children (81 (22) mumols/l). A significantly lower ratio of plasma tryptophan to large neutral amino acids (tyrosine, valine, isoleucine, leucine, and phenylalanine) was also observed, which could indicate impaired brain availability of tryptophan in coeliac children and was more pronounced in untreated children. The impaired availability of tryptophan could produce decreased central serotonin synthesis and in turn behaviour disorders in children with coeliac disease." I would be interested what people think.....is impaired tryptophan metabolism in children with celiac disease proof enough for you to convenience you that at least at a "Metabolic" level Pellagra is occurring in Celiac disease going undiagnosed? This same metabolic maker of impaired tryptophan metabolism has also been found in adult Celiac's as well! I hope this is helpful but it is not medical advice. Posterboy,
- 2 replies
-
- celiac disease
- corn
- (and 8 more)
-
To All, I don't have as much time as I once did.....to focus on the forum but I wanted to share this new research that I came across that explains (summarizes) perfectly (IMO) all the research I have done on this topic over the years. Entitled "Acne Vulgaris Is a Special Clinical Type of Pellagra" https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=254&doi=10.11648/j.ajcem.20210906.13#:~:text=Foam cells are an important pathological change in,that patients with acne are deficient in niacin. This is “SMOKING GUN” research that proves that Acne Vulgaris is sign of Pellagra…..or as they say is a “Sub-Type” or Special Clinical form of Pellagra! And I would say (IMHO) that the DH of Celiac disease is a special "Sub-Type" of Pellagra that shows up in Celiac patients......or if you prefer their terminolgy.... that DH is a "Special Clinical" form of Pellagra in Celiac's.... Now to be fair.....I wasn't the first to seize on this idea.....the International Journal of Celiac Disease more than 7 years ago now.....I was just the one....who has beat the drum the most.....I agree! Here is the original researsch. http://pubs.sciepub.com/ijcd/3/1/6/#:~:text=Celiac Disease%3A Intestinal%2C Heart and Skin Interconnections The,versa%2C multiple cardiac manifestations exist in celiac disease. Here is the article Scott graciously agreed to publish on this topic... If someone wants to read the whole article just click on the PDF link.....which I highly recommend you do if you have DH....the special form of Pellagra in Celiac disese (IMHO).... Where they make a great point!!!! and this is the same in Beri Beri (to a great degree as well).....unless you are an alcoholic or homeless you can't have Beri Beri or Pellagra in America (it commonly thought and taught)....but what if the wrong people got.....like GI patients.....then the doctor's can't see it....they are EYE Blind too it! quoting "The current diagnostic approach to pellagra does not provide a basis for early warning, definitive diagnosis, timely treatment, nor prevent pellagra from deteriorating and aggravating. Medical doctor cannot diagnose a patient as mild and moderate pellagra clearly." Until a doctor can SEE Pellagra they can't diagnosis it......and if they see Acne, Psorsias, Ezcema, DH etc.....then they can't see the forest for the trees! As a matter of fact a/this link between Ezcema (skin issues) in babies has been tied to Niacin levels in the Mothers Children has been established but the doctors can't SEE it today.....beause this form of Niacin deficiency is subclinical and being diagnosed as a seperate skin disease.....totally unaware of these established connections... Not surpisinlgy this research is 5+ years old.....but mothers and babies still suffer from low Niacin levels going clincially unregnozied as metabolic Pellagra.... https://www.thehealthsite.com/news/high-levels-of-vitamin-b3-during-pregnancy-may-lower-the-risk-of-eczema-in-babies-ag0916-436755/ Which I think this research conclusively proves IMO! Where they summarize it well... "Summary: Based on an analysis of the clinical feature of acne patients, pathological changes in acne lesions and the therapeutic effects of niacin on acne, we propose that acne can be diagnosed as a specific clinical type of pellagra, and niacin is the first choice for the treatment of acne vulgaris." Note: Similar studies have been found in the study of DH in Celiac disease as well.....but these conditions are no longer assoicated......and therefore it goes un/misdiagnosed too this day! I hope this is helpful as always but it is not medical advice. 2 Timothy 2:7 As always, “Consider what I say; and the Lord give thee understanding in all things” Posterboy by the grace of God,
- 11 replies
-
- celiac disease
- celiac posterboy
-
(and 3 more)
Tagged with:
-
Inflammation Model for Sickness Beginning with B-Vitamin Deficiency in Celiac's and other Inflammation triggered diseases…. AKA The LUPUS Inflammation Model or How the ignorance about nutrition is killing us today or how and why B Vitamins are being diagnosed as genetic GI diseases like Celiac disease today Note to blog reader :::::::) I get in the weeds sometimes...If you decide to read this anyway...don't say I didn't warn you.... from an earlier correspondence with Scott who said It would be ok? to post here in the blog area of Celiac.com I did this research originally for myself and how the pieces finally came together....and now posting here below my collected thoughts on this research I have done over the years...here goes nothing...with everything that is going on with COVID-19... It seemed the right time to post it....... Since the day I was diagnosed as a Celiac patient 12+ years ago I began to see if I could confirm my diagnosis or come to the same conclusion based on the current available research. It is said knowledge is power and ignorance kills or at least maims us in this case...the ignorance about nutrition in the medical field is striking because genetics and environment mix/intersect with B-Vitamins. I choose early on in my research the Capstone B-Vitamin --- Niacin because it has been linked to building stomach acid in the body....it was an easy choice I thought but as I begin to make this argument it was apparent .... this model had some holes in the barrel.... Meaning while some Celiac's can/do develop Celiac disease (in time) ...it did explain the majority of the cases. You can read the original article here... Now with two years more study the clinical picture has become more distinct. I choose capstone disease...not the Cornerstone disease. A good model is predictive (or should be)....Pellagra predicts the 25 to 30 pct of those that get DH....so I was only 1/4 to a 1/3 right? It didn't cover the 2/3 of Celiac's who the IJCD in 2015said might go one to develop Pellagra.... and what encourage me to begin talking about Pellagra as a differential diagnosis. First published 5 years ago in the IJCD http://pubs.sciepub.com/ijcd/3/1/6/index.html I made the same mistake the did....I believe they identified Pellagra Sine Pellagra aka a Riboflavin deficiency as Pellagra instead. Which is an honest mistake even for seasoned researchers because one mimics the other.... In fact, because it is a cascade reaction....one stone build’s upon the other...B-Vitamins don't happen in an uncomplicated matter. If you have developed Pellagra a Niacin deficiency you have already developed Pellagra Sine Pellagra (hereafter) PSP a Riboflavin deficiency. Pellagra is like……a 3 alarm fire.....if you have it....everybody else knows you are sick....because the raging nutritional fire in your body has broken out to the surface...and you have terrible skin rashes....IE DH etc.... The main difference between PSP and Pellagra is the level of skin involvement..... PSP only develops skin rashes at junctions of the skin like gentalia, corners of mouth, folds of the skin etc... You might also have hives or various not my hair/skin is on fire itching.....just whelps not itchy ones... Today this might be called a MCAS disease 15+ years ago Prousky proved this a Niacin deficiency orthomolecular.org/library/jom/2002/pdf/2002-v17n01-p017.pdf Then known as a Histadelia or known today as a Histamine Intolerance But this the Capstone nutrient and only a 1/3 of Celiac's will ever develop DH. By now you won't be able to develop any stomach acid.... https://www.ncbi.nlm.nih.gov/pubmed/3992169 Studied 30+ years ago.....NO stomach acid leads to DH.... But other things have happened before this happens.....Like the low Riboflavin that has triggered your PSP. We know it is PSP because organs other than your GI system is involved like your Thyroid for example.... Low Riboflavin levels leads to low thyroid production.... In fact, the bodies ability to synthesize it's own Thyroxine can be/is a sign your body is now low in Riboflavin... https://www.ncbi.nlm.nih.gov/pubmed/3809170 And why in part....Celiac develops/affect multiple organ systems because you have multiple vitamin deficiencies.... Like a web of life....deficiencies are connected in a cascade/feedback loop. ONCE this feedback loop is broken your immune system begins attacking itself triggered by gluten.... The 64K question is how do we stop this auto-immune reaction from happening in the first place or can we? If Celiac disease involves a trigger like gluten to set it off....I believe we can...it is Epigenetics.... and something that is not well understood today...even Genetics have a trigger... we see this in many ways like how stress in Spouses of Celiac's make them have a higher rate of diagnosis even without Celiac genes??? The environment is the trigger! The hormone matters site does a good job of summarizing this... https://www.hormonesmatter.com/mitochondria-energy-not-genetics-underlies-health-disease/ yet we tend to think disease is 70pct genes and only 30pct environment when it much closer to 50/50 for Celiac disease. The latest research confirms this hypothesis.... https://www.genengnews.com/news/dna-has-relatively-little-say-in-disease-risk-usually/ quoting.... "Notice that Wishart referred to most diseases. According to Wishart and colleagues, these include many cancers, diabetes, and Alzheimer’s. In fact, for such diseases, the genetic contribution to disease risk is just 5–10%. There are diseases, however, for which the genetic contribution is about 40–50%. These diseases include Crohn’s disease, celiac disease, and macular degeneration." Now let's see if can see why this is? We know from previous research on air pollution B-Vitamins help us fight the negative effects of our environment .... down regulating our Immune System... https://www.sciencedaily.com/releases/2017/04/170412111211.htm And why taking B-2 or B-3 can help those in the 2nd or 3rd phase of Celiac disease.... But yet we still have not reached the "Cornerstone" Nutrient... Remember this a complex biological system we are dealing with --- one deficiency effects the other deficiencies.... So, we need an analysis (model) that can determine the capstone from the cornerstone....like I confused them and the IJCD did? If this updated hypothesis (Model) is correct? WE know B1, B2, and B3 work together to control our immune system because their synergistic effect has been studied together. https://www.ncbi.nlm.nih.gov/pubmed/30903555 B1, B2, and B3 together protects us from our immune system. But this doesn't tell us what (which of the B-Vitamins) is the trigger? we just know which ones it is.... if our analysis is right and it is a combination of factors/nutrient deficiencies depending on the phase of the disease... But we do know they work in a synergistic way.... We now know and can reasonably conclude stress and the resultant inflammation is the trigger for our Celiac disease in a 50/50 manner.... Let' look at other associated diseases to see if they can help us? Often Celiac is said to have many wicked sister/associated diseases and in our simplicity we like of them as separate diseases.... but an elegant model says/sees a connection (explains) their association. This "Inflammation" model explains how Celiac disease can have many different "faces" or show up in other associated diseases like Lupus as an example....because we only have ONE inflammation model in the body....presenting (being diagnosed with diffuse symptom's in other diseases) all related to Celiac disease....because they are in different phases of the disease IE Celiac disease... or Pellagra or PSP or LUPUS because it is the same "Inflammation" model. This ordered step by connection has been worked out for Lupus recently and why Lupus shows up as an associated disease of Celiac disease because they are the same inflammation model. https://www.eurekalert.org/pub_releases/2019-09/uoaa-hia091319.php We know the same Interleukins involved in Lupus are also involved in Celiac disease which is instructive too us if they are are the same disease in different stage/phases with different faces... The reason Celiac disease has 200+ symptom's because our body uses the same Kyneurine Pathway to develop Niacin.... and by the time Pellagra show up we really are half dead...(Metabolically) speaking....this connection has been established in human diseases effecting nearly every organ system in the body.....because Inflammation shows up everywhere in time... after this pathway breaks down... https://www.ncbi.nlm.nih.gov/pubmed/22084578 But what start/triggers the break? If it is not Niacin as the Capstone nutrient? (I will skip over the discussion of B-2 for brevity purposes (which deserves it's own paper) and skip down to the Cornerstone nutrient.....Thiamine aka Vitamin B1 Think of your body like an engine for a moment....every ICE (Internal Combustion Engine) has a Top Dead Center (TDC) IE firing order etc....the way the engine runs smoothly and in tune...mess with the firing sequence... and the engine won't run at alll......and the same is so for the Krebs’s cycle... It is a robust but fragile cycle that let's make our own energy from our food....like chlorophyll for photosynthesis.... Magnesium and Thiamine are the TDC of the Krebs cycle... (Again to make this short as possible I will not elaborate on the role Magnesium plays in this analysis but only mention in passing (like a spark plug) for analogy purposes the engine won't run without gas....and magnesium acts like a spark plug/catalysis for us to use our Thiamine (gas) for energy in the cell).... Lonsdale says Magnesium and Thiamine are the keys to disease... https://www.ncbi.nlm.nih.gov/pubmed/25542071 This analysis is based on the key neurotransmitter Acetylcholine that regulates our biofeedback system in the body that triggers our immune system in the body. Note: to Celiac.com forum/blog readers much of the above was written free hand...as I collected my thoughts some of the remaining thoughts have been shared first with Ch88 or Knitty Kitty and EnnisTx (in a piece meal fashion) haven written these thoughts out before (but not shared publicly) I am collecting them here for others to research, test out and prove, contest and confirm with more research... but consider it as always (2 Timothy 2:7) and the Lord give you understand (and have your medical experts (doctor's)) review this idea as plausible.... This analysis stands and falls on Acetylcholine....and how we can't make it without Thiamine... when we get low in thiamine ...the acetylcholine (link) is what breaks...that put's our body in an alarm state... but we get low in thiamine FIRST... the low thiamine causes thin villi and leads to lactose intolerance etc... see this research entitled "Effect of dietary thiamin deficiency on intestinal functions in rats. " https://www.ncbi.nlm.nih.gov/pubmed/6465054 the role of acetylcholine was recently confirmed as the triggering mechanism to alert our body to go into alert mode or auto-immune mode by triggering inflammation in our tissues/organs etc.. https://www.medicalnewstoday.com/articles/321624.php and how the use of Baking Soda can help tame this auto-immune effect by turning off this alarm mode for the body... Baking Soda can mitigate this alarm mode by triggering the stomach to produce more stomach acid... And since acetylcholine is one of three triggering mechanism in the stomach in the production of stomach acid along with Histamine they (and gastrin ) I believe regulate when we produce stomach acid and why being low in thiamine lead to be low in stomach acid...but not completely disabling our stomach acid production....Niacin does that... But we are in limp home mode at this point... and auto-immune system is now triggered... Because Thiamine is used in the synthesis of Acetylcholine and it's role in the Parasympathetic Nervous System organs through out the whole body are affected... See this Wikipedia figure that expands how this simple neurotransmitter is used in multiple organs in the body not just the brain (at the name implies) https://en.wikipedia.org/wiki/Acetylcholine#/media/File:1503_Connections_of_the_Parasympathetic_Nervous_System.jpg since Acetylcholine is used by the intestines to regulate our smooth muscle tissues (think peristalsic action of GI tract) often times the GI tract is the first place people notice it...medical definition of peristalsis.... "the wormlike movement by which the alimentary canal IE (the GI tract) or other tubular organs with both longitudinal and circular muscle fibers propel their contents, consisting of a wave of contraction passing along the tube" see this great overview on how thiamine effects the body...on the health supplements guide website... https://healthsupplementsnutritionalguide.com/vitamin-b1/ quoting how Acetylcholine is used to regulate key organ systems including the Brain, Heart and GI tract.... "11. used by the nervous system to ensure normal muscle tone of the heart, stomach and intestines" causing intermittent constipation and diarrhea... People don’t' put 2+2 together because we think these complex systems are acting independently but the Parasympathetic Nervous system (as a neurotransmitter acetylcholine) connects them all... But this research shows how low thiamine status leads to an interruption of Acetylcholine production by the body... and not surprisingly it is 30 years old and a generation has forgot about it...entitled "Impairment of acetylcholine synthesis in thiamine deficient rats developed by prolonged tea consumption" https://www.sciencedirect.com/science/article/abs/pii/0024320584906258 For must humans we don't consume enough "sweet" tea to trigger this ...but more than 6 to 8 or more cups of coffee a day... could do it..as an example.... The reason most humans develop Beri Beri is a high CARB load....not just high wheat etc.... Anybody that (is lacking protein in a well balanced diet) could on a high (SAD) diet could develop Beri Beri (fatigue etc.) PSP (thyroid problems) Skin Issues (DH, Pellagra etc.)...as the diseases pile on ever more symptom's... Pharmacy Times has a nice article about Thiamine, Magnesium and Obesity on this topic.... https://www.pharmacytimes.com/contributor/adam-remick/2018/07/thiamine-and-magnesium-in-obesity-a-possible-factor-in-disease-prevention-and-co-treatment this article has a nice overview as well... https://www.eonutrition.co.uk/blog/thiamine-deficiency-a-major-cause-of-sibo In fact, up to a 1/3 of patients obese enough to have gastric bypass surgery due to an over reliance to CARBS in their diet triggering sub-clinical Beri Beri... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352173/ Now people (Celiac's) just need to get tested for it....to confirm this analysis??? But be aware tests can be tricky...because they often test for the wrong things...It is much quicker to take a high quality supplement like Benfotiamine than to confirm a Beri Beri diagnosis because the symptom's are so diffuse and common in other diseases today the doctor's don’t' recognize Beri Beri anymore as a separate disease unless you are drinking... Here are more resources from the hormones matters website that might be helpful to you... http://www.hormonesmatter.com/thiamine-deficiency-testing-understanding-labs/ https://www.hormonesmatter.com/navigating-thiamine-supplements/ As I told EnnisTx....doctor's are much more likely when your 1/3 to a 1/2 dead today like in emergency room today... https://www.sciencedirect.com/science/article/pii/S0872817813001197 When diagnosed in Celiac's ....they term it a "rare" condition (as usual) because they rarely recognize it today ... and even Celiac's have a claim too it .....it is called a Celiac Crisis.... I say it is a crisis today that B-Vitamins deficiencies like Thiamine, Riboflavin, and Niacin are not being diagnoses and worse tested for these deficiencies so the real rate of this high calorie malnutrition is being diagnosed and treated so people can get better from these (often) misdiagnosed disease in Celiac disease.... Beri Beri being the Cornerstone for the Cascade (house of cards) to come tumbling down. I know it was in my case....burning feet (pins and needles), Creatine in Kidneys, Angular Cheilitis, begins of a thyroid problems, chronic fatigue, low stomach acid, lingering constipation and diarrhea, Low T, chronic fatigue all got better with a B-complex and/or B-1, B-2 and B-3 supplementation.... And I now know after 12+ years of research that low Thiamine was the beginning of the cascade causing thin Villi, leading in time to Leaky Gut... I hope this is helpful....share with as many Celiac experts as you think would listen, this is about educating others...."For to Educate is to Free" Tests need to be done to confirm the years of research I've done so it can benefit other still suffering.... and all I ever wanted to do.... I just hope it is not another 20+ years before doctor's begin testing for these nutritional deficiencies in Celiac's... 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God, Note: For the intrepid reader still reading this blog post....I have tried to make this as exhaustive as possible (but you can stop reading now if you want) what follows is additional resources added later (after I composed this blog post/originally meant as two separate posts) but presented here today as a long, rambling post in the eclectic posterboy style.... I am known for...see references for more study for yourself below.. PART 2 References Micronutrient deficiencies in inflammatory bowel disease trivial or crucial like IBS and Chrons one third have a thiamine deficiency https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863043/ 1/3 develop a thiamine deficiency …..the other 1/3 develop Chronic Fatigue etc…or Beri Beri.. Thiamine and fatigue in inflammatory bowel diseases an open label pilot study albumin synthesis, increased albumin breakdown, a redistribution of albumin in body fluids and greater losses of albumin can all contribute to lower serum levels with the stress response. Forum/Blog reader: I had all these things …..but it was being diagnosed as part of my Celiac disease…. Chronic Fatigue (Magnesium and Thiamine) , Burning Feet, Depression etc….Low Albumin levels (for an unknown reason) etc…. and they all got better after taking Thiamine (undiagnosed Beri Beri)….at one point from complications in my diabetes…. I had creatine in my kidney’s now it is under control… To demonstrate that fatigue and other disorders related to ulcerative colitis and Crohn's disease are the manifestation of an intracellular mild thiamine deficiency and not due to malabsorbtion, augmented https://www.ncbi.nlm.nih.gov/pubmed/23379830 Gastrointestinal beriberi a forme fruste of Wernickes encephalopathy in India BMJ Case report? https://www.ncbi.nlm.nih.gov/pubmed/29982183 The difference between a thiamine deficiency and Beri Beri….reference work by Lonsdale A Review of the Biochemistry Metabolism and Clinical Benefits of Thiamine and Its Derivatives Lonsdale knitty kitty Reference work on the difference between a thiamine deficiency and Beri Beri…. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1375232/ Useful resources::::::::::) Things added on the 2nd day Lays out Stress Response in the body and how Interleukins help manage this in the body…. about Albumin Deficiency and Cytokine production….see paragraph on stress response in the body https://healthfully.com/albumin-deficiency-8042757.html Stress Response Hypoalbuminemia is often caused by an acute or chronic inflammatory response to stress. Infections, surgery, trauma or burns can lead to an increase in cytokine release and reduced albumin production. Decreased albumin synthesis, increased albumin breakdown, ****I apologize for the length of this post.....this even too long for me...I (usually as noted above might break this into 2 or 3 blog posts) but with what is happening right now in our society and the world with Corona virus...WE never know how long the outbreak might last or who it might effect....so in case I don't make back it to the forum (or another posterboy blog post) for awhile.... I unloaded the kitchen sink... in hopes it might help the next person who has similar symptom's and/is being misdiagnosed/or going undiagnosed like I was for so.....soooo.... many years! If this helps anybody in anyway....praise God! ....I know must will never finish this blog post....but I truly believe it can/will help those who do completely read it and follow up with their doctor's on it.... 2 Corinthians 1:3, 4 3 Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.
- 1 comment
-
- celiac
- inflammation
-
(and 4 more)
Tagged with:
-
To All, I told Scott months ago I would start this resource page of sources and now I am finally making good on my promise(s). I am combining this page into a resource for Vitamin B-3 and Vitamin B-2 because they are related and do not happen in an uncomplicated way. I will start with some Niaicin and/or Niacinamide resources but it is ok to post both B-2 and B-3 resources on this page. There is a similar resource page started by Knitty Kitty on Thiamine.....callled Thiamine, Thiamine, Thiamine. And one on Magnesium, Magnesium, Magnesium etc. This one on Niacin and Riboflavin in a way you might say completes the Triology etc. So here goes nothing as they say... This came up in a different thread and deserves its own thread talking about the role Niacin plays in a healhty GI system. Entitled "Niacin ameliorates ulcerative colitis (aka UC) via prostaglandin D2-mediated D prostanoid receptor 1 activation" https://www.embopress.org/doi/full/10.15252/emmm.201606987 And this one entitled "Two Cases of Dermatitis Herpetiformis (aka DH) Successfully Treated with Tetracycline and Niacinamide" https://pubmed.ncbi.nlm.nih.gov/30390734/ I will try and add more later but that is about all the time I have for tonight. I hope this is helpful but it is not medical advice. Posterboy,
- 3 replies
-
- b-complex
- celiac disease
- (and 7 more)
-
To All, This research was quoted by RMJ and I thought it was worth sharing! And I wanted to start a conversation about it considering how and what role B-Vitamins have in Cytokine production and/or the management of our Immune System(s) since we know B-Vitamins are involved in controlling Cytokine production we know they play a role in activating and controlling our immune responses. I will start with this research. Entitled "Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund’s adjuvant" https://www.sciencedirect.com/science/article/abs/pii/S1734114016302729 I hope this is helpful but it is not medical advice. Posterboy,
-
Is there a Type I and Type II Celiac Disease IF so what is your Type: What the Diabetic Model can tell us about Celiac Disease Subtypes? ****these opinions are my own and are not an endorsement by Celiac.com….these are only my conclusions after years of research. I am sharing to generate thought, feedback, opinions, progress on the topic and change if they make sense to you. I would say there are two types of Celiac disease based on all the available research I have read. Think Type I and Type II like diabetes. I share/post this for your feedback, education, careful thought, insight and opinion(s). Maybe it will spur your thinking! This Model of a "Type I" and "Type II" Celiac disease explains best what is happening IMO! These type of grand break though ideas deserve to be shared on Celiac.com.....I suspect it will be another 10 or 15 years (IF then) that this "Working Hypothesis" will be confirmed with more studies proving IT is a "Working Theory"....I just hope some intrepid medical who might read this will be courageous enough to do a a thorough study on this topic confirming my many years of research as the Lord has been my help! I only ask that you be Berean in your thought! as you read this Posterboy blog post and Consider what I say.... Acts 17:10, 11 10 And the brethren immediately sent away Paul and Silas by night unto Berea: who coming thither went into the synagogue of the Jews. 11 These were more noble than those in Thessalonica, in that they received the word with all readiness of mind, and searched the scriptures (research) daily, whether those things were so. Type I happens as a kid (refractory often)... and Type II happens as an adult (often triggered by PPIs or Stress) see below... and why kid's don't get better (probably)....the age you get these deficiencies effects your bodies response.... triggered, in part, by congenital Vitamin deficiencies in children IMO. I concluded this based on research I recently discovered about how Riboflavin aka Vitamin B2 can affect Villi formation in children…… and why it was first diagnosed in Children in IMO. See these links on Riboflavin....I will summarize....if you get low Riboflavin, Thiamine etc. as a kid...you villi won't recover but if it happens as an adult you can recover from PPIs (low stomach acid) triggered Celiac disease. Here is the research on Riboflavin and Thiamine and Niacin and how they work together to regulate our immune system. https://pubmed.ncbi.nlm.nih.gov/7857908/ https://www.ncbi.nlm.nih.gov/pubmed/8785207 https://www.sciencedirect.com/science/article/pii/S0278691510002474 thiamine and riboflavin together https://www.sciencedirect.com/science/article/abs/pii/S1734114016302729 thiamine, riboflavin and niacin together completely down regulated inflammation/toxicity... https://www.ncbi.nlm.nih.gov/pubmed/30903555 If this Posterboy blog post doesn’t make sense to you? It will have to be someone else to rediscover this again in 15 to 20+ years... I have tried to educate the best I could! Too Educate is Too Free!!!! I have tried to share how supplementing with B-Vitamins helped my GI problems, but it seems/seemed to be a “bridge to far” for some…. May this Posterboy blog post....help you "bridge" over the connection between Genetics and Environment IE....Epigenetics...(STRESS) To discovery this I haven't cared what the truth is....I have just wanted it as it is! Truth Frees us from Error! I only know that...... Magnesium, Thiamine, Riboflavin and Niacin(amide) changed my life! ****note this comments that follows are notes to myself that quickly summarize these points (written previously) as cliff notes version of the above...(this I wrote for you as a summary for myself) "Low stomach acid triggered by stress and we lock in with antacids.. Then being low in stomach aid makes you low in Magnesium in 6 months.. Being low in Magnesium makes thiamine unavailable to the body When thiamine is low – you get low in Riboflavin after a month.. And villi begin swelling --- affecting absorption of other nutrients.. Then because riboflavin is a cofactor for Niacin synthesis via the Kyneurine pathway…. and you develop perfuse Skin Lesions diagnosed as DH… When low in meat and dairy (or take mitochondria toxic medicine) you develop pellagra when you can’t synthesize niacin from low tryptophan and riboflavin levels…" This has recently been confirmed in IMO by the discovery that Tryptophan can be used as Therapeutic in the treatment of Celiacs… https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx Otherwise you rest/settle on just having (PSP) aka Pellagra Sine Pellagra (think thyroid problems) Or Pellagra without Skin Involvements… https://pubmed.ncbi.nlm.nih.gov/3809170/ If this is triggered by infantile Beri Beri or more probably a Riboflavin deficiency your Villi might never recover... SIDS has been linked to a thiamine deficiency in kids. Heck even in old age Beri Beri will cause blindness due to glaucoma...and 80pct of WE (brain version of Beri Beri) is not diagnosed until autopsy upon death... https://www.ncbi.nlm.nih.gov/pubmed/485004 Here is link https://academic.oup.com/ajcn/article/77/6/1352/4689829 focus on the riboflavin and gastrointestinal development paragraph... quoting from that paragraph (read it all) it very informative... "Recent work has shown that even when riboflavin is supplied to tissues intraperitoneally, the absence of riboflavin from the lumen of the gastrointestinal tract from the time of weaning leads to a disruption of normal gastrointestinal development in rats." Meaning in young children probably 2 or 3 years or young never (maybe up to 5 years of age estimate only) (fully) develop Villi if their mother was also low in Riboflavin.... cleft palates develop this way....Riboflavin deficiencies in new born baby's.....Vitamin deficiencies passed from mother to baby.... The below link was recently rediscovered by me even though it is almost 10 years people don't know its role in regulating our immune system our helping keep our GI tract healthy Here is Riboflavin’s role in protecting against the Heatshock protein in SIBO https://www.sciencedirect.com/science/article/pii/S0278691510002474 Entitled "Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25" in SIBO. This also probably happening in Celiac disease as well…..we can surmise if it helps one of the GI disease’s that mimic Celiac disease….it could help Celiac disease as well. See this old forgotten article about how SIBO is common in Celiac disease. Entitled Bacterial Overgrowth of Small Intestine aka SIBO Common in Treated Celiac Disease https://www.celiac.com/celiac-disease/bacterial-overgrowth-of-small-intestine-common-in-treated-celiac-disease-r791/ Note: a couple things here….this Is not suspected Celiac disease but “Treated Celiac Disease”….. SIBO is common in treated Celiac disease….meaning these were people eating a gluten free diet already…. And as I often site and say in my Posterboy blog post this research 10 or 15+ years old…. And yet people (doctor’s/clinician’s) are not aware of these connections/associations…. I set out to confirm my diagnosis and it took me approx. 4+ years to realize I had Low/NO stomach acid going un/misdiagnosed. I have continued studying since then….and I am convinced now more than ever 10 to 12+ years later that Low/NO stomach acid could help Celiac’s….. But we have a “Long Tail” Memory…..and can’t seem to move onto another possible diagnosis like Low/NO stomach acid despite what the research seems to say! I am not the first to discover, study or conclude this… This was studied 30+ years ago....but through much study and the grace of God I have rediscovered it..... will it be another 10 or 15 years before it is accepted??? I hope and pray not! But I honestly don't have much hope.... That people will read it and believe it.....it has been lost for 30+ years for a reason.....nobody believes it! See this research entitled Gastric morphology and function in dermatitis herpetiformis and in C(o)eliac disease. https://pubmed.ncbi.nlm.nih.gov/3992169/ quoting “Antrum-sparing chronic atrophic gastritis was present in 92% of the achlorhydric patients, and hypergastrinaemia and serum parietal cell antibodies were found in most of them. The prevalence of chronic gastritis of the body and of the antrum increased with age.” Note again: this was not in NCGS patients….but diagnosed Celiac and DH patients…. Surely Low/NO stomach acid is the trigger for Celiac disease. IF this is so we would see the same thing in PPIs users… And WE do….recent research confirmed this analysis….among PPIs users….for those who used them for a year or more Low Stomach Acid (from PPIs Acid reducers) were found to be the trigger (CAUSE) of their Celiac diagnosis! See this article about it on Celiac.com entitled “Do Proton Pump Inhibitors Increase Risk of Celiac Disease” https://www.celiac.com/celiac-disease/do-proton-pump-inhibitors-increase-risk-of-celiac-disease-r2860/ They summarize it very well…. Quoting “The data clearly show that patients who use anti-secretory medications are at much greater risk for developing celiac disease following the use of these medicines. The fact that this connection persisted even after the team excluded prescriptions for anti-secretory medicines in the year preceding the celiac disease diagnosis suggests a causal relationship.” See also this thread started by Knitty Kitty https://www.celiac.com/forums/topic/117685-atrophy-associated-with-ppis-nsaids-and-ssris/ Back to the main point of this Posterboy blog post….Low stomach is triggerable and reversible a “Type II” Celiac disease. A congenital Celiac disease diagnosed as a kid…could not be reversed (in most people)…. and why it was originally diagnosed as a “Type I” genetic disease once Celiac antibodies were discovered IMHO. I don’t believe it fair to someone who at 40 or 50 started taking PPIs to then tell them…you now have a genetic disease…. No, it was triggered by your PPIs usage….and is reversible like most EPI (Environmentally) genetic triggered diseases are…. B-Vitamins are the very definition of Epigenetics….you got low in Vitamins….and you got a disease from the deficiency…. This might not show up for years….until the Doctor’s recognize as a deficiency…..hence a “Type II” diagnosis! I have written a couple other Posterboy blog posts that might help you. An “Open Letter” Part 1 and Part 2 that explains how these things are connected if you think it would help you to read some more on these connections. I didn’t understand it at the beginning of my journey, but I hope it will help start you on your journey back to heath as it did me! It has been a long journey for me….but It can be short(er) for you….because you know the way back….I have shown you how I got back! https://www.celiac.com/blogs/entry/2167-open-letter-part-1-to-fellow-gi-sufferers-etc-like-ibs-uc-and-other-gi-diseases-like-infant-heartburn-gerd-that-grows-into-in-time-to-ibs-uc-chrons-and-ncgs-as-a-teenager-or-celiac-disease-in-time-as-an-adult-look-beyond-to-the-parent-disease/ https://www.celiac.com/blogs/entry/2515-open-letter-to-the-many-gi-sufferers-part-2-still-suffering-look-beyond-these-symptom%E2%80%99s-to-the-parent-disease-pellagra-with-these-many-unruly-children-like-ibs-gerd-uc-etc-up-to-and-including-ncgs-and-celiac-disease-in-time-i-believe-part-2/ Just trying to help those still suffering (I believe) unnecessarily. Who think there is only one Type of Celiac disease? 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” I hope this is helpful but it is not medical advice. 2 Timothy 2:7 As always, “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God, ADDENDUM: I am adding this Posterboy blog post from an earlier blog post maybe it will help you…. https://www.celiac.com/blogs/entry/2103-why-and-how-pellagra-is-often-confused-with-celiac-disease-andor-other-gidigestive-problems-the-science-of-pellagra-a-hidden-epidemic-in-the-21st-century-presentingrevealing-as-ncgs-andor-possbily-celiac-disease/ At the time not many people read it…..but maybe this time more people will read and understand it! The presenting symptom of DH in Celiac disease is confirmation that the Kynurenine Pathway has broken down and who have developed the 3rd "D" of Pellagra…. Let’s hope the doctors realize this before the 4th "D" symptom DEATH occurs! Since 80 percent of Wernicke Encephalopathy better known as the mental/brain symptom of Beri Beri is diagnosed on autopsy I have my doubts they will notice the Pellagra Co-morbid in 58% (Majority) of Celiac noted no less than by the IJCD (see Posterboy blog post link above) and why I continued to emphasis this in my Posterboy blog posts….. because the IJCD noted the same thing! I only ask that you believe you own research (prophets)…..and agree with them that Beri Beri, Pellagra Sine Pellagra, and Pellagra is happening in Celiac’s. https://www.celiac.com/celiac-disease/how-low-thiamine-can-thin-villi-old-research-rediscovered-and-its-clinical-significance-in-celiac-disease-r5100/:~:text=Beriberi%20is%20is%20caused%20by%20low%20thiamine%20(B1).,dietary%20thiamin%20deficiency%20on%20intestinal%20functions%20in%20rats.” At what rate only more tests/studies can prove. I ask that others in the Celiac community that might read this…. Do these studies….so that future doctors are aware of these connections/associations. I just know we can't wait another 10 or 15 years before this trickles down to the clinical (Medical) level when current (today's) research shows that Tryptophan can be used as a Therapeutic for Celiac disease.....IMHO confirming this theory! https://www.celiac.com/celiac-disease/tryptophan-in-turkey-meat-can-speed-gut-healing-in-celiac-disease-r5338/ Isn't that we ALL want to speed our healing! This is happening in other auto-immune diseases too/also because we only have ONE immune system! With many difference (faces)….IE symptom’s….. Note: Pellagra is found in Lupus too! https://www.celiac.com/blogs/entry/2709-the-lupus-inflammation-model-for-sickness-beginning-with-b-vitamin-deficiencies-in-celiacs-and-other-inflammation-triggered-diseases%E2%80%A6/ I must stop for now, or this will be way too long again!
-
In Part 1 I mentioned many of the GI issues diseases I think this might help and have seen it help. But most people only think of an “official diagnosis” and not co-morbidities in the same person. Treating your Vitamin deficiency lets you treat your co-morbidities. It is known as a 2ndary diagnosis in Sjorgen’s diesease as Pellagra has also been diagnosed with SJD for example. https://www.researchgate.net/publication/263324686_Pellagra_in_a_patient_with_primary_Sjogren's_syndrome Despite the conditions responding to Niacin(amide) --- Pellagra was still considered the 2ndary disease. This is more common than people realize often. You hear often “you” the average person doesn’t need to take a Vitamin but if you are reading this blog you are not average. People with Celiac disease and other GI problems are known to be low in a range of Vitamins. See this link for appropriate supplementation with a celiac diagnosis. https://www.ncbi.nlm.nih.gov/pubmed/24195595 Niacin(amide) was not mentioned in this study but should be added/studied since B-Vitamins are known to help Celiac’s. At 58% co-morbidity of Pellagra in Celiac’s there is better than 50/50 chance your symptom’s can be in remission in 6 months? If you are ONE of the many Pellagrins being diagnosed as Celiac disease today. Gluten free works actually summarizes this topic well. https://glutenfreeworks.com/blog/2017/07/18/niacin-vitamin-b3-deficiency-in-celiac-disease/ But still people are afraid to take a water soluble Vitamin that is known to help digestion problems. Are you Afraid of a Vitamin? You needn’t bee! Praise bee to God! I must always say *** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen but it helped me. And I think it can help you too and why I share for “Sharing is Caring”. 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God, *****Addendum I mean this to be some kind of “Opus”. My story! Yours might be different. Now the onus is on you to try? What you can do is urge your doctor to have you tested for Pellagra (though I doubt very seriously you will test low). See this posterboy blog post that explains the difference in Primary and 2ndary Pellagra. Anyone who eats a protein rich diet will not test low enough to be diagnosed as a Pellagrin at least in the Western world. You have bee near death, an alcoholic or homeless to be diagnosed as a Pellagrin today or maybe an alcoholic homeless fellow who has severe Psorsias. . . might test positive for Pellagra if they knew to test for it. And why it usually shows up in war torn areas today because protein is limited in war. (and Alcoholics) as seen in this House MD episode on Celiacs called Forever because Alcoholics have poor diets and thus low in protein in their diets. https://www.bing.com/videos/search?q=house+season+2+episode+22+forever+daily+motion&view=detail&mid=C2050653028DE02DBDE6C2050653028DE02DBDE6&FORM=VIRE What needs to be done to change this oft over looked fact is a study with Niacin to see if it helps Celiac’s. See here where other B-Vitamins were shown to help Celiac’s. https://www.celiac.com/articles/21783/1/B-Vitamins-Beneficial-for-Celiacs-on-Gluten-Free-Diet/Page1.html this study was only as to how it (B-Vitamin supplementation) effects homeocysteine levels in people diagnosed with Celiac disease. Not if taking a B-complex or specifically the Niacinamide version of Niacin could help treat or alleviate gluten antibodies in Celiacs with cross contamination. A double blind study would have to be done but could be effectively tested with some time and effort. This is only antidotal information with no confirmed medical research unless someone else takes the ball and runs with it. Plumbago you come to mind. But it doesn’t matter who it is. The time has come to test this hypothesis to see if it is a “working theory”. I only know it helped me and helps other I give the Vitamin B-3 as Niacinamide to . . . up to and including people who have had an official NCGS diagnosis. Which tells’ me it would help other Celiac’s too if they would try it (Niaciamide) 3/day for 6 months. Note: No Follow up is done at two years to see if they are in remission after cross contamination or if they have adhered strictly to a gluten free diet. But their clinical outcomes (symptom relief) appear to greatly improve at 6 months including re-introducing problem foods such as dairy which they now tolerate without GI distress. I have tried to be a witness to what I have experienced. (I speak as a man) that no other person Pellagin being diagnosed as Celiac disease instead would be in the dark about this fact. Romans 10:13-15 King James Version (KJV) 13 For whosoever shall call upon the name of the Lord shall be saved. 14 How then shall they call on him in whom they have not believed? and how shall they believe in him of whom they have not heard? and how shall they hear without a preacher? 15 And how shall they preach, except they be sent? as it is written, How beautiful are the feet of them that preach the gospel of peace, and bring glad tidings of good things! When you get the right/correct diagnosis (if Pellagra is correct/parent diagnosis) it’s unruly child Celiac will get better. See this posterboy celiac.com blog post. I only know it is a devastating delay. To ignore one disease at the expense of the other. quoting the celiac posterboy again “A differential diagnosis is one of the best standard of medicine rarely practiced today and how specialists decide between competing diseases like UC or Chron’s or IBS or Celiac Disease and if I am right Co-Morbid Pellagra now forgotten for 75+ years since the “War on Pellagra” is now over according to medical professionals’ but sadly the battle rages on for at least for the potential 3 Million American’s who are now being diagnosed as Celiac disease today instead.” AS someone who has had BOTH Celiac and Pellagra. I can tell you that it can be difficult to tell them apart sometimes (most times). What we fail to understand often with any diagnosis there is continuum of disease/symptoms. Yet we think of them as separate diseases Right? I have unwittingly become the Celiac and Pellagra Posterboy . Learn from my mistakes! I have made too many (mistakes) to count. Take as much honey (knowledge) as you can from my mistakes so bad (lack of knowledge) health will not sting your quality of life. So let’s say. Today they find a miraculous cure for Celiac disease or NCGS. . . it would take on average 17 years for doctor’s in Clinical settings to apply these technique’s to eradicate new Celiac cases/diagnosis’s from occurring. Now in this hypothetical case (which doesn’t exist yet or does IT? As a differential diagnosis the answer is a definite YES) it would take another 17 years on average for doctors if they knew today that Pellagra (which they don’t) can mimic Celiac disease in a Clinical setting. But one does exist (it is not hypothetical) – a cure for Pellagra exists today. It has in fact existed for 100+ years and still doctors don’t recognize it today. I share/write these posterboy blog post’s so that others might not have to suffer the same things’ I have again in the future someday. . . I pray soon! Now that you have the knowledge of my experience what will you do with it? Every hour/patient/person matters. And why I have tried diligently to educate other Celiac’s of this maddening fact. All those who have ears to hear may they listen! Feel free to read all my posterboy blog post’s if this pique’s your curiosity/interest but there is only so much in a/one blog post than can be explained but it really Is not necessary or visit the website/blog in my profile where I have told the same story hundreds of time that ONE fellow sufferer like myself may/might be helped by the same wisdom, I found God being my help, when I learned Pellagra and Celiac disease are Siamese twins and separating one (supplementing one to death) will kill the other (cause the other to go into remission). And I believe you can too! Praise bee to God! 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them (fellow sufferer) which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” Posterboy by the Grace of God, EPILOGUE A simple self-test is to prove this works for you and your friends. It is to take Niacin as NIACINAMIDE usually one 300 count bottle is enough for a 3month supply. I call it the NIACINAMIDE CHALLENGE. You and a friend/family member begin taking it at the same rate. Whatever that rate is – is fine. But it needs to be at the same rate – consistently. 2/day or 3/day works (i.e., with each meal) works for most people. If so two things will happen for you/them (if Pellagra is indeed Co-Morbid presenting as Celiac Disease) then you/they will begin BURPING for the first time in years and years (if at all) and their stool will begin to SINK to the bottom of the bowl. ***Not twenty minutes after eating something with bloating or burping with carbonation/soda or beer etc. but BURPING 2 hours after a meal without the bloating you used to have. It will start slowly and then be your new normal. The burping within a month of each other will match up with your stool beginning to SINK where it did not before (or it did for me). A witness of two is “true”. Usually it takes 3 to 4 months taking the Niacinamide 1/day to notice these results Usually it takes 2 to 3 months taking the Niacinamide 2/day to notice these results Usually it takes 6 weeks to 2 months taking the Niacinamide 3/day to notice these results If these are your results then together ya’ll have completed a self-test to confirm Pellagra was causing your GI problems. If it is the Vitamin making the difference your GI symptoms’ will improve. It is as simple as that. I would recommend a 6 months regimen for most people. Two 300 count bottles equal $50 Dollars worth of a B-Vitamin. As I called this an open a letter to the many GI sufferers etc. It doesn’t matter what part phase (spectrum) of the disease you are in it will (should) get better. GERD, IBS, UC, NCGS or even Celiac disease if (low Niacin(amide) was the cause) you will have a cause and effect reaction. If you had Pellagra Co-Morbid and your GI improves with supplementation. This almost always works if you are not now taking PPI’s like Nexium or Prilosec etc. . . . If you are taking PPI’s then your “Way Back” may be a little longer but the trip back is the same. ****Again this is not medical advice but it is too cheap not to try and see if it works for you . . . I have found it work for others. ****Note: I am only reporting what medical journals have concluded. It is just not well understood today one disease is being diagnosed as the other because it can take a generation for this knowledge to filter down to the clinical level. Again a “Witness of Two” – you Both having the same reaction to the Vitamin proves Pellagra was causing your symptom’s and the doctor’s don’t recognize it today in a Clinical setting. The Journal of Psychosomatics says its well and I can’t say it better. https://www.sciencedirect.com/science/article/pii/S003331821070668X?via%3Dihub quoting the abstract Pellagra: An Old Enemy of Timeless Importance Author links open overlay panelThomas M.BrownM.D. Show more https://doi.org/10.1016/S0033-3182(10)70668-XGet rights and content Background “In the United States, pellagra is infrequently reported. Yet this disorder does occur among malnourished persons. Objective The author seeks to clarify diagnosis and treatment. Method The author describes various presentations and effects of this disorder. Results Knowledge of classic and atypical presentations can assist in making the diagnosis. The author presents two cases of pellagra that exemplify the classic and atypical presentations. Conclusion The typically robust response of the disorder to physiologic doses of niacin can assist in confirming the diagnosis.” *** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. But I am your witness people, have and do get better using this technique realizing a mistake has been made in your/their diagnosis. It is the time honored medical “Second Opinion” AKA a Differential Diagnosis. Isn’t it about time to see if supplementing with Niacinamide will help your co-morbid Pellagra symptom’s to see if your Celiac disease diagnosis was arrived at in error – no matter well intended has keep you from getting better from Pellagra. Quoting an old friend J. Dan Gill when he talks about the power of Truth to Free us! Where/when he (Dan) talks about the difference between Truth and Error. “The Truth is Always Better The Truth, whatever it is, Is always better than error, Whatever it is.” By J. Dan Gill The truth is when an error/mistake is made. Admit it and move on to the correct/better diagnosis so you can then get better! And we have known how to treat Pellagra for a 100+ years but this generation having not seen it in their lifetimes have forgot how to diagnose it! When they see it in its earliest forms. .. they do not recognize it in a clinical setting anymore! Those that have ears to hear? Listen! You can get better from Co-morbid Pellagra. SADLY! Few listen. But some (Celiac’s) have heard (listened to) the good news that Pellagra is reversible and have gotten better. Don’t be the Last! ****Again this is not medical advice but it is too easy, simple and cheap not too try and see if it works for you too!. . . I have found it works for others. . . not already taking a Proton Pump Inhibitor (PPIs) like Nexium or Prilosec etc . . . Praise bee to God! To those who have listened and got better! Just trying to help those still suffering (I believe) unnecessarily. 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” Posterboy by the Grace of God, 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included.
- 35 comments
-
- celiac
- differential diagnosis
- (and 8 more)
-
When Myth becomes Medical Fact people suffer unnecessarily; the case of mistaken Identity: How Pellagra now thought to be rare today became known as Celiac Disease — A White Paper better said as a Grey paper or ahead of Print Paper To Who Ever might read this......may it be a blessing to you......this is the Capstone blog post to more than 12 Plus years of research. May it bless you to read it. Blessed are those who read it and understand and put into practice in their lives, I pray! I called this a grey paper and or white paper because it is the first time I know this conclusion/hypothesis has appeared in print in any form (note: this is a REPOST from a former blog post) and 2) it has not been proofed by other medical reviewers). These thoughts are my own and do not reflect the opinions of Celiac.com. and should not be considered an endorsement by them.....but is for use only as education on the part of the reader......but hopefully after you have read it all (or other Posterboy blog post) you will not have any remaining questions..... Getting a Peer review paper published requires you agree with the previously published papers and since this is “A New Thinking’ in Celiac disease it is rejected and thus can’t be published by Peer review journals……thus making it a Grey Paper…..kind of like MedRxiv.org etc. and preprint editions on COVID-19 papers etc.…….the results are NO less valid but not approved (as of yet) by their peers. See this article about this topic of Grey Papers or Prepint findings not medically reviewed….. https://newatlas.com/medical/anti-inflammatory-drugs-risk-chronic-back-pain/ Quoting their results “The researchers are aware their findings will likely be controversial as treating acute pain with anti-inflammatory drugs has been standard practice for decades. Speaking to STATnews Mogil said the research team faced challenges getting the new study published in a journal as peer-reviewers were concerned at the radical implications of the findings.” Medical researchers don’t like surprises…..it means they have been wrong about their conclusions all this time…..and that makes them look bad…… and they don’t like that…..so they won’t print any “New and Original” thinking that contradicts their established Dogma (teaching) about the topic. Now begins the Posterboy blog that is modified to show that when Pellagra Sine Pellagra showed up in Wheat based “Food stuffs”….. it was not properly understood as a lesser form of Pellagra that showed up almost exclusively in Corn based “Food Stuffs” and was mistakenly given a new and trendy diagnosis of Celiac disease and/or NCGS instead thus passing into history as Medical Fact too this day a Case of Mistaken Medical Myth. Note: For simplicity this Posterboy blog mentions Pellagra and not Pellagra Sine Pellagra, though Pellagra is also Pellagra Sine Pellagra plus Skin issues etc. Really in most cases 2/3 of the time only Pellagra Sine Pellagra ever develops……unless you also develop Skin issues like DH, Acne, Psoriasis, LUPUS or Sjorgen’s disease etc……then you have developed full blown Pellagra going misdiagnosed…… otherwise the information contained below is accurate as I can make it…..keeping in mind I wrote this originally from the viewpoint that Wheat (IE Gluten) was triggering Pellagra (aka Low or NO Stomach Acid) where before it was being triggered by Corn and this confused the medical (and still does) to this day. If you want to see other Posterboy blog posts on Celiac.com just search for the Posterboy of both Pellagra Sine Pellagra and Celiac disease. Pellagra is/was first identified as occurring in Corn based feed stuffs it is/was only natural that when STRESS (WWII) triggered it..... (Celiac Disease/Pellagra by another name) in wheat based grain diets that doctor’s didn’t see the similarities. So a new disease was being described/created to explain why wheat consuming people developed a malabsorption syndrome that could/would be mistaken for Pellagra if the diet was Corn based. So this medical myth became medical fact in the 50’s and it has not been challenged really until the functional medicine doctor Prousky conclusively proved Niacin treats digestive problems just as Pellagra Preventive Factor Vitamin B-3 did then protect (cause remission) people from Diarrhea, IBS, and other GI problems not yet classified in the early 20th century so too can/does Niacin(amide) (I believe) now treat Celiac disease today because Celiac disease was the first time Pellagra was described in a wheat based diet. The One (Pellagra faded away) and is replaced now by Celiac disease. See Dr. Alessio Fasano’s 5 myths about (of) Gluten in the Washington Post a founder and director of the Center for Celiac Research at Massachusetts General and Author of Gluten Freedom. https://www.washingtonpost.com/opinions/five-myths-about-gluten/2015/12/18/a803377e-a279-11e5-ad3f-991ce3374e23_story.html I want to talk about his 5th myth today. 5) If you have Celiac disease as a child, you will outgrow it. In the same point he contradicts himself (as people often do when they don’t understand the cause of something) when he says to close his point quoting Fasano “Another milestone was when we determined that people can develop celiac disease at any time in their lives, even into old age. Now we know it is a permanent condition, and the best medical intervention we have is a gluten-free diet.” Which is it Doc? You don’t grow out of it but you can grow into it? Is it a genetically triggered disease which patients can’t outgrow? Or is it a disease triggered in time http://www.bloomberg.com/news/articles/2010-09-27/celiac-disease-incidence-increases-as-people-grow-older-u-s-study-shows If you doc are saying your chance of Celiac disease increases with time as you cite then clearly genetics is not the trigger? Clearly doctor you don’t understand the trigger. It makes more sense to say if as child you encountered something in your environment that triggered Celiac disease then you could get better if the trigger (STRESS) was removed just as in older individuals who had not YET encountered stress in their live HAVE not yet triggered Celiac disease genes in their life. One has been substituted for the other. A myth has become (medical) fact. It happens a lot more than you think. See Dr. Dana Myatt’s seven-not-surprising-health-updates-from-2015 she call’s them kindly calls them “updates” but they were really myths. Something told as truth/fact but still persists though proven untrue. If Dr. Fasano is still telling people it is genetic (only) disease but in the same post says you can develop it in old age ONE is wrong? OR it doesn’t well explain what is actually happening. To investigate further his comments in point 5 Dr. Fasano cites Dr. Dicke’s work in the 1950’s “After watching the mortality rate of children with Celiac disease drop during World War II, Dicke suspected that the decline might be related to the scarcity of bread at that time. Still, it would be decades before the notion that you can outgrow Celiac disease was challenged.” Let’s consider our environment here for a second – WWII. I would say that is a pretty STRESSFUL environment to say the least. Any war is stressful but a world war could/might trigger any number of syndromes. So the further we get away (in time) from that stress it only makes sense these children’s health would improve tremendously. And while there was a scarcity of wheat and any food stuffs to a degree (specifically high quality meat proteins known to hold Pellagra at bay) what was not taken into account when considering the possible causes of Celiac disease was you guessed environment (STRESS). Have you experience a lot of stress in your life. Then you are experiencing what researchers are now discovering (again) Lifestyle is risk factor for Celiac Disease and you can develop Celiac Disease at any age (see citation above “Celiac disease risk increases as you grow older (again at ANY AGE) as Fasano himself has proven (again not genetics only) there is a trigger he is still missing because he doesn’t understand completely why this is happening. Now if stress was the only trigger then Celiac disease would of/have shown up in other theaters’ of war presumably the pacific theater as well. But here it is silent. Let’s see if we can’t figure out why? The answer lies in food fortification? I quote “In the U.S., only 40 percent of the nation’s manufactured flour was enriched, because smaller companies continued to produce cheaper unenriched flour to compete with larger manufactures. In 1942, the U.S. Army decided it would purchase only enriched flour.” Which lead to all (100 percent) of the flour being enriched with what was called the Pellagra Preventive Factor at the time the newly discovered third Vitamin or what we know today as Vitamin B-3 Niacin. See this article entitled "Food fortification spurred by military purchases" https://www.eurekalert.org/news-releases/634050 for a great summary. And while flour as a rule was scarce in Europe during WWII especially in latter years what is often overlooked is that the flour that did arrive now had Pellagra Preventive Factor enriched in it aka Vitamin B-3 or Niacin today put the Celiac crisis in remission. A Pellagra outbreak was already successfully quelled once with fortified food stuffs when the Red Cross reversed its incidence during the great flood of 1927 by following Goldberg’s directive of distributing yeast a good nutritional source of Vitamin B-3. See this link http://www.encyclopediaofarkansas.net/encyclopedia/entry-detail.aspx?entryID=2230 Remember Celiac Disease was not classified as a definable disease until the 1950’s when Dicke hypothized that the lack of wheat in the diet improved what was then also known as Gee-Herter’s disease when really it was the presence of Pellagra Preventive Factor as correctly hypothized by Goldberg in the 20’s that caused Pellagra to go into remission in the European theater. I note again for emphasis “After watching the mortality rate of children with Celiac disease drop during World War II, Dicke suspected that the decline might be related to the scarcity of bread at that time” If stress is a trigger for disease and it is. WWII should of increased Celiac disease UNLESS enriched bread with Pellagra Preventive Factor became MORE common and it did halfway through/during WWII in 1942 exactly when we might suspect improvement in Pellagra patients if indeed Celiac disease (Pellagra misdiagnosed) was now being diagnosed in patients who primary dietary staple was wheat and not Corn Maize where/when it was first described/diagnosed in the “War on Pellagra” as summarized well by Dr. Heaney here http://blogs.creighton.edu/heaney/2013/11/18/pellagra-and-the-four-ds/ Because Pellagra is/was first identified as occurring in Corn based feed stuffs it is only natural that when STRESS (WWII) triggered it in wheat based grain diets that doctor’s didn’t see the similarities. So a new disease was being described/created to explain why wheat consuming people developed a malabsorption syndrome that could/would be mistaken for Pellagra if the diet was Corn based. But we got lucky in a way. The US Army knowing the old adage “an army marches on its stomach” got smart and begin requiring all its flour to be enriched thus not only reversing a developing epidemic (Pellagra confused for Celiac disease in Europe) but the US Army not only fighting/keeping in remission Pellagra in its own soldiers but the whole country and continental Europe benefited. For when the Army required enriched flour the country went from 40 percent enriched flour to 100% enriched flours and this new developing epidemic of Celiac disease went into REMISSION too (just as Pellagra too was beaten in the poor South) indicating an environmental trigger 70+ years ago and still (confused) experts in the field saying things like myth #5 not only can you not grow out of it as a child but YOU can grow in to it as an adult. Stop the Madness! How much longer must people suffer before we relearn histories lesson’s that STRESS triggers sickness and Vitamin’s make us healthy? I sometime think we have been hit with this “genetic stick” so much if we don’t understand something well it must be genetic then. We don’t understand it so it must be genetics. Some researchers’ are finally waking up and saying NO Lifestyle is risk factor for Celiac Disease you can get Celiac disease at ANY age. But even doctor’ Fasano doesn’t understand STRESS is the trigger! Why else quoting Fasano again would you say “The fact that about 1 percent of the population is affected by Celiac disease, while almost 100 percent of humankind is exposed to gluten-containing grains, is evidence that these grains are safe for most people” and in the same article say “ Another milestone was when we determined that people can develop Celiac disease at any time in their lives, even into old age.” IT IS NOT GENETICS’ ALONE if you can increase your risk at ANY age. Their might be a pregenetic disposition if STRESS is high enough. Then after saying that we “determined that people can develop Celiac disease at any time” he says exactly the OPPOSITE thing. Quoting Fasano again in his VERY next statement “Now we know it is a permanent condition, and the best medical intervention we have is a gluten-free diet. “ NO doctor it is not permanent or you could not develop it at ANY age. The best medical intervention is vitamins specifically Pellagra Preventive Factor now known as Niacin(amide) Vitamin B-3 as Prousky proved over almost 15 years ago Niacin treats digestive problems. See this Italian Study on Pregnant women prove this summarized by Very Well health that I have subtitled “First Comes Baby, then Comes Celiac Disease” https://www.verywell.com/can-pregnancy-trigger-celiac-disease-562302 I could go on . . . all the inconsistencies trying to fit a round peg into a square hole. EVEN though he say’s and research (HIS) bares it out that it NOT genetic’s alone he (Fasano) can’t let go of his genetic paradigm . . . you want to say . . . wait a minute this disease develops at any age but you still say it is permanent. No your argument has holes in it that doesn’t fit the disease patterns. But Epigenetics (Environment/Stress) triggering this disease does. And Epigenetics is reversible just as Fasano research bares out IS triggerable at any age. And other researchers agree Researchers have not been able to explain why Celiac Disease develops until now; Part 2 Epigenetics (STRESS) discovered as the cause of Celiac Disease/NCGS by the Celiac Posterboy. “According to Dr. Decker Butzner, a Calgary-based pediatric gastroenterologist, there are another triggering factor which we’ve never understood…[t]here is an environmental trigger.“ To summarize I will quote for emphasis me The Celiac Posterboy what I said earlier in this blog post because “Pellagra is/was first identified as occurring in Corn based feed stuffs it is/was only natural that when STRESS (WWII) triggered it (Celiac Disease/Pellagra by another name) in wheat based grain diets that doctor’s didn’t see the similarities. So a new disease was being described/created to explain why wheat consuming people developed a malabsorption syndrome that could/would be mistaken for Pellagra if the diet was Corn based.” So this medical myth became medical fact in the 1950’s and it has not been challenged really until the functional medicine doctor Prousky conclusively proved Niacin treats digestive problems see above citation just as Pellagra Preventive Factor Vitamin B-3 did then protect (cause remission) people from Diarrhea, IBS, and other GI problems not yet classified in the early 20th century so too can/does Niacin(amide) (I believe) now treat Celiac disease today because Celiac disease was the first time Pellagra was described in a wheat based diet. The One (Pellagra faded away) and is replaced now by Celiac disease. See my earlier post where I quote Dr. Heaney of Creighton University and he says as much “Pellagra is a disease of the past” see this link for the whole article Dr. Heaney does correctly state” it is doubtful today that most health professionals (doctors) would recognize it if a case (of Pellagra) happened to come to their attention.” http://blogs.creighton.edu/heaney/2013/11/18/pellagra-and-the-four-ds/ And why should they when Celiac disease has replaced it (Pellagra) today! Well it is not as in the past as people/doctor’s think it just known (goes) now as Celiac disease TODAY! unless your an alcoholic and homeless..... then the doctor's can spot it.....but only if you are also a drinker etc.....it is affluent confirmation basis.....or as Dr. Derrick Lonsdale call's it... High Calorie Malnutrition.....but we know from the Russian Japanese War Circa 1904 to 1905 and the Japanese Navy/Army Beri Beri can still develop even in well fed troops if their Carbs to Protein ratio exceeds 15 to 1 Carbs to Protein ratio etc... See this article about it....https://medium.com/war-is-boring/eating-too-much-rice-almost-sank-the-japanese-navy-f985772c81a6 And is a precedent for how Pellagra Sine Pellagra and/or Pellagra showed up in the middle of WWII in Wheat Based Food Stuffs and the doctor's after the war..... created a new disease from the symptom's......and it has been wrong ever since IMHO. I called this a white/grey paper because it is the first time I know this conclusion/hypothesis has appeared in print in any form. How do we know this is true? We can’t really UNLESS we are willing to try The Niacin (Niacinamide) Challenge and see if your digestive problems don’t’ go into remission as Prousky proved almost 15 years ago this year. You can find the Niacinamide Challenge by Googling for it and you should see it by the Celiac and Pellagra Posterboy..... What have you got to loose.....it is a water soluble Vitamin shown to help GI problems.... We can’t really prove this until medical trials are performed. “Keys” as I call them. Or can we....see the Addendum at the end of the blog post.....I think we can and I have found the research that show 50+ years old Celiac's were shown to have trouble with Tryptophan metabolism.....showing at least Metabolically Pellagra is occurring in Celiac's and it has been over looked by modern medicine in this genetic age when it is/was Epigenetics all along! See my blog post To Educate is to Free by the Celiac Posterboy if you want to read more about this. There are reason’s the doctor’s don’t find Pellagra instead of Celiac disease it is partly because they are commonly taught that “Pellagra is a disease of the Past” to quote Dr. Heaney. But we can “buzz” the doctor’s with this information till they submit to either let you take the Vitamin see my post Who’s Afraid of a B Vitamin or through your improvement/remission assent to do “key” studies proving (again) what the Canadian research Prousky discovered 15 years ago this year that “Niacin(amide) treats digestive problems” And what’s worse 35+ years ago researchers proved that Celiac disease happens when we get low in stomach acid or have NO stomach acid to protect us against the proteins in our diet we are eating……. See this research that show NCGS and Celiac disease start with Low and/or NO Stomach Acid in the case of DH especially. Entitled “Gastric morphology and function in dermatitis herpetiformis and in Celiac disease” https://pubmed.ncbi.nlm.nih.gov/3992169/ Where they note quoting “The frequency of achlorhydria (aka NO stomach acid) was significantly higher in patients with dermatitis herpetiformis than in 69 patients with celiac disease.” And it is worth noting……this study was in ACTIVE Celiacs ……not in candidates….so we can say with Certainty…… this is happening in Celiac’s and continues to --- TOOOOOO! this day! Because we can say with certainty (above 90+ percent) in DH patients and Celiac’s will have little to NO stomach acid. Quoting again…. “Antrum-sparing chronic atrophic gastritis was present in 92% of the achlorhydric patients, (remember this is in ACTIVE Celiac disease) and hypergastrinaemia and serum parietal cell antibodies were found in most of them.” And yet the doctor’s toooooo this day are still groping in the dark still looking for answers in all the wrong places……. I said it here first healing for Celiac’s begin in the STOMACH because it protects us from the (now) harmful proteins IE food allergen like CASEIN and GLUTEN that are still passing into our (your) small intestines UNDIGESTED. I always say share – share what you learned here today! (Class/reader) because a lot of people are suffering unnecessarily while the doctor’s find the right (keys’) disease. Tell someone (share) is all I ask Are You a Starfish (Part 2 – of a Former Sufferer’s Journey) tell others is all I ask – when you are BURPING for the first time in years or (EVER) – tell a friend about this blog is all I ask but don’t let the chain break with you. There a lot of starfish (sufferers’) who need help. See my Celiac Posterboy WordPress blog entry To Educate is to Free Part Two: A Physician’s Guide If you want to try and educate your doctor and think he will listen. I argue (maintain) theorize that based on triggers in our environment we get low in stomach acid and THEN develop Celiac disease and if you want to read more about how there are two Types of Celiac disease please see and read this Posterboy blog posts that explains how there are two types of Celiac disease today a Type I (one you are born with) and Type II (one triggered by the stresses of life and is reversible for any thing triggered is reversible once you understand it). Blessed is everyone who reads and understands it…..because then healing and recovery can take place. And before everyone gets all upset…..this what even modern medical science has confirmed today! That Tryptophan heals Villi in Celiac’s proving in IMHO that Pellagra is going undiagnosed in Celiac’s and especially Dermatitis Herpetiformis patients aka DH in Celiac’s and other skin diseases in Non-Celiac’s.......I say it is about TIME! ......they are 50+ Years late according to the research! https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx Sadly it will take another 20+ years (a generation) for medical practice to catch up to medical science (IF then Sadly)….. remember the research on Low (really) NO Stomach acid in Celiac’s and DH patients is over 35+ years old…… and they (doctor’s) still don’t get it today! *** Remember: This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. But mine has taken The Niacinamide Challenge and his digestive/GI problems are in remission. The Celiac and Pellagra Posterboy by the Grace of God, 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble (starfish), by the comfort wherewith we ourselves are comforted of God.” 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. ADDENDUM Found this research this week that confirms the same thing 50+ years ago that modern medical science has forgotten. That Abnormal Tryptophan Metabolism is Occurring in Celiac disease confirming a diagnosis of Pellagra at worst and Pellagra Sine Pellagra at best! https://pubmed.ncbi.nlm.nih.gov/14169518/ It is worth noting that this is BEFORE Celiac disease was known as a “Genetic Disease” and we have been wrong EVER Since IMHO! Those who don’t learn from history are doomed to repeat it! To whom ever has read down to the end of this Celiac Posterboy "Magnum Opus" blog post may God be with you in your continued journeys in life! And God Speed as you continue in your recovery. If this blog post has helped you in anyway......check back in and let other knows it was helpful to you....... PTL!
- 11 comments
-
- beri beri
- celiac posterboy
- (and 8 more)
-
Supplementing with the eight essential B vitamins can help stop gluten cravings. Wheat products are required by law to be enriched with vitamins and minerals lost in processing. In other words, wheat products have vitamins added to them. Celiac Disease damages the small intestine where the B vitamins are normally absorbed. We often do not get enough B Complex vitamins while we are healing because of the damage done by Celiac and because the gluten free diet can be deficient in these vitamins. By supplementing with B Complex vitamins, the body will be ensured of getting all the B vitamins it needs to recover and function properly. I became very ill with vitamin and mineral deficiencies. The doctors I saw did not recognise vitamin deficiency symptoms. I'm a microbiologist, so I had studied this stuff at university. I knew the pharmaceuticals the doctors threw at me were not helping, the pharmaceuticals only covered up the symptoms, but the real problem remained. And I craved gluten, not for the gluten, but because they were a source of the vitamins my body was craving. I started supplementing with all eight essential B vitamins. Our bodies can't make them so they must be consumed every day, hence they are called "essential". Deficiency in many of the B vitamins will cause altered mentality. It's rare to have just a single vitamin deficiency. I've had Thiamine (Vitamin B1) deficiency that resulted in Wernicke's- Korsakoff syndrome and was written off as crazy by doctors and psychiatric "experts". High dose (more than 500 mg/day) thiamine therapy was the only thing that corrected that. Thiamine deficiency is associated with Anorexia, Bulimia, and Binge and Purge disorders, and Obsessive Compulsive Disorder. I've had Niacin deficiency that resulted in Pellagra and had mental changes with that. I've had Cobalamine deficiency (Vitamin B12) and experienced B12 deficiency dementia. Vitamin D deficiency caused severe depression. Magnesium deficiency caused horrible nightmares. Vitamin C deficiency caused skin problems and delirium. If we give our bodies the building blocks of essential nutrients, our bodies can heal themselves. I was ill because I was deficient in vitamins and minerals, not because I was deficient in pharmaceuticals. Doctors don't recognize vitamin deficiency symptoms. Doctors are trained in medical training institutions funded by big pharmaceutical companies to prescribe pharmaceuticals. I've posted previously in this thread studies done on mental health and vitamin deficiencies. Please read them. Vitamin and mineral deficiencies will affect your mental health. Correcting vitamin and mineral deficiencies will help more than putting a bandaid antidepressant on the problems. Correcting deficiencies promptly is important. Deficiencies left untreated can cause permanent brain damage which can be seen on MRIs. Here's some helpful reading... Nutritional therapies for mental disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248201/ And... Bread and Other Edible Agents of Mental Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809873/#!po=18.0556 And... The Role of Vitamins and Minerals in Psychiatry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/#!po=10.0000
-
To Whom Ever Might Read This, This is triggered by some research Scott shared with me. Entitled "With age, insufficient tryptophan alters gut microbiota, increases inflammation" https://www.eurekalert.org/pub_releases/2021-06/mcog-wai062321.php And the very recent research I came across that shows Celiac disease (by monitoring our Microbiome) can be predicted up to 18 months in advance..... (Which I believe Scott will summarize soon as an article soon).....but this thread is more about the recent research I rediscovered on how LPS production triggering a Leaky gut can be triggered by Low B-Vitamins....and the accompanying research showing how each of the B-Vitamins (B1, B2, B3) play a role in controlling LPS production in our GI Tract... Entitled "Changes in gut microbiome in longitudinal study of infants precede onset of celiac disease" https://medicalxpress.com/news/2021-07-gut-microbiome-longitudinal-infants-onset.html 18 months in advance of a Celiac diagnosis is much earlier than you would suspect if Celiac disease is a 100 percent genetic disease (as they mused) surprising the researchers....but if SIBO or LPS production is the trigger for a leaky gut then.....it is what one might conclude if Low B-Vitamins are or could be the trigger.....what one might theorize...that your microbiome is triggering a Leaky gut.....(and why I have always argued that Celiac disease (and/or SIBO) if you believe SIBO can be a trigger for Celiac disease is a 50/50 proposition.....of your environment (IE Low B-Vitamins) affecting your genes... Proving to me, at least, that the genetic Celiac disease has an environment trigger....triggered, in part, by Low B-Vitamins. Here is the research that shows how B-Vitamins (B1 (Thiamine), B2 (Riboflavin) and B3 (Niacin) specifically) are involved in the regulation of LPS production in our GI tract leading, in time, to not only a Leaky Gut, but both SIBO and Celiac disease IMHO. For those who don't know or haven't studied it Liposaccharide aka LPS (and hereafter abbreviated LPS) is the portion of bacteria (known as a Endotoxin) thought to lead to a Leaky Gut in patients with SIBO.... The below research shows how Tryptophan, B1, B2 and B3 help down regulate the toxicity of LPS leading, in time, and with high enough (amounts) the toxicity (from LPS) can result in a Leaky Gut triggered by our Microbiome.... If low in any of these Vitamins or metabolites then you can develop SIBO and a leaky gut.....IMHO See this research entitled "Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide (LPS)induced cytotoxic signals in murine macrophages" https://pubmed.ncbi.nlm.nih.gov/20219672/ See this research entitled "Riboflavin (aka Vitamin B2) protects mice against liposaccharide (LPS) induced shock through expression of heat shock protein 25" https://www.sciencedirect.com/science/article/abs/pii/S0278691510002474 See this research entitled "Niacinamide is a potent inhibitor of proinflammatory cytokines" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808598/ This would explain why Tryptophan has recently been shown to help heal Villi in Celiac's.... https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx If any of these is true.....then it will take another 15 to 20 years (sadly) for the medical community to "Catch UP" with this latest medical research. The research on Niacin alone is 18+ years old..... And why they only "theorized" this.....much more recent research I found is less than 5 year old.....confirming these findings (as well as the new Tryptophan research) Entitled "Niacin (aka Niacinamide or Vitamin B3) and its metabolites as master regulators of Macrophage activation" https://www.sciencedirect.com/science/article/abs/pii/S0955286316302960 Where they note "This study reveals for the first time that niacin and its metabolites possess antioxidant, reprogramming and antiinflammatory properties on human primary monocytes and monocyte-derived macrophages." Which if the above research on B-Vitamins is correct trigger a Leaky gut when all these B-Vitamins (B1, B2, B3 and Tryptophan) get low and we get over run with the LPS endotoxin common in SIBO and other leaky gut syndrome(s) which include Celiac disease....etc. We now SIBO can be trigger for Celiac disease because people still struggling on a gluten free diet get better once their SIBO has also been treated. See this article about this topic... They concluded quoting... "The researchers conclude that SIBO affects most celiacs who have persistent gastrointestinal symptoms after going gluten-free." My argument is to treat the underlying trigger for Both.....Low B-Vitamins! I welcome anyone's feedback and insights? I hope this is helpful but it is not medical advice. Posterboy,
- 4 replies
-
- b-vitamins
- low stomach acid
-
(and 8 more)
Tagged with:
-
To All, Here is the thread I said I was going to start for Wheatwacked and Knitty Kitty. First part of this discussion can be found in this thread... Wheatwacked......Knitty Kitty has give you good advice as usual. I was only trying to be quick and left off my medical use of Niacin.....I had taken Niacin (as a doctor proscribed) treatment for High Cholesterol......but it didn't keep it low....only when I was taking Niacin did it help my high cholesterol. I will be short/brief tonight because I have already commented on a thread already and need to do some other things tonight. But here is the best article I have read on Niacin.... https://www.hindawi.com/journals/mi/2014/263786/ Niacin is a natural vasodilators and increases blood flow into your capillaries causing the flushing people feel when taking Niacin in high doses.... Here is a nice overview on why "inviting" the Niacin flush is healthy for you... https://www.healthline.com/nutrition/niacin-flush#Why-people-take-large-doses-of-niacin I hope this is helpful but it is not medical advice. Posterboy,
- 31 replies
-
- b-vitamins
- benfotiamine
-
(and 6 more)
Tagged with:
-
Genetics Nutrition and Stress the Threeway Model of How Gluten Triggers an Immune Reaction in Severely Malnourished IE Vitamin Deficient Individuals consuming a High Calorie Diet This blog post is WTL again....I tried breaking it into to two Posterboy Blog posts but decided to go ahead.... And post it instead as one due to other things IRL that are taking up most of my time these days..... So thanks in advance to every one who actually completes it! I truly believe it will help everyone who reads it and UNDERSTANDS! This Posterboy blog post is for everyone who got lost in the “Forest of Data” and never found their way out! As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health and peace for one’s soul and body! The journey of a thousand miles begins with the first step….that step back to health for me was my seemingly rare and not well understood Celiac disease diagnosis… I then began my journey….to learn at least what the doctor’s knew about this diagnosis….and exceed it if I could… But I got lost in the forest of data….for years…going around in circles…or so it seemed at the time… See my first attempt to hack/machete my way out of this sad forest (of illness) I was in… https://www.celiac.com/celiac-disease/a-differential-diagnosis-how-pellagra-can-be-confused-with-celiac-disease-r3989/ But I soon learned to spot clues as I read more and more studies….trends, patterns…in the data begin to emerge… one tree (study) at a time…I was able to blaze a trail back out of the forest… I can honestly say I am out of the forest now….and by blazing this trail….I hope I have left enough markers (IE posterboy blog posts/articles etc.) to help the next person out of this forest of symptom’s….. I had over focused on every shiny thing I found (individual Vitamin Deficiency one tree at a time)…. I begin to identify each Vitamin (tree of health) in this vast forest… I had settled on the 3 alarm fire of Pellagra….I didn’t know how wrong and right I was at the same time… It would take years to figure this out (as I walked around in circles)….it is what others had concluded before… The IJCD had concluded the same thing a couple years earlier… http://pubs.sciepub.com/ijcd/3/1/6/ They confirmed for me…it was possible… They noted: on how Pellagra occurred in Celiac disease… Pellagra and celiac disease “The two diseases can be connected in two aspects. 58% of pellagra patients were shown to have malabsorption and many had intestinal pathology on biopsies [36, 37]. Alternatively, Pellagra was described in celiac disease [38]. The skin manifestations in pellagra might have some additional etiologies, since multiple nutrient deficiencies are at the origin of the cutaneous manifestations in celiac disease. The following nutritional deficiencies inducing skin rashes, were describe in celiac disease: Zinc, Iron, Vitamin A, E, B12, niacin, folate, selenium and essential fatty acids [39, 40].” So Eureka! I had found what was being misdiagnosed as Celiac disease instead… 58% was good….I was more than halfway there….being right and wrong all at the same time! Then I found that there was another disease that explained these connections even better! https://www.celiac.com/celiac-disease/how-low-thiamine-can-thin-villi-old-research-rediscovered-and-its-clinical-significance-in-celiac-disease-r5100/ Now I had found out what was really causing my problems! I thought…and once again I was right and wrong all at the same time…. While my aim was dead on….it was nutrients (or lack thereof more correctly) causing my health problems… I had become too myopic only seeing individual trees and the not the forest ….for what it was a healthy place to live and thrive and fruit for meat and leaves for medicine… It was all the trees (at least 3 in particular)….together forming a Web of Life… To pivot from the metaphor to hard science (in real life aka IRL) ….how do know this analogy is true….or truer than not! To see if this is true we have to dig deep in the forest of data….and see what it tells us… See this research entitled “Pellagra in the USA: unusual manifestations of a rare entity” https://casereports.bmj.com/content/12/9/e230972 On the surface….it is just as we would suspect…Pellagra is rare in the USA…right only in Alcoholic’s right…. But we if we dig a little deeper….we learn something from this good research… Quoting from their abstract… “They/She had adrenal function testing which revealed adrenal insufficiency. Vitamin testing revealed normal B12 and folate levels but undetectable levels of thiamine, riboflavin and niacin. Her symptoms and signs resolved entirely with appropriate vitamin supplementation. Niacin (vitamin B3) is essential for multiple metabolic pathways, and severe deficiency may cause clinical syndrome of pellagra, which is most commonly associated with diarrhoea, delirium and dermatitis.” Notice the bolded Vitamin Deficiencie(S)….not one deficiency but many deficiencies culminating the a “Capstone” disease diagnosis…. Now why did this researcher not say the patient had Beri Beri (B1 deficiency), or Pellagra Sine Pellagra (B2 deficiency) instead…they/she had ALL these deficiencies…. Because B-Vitamins don’t occur alone or uncomplicated….so I was right to say I had gone on to develop (mostly) Pellagra ….except I didn’t have Skin (dermatitis) problems like DH etc….so I had only developed Pellagra Sine Pellagra instead…(so far)… But I had already gone on to develop Thiamine deficiency aka Beri Beri and the doctor’s had already missed it…. So why should I be surprised they missed me having a Riboflavin deficiency too! What most people don’t know (even doctor’s) don’t realize today….and I have recently found out that Pellagra has been incorporated into Celiac disease today….. Celiac disease is a three alarm metabolic (deficiency syndrome/disease) ramped up by each B-Vitamin you become low in …..in time…. It is a Cascade….like falling domino’s….one falling triggers the others too fall as well… Let’s see if there is research to backup this claim…. See this research published before 1950 (15+ years) before DH was associated with Celiac disease…. https://www.jidonline.org/article/S0022-202X(15)50482-X/pdf They show that DH was successfully being treated with Nictonic Acid aka Niacin more than 15 years before DH was described in the Skin of Celiac patients… Quoting from their summary “In a series of 12 patients with dermatitis herpetiformis of various degrees of severity, the oral administration of niacin in doses of 50 to 200 mgm. four times daily relieved the pruritus (Itching) and improved the cutaneous manifestations.” Yet today we exclusively “see” through50+ years of error(s)…having forgotten that DH can be treated with Niacin…. thus confirming a Pellagra diagnosis in a Celiac patient… It is the third phase (3 alarm stage) of the Vitamin Deficiencies you have now developed…. Don’t be surprised if the doctor’s don’t see your Vitamin Deficiency even then… Because in classic genetics….the environment and nutrition is discounted as limited factors….in disease… But other researchers are now rejecting this myopic view realizing Environment (Viruses etc.) and Deficiencies IE (Vitamins and Minerals) ALSO play a part in the pathogenesis of disease in an equal 50/50 mix…. See this 2 year old research that summarizes such an hypothesis entitled… Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease Here is the link…to this seminal and groundbreaking research… https://science.sciencemag.org/content/356/6333/44 /tab-e-letters Where Doctor Leslie M. Klevay , Prof. Emeritus, Department of Internal Medicine University of North Dakota School of Medicine and Health Sciences says quoting “In the original classification scheme, Celiac disease would have been considered a toxic deficiency (3) similar to Wernicke’s encephalopathy in which excessive ingestion of ethanol induces thiamine deficiency. Now some celiac disease can be considered a three-way cooperation among an infection, a toxin and a deficiency. Other three- and four-way cooperations have been identified.” Here is longer and probably better description how Virus's (Environment) or IE Epigenetics could/can trigger an Genetic disease like Celiac disease... https://www.gutmicrobiotaforhealth.com/virus-may-lead-celiac-disease-disruption-intestinal-immune-homeostasis/ The research is a couple years old.....also the Epstein Barr Virus has also been associated with Celiac disease. Dr. Londsdale says we need a “new Model” for Medicine… https://www.hormonesmatter.com/new-model-medicine/ I say we need a better one that acknowledges the environment and deficiencies as important or as important as genetics…. Other researchers have noticed the same thing….your environment and deficiencies are not being taken into account for Celiac’s. See this recent research that says the same thing entitled “Genetic risk factors for disease can be affected by environment” https://www.upi.com/Health_News/2017/08/16/Genetic-risk-factors-for-disease-can-be-affected-by-environment/4251502820421/ Not only are genetic risk factors for Celiac disease being affected by your environment…. they are effected by your deficiencies like Thiamine, Riboflavin and Niacin…. We know this because they have been studied (these three B-Vitamins) for toxic overload in Sepsis…. where the Auto-immune system goes haywire and results in death… See this research in Rats https://pubmed.ncbi.nlm.nih.gov/30903555/ It will take a few years for this study to be confirmed in humans….while more studies are performed more people will be dying of Vitamin Deficiencies…. Despite 8+ years ago Riboflavin has been proven to treat (MADD) disorder resulting in acute Renal Failure…. https://www.jstage.jst.go.jp/article/internalmedicine/50/21/50_21_2663/_pdf/-char/en People still think it is 70/30 genetics or even 80/20 genetics… Recent research for Celiac disease proves it is no more than 50/50 percent Genetics/Environment IE (Vitamins deficiency etc. AKA malnutrition) It is my hope that clinical practice will quickly catchup with the newest/latest research proving DNA/Genetics usually has less than 50pct of the risk factors for Celiac disease and accept many Vitamin deficiencies are prevalent as co-morbidities and need to be addressed before a Valid Celiac diagnosis can be accepted/confirmed…. See this studied that confirms this in Celiac’s https://www.genengnews.com/news/dna-has-relatively-little-say-in-disease-risk-usually/ Where they say quoting “It is becoming increasingly clear,” explained Wishart, “that the risks for getting most diseases arise from your metabolism, your environment, your lifestyle, or your exposure to various kinds of nutrients, chemicals, bacteria, or viruses.” And though Celiac disease is a disease consider to have a higher genetic factor it is now believed to be no more than 50% of the risk factor …..as once commonly believed… quoting again “There are diseases, however, for which the genetic contribution is about 40–50%. These diseases include Crohn’s disease, Celiac disease, and macular degeneration.” But I don’t believe they (doctor’s/Clinicians) will……memory has a “longtail” of approximately 18 years from new research reaching clinical practice on average… Appropriate supplementation is consider a key part of “Aftercare” for Celiac’s ….it needs to be part of appropriate disease diagnosis (IMHO)….so you don’t continue to suffer from the avoidable and treatable diseases that often in as many as 80pct of patients are found out Post-Mortem….as is the case in Wernicke Encephalopathy (WE)… etc.…and it should be NOTED 80% of WE is not diagnosed in Alcoholics….. it is happening in Celiac’s today and/or passed off as other GI diseases like Chrons, IBS, UC etc. and psychiatric or neurogenerative diseases today…. https://www.hormonesmatter.com/beriberi-the-great-imitator/ see this current research on Thiamine Deficiency and Benfotiamine Therapy in Brain Diseases https://biomedgrid.com/fulltext/volume3/thiamine-deficiency-and-benfotiamine-therapy-in-brain-diseases.000621.php You will fell half-dead if you continue to have these deficiencies if they doctor don’t also treat you for these co-morbidities despite being on a gluten free diet! I know I did….Ignorance kills!....but It maims us first! I hope this is helpful but it is not medical advice…. Posterboy by the Grace of God At this point I am only making one Posterboy blog post....see following/below for more technical studies...... Showing how and why this is true and how the doctor's missed it! Note to Self::::::))))) Put this a Part 1 of the Blog post and then link the Smoking Gun research on Tryptophan… ADDENDUM IF this analysis is true and a good working Theory and not just a good hypothesis we would find research that shows Tryptophan is important in the pathogenesis of Celiac disease and new research in 2020 confirmed this analysis. Celiac.com ran a summary of the research but I will link a good synopsis for others to read for themselves showing how Celiac’s have impaired metabolism of Tryptophan. https://www.celiac.com/celiac-disease/tryptophan-in-turkey-meat-can-speed-gut-healing-in-celiac-disease-r5338/ This good synopsis of this working theory shows how Tryptophan speeds gut healing in Celiac IMHO proving Pellagra is happening in Celiac’s. I would recommend reading it ALL when you get a chance. https://www.gutmicrobiotaforhealth.com/gut-microbes-in-celiac-disease-show-impaired-metabolism-of-dietary-tryptophan-according-to-researchers-at-mcmaster-university/ And like most “All” good medical research….they always conclude “more research/study” is needed…. Well people can’t want another 10 or 15 years until this research is again confirmed (and again) See this research entitled “Kynurenine pathway metabolites in humans: disease and healthy States” https://pubmed.ncbi.nlm.nih.gov/22084578/ This connection was established at least 10+ years ago….and now we can say for SURE IMHO that this metabolic breakdown is triggering inflammation in Celiac’s leading, in time, to a Leaky Gut! Again, I want to say (make note) that the International Journal of Celiac disease aka IJCD first noticed this connection 5 years ago…will it take another 10 or 15 years before it is “accepted” medical research??? I hope not: but I AM honestly not encouraged!!! This was meant to be a 2 part blog post….so It doesn’t get too long and too technical…but I have decided to publish it all at once now that I am working through some other health issues at the moment! If this is true….there should be studies about these facts….and there is…. I have argued IT is ONE immune system with multiple presentations of the difference Phases of Vitamin Deficiencies…. We see how this works in the LUPUS Inflammation Model I wrote a Posterboy blog post about these connections…. https://www.celiac.com/blogs/entry/2709-the-lupus-inflammation-model-for-sickness-beginning-with-b-vitamin-deficiencies-in-celiacs-and-other-inflammation-triggered-diseases…/ Here is the recent research it is based on…describing how IL-2 and IL-6 combine to help control the immune system…. We see this Alcoholic’s too…in how Niacin can help Leaky guts… See this Celiac.com thread about this topic… https://www.celiac.com/forums/topic/126496-intestional-permability-could-a-vitamin-deficiency-cause-it/?tab=comments#comment-1009633 And that is exactly what we want to fix in Celiac’s right….well B-Vitamins do that! And we see B-Vitamins are low in other chronic inflammation GI diseases like IBS, Chron’s and UC…because there is ONE Immune System! See this research entitled “Blood Concentrations and Renal Clearance of Water-Soluble Vitamins in Outpatients With Ulcerative Colitis” https://pubmed.ncbi.nlm.nih.gov/30906550/ Quoting “The blood concentrations of vitamins B2, C, niacin and folate were markedly lower in the patients with UC than those in the control group, and the renal clearance of vitamins B1, B6, B12 and folate was notably higher in the UC cohort. It was concluded that vitamins B2, C, niacin and folate were at significantly lower concentrations in patients with UC following adjustment for coexisting factors. The lower levels of niacin may be partially due to impaired reabsorption. Chronic inflammation, common in patients with(my words and/or chrons, IBS etc. and Celiac disease), with UC may contribute to the lower levels of other vitamins by rendering amino acid and carbohydrate metabolism into a hypermetabolic state. As the role of vitamins in metabolic activity is constant and pervasive, nutritional management including the application of water-soluble vitamins appears important for patients suffering from UC.” It is me again….why wouldn’t we think this would be the same in Celiac’s…..and why I believe the new research that shows Tryptophan helps heal Celiac Villi is key to understanding/proving Celiac is Pellagra in disguise in the 21st Century! It is time testing is done to confirm these same B-Vitamin deficiencies in Celiac’s is all I am saying so the Co-morbidities can be treated…leaving a true diagnosis… If not the same Vitamin Deficiencies could be confused for Celiac and you will never be sure if you ever received the proper diagnosis…. I have had to figure this out on my own….this is written so you won’t have t o suffer like I did for year’s going undiagnosed despite a Celiac diagnosis…. Two front wars are rarely winnable. Disguise is a great trick of the enemy. For if you get the wrong diagnosis then the symptom’s never getting better and the battle/war rages on. But What If you have the wrong disease? Would you get better? This is dedicated to those still suffering who are willing to ask why? am I still suffering GI symptom’s on a Gluten free diet? Since (auto-immune) or disease in general rarely occur alone it only makes sense to tackle the easiest one’s first. There are two camps/type of people. (It is true in many things of life). Supplementing or not to supplement is the 64K dollar question. The one’s who believes in supplementing readily attack the front (symptom’s) on/from whatever artillery (vitamins and minerals) they can find to shore up their defenses. The other camp prefers to hunker/bunker down and wait for reinforcement/symptom’s to get better and the battle/siege to pass. But in war there is an old saying. “A city besieged is a city taken”. I know there is a lot of confusion out there. … I have been YOU! I am just trying to help those who are still suffering (losing the war). For a battle the war was lost. And many battles’ are lost from confusion…. Knowledge is power …..know you have to power to move forward! It is been said Doctor’s miss Celiac’s in 90% of their patients… https://www.celiac.com/articles/24919/1/Are-Doctors-Missing-90-of-Celiac-Disease-Cases/Page1.html It is equally true about how often Vitamin Deficiency are missed in Celiac’s… “How could this be? One reason is that even classic Celiac disease symptom, such as abdominal pain, bloating, gas, diarrhea, anemia and weight losscan mimic other conditions. Less classic symptoms such as fatigue, low vitamin C, D and calcium levels can be misleading.” Lupus is known as the great imitator disease. And Celiac or is it Pellagra could be called the same in 87% of cases if you are lucky. And so is Beri Beri… https://www.hormonesmatter.com/beriberi-the-great-imitator/ Imitation is the sincerest form of flattery — Unless it is medicine then it is the unkindest cut. . . How do we know this is true…we can predict that Pellagra would develop in Sorgen’s disease aka SLE or LUPUS and it does…where they ask how confident are you of your diagnosis…explaining DH in detail (IF) you did not know it also described Pellagra instead (Rough Skin)… https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/pellagra/ Dermatology doctor’s get it because a Niacin deficiency is 90% classically described as a skin disorder first and foremost…. But Beri Beri and Pellagra GI’s problems are a forme fustre of WE’s….FIRST a Thiamine deficiency and finally a Niacin deficiency when it present’s as DH today! See this research that explains how the first signs of these Vitamin Deficiencies are GI related… .entitled“Gastrointestinal Beriberi: A Forme Fruste of Wernicke's Encephalopathy?” https://pubmed.ncbi.nlm.nih.gov/29982183/ I can only hope what I have shared here has lifted the tide of knowledge a little and your boat/that has been lifted enough for you to freely sail again. Learn from my mistakes! No body is so dumb who won’t learn from other people’s mistakes! A valid I dare say standard “process” of modern/good medicine is the differential diagnosis. If it is not the doctor has not done justice for you or YOU for yourself . … A “differential diagnosis” makes more sense. They have not done YOU justice. Isn’t that what we all want – to know just what we need to do to get better that is justice/peace and good medicine. We are our own best advocate! I share that other’s may know to look for these Vitamin Deficiencies if you too received a Celiac diagnosis and the Doctor’s don’t “See” it in your face….like those of nearly 70 years ago who were treated for DH by Niacin(amide)…… 15+ years before DH was ever linked to Celiac disease Remember **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your regimen. 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health and peace for one’s soul and body! Let’s all make peace for to educate is to empower to change. Change is not easy . . especially if you have a bunker mentality I grant . . . but possible with education for with education comes understanding! 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble (starfish/sufferer), by the comfort wherewith we ourselvesare comforted of God.” Posterboy by the Grace of God, EPILOGUE We know this is a good working theory because both B1 (Thiamine) and B3 (Niacin) are used in the production of stomach acid. Quoting from the Celiac.com article on How Low Thiamine Can Thin Villi How Low Thiamine Can Thin Villi: Old Research Rediscovered and its Clinical Significance in Celiac Disease - Celiac.com “Via the Parasympathetic Nervous System (PNS) the neurotransmitter "acetylcholine" regulates our organ functions throughout the body, and could be why both undiagnosed celiac disease and Beri Beri affect so many organs in the body. Without enough thiamine our body can’t synthesize enough acetylcholine to regulate it’s organs, which may cause the body to go into high alert mode and trigger a runaway auto-immune reaction like celiac disease. Another study shows a connection with the microvilli that line organs and how they can trigger auto-immune reactions throughout the body.” B3 aka Niacin via Histamine is used to trigger stomach acid production and why an H2 Blocker is used to treat stomach acid issues….and can be used for other immune mediated conditions like allergies etc… Low Thiamine (B1) triggers the Auto-Immune Cascade….leading to low B2 (Riboflavin) and finally resulting in Low B3 (Niacin)…. who’s production in the body is regulated by Tryptophan via the Knyneurine Pathway and why Tryptophan recently was shown to help heal Villi in Celiac’s. And why just over 7 years ago PPIs were shown to be able to trigger a Celiac diagnosis. Do Proton Pump Inhibitors Increase Risk of Celiac Disease? - Celiac.com See my previous Posterboy blog post about why this so. Is there a Type I and Type II Celiac Disease IF so what is your Type: What the Diabetic Model can tell us about Celiac Disease Subtypes? - Celiac.com Niacin (B3) and Thiamine both help control the Biofeedback loop in the body and why being low in either one will trigger an auto-immune cascade! And Note: it is not just humans who need Thiamine to live/survive ALL animals need it even Bacteria and Fungus. See this latest research from 2020 entitled "Born to be wild: Fungal highways let bacteria travel in exchange for thiamine" that shows/explains how Bacteria and Fungi or Fungus use Thiamine as "Currency" along "Life's" highway.... https://www.sciencedaily.com/releases/2020/09/200924114128.htm Dr. Lonsdale called Thiamine the "Spark of Life".....I have called it the "Currency of Life"....because your health will be poor without IT! So we know this is true! Even at the microscopic level! You will feel half-dead if you continue to have these deficiencies if they doctor don’t also treat you for these co-morbidities despite being on a gluten free diet! I know I did….Ignorance kills!....but It maims us first! Lord willing it has been helpful and will it will help someone before the medical community catches up with the latest research on the topic. As always 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God
- 2 comments
-
- beri beri
- epigenetics
-
(and 8 more)
Tagged with:
-
I found this site linked below, written by a pathologist for doctors doing vitamin deficiency testing. https://arupconsult.com/content/vitamins-deficiency-and-toxicity Points of interest include: Patient should not be taking supplements at time of testing. Ideally, supplements should be discontinued three to six weeks before testing for vitamin deficiencies. There are exceptions. Most B vitamins can not be stored in the body longer than three weeks. Supplementing with vitamins will skew the tests for deficiencies. Patient should be fasting before vitamin deficiency testing because eating food can temporarily raise vitamin levels. Most of the B vitamins do not have an upper limit or toxicity level because they are safe and water soluble (the body can easily flush excesses out). Plasma concentrations of vitamins do not directly reflect concentrations in tissues. Concentrations of vitamins in urine tests do not reflect tissue stores. Risk factors for vitamin deficiencies include malabsorption diseases (Celiac Disease) and inflammatory bowel diseases (Crohn's and Colitis). Deficiency in one vitamin is rare. The group of B vitamins all work together and are dependent on each other to function properly. If you're deficient in one, you need to supplement all the B vitamins.
- 7 comments
-
- b12
- deficiency
- (and 4 more)
-
To All, About 5 years ago research was done that discovered Tryptophan was involved in the Pathogenesis of IBS well new research has now linked that same Tryptophan to the same Pathogenesis in Celiac's. See this link on the role Typhtophan lays in IBS. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266036/ Here is the latest research on the topic that now indicates Tryptophan could also be beneficial to Celiac's in a similar way. https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx What do you think have they found the "Smoking Gun" for the Pathogenesis of Celiac disease. I know Celiac.com will do an article on this soon.....I just wanted to go ahead and get the discussion started. It is very exciting new research! To indicate that quoting this "study findings highlight the potential therapeutic value of targeting tryptophan metabolism in the gut in celiac disease to better control symptoms." Highlighting Tryptophan as a possible therapeutic in Celiac's who do not respond to a gluten free diet. As I always I hope this is helpful but it is not medical advise. Posterboy,
- 1 reply
-
- celiac
- celiac posterboy
-
(and 8 more)
Tagged with:
-
To All, Who might read this Posterboy blog post. Some house keeping to start with by way of some notes: This is as I see it currently so this a "Cliff Notes" version as a working hypothesis to keep it short enough to read…. I didn’t mention Magnesium or explain how Magnesium Is necessary for the body to use….Thiamine as an example… see Addendum at the end if you have more interest of learning how Pellagra, Beri Beri and Pellagra Sine Pellgra presents today ALL together in the same person today in America as NCGS and/or Celiac disease with or without DH as a presenting symptoms and How and Why this is possible! If their is interest this Posterboy blog post can be made into an article....I am just trying to get it out their in "Grey Paper" format... As a Posterboy blog post.... .in my eclectic, rambling style.... So people can find it.....and react to it if they wish....my forum time has been reduced lately...so I am just sharing to get this "off my chest" so to speak....and I hope Lord willing, it helps someone else......I can't be the only one! The B-Vitamin and Immune Health document mentioned B5 Panothenic Acid and Biotin being important as well possibly Folic Acid…. but I am not sure how they fit in the model. I think it is as least 6 to 8 things (Vitamins/Minerals) that are needed to regulate our immune system… I have identified these 4 four In this Posterboy blog post B1, B2, B3, and Zinc…..with Magnesium definitely being a fifth one (beyond the scope of this blog post)….. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478888/ Maybe Knitty Kitty can pick up the mantle and add to this discussion…. At least one researcher also mentions a Cooper deficiency as a possible cause of Villous atrophy….but they might be just noticing the Zinc deficiency common in Celiac's since Zinc/Copper have a symbiotic relationship in the body.... Kind of like Vitamin D/Calcium or Magnesium/Calcium.....they are Co-Factors for each other...and why this is very hard to figure to out! but you can only cover so much in one blog post… But I think these 5 are a great place to start (Note: I include Magnesium) in this list as a Co-factor for Thiamine but I don’t’ have time to explain it here in this blog post… If you want to see more how Magnesium is important in Chronic Fatigue specifically see this online article about Magnesium’s role in ME/CFS. http://simmaronresearch.com/2015/08/epstein-barr-virus-the-magnesium-connection/ As always, I hope this is helpful but it is not medical advise. This blog post starts now..... This Posterboy blog post was triggered by the thread “Unique antibody profile differentiates people between non celiac gluten sensitivity aka NCGS and Celiac disease” This theory, opinion and hypotheses are not endorsed by Celiac.com they are the ideas of the Posterboy alone and should not be considered medical advice. I am not trying to diagnose by sharing my insights, ideas and research but only to educate and inform that B-Vitamins, in part, help regulate our Immune System and this idea needs further study and research on this topic to confirm this working hypothesis. It is based on this latest research entitled “Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity” published in the Frontiers of Nutrition Circa 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478888/ The problem is we can’t wait another 20 years if this is right….people are suffering from B-Vitamin deficiencies today! It will be at least that long before Clinical practice catches up with the research that Host Immunity IE Celiac disease can, in part, be triggered by low B-Vitamin status. I have learned to say in, in part……. This is only part of the equation….but it is an important part of the equation….that has been too long overlooked! Now back to the thread that triggered this thought idea… We know B1 can thin Villi… From the above thread we know that Vitamin B2 kicks up our immune response. From a previous thread/research we know Vitamin B3 can treat a Leaky Gut in Alcoholics… See this research entitled “Intestinal permeability (IE Leaky Gut) and oxidative stress in patients with alcoholic pellagra” https://pubmed.ncbi.nlm.nih.gov/16713031/ See this thread where this topic is discussed in more detail… In this thread user/moderator kareng pushed me to be more inclusive/comprehensive in my views…. Not restricting myself to one Vitamin alone……so, in part, this is a response to this criticism… IF the data doesn’t fit the facts you must iterate… Here is what is happening (IMO)….B1 (Thiamine), B2 (Riboflavin), B3 (Niacin) vitamin deficiencies are being diagnosed as Celiac disease today… Think of it as a 3 alarm fire! The first alarm is Vitamin B1 aka Thiamine….you get thin villi and your immune system is triggered and you develop NCGS. The 2nd alarm is Vitamin B2 aka Riboflavin….your auto-immune response is ratcheted up…. And you are diagnosed as having Celiac disease. The 3rd alarm is Vitamin B3 aka Niacin or Niacinamide….your GI tract begins to leak from the Oxidative stress it is now under… What I don’t is how and what other Vitamins play in this auto-immune reaction…. At least, in part, Zinc plays a role in host immunity by changing/modifying the Th1/Th2 balance….IE Immune Homeostasis…. which almost 60% of Celiacs’ are low in at the time of their diagnosis… See this research from the Journal of Infectious diseases entitled “Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts” https://academic.oup.com/jid/article/182/Supplement_1/S62/2191506 It shouldn’t surprise us/you by now that this research is 20 years old….because doctor’s don’t know how to incorporate Vitamins in to a genetic model! Being low in Vitamins/Minerals are making us sick, sometimes very sick! Again, see this research 20 years old (not surprisingly) has been overlooked for 20 years… Entitled “Zinc-Altered Immune Function and Cytokine Production” from the Journal of Nutrition…. https://academic.oup.com/jn/article/130/5/1407S/4686394 And since Zinc Is not a medicine (Or other B-Vitamins to be matter of Fact)…..it can be ignored as a possible treatment… See this recent research on low Zinc blood levels in Corona virus patients… Entitled “Lower zinc levels in the blood are associated with an increased risk (2.3x rate) of death in patients with COVID-19” https://medicalxpress.com/news/2020-09-zinc-blood-death-patients-covid-.html How long can we afford to overlook the fact that nutrition governs our genes…. Can you wait another 20 years before medical science wakes up to the fact that B-Vitamins are important for Immune Homeostasis! And could be triggering a 3 alarm metabolic fire showing up eventually as Pellagra being misdiagnosed as DH instead. Let’s recap for easy review…B-Vitamins never deficiencies never occur alone IE uncomplicated. B-1 deficiency occurs with a B-2 deficiency. Having one or both will lead to Villous Atrophy and a subsequent NCGS or Celiac disease depending on the stage of the metabolic fire. Is it a stage 1 alarm fire or a stage 2 alarm fire! If it is a stage 3 fire IE a stage three alarm fire then you have developed Pellagra being diagnosed as DH instead today! How do we know this…because DH was once treated with Niacin (hence we can say for sure DH is Pellagra in disguise today) and not just once….but good studies exist from more than 15 years before antibodies tied DH to Celiac disease…? In fact, as late the 1950’s DH was regularly being treated with Niacin! Being conservative we know it was until the late 60’s and early 70’s until antibodies tied DH to Celiac disease seemingly for good discarding approx.. .. 15 plus years of good clinical practice of using Niacin(amide) to treat DH! IE, Of DH responding to Niacin(amide) treatment…has been lost to history for 50+ years! The Dermatology Advisor confirms this reporting DH responding to Niacinamide treatment in less than a month or 2 to 3 three weeks on average when Dapsone treatment fails for the treatment of DH. https://www.dermatologyadvisor.com/home/decision-support-in-medicine/dermatology/dermatitis-herpetiformis-duhring-disease/ Here is the link to the original research if there is any interest… https://core.ac.uk/download/pdf/82674034.pdf Every now and then an intrepid researcher will rediscover this fact…..that DH can be treated with Niacin(amide)…. but it promptly is forgotten! or not believed??? or Dismissed as being a "Small Study".... See this research entitled “Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide” as published in 2018 https://pubmed.ncbi.nlm.nih.gov/30390734/ This is good news! And should be shouted from the roof tops! But people get hit with a “genetic” dumb stick because we don’t think Vitamins can regulate our genes…. but about 90% of the time today we think it is a one way street… But we get stuck in our genetic silos believing it is our destiny! See the a the movie “The Knights Tale for this logic/way of thinking our “destiny in written in our Genes/Stars”…. Well it is time to realize/admit our nutritional status can and does affect our genes and trigger disease! He changed his “Stars” destiny fortune and you can change your health too if you are willing to try and take some B-Vitamins for health! I did mine! PTL! It is a two way street, Genes and Vitamins interact to regulate our health! If you want a big picture view (analogy) of how this happens see happens see this Posterboy blog post about how I lay this out analogy as a child that grows up into adult hood (Pellagra) as the disease develops through its stages! 2 Timothy 2:7 As always, “Consider what I say; and the Lord give thee understanding in all things” this included. I hope this is helpful, but it is not medical advice. Posterboy by the grace of God, ADDENDUM: This from the thread “Been severely let down and at my wits end” started by the user Never Like Rollercoasters…. and how you can feel when you low are in B-Vitamins! I will quote from it IE from the Posterboy (me) because it summarizes well what I said in a few short paragraphs with out me having to retype everything again… Never Liked Roller Coasters and Cyclinglady et Al, I have written a Posterboy blog post that might help you. I have tried to share my experience so that others might be helped by my suffering going undiagnosed. The symmetrical rash could be the first sign that Pellagra is developing.... It (Pellagra) like Cyclinglady notes about Beri Beri too is hard to diagnose by tests.....instead just taking the B-Complex with Benfotaimine is usually enough to treat the symptom's and/or with Magnesium Glycinate/Citrate (as a Co-factor) to help active the the fat soluble Thiamine IE Benfotiamine you are now taking! Cyclinglady (correct me if I am wrong) JM34 (Or someone close to that name) once tested for a Niacin deficiency and they found him to be borderline low....then we lost contact with him.... B-Vitamin deficiencies don't happen in uncomplicated way (usually) they occur together.... See this article about a case of Pellagra in America... https://casereports.bmj.com/content/12/9/e230972 I will quote the test results... "Vitamin testing revealed normal B12 and folate levels but undetectable levels of Thiamine (B1), Riboflavin (B2) and Niacin (B3). Her symptoms and signs resolved entirely with appropriate vitamin supplementation. Pellagra in Italian means "rough skin" and hence the name that comes to us... The clinical delay in recognizing vitamin deficiencies in Celiac's is causing many treatable co-morbidities like fatigue to go untreated when a simple supplementation program can help in addition to going gluten free.... These are complimentary things.... Micronutrients are low in Celiac's.....it is not well known but recent research is now bearing this out... And it should be noted that Low Thiamine levels has been shown to Thin Villi in Mammals.... Here is an article about it... I would also recommend this youtube link to you...entitled "Is Thiamine Deficiency Destroying Your Digestive Health Why B1 Is ESSENTIAL For Gut Function" It is little over an hour....so I will give you some notes (bookmark) of things to look for that I made for myself.... so you won't have to watch it all.....and give you some points to look at briefly... 30 minutes GI or Intestine contractions 35 minute reduces brush border enzymes like Lactose Interolance Note: they were diagnosed with Pellagra a CAPSTONE diagnosis but they had already developed Beri Beri and Pellagra Sine Pellagra (which is what happened to me) evidenced by undetectable levels of Riboflavin and Niacin. Meaning they (the doctors) had already missed two CORNERSTONE diseases triggered by B-Vitamin deficiencies BEFORE the capstone symptom's developed of per fuse skin lesions....(see research from the 1950s above) showing how Niacin treats DH! As I once said in a Posterboy blog post Vitamins these days have a KIA problem....Knowledge, Image and Awareness problem. As always I hope this is helpful but it is not medical advise. I could go on and on and on . .. but there is no need for that. I need to stop for now. Either you will believe and be helped or go on suffering needlessly if indeed Pellagra and Beri Beri is the parent disease(s) and GERD, IBS, UC, Chrons, NCGS and Celiac disease it‘s unruly children. 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” ****Again this is not medical advice but it is too easy, simple and cheap not to try and see if it works for you . . . Remember Occams’ Razor. . . The Simple answer is a Vitamin. But convincing people of that fact has not been simple or easy. I can’t convince you either way. You will have to decide for yourself . . . I only know it help’s those (of my friends) who have tried it for themselves with their heartburn aka GERD and IBS, UC, NCGS etc.. .(for those not already on an acid reducer like a PPIs already....) Praise bee to God and I want other’s still suffering from Pellagra (if you have developed DH) and Beri Beri disease if the research is to be believed being diagnosed as Celiac disease or NCGS to be the next to be helped Praise bee to God! But I know now you will have to discover it for yourself. I stand as your witness. I tried! As always, “Consider what I say; and the Lord give thee understanding in all things” 2 Timothy 2:7, this included. Posterboy by the Grace of God,
- 1 comment
-
- b vitamins
- beri beri
-
(and 8 more)
Tagged with:
-
A Case for Thiamine Supplemenation in Celiacs IF only for a Season in Time
Posterboy posted a blog entry in Posterboy's Blog
A Case for Thiamine Supplementation in Celiac’s IF only for a Season in Time I have been doing Posterboy blog posts every so often now for a while now to share my experience with supplementation. I have settled on the fact that many of the existing GI issues can triggered by existing nutritional deficiencies. ((I think most people must think I still take Niacinamide or Thiamine or a B-complex.....I do not now take any of these things. I only took them for a Season in Time and the reason for the name of this Posterboy blog post. For many taking an Enzymic B-Complex with Benfotiamine (preferably with Magnesium Glycinate or Magnesium Citrate with meals) for 3 to 6 months when taken with meals will be enough, for some 6 months or longer might be needed..... you decide the Season and the times that is best for you!)) See this research entitled “Nutritional inadequacies of the gluten free diet in both recently diagnosed and long term patients with celiac disease” https://pubmed.ncbi.nlm.nih.gov/23198728/ As I often note….. research is 5 or 10 years old (for whatever topic it is)…in this case that Thiamine is not only Low at diagnosis of a Celiac diagnosis…continuing to eat a gluten free diet without supplementation will make you even LOWER in Thiamine. This is not a case of the “Chicken or the Egg”….. a Thiamine deficiency comes FIRST….then you develop GI problems IMHO. This leads to an impaired Vagus Nerve response…. https://www.md-health.com/Vagus-Nerve.html I once thought this was a Niacin deficiency (and in part it still can be) but it begins with a Thiamine Deficiency first (beyond the scope of this Posterboy blog post)…..when one develops the skin condition of DH in/with their Celiac diagnosis…. the Celiac has gone onto to develop a Niacin deficiency. I never developed full blown Pellagra (beyond limited skin involvement) I did not develop symptom’s beyond Pellagra Sine Pellagra aka as a Riboflavin deficiency as noted by horrid Angular Cheiliitis (Leaky Lips)…. After extensive PMing back and forth with EnnisTx (I don’t think I ever told him) I realized….I had gotten the wrong diagnosis…. so from then I adjusted/iterated the model. I changed my opinions/mind about my conclusions…..and realized I had been wrong…. So that sent me back to the drawing board(s) so to speak…..if it wasn’t Pellagra what was it…. And I will skim over this portion because it is only an intermediate step in the process as noted above I had developed not Pellagra but Pellagra Sine Pellagra a Riboflavin deficiency. See this research entitled “Kynurenine pathway metabolites in humans: disease and healthy States” Here is the abstract to keep it on the lighter side…. https://pubmed.ncbi.nlm.nih.gov/22084578/ Once the Kynurenine Pathway breaks down…essentially your immune system goes haywire… Here is the more technical answer via their conclusion on the Kynurenine Pathway and disease states… “Conclusion The kynurenine pathway is an effective mechanism in modulating the immune response and in inducing immune tolerance. This is achieved by accelerating the degradation of tryptophan and the generation of kynurenines. The metabolites of the pathway, with their different inherent properties, can also synergize or antagonize the effects of one another. By measuring the levels of tryptophan, kynurenines and the K/T ratio under various pathological conditions, the degree of immune activation and the relationship between the kynurenine pathway and disease states may be gleaned. However, much research is still needed to fully understand the complex interaction between tryptophan, IDO and kynurenines among themselves and within the CNS and in the periphery. With the seemingly prevalent involvement of the kynurenine pathway in a wide range of different diseases and disorders, the knowledge gained from research focusing on the kynurenine pathway may be translated into designing novel and more effective treatment strategies.” I did not set out to learn this….but only set out for the truth of the matter. But from there I was able to back track and find out the trigger for this cascade… It was not B3 or B2 (not really) but B1….(Or lack thereof) that was the real trigger… I have been counting down B-Vitamins all this time….you might say I have been counting down to One! The combination of these B-Vitamins (B1, B2, B3) had been shown to down regulate inflammation in the body. See where this was recently studied in the mouse model for health entitled “Vitamin B combination (of B1, B2, B3) reduces fluconazole toxicity in Wistar rats” https://pubmed.ncbi.nlm.nih.gov/30903555/ And while they each work to down regulate inflammation…..together they are dynamite! But what was the Spark??? That creates the BOOM! Thiamine is the Spark for Energy! According to Lonsdale it (Thiamine) is the “Spark of Life”…. http://europepmc.org/article/MED/22116701 Stress requires energy and we absolutely can NOT make energy without Thiamine. The Thiamine deficiency came First…..It is not a “Chicken AND the Egg” scenario. One interesting new study that illustrates this point and I will try and wrap up this Posterboy blog post at least for a Season of Time. Let’s go back to the B1, B2, B3 issue of picking which one is the Spark for the Autoimmune BOOM triggered by inflammation..... Sepsis is a condition in the body that is triggered by unchecked infection often….and what down regulates inflammation in the body??? Answer B-Vitamins at least in part…..we know B1, B2, and B3 work synergistically to down regulate inflammation in the body thereby controlling first inflammation and thus Sepsis. How can we know it is B1 instead of B3…because new research bears this fact out! See this Sciencedirect article about Thiamine and Sepsis and how unchecked inflammation can be a sign of a Thiamine deficiency not the other way around … https://www.sciencedirect.com/topics/nursing-and-health-professions/thiamine-deficiency quoting Effect of Sepsis on Intestinal Thiamine Uptake Thiamine deficiency is prevalent in patients with sepsis.15–17 This appears to be mediated in part via an effect of sepsis on intestinal thiamine uptake37 given recently reported observations of a significant inhibition in intestinal thiamine uptake in rat model of sepsis where the degree of inhibition was shown to correlate with the severity of sepsis. The degree of the Thiamine Deficiency correlated with the degree of the Sepsis! Again, the Thiamine deficiency came First…..It is not a “Chicken AND the Egg” scenario. To quote Ecclesiastes 3 (read it all if you get chance) it is so well known the first few verses can be quoted (or commonly known). And it is often quoted at major life events such as death and at marriages or when one gets sick…..this too can pass! But if you want energy during these emotional times you can’t pass by Thiamine! Ecclesiastes 3:1 “To everything there is a season, and a time to every purpose under the heaven:” It is time for a “Season of Thiamine” to fight off the stress and inflammation your GI tract is now experiencing because your body is low in Thiamine…… before medically diagnosable Beri Beri develops from unchecked inflammation in the body! There will be time of Joy! Of Celebration that you found out what was causing your “Chronic” Fatigue that the doctors couldn’t diagnose! Because they didn’t know the cause of the unchecked inflammation https://www.msn.com/en-us/health/other/chronic-fatigue-syndrome-may-be-due-to-an-overactive-immune-system-study-shows/ar-BBR5ba3 I had similar things happen to me….before Sepsis develops someone in a Celiac Crisis will develop Refeeding Syndrome….. presenting itself as “Electrolyte Abnormalities” See my Posterboy blog post how I was a Posterboy for a Thiamine deficiency post and the doctor’s were misdiagnosing it! If this is the right diagnosis you would expect patterns to emerge in the research and when we look we see we/they do! 2 out of 3 Celiac’s who do not respond to a gluten free diet get (feel) better when they are treated for SIBO or unchecked inflammation from an overgrowth of bacteria! And a Thiamine Deficiency is known to be common in a SIBO diagnosis. It Turns out the Bacteria need Thiamine for their Spark of Life too! Draining your in the process leading to your Fatigue! And new research is emerging that Toxic Shock (this is no longer an hypothesis) but a working Theory that “Thiamine (vitamin B1) (can be used) in septic shock: a targeted therapy” which IMO is being triggered by gluten in Celiac’s when you First get low in Thiamine presenting as a Celiac Crisis or being Misdianosed as Refeeding Syndrome or SIBO in IMO. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024754/ I must stop before this blog post gets too long again…… I truly hope it helps someone else! It is time for a Season of health! I share that it might help the next person…..so they won’t have to suffer without the doctor’s help the way I did! I hope this is helpful but it is not medical advise. 2 Corinthians 1:3, 4 3 Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God. 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the grace of God, ADDENDUM IF you have a spare hour of your time this youtube link about how a Thiamine Deficiency can lead to Vagus Nerve disorders is worth your time! Entitled “Is Thiamine Deficiency Destroying Your Digestive Health? Why B1 Is ESSENTIAL For Gut Function” Or if you prefer to reading to video this is a nice article that shows the Thiamine Deficiency in a SIBO Patient connection… and remember in 2 out of 3 Celiac’s who do not get better eating a gluten free diet feel better after treating their SIBO Or is it more appropriately treating their Thiamine Deficiency??? A Season of Thiamine (or a B-complex) can tell you if it was the "Chicken or the Egg". What have you got to loose but Time! It is time for a Season of Health! https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo -
Micronutrient deficiencies remain common in adults with Celiac Disease despite increased non classic presentation new Mayo Clinic study shows; or How Under/Undiagnosed Malnutrition is making you Sick…. The Posterboys Story of How Taking Magnesium and a B-Complex help him address asymptomatic Vitamin Deficiencies in Celiac disease They (Mayo Clinic) titled it… Micronutrient Deficiencies Are Common in Contemporary Celiac Disease Despite Lack of Overt Malabsorption Symptoms…but as usual some of the usual suspect’s are missing… IE many B-Vitamins https://www.ncbi.nlm.nih.gov/pubmed/31248695 Like Niacinamide (best form to take without flushing side effects)…Thiamine, and Riboflavin… Eating a gluten free diet will make you low in Thiamine…. See this 5+ year old study on this effect/relationship to Malnutrition in Celiacs’ entitled…. Nutritional inadequacies of the gluten-free diet in both recently-diagnosed and long-term patients with coeliac disease commonly spelt Celiac disease in North America… https://www.ncbi.nlm.nih.gov/pubmed/23198728 And note quoting…someone eating a gluten free diet will become low in Thiamine... “The frequency of inadequacies was similar pre- and post-diagnosis, except for thiamine and vitamin A, where inadequacies were more common after GFD implementation.” Gluten free foods are un-enriched…and are from common sources like Rice that typically low in Thiamine already…. (A great argument for Fortification of Gluten Free Foods) keeping Thiamine levels’ low even in Celiac’s…who have been Gluten Free for some time… Now the Mayo Clinic is picking up on these same issues in Celiac’s 5+ years later…. Progress takes time….but it comes with awareness… And Why I am writing this posterboy blog post to share my experience…. Low Thiamine levels have been linked to Villi thinning… See this article explaining these connections….featured on celiac.com Here are a few links that will help you understand Magnesium vital role in the body… https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-229 https://www.ncbi.nlm.nih.gov/pubmed/29480918 https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0954-6820.1985.tb08836.x Magnesium deficiency has also been shown to be a key way into how the Epstein Barr Virus (EBV) causes/contributes to Chronic Fatigue Syndrome (CFS) in people who have Chronic Active EBV… http://simmaronresearch.com/2015/08/epstein-barr-virus-the-magnesium-connection/ But people (doctors etc.) don’t really have a good understanding today of how important it (Magnesium) is to the body… I believe mainly because of all the confusion of different Magnesium supplement types….It is like a maze to just find one that your body can use….and why I have simply told you the best kinds to take… Find a Magnesium Glycinate or Magnesium Citrate and your body will think you with some very lucid dreams! Special Note: on Taking B-Complex’s….after a 3 or 4 days…urine color will often change…this is normal… Note: (Taking an Enzymic B-Vitamin) is often easier to absorb for people with low stomach acid because they have already been converted into their active form...used by the body (that normally takes) place with a strong stomach acid...sold usually as a CoEnzyme B-Complex etc...I hope this is helpful. B-Complex’s half life is 12 hours so…take them twice a day or with meals…they are water soluble and leak out… I describe it as being a quart low in blood etc…you just drag…when you are low….(same with Magnesium by the way)… you are said to “Waste Away” when low in Magnesium! You can test this by the color of your urine….take one every other day…and you will notice a change in your urine color…. as you become low in B-2 aka Riboflavin… Your now “yellow” urine will become clear 12 to 24 hours later… Taking them 2x a day ensures you have enough to get by for 24 hours in the day…without feeling a “quart” low… As the intensity of your urine color becomes brighter….this is a sign your body is now storing more in your body (liver mostly)…. Once…it begins to (GLOW) in the dark….your body is now bypassing all the B-2 (Riboflavin) through the kidneys… It is a sign you can give the B-Complex and/or Riboflavin a break… If I take B2 now…..it immediately (in 3 to 4 hours) turns…it yellow…and will stay that way for another 12 hours or so… (Similar to the Asparagus effect about 1/2 the population) encounters....of a strong order to their urine...harmless but noticeable... until being water soluble (and the body) not able to store extra…leaks out again… Another distinct sign (if you are NOT taking) an acid reducer now….is burping replacing bloating and indigestion in your stomach… As your acid rebuilds in the stomach (from the B-Complex) another sign you are getting your body’s stress under control is a distinct and noticeable burping….this will be your new normal… This effect (of burping without bloating) will usually take about 6 weeks to notice and 3 to 4 months to ensure it is your new normal…unless you are stressed “out” again… Stress is related to heartburn….see this research about it…entitled “The effect of life stress on symptoms of heartburn.” https://www.ncbi.nlm.nih.gov/pubmed/15184707 I have to stop for now…but I hope this is helpful to whomever might read this Posterboy blog post… Stress kills…but it maims us first! As always I hope this is helpful but it is not medical advise… I just know it helped me and I have tried diligently to share what helped me…. so that other could be helped the same way Lord willing. No people or blog post is perfect...but this covers the basics without it being Way Too Long (at least by my standards)... 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble (fellow sufferer), by the comfort wherewith we ourselves are comforted of God.” 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the grace of God,
- 26 comments
-
Whos Afraid of a B Vitamin You needn’t Bee? An FAQs on Niacin(amide) and how to take Niacinamide and why you would want too in the first place. The very definition of a Vitamin is a Vital (life giving) nutrient needed in a minimum amount without which we become sick. This is especially so for B Vitamins since the body does not have good way to store more than 3 months’ worth on average. STRESS makes us low! If you had Cancer and someone told you a Vitamin could help would you try to take it? Most people I dare say would – probably readily. While unfortunately this is not the case for Cancer but what if you had Beri Beri, or Anemia or (Pellagra misdiagnosed as Celiac Disease anyone) and the doctor’s didn’t know or recognize it in a clinical setting see and you were told a Vitamin could help you. Would you try a B-Vitamin? All these (Beri Beri, Anemia, Pellagra) are diseases (and others not mentioned here like Scurvy and Rickets etc) are disease’s that a Vitamin could/does help? And possibly Celiac Disease if you are in the majority of those Pellagra Patients who present as Celiac Disease or NCGS presenting as IBS or have Pellagra misdiagnosed. Your disease profile might differentially be called something else. It is a standard practice of medicine called: A Differential Diagnosis. You hear this a lot but don’t think about it probably when someone is giving a horrible diagnosis such as cancer we say “I am going to get a 2nd Opinion” on that right. Well you have asked for “A Differential Diagnosis” of the diagnosis of the disease you have been said to have. Often today Common Vitamin deficiencies are thought to be “cured” in the modern world by enriching our foods presenting/revealing as Celiac Disease and/or GERD/ Heartburn. When stressed you often lack enough of certain B Vitamins to function properly hence disease develops. If a Vitamin could be taken to reverse this disease (STRESS) why wouldn’t you want too or at least try? We don’t think of STRESS in these terms often but High Blood Pressure is often the first sign of a Folic Acid deficiency – the beginning of disease. That really is what UN-controlled stress /inflammation is in the body. It is disease or will become disease if left unchecked. What if there was a Vitamin that helped us regulate STRESS in the body. Well there is! It is called Niacin (Vitamin B-3) regulates our fight or flight responses. All of this requires massive amounts of energy when a shock/trauma affects our system. Our body functions break down. And disease develops’. This is what happens when someone develops GERD/IBS/NCGS/Celiac Disease (Pellagra in disguise I believe – a Niacin deficiency/dependency). The longer or more deficient (lower) you are in this cornerstone nutrient (Vitamin) the more of your body stop functioning. Yet few people are willing to believe (take) a Vitamin that might help their bodies function better? I ask again who’s afraid of a (water soluble) Bee Vitamin that is known to regulate stress in the body? Ok great? A B-Vitamin can help me. How do I take it and how much? Here is where I have been conservation and have recommended (anyone who has read my other posterboy posts) 500mgs of Niacinamide. This is for 2 reasons mainly. 1 The Niacinamide version does not flush the way higher doses of Niacin does. So it is inherently easier form to take without feeling you have “overdosed” (Flushed) on this Vitamin (Which is a misnomer) -- Flushing when understood properly is a healthy response to the Vitamin. Niacin is a natural vasodilator allowing more oxygen into our capillaries indicating a sufficient dose of the vitamin has been achieved to cause capillary relaxation. (This is most pronounced on an empty stomach) But since people mistakenly take this as an adverse reaction and why I emphasize the Niacinamide form it is the Non-Flushing Amide form of Niacin. 2 Since 500mg is the most commonly found size of Niacinamide I recommend(ed) it out of defense mainly. Smaller doses work as well indeed -- As a matter of fact smaller more frequent doses works 40 percent better than larger one time doses. And the reason I am writing this FAQs about Niacin. B-Vitamins by their nature are hard to store by the body so even in larger doses (500mg) as much as half the dose is essentially wasted by the body – excreted through the kidneys’ since the body has no long term way to store excess amounts of B-Vitamins. And why smaller more frequent doses help 2X to 3X times quicker because the Vitamins serum level’s are maintained for longer periods thus enhanced absorption. It is not the size above about 250mgs that is important but the frequency of the Vitamin. If Niacinamide was widely available in smaller doses 100mg I would of have recommended that instead. Niacin is available in100mg doses but can still mildly flush at that dose (especially on an empty stomach without food to compete for absorption) and again why by default I recommend the Niacinamide form. Medical doctor’s know this and use the smaller doses more frequently when treating Pellagra. See this link from the American Journal of Clinical Nutrition http://ajcn.nutrition.org/content/85/1/218.full See their “subjects” paragraphs on how smaller doses effectively treated the symptoms’ of Pellagra. Quoting “The patients were treated according to the standard local clinical protocol and received a 100-mg nicotinamide supplement and a B complex tablet 3 times daily for 17 d if an adult or a 50-mg nicotinamide supplement and a B complex tablet 3 times daily for 15 d if aged <15 y. In addition, all patients received a weekly food supplement—400 g of a fortified blended food (corn soy blend, oil, and sugar)—for 3 wk. Families of the pellagra patients were also eligible for a food ration from the World Food Programme, which was distributed monthly for 3 months.” **** Note: This is a much shorter time than I often (have) advocate(d) because I want to be absolutely 100 percent sure these symptom’s will never EVER come back (unless you have more STRESS more on that later). But as you can see much lower doses for a much shorter time than 4 to 6 months can works as well. I/posterboy say conservatively 3 months (see the time a rich niacin and protein rich food plan was provided) to avoid remission because that is the time your body can store most B-Vitamins. But the amount is not important it the FREQUENCY that is key! By being conservative (some might say aggressive) with how long I recommend to take it (Niacin(amide)) (and the amount see above about why I recommended this amount in the first place) people are reluctant to take Niacinamide at ALL. And this in turn leads to disbelief that taking a B-Vitamin can help people with GI problems. But we see in this study (above link) by the American Journal of Nutrition that even low doses in divided doses as quickly as (or as little as a month’s time) can dramatically help people with the trifecta of Pellagra symptom’s. Note: Read the whole article for yourself when you get a chance because it explains in detail how to have your doctor check your Niacin levels’ and why this can confirm your diagnosis (but taking the Vitamin can too! As confirmed by clinical remission in less than a month on/of divided 100mgs doses) But instead Pellagra 3 D’s are diagnosed as separate diseases today. See their discussion section (a great read for anyone doing nutritional/medical research) the discussion section is most always the “real story” and not the headlines (title) often. Whatever you are researching beeeeeeee! sure to get all the facts of the story not just the headlines by reading the discussion section. The American Journal of Nutrition (AJN) summarizes Quoting “The lack of knowledge about pellagra was slightly surprising given the endemic nature of the disease. However, it may be that the symptoms of severe niacin deficiency are so diverse that people do not understand them as a single disease and account for them separately using other terminology.” And I believe that is why Pellagra explains most of the symptom’s of a Celiac Disease patient experiences today because of the “Lack of Knowledge” about how Niacin treats digestive problems today! But you won’t know if you are not willing to try it and the reason for the Who’s Afraid of a B-Vitamin post or this FAQ blog post on Niaicin and the best way to take Niacin(amide) I hope this is helpful. By all means please check with your doctor before taking megadoses of any Vitamin even when you think it might help. But what could a relatively low dose of Niacinamide 250mg (if you can find it) or Niacin 100mg with food hurt when it used in much higher doses (500mg day to start titrated up to 3 grams a day in divided doses) to treat Cholesterol already by doctors. See this link by the mayoclinic that discusses dosing recommendations for Niacin(amide) http://www.mayoclinic.org/drugs-supplements/niacin--niacinamide/dosing/HRB-20059838 People regularly are prescribe/take Niacin for over a year with no side effect (see Mayo clinic link) and often for twice that time or longer. So I hardly think taking Niacinamide in divided dosages for 1 to 3 months is mega dosing but I understand why people think it is. I am not trying to diagnose of treat your condition(s) I am only trying to share/educate you on what helped me. For to Educate is to truly free! How can you know (learn) these things (about Pellagra) or how/why Celiac Disease could be being diagnosed as Pellagra today if you do not hear! And if it helps (your symptoms’) improve in as little as a month (in divided doses) up to 3 to 4 months (to be conservative) then you had Pellagra Co-Morbid and now at least your Pellagra is in remission and you can concentrate on just getting one disease better. But you say I don’t live in Angola (how does this affect me)???? I am glad you asked! Remember what I said about STRESS https://www.celiac.com/articles/23506/1/Stress-Common-Before-Celiac-Diagnosis/Page1.html Stress makes us low! Think car accident, surgery, pregnancy, divorce, medical emergency etc. and so it goes. Anything traumatic can lower our B-Vitamin levels and cause us STRESS! Some of us which will/do not recover from without eating nutrient rich Niacin foods or supplementing with Niacin(amide) as they did in the Pellagra outbreak discussed. And the doctors have forgotten the old phrase “STRESS KILLS” and surely war kills people but many (most) of those who die don’t die immediately from a gunshot or wound but stress of surviving has harmed them. But we forget before STRESS kills us it maims us first. So too does it (harm/ maim) us first us too the same way! In our doctor’s eyes they see the same thing. It is just stress you will live. But not recognizing this condition soon enough can lead to death in time. See this link that discusses why this is commonly misdiagnosed in most doctors’ office’s today. http://www.medscape.com/medline/abstract/19624986 Quoting from the Dermatology Online Journal "Pellagra is a nutritional disease caused by the deficiency of niacin. It presents with a photodistributed rash, gastrointestinal symptoms, and neuropsychiatric disturbances. In the Western world, this disease is mostly confined to alcoholics or the impoverished. However, this condition must be recognized in other clinical settings because it is easily treated and can be fatal if not identified." And this great summary of Pellagra and the 4 D’s which I think now are the 3 D’s of Celiac Disease. http://blogs.creighton.edu/heaney/2013/11/18/pellagra-and-the-four-ds/ YOU will only know if you are not afraid of a B-Vitamin. You needn’t Bee! And by writing this (if) I put this dosage information all in one post maybe I won’t have to write it again and again in each thread I comment on. I repeat for(e) emphasize. For to Educate is to truly free! How can you know (learn) these things (about Pellagra) or how/why Celiac Disease could be being diagnosed as Pellagra today if you do not hear! Good luck on your continued journey. I could write many more pages on this topic because it has helped me soooooo! much but need to quit so as to not bore you too much and it is getting longer than I planned. (sorry about the formatting every time (I try to import a post it messes up my formatting) and thank you in advance for anyone who reads this. I truly hope it helps you the way it did me! Praise bee to God! 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble (starfish those still suffering), by the comfort wherewith we ourselves are comforted of God.” **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God,
-
The Grey Science of Nutrition in a black and white world of Genetics and disease or the Elegant Neat IE Key method to (uncontrolled) inflammation in the body or How/Why low micronutrients IE Vitamins and restoring micronutrients aka(B-Vitamins) are key to maintaining good GI health or Why Vitamin Deficiency Test often fail to give us a black and white answer. The Purpose of this Blog post Is To Educate for “To Educate is to Free” for those who want to know and would try a Vitamin for their health…(sorry about the formatting I will endeavor to add breaks but the flow of the matter might not be concise) This Posterboy blog post is to encourage you to be tested for a B-Vitamin deficiency…but I betting you won’t test low… Through my research on Nutrients/Vitamins/Minerals IE Nutrients I with other deep researchers have come to similar opinions from different perspectives or journeys… For now …I just wanted to float the idea…of an “Elegant” theory of supplementation and how it can help people’s GI problems…. Last time I spoke of KIA’s and Jaguar’s… This time I am writing/speaking on “The Grey Science of Nutrition”…referring to an early DRAFT version of a “White” paper (new idea) not spoken or discussed before…. This will be wrong as much as right hence….the Grey Science…thought provoking ideas… though while sound in their logic and reasoning….totally unproven as to the science… the difference between an Hypothesis… and a theory… Even good working theories can take years let’s say 20+ years for this model/example… to be proven more than a good hypothesis… I will refer you to the “hormone smatter” site if you want to know more about Thiamine…which I will cite at the end regarding how and why vitamin deficiency test often fail us.... https://www.hormonesmatter.com/mitochondria-energy-not-genetics-underlies-health-disease/ Where they will say similar things …only having Thiamine aka B1 as their focus… I have spoken about my experience with Niacin aka B3 here before so I will not belabor that point now… What I want to discuss/talk about is how these B-Vitamins B1,B2, B3 together ---- work in a neat/elegant way to help control our immune system… Without which our immune system becomes disordered…IE attacks itself…. B3 was an easy target….because without it you will die…it is a medical fact… A short summary of why this is so can be seen here by a 2nd Year biology student that says it well you find “Pellagra in unexpected places” today every where are bodies needs energy… eventually Pellagra will show up… https://pellagradisease.wordpress.com/ Described here as “Pellagra: A Non-Eradicated Old Disease” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019925/ But you do not have Pellagra but more like Pellagra Sine Pellagra aka Ariboflavinosis or a severe Riboflavin deficiency… Without energy…we can’t manage our bodies properly and stress kills us…but it maims us first… We all know stress kills but rarely do we think of it maiming us. “Fight or Flight” right! Well all these fleeing or fighting causes use to use up great amounts of energy (think Adrenaline and a young child lifting a car). Our body has a instant decision to make. Think for yourself when your GI flares up … are not you going through some personal stress in your life. Who has ever heard of the phrase – “A place for everything and everything in its place” We like for things to look neat and be neat most of the time right??? When we are low in B-Vitamins our bodies place for things get’s disordered… More importantly it should make sense to us IE be in black and white. We want to be able to find things in a moment’s notice. And why nutrition is a “Grey Science” Admit it you have gone to google and typed in a few symptoms on webmd etc (web) and diagnosed yourself of the latest plague to hit the airways. But seriously, the medical community does this almost to the extreme. If you have xxx, then it is yyy because zzz happens when you are allergic, sick, etc ad naseum. They are called “keys” in the medical community. That is why the doctor in 15 minutes can diagnose low body temperature as a thyroid problem because it is our thermostat…but nutrition rarely can be reduced to just one thing/Vitamin right? But We want these quick hits. Because it make’s sense and is easy(ier) to diagnose that way. But what if a disease is more general in scope say malaise (celiac)/NCGS or has a possible nutrition base then it get complicated (messy) more test’s (keys) are needed to see which one fits. The problem with Celiac disease today is there are many “keys” than can fit in the door and seemingly all the keys work. 200 symptom’s all least by some estimates. So it can be hard if you are not looking at the right key’s to determine if have the right diagnosis. … IBS, Chrons, NCGS etc…. The problem with this solution is the more (longer) the doctor/practitioner/clinician looks for the right key the more their patients suffers. The “key” solution works fine if the medical problem is “Neat”. “ A place (key/symptom) for Everything and everything in it’s place.” But those of who have ever been diagnosed with Celiac disease or a gluten allergy know it is anything but “Neat”. It is a very messy process at times. But if you find/are a “good” doctor/practitioner/clinician who has been through the process with another patient then luckily your diagnosis goes more smoothly. Or not? Maybe they haven’t learned the keys yet. They have seen them before maybe. IBS, NCGS, Celiac Disease, UC etc all look a lot of like. Now remember for the most part these are all “general” practitioner’s. They have a lot of keys to juggle. And after a while they all look the same. Especially if it is a “sprue” tropical or non-tropical in nature disease like Celiac is. According to the medical dictionary “sprues” are a chronic form of malabsorption syndrome Time for a little vocabulary lesson chronic what does – Chronic mean? According to google dictionary “(of an illness) persisting for a long time or constantly recurring.” … most doctor’s will call it chronic if it lasts more than 6 months. So now we have a disease/syndrome of symptom’s (more on that later) that does not fit a “neat” picture in fact it can be very messy for the patient at times (and the clinician) who is doing his/her best to help you one key at a time. INSTEAD of 15 minutes it might take 5 to 10 years until a doctor/practitioner/clinician makes sense of all his or her keys. The fact that the problem is chronic “of an illness persisting for a long time or constantly relapsing” tells him/her that she has not found the right key yet right??? Is there a better way more Elegant way? (The Answer is YES there is – It is called Vitamins/Nutrition) Disease need not be CHRONIC when one understands the underlying cause. Indeed I believe we need got to all the way back to the root cause of nutrition — Pellagra Sine Pellagra presenting as digestive disorder which is healed (put in to remission) with supplementation in as little as 3 to 4 months depending on how many times a day it (B-complex) is taken. Knowledge is power as they say….use this new found knowledge to have your doctor test for B-Vitamin deficiencies is all I ask …. have them test for Vitamin B1, B2, B3 you might be surprised…or not depending on what you expect to find... or how well the test(s) are done... The researchers where who said “Pellagra, an Almost‐Forgotten Differential Diagnosis of Chronic Diarrhea: More Prevalent Than We Think” https://onlinelibrary.wiley.com/doi/abs/10.1002/ncp.10418 That is too Elegant to theorize/propose/diagnose Vitamins’ (more correctly the lack thereof) as the (possible) cause of (Celiac) disease/GI/digestive problem’s? Vitamins are the very definition of ‘elegant’ a nutrient needed in a minimum amount without which we become sick and develop malaise, disease and syndromes (like Pellagra) or Pellagra Sine Pellagra presenting as Celiac Disease or even Beri Beri etc). See this research on a Thiamine deficiency in someone with IBS and Chronic Fatigue… Entitled Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study. https://www.ncbi.nlm.nih.gov/pubmed/23379830 The researchers were surprised to find it and your doctor probably will be too! And the doctor’s can’t find there keys/studies in the medical record until more patients are diagnosed with these Vitamin deficiencies in (More) GI patients….because a “small cohort” is not deemed to be medically significant ….you can change the future today by being tested for these Vitamin deficiencies…it is really up to you now! But you we can educate them so they will begin looking! For this key nutrient Vitamin deficiency/dependency for “To Educate is To Free” …the next generation…. But note: Pellagra did not happen in a uncomplicated way (single nutrient) IE elegant way but in complicated Triad of nutrient deficiencies….a syndrome of symptom’s…from a complex of Vitamins… hence the “Grey Area” of Nutrition have left doctor’s/clinician’s in the dark as to the true cause of your syndrome of GI symptom’s… https://casereports.bmj.com/content/12/9/e230972 **** Note: This is not medical advice. I am not diagnosing, treating or recommending you change your routine before consulting your doctor but only advocating that nutrition needs to be rediscovered today as possible cause of your GI problems….More testing will need to be performed to confirm this analysis…. I meant this to be shorter than it is but you can only cover so much in one blog post I guess. It is important to note I do not NOW take Niacinamide or Riboflavin or Thiamine and have not for several years now. If it (B-complex) is the missing ingredient/nutrient(s) you will get better UNLESS more stress/trauma occurs robbing you of your God given burp indicating to you stress is now a problem again for you. If it helps (you find you have these deficiencies) and you feel better…tell someone else who is not better yet… get your doctor to do a key/study on your experience so future doctor’s will have the key/study in the medical record to find that Pellagra Sine Pellagra or Pellagra or Beri Beri is more prevalent today than once realized… presenting together (I believe) in the capstone disease Pellagra or Pellagra Sine Pellagra (without skin manifestations) much more commonly…as It did in me…as/with Angular Cheilitis…. It (Ariboflavinosis) low Riboflavin could of presented with many other symptom’s…and I wouldn’t have and (and doctors don’t) didn’t recognize it then…until it presented with a “Capstone” symptom… with it’s many other earlier symptom’s most doctor’s (and myself) did not know Geographic tongue for instance was an early sign of low Riboflavin aka Pellagra Sine Pellagra… https://glutenfreeworks.com/health/tongue-magenta-swollen/ The earlier you recognize any disease/syndrome the more symptom’s you can spare yourself of… Knowledge is power…pass it on…hopefully to your doctor ….and you have put your “key” diagnosis in the medical record so other doctor’s can find their keys for the next patient…we can’t wait another 15 to 20 years… (has been my thing) till this nutrition(al) knowledge filters down to the medical/clinical practitioner’s level…. I am not a doctor but I like most other sufferers have armed myself with knowledge. I studied every day diligently for 4+ years before the Lord being my help …. I was able to figure out I had a Vitamin deficiency (many reallly)… now it is up to those still suffering to put it in the/your medical record(s) for others doctor’s to find it in the future! In black and white! Praise be to God! To those who hear and listen. 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. 2 Cor 1:3,4 3)Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God Posterboy by God’s Grace, Addendum: This Posterboy blog post is/was to encourage you to be tested for a B-Vitamin deficiency… but I betting you won’t test low…but I hope and pray you will get tested...to see if (it) is happening...and if you only needed a test to diagnose you...why wouldn't you do it...even a low normal test can be helpful to guide you...in your journey back to health....right now I am low normal in Vitamin D...but I didn't know until I got tested... See this Hormones Matter blog post about why most people (even when low in Thiamine) will test normal… http://www.hormonesmatter.com/thiamine-deficiency-testing-understanding-labs/ the same is true for Riboflavin (and Niacin often) as well….depending on the factor you used in the test … a deficiency might show as being normal… see this study in the UK… https://www.ncbi.nlm.nih.gov/pubmed/19102813 factor’s have not (at the time of their test (yet)) been standardized to determine what constitutes a Vitamin deficiency (for many B-Vitamins)...so we guess often...(at least when it comes to B-2 aka Riboflavin) though we know what to test for... soooooo many people go undiagnosed……they (UK researchers) estimated as many as 1/3 of the (UK) population might have a “hidden” deficiency depending on the “factor” used to determine a Riboflavin deficiency….etc… Note: I can't tell how much a cow weighs by looking at it...I have to have it tested/weighed to see if my guess is accurate... and neither will you be able to "guess" what deficiency (if any) you have without being tested for them... I wish everybody well....I hope this is helpful but it is not medical advise. I must stop for now...but good luck and God speed on your continued journey...and if you do test low at least then you will know.... Posterboy,
-
To Whomever Might Read This, This is metaphor only …not intended to diagnosis or treat anyone but to educate…. There is an old joke told about Jaguar cars in the 1980s’ and early 1990s etc… that you needed two to drive one… Kia might have been in/on that same boat…when first introduced in circa 1992 but since the early 2000s IE this Millennium or so…. They have improved tremendously….and truth be told soooo have Jaguar’s ….but you might still want to have more than one on hand….if you still want to drive one etc… This is because both Medicines (Jaguars)/Vitamins (KIAs) etc… often work better in pairs…the strength of a team can be described best in this phrase….two can do the work of three….it is additive… So two often in medicine and with vitamins ….everyone who reads my posterboy blog posts know I have over emphasized (probably) Niacin…over the other B-Vitamins…. See this blog post about how and why supplementing with B-Vitamins might be helpful for those still suffering with GI problems on a gluten free diet… And why I still think it is a good theory…one I admittedly can’t prove (easily) or at least is hard too…. So I punted that strategy….sometimes a punt is a good play… Or why B-complexes are a better play than a monotherapy/star regimen…because teamwork and health/life work’s better when we work together… When we get low in B-Vitamins we develop something called the “Hidden Hunger”…commonly found in 3rd world countries….but it has a KIA problem in the US…still here…but rarely recognized… See this link about how Biofortication called “Enrichment” in which white bread has helped keep this hidden hunger in check mostly in the US….unless we have too much stress or other stressors like sickness that can trigger a Secondary Pellagra diagnosis https://onlinelibrary.wiley.com/doi/full/10.1111/1541-4337.12491 I also recommend this article on “enriched” white bread and why it was called “Wonder Bread” in it’s day…because it really was wonderful in it’s day… https://www.chicagomag.com/city-life/March-2014/How-Wonder-Bread-Became-the-Healthand-then-the-Ill-Healthof-the-State as it turns out there is a reason why “enrichment” programs included Thiamine, Riboflavin, and Niacin….because we get really sick when we don’t get enough… the biggest issue today is we have forgotten what these Vitamin deficiencies look like today in the US because almost nobody alive today has seen what they look like….except in history or text books… (K) B1 aka Thiamine has a Knowledge problem… (I) B3 aka Niacin has an Image issue (A) B2 aka Riboflavin has an Awareness Issue Vitamins have the same problem as KIA’s today…most don’t even know they exist…if they do they have an Image problem…still left over from the 1940s and 1950s etc.…(vestigial) …or if they have overcome their image problem ….most are not even aware…KIA still sells cars in the US because they though they failed ….when Daewoo left the US….think the way a healthy person doesn’t need Vitamins today… A hard image to fight for sure…. What I am trying to say….in an around the barn kind of way….get yourself tested for these deficiencies…you might still (probably) have them today… and don’t even know it… The Global Concerns with B Vitamin Statuses and their hidden hunger link has the standard test for these B-Vitamin deficiencies… This link says it well…. “Pellagra an Almost Forgotten Differential Diagnosis of Chronic Diarrhea More Prevalent Than We Think in US” https://onlinelibrary.wiley.com/doi/abs/10.1002/ncp.10418 this paper was from last month (October 2019) in the US…. And there was one (another case study) the month before too in September… Entitled “Pellagra in the USA: unusual manifestations of a rare entity” https://casereports.bmj.com/content/12/9/e230972 Now two cases in two months is not rare…just rarely looked for …today….remember the Knowledge, Image Awareness problem.. And I will focus my attention to this (KIA) research going forward… The abstract in it’s entirety…. Pellagra in the USA: unusual manifestations of a rare entity: Abstract “The case involves a 62-year-old female native of the USA with a history of bipolar disorder and chronic obstructive pulmonary disease who presented with intractable diarrhoea. Prior to the index admission, she was admitted to the intensive care unit and required pericardiocentesis for an idiopathic pericardial effusion with tamponade physiology. Following discharge, she suffered intractable diarrhoea and represented for medical evaluation. She had a painful, swollen tongue as well as persistent hypoglycaemia and required glucose infusions. She had adrenal function testing which revealed adrenal insufficiency. Vitamin testing revealed normal B12 and folate levels but undetectable levels of thiamine, riboflavin and niacin. Her symptoms and signs resolved entirely with appropriate vitamin supplementation. Niacin (vitamin B3) is essential for multiple metabolic pathways, and severe deficiency may cause clinical syndrome of pellagra which is most commonly associated with diarrhoea, delirium and dermatitis. Additional physiological derangements may include adrenal insufficiency, insulin hypersensitivity and pericarditis.” Pickuped by count them ONE news outlet/agency….you probably never heard of it…an Awareness issue for sure… Note: she had already tried the Jaguar method of multiple medical referrals’ …..and they still had one sick patient….all well supported by the medical community… And after trying the KIA (vitamin) model ….her symptom’s improved… And why I have shared my story on/in my posterboy blog post’s to try and help those still suffering…few listen about 1 in 7 if I am lucky…about as many as the number of news outlet’s that picked up this abstract….Pellagra has an Knowledge, Image and Awareness issue…Pellagra Sine Pellagra aka Ariboflavinosis -- a Riboflavin deficiency has an even bigger Awareness Issue! I have tried hard to education on the Awareness side,……but the Image is still faded to most people….having little or no knowledge of any one having being diagnosed with Pellagra in their lifetimes….when It does happen…nobody recognizes it… Except when one or two Intrepid researches (in as many months)….go looking for it …they find it… Yes KIA’s are still being made today…they even have a high performance STINGER model that goes toe to toe with Jaguars and BMW’s today….but most people are just NOT aware of KIA’s even today despite them having been sold for 25+ years in the USA…people just don’t recognize them when they see (them/it (Pellagra) unless they start looking for it (Pellagra or more commonly Pellagra Sine Pellagra)…two intrepid researchers in the last two months have figured this out… ****** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen and verify with appropriate testing if these things are so for you ….but if you have intractable GI problems or (chronic diarrhea see link above) for 6 months or more (after going gluten free) your doctor’s should test for or you yourself should encourage your doctor’s to test you for B Vitamin deficiencies…if you still feel being gluten free still has not helped your GI symptom’s….which improve for most people on a gluten free diet in that time frame…and long enough to be considered intractable or IE chronic for most people… 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God, P.S…I must stop for now headed out to do farm work one of the 4F's in my life…if I have time I will update this with a part 2…probably in a month or two…about the complicated manner in which Pellagra presents itself in a nod to KG….the patient had B1, B2, and B3 deficiencies…not an easy uncomplicated B3 deficiency alone by itself…NO man or Vitamin is an Island….
-
Open Letter Part 1 to Fellow GI Sufferers etc. Like IBS, UC, and other GI diseases like Infant Heartburn (GERD) that grows into (in time) to IBS, UC, Chron's and NCGS as a teenager or Celiac disease in time as an adult - Look beyond to the Parent disease
Posterboy posted a blog entry in Posterboy's Blog
Open Letter to the many GI sufferers etc Part 1’ Like IBS, UC and other GI diseases like Infant Heartburn (GERD) that grows into (in time) to IBS, UC, Chron’s and NCGS as a teenager or Celiac disease in time as an adult— Look Beyond these symptom’s to the parent disease –- Pellagra. *** a couple of notes to begin with. You can see I meant this to be one post -- but as usual it got too long to read at one seating. 2) because I might be having a medical procedure soon (I am posting part 1) in case I don't get to part 2 until latter. ****This is only my experience (and my research) that has lead me to my conclusions. They are NOT endorsed by celiac.com nor should this blog post be considered and endorsement of these ideas by celiac.com. Thank you in advance for letting me share my opinions and conclusions. (God being my help) may this posterboy blog post benefit those who take the time to read them/it. What follows is something that has been on my heart to share for a while. It is my story only. . . yours may be different but I have found if it helps you . . . it will help others too! And as they say "Without Further Ado" Here are my thoughts about my original celiac diagnosis and what/why I think was also low in stomach acid but a proper diagnosis was not made because not enough/proper test's were done to rule it out as an official "differential diagnosis". If it is happening to me. . . it is happening to others! Below begins the body of blog post of "An Open Letter Part 1 to Fellow GI Sufferers" Because as I am fond of saying “To Educate is to (Truly) Free” God being my help 2 Timothy 2: 7 as always“Consider what I say; and the Lord give thee understanding in all things” this included and all the knowledge I have absorbed in 10 years of researching this topic for myself (God being my help) how I discovered this forgotten medical fact after 4 years of research (see below) and have been helping people for over 6 years (those who will listen) and who better to learn from than someone who has done it himself and not only for himself but 100’s of his friend too! See this celiac.com article where much of this information is summarized in something called a white paper about the “When Myth becomes Medical Fact People suffer unnecessarily; The Case of Mistaken Identity: How Pellagra now thought to be rare became known as Celiac Disease — A White Paper linked at the end of the article. Referenced here if you have not had a chance to read the article since it was featured on celiac.com https://www.celiac.com/articles/24658/1/A-Differential-Diagnosis-How-Pellagra-Can-be-Confused-with-Celiac-Disease/Page1.html “A white paper is an authoritative report or guide that informs readers concisely about a complex issue and presents the issuing body’s philosophy on the matter. It is meant to help readers understand a (complex) issue, solve a problem, or make a decision.” By reading this blog post I hope to convenience you that your experience can be the same as mine. A differential diagnosis is one of the best standard of medicine rarely practiced today and how specialists decide between competing diseases like UC or Chron’s or IBS or Celiac Disease and if I am right Co-Morbid Pellagra now forgotten for 75+ years since the “War on Pellagra” is now over according to medical professionals’ but sadly the battle rages on for at least for the 60 Million American’s alone who get (Infant) Heartburn once a month not counting the heartburn that grows up to be IBS, UC, Chron’s or Celiac disease. See link below from Creighton University that mention’s this medical fact. Pellagra is not a disease of TODAY. Celiac is the disease of Choice today! But in 58% of those diagnosed with Celiac TODAY 58% are Co-Morbid with Pellagra as I was and most ALL my friends because they ALL get better when they take the Niacinamide. I now it works. I have seen it work for too many people. And I believe it can/could work for you too! See end of this blog posts and my doctor does too. He now uses this method in his practice with great success! And it can work for you too! (I believe) Lord willing if you do as I suggest and take Niacinamide 2or 3/day for 6 months (see below). I now describe myself as the Celiac and Pellgara Posterboy as a “Former Celiac Sufferer” who blogs about digestive disorders that Co-Morbid Pellagra causes often presenting as other GI diseases like IBS, UC, Chons, NCGS and GERD” Note **** This IS NOT medical advice only my personal experience of how through deep research (and the Grace of God) after 4 years of study I found what the doctors have always known but overlook in treating the many symptoms of Celiac Disease. The true cause as recorded in medical textbooks the world over the cause of 90+ percent of Digestive disorders (I believe) is because of one Vitamin Deficiency/Dependency. This blog post and (Posterboy blog) is about that ONE nutrient/vitamin/mineral that is lacking and the causative agent for most Digestive Disorder(s) presenting as the Iceberg Disease(s) of Gluten Insensitivity aka Celiac Disease in its most advanced stage (with enough time). And I hope at least ONE other Celiac besides me will believe also and be helped from this post. As proven/researched by Prousky almost 17 years ago that low Niacin levels lead too low stomach acid. It is time this information was known by a wider audience – the Celiac audience. http://www.yourhealthbase.com/database/niacin-treats-digestive-problems.htm see also by posterboy blog about this topic. It is a devastating delay. 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. When Celiac Disease points it head (rears it head) out of the water 20+ symptoms (known as associated diseases) have already presented themselves in various malady’s. When only 3 (the 3 Ds) symptoms where need 75 years ago to diagnose the condition once considered cured but is rampant in today’s society because we are more STRESSED than ever. Digestive disorders, dermatitis syndromes, and dementia disorders – known then as Pellagra 75+ years ago but now is known mostly as various GI diseases depending on how long or low you are in Pellagra Preventive Factor as it was called in the day. Here is the best research article I have ever read on the topic. https://www.hindawi.com/journals/cggr/2012/302875/ They called it “Lessons from Pellagra” but the problem is we haven’t learned them. What does this look like in human beings? If one is critically low in Niacin the 3 D’s of Pellagra (Dementias, Dermatitis’s, and Digestive Issues) show up. (see hindawi link about for the exhaustive complete diagnostic picture of all the ways Pellagra might present itself. It is very exhaustive and informative) We will not count the 4th D of death if you are reading this blog. Explained here well http://blogs.creighton.edu/heaney/2013/11/18/pellagra-and-the-four-ds/ To quote Dr. Heaney a Past Professor of Medicine at Creighton University “2014 marks the 100th anniversary of the war on Pellagra, a war that lasted nearly 25 of those years before victory could finally be declared. You have not heard of the war on Pellagra? The celebration is not on your calendar? You’re not alone.” I have been in remission now for 5+ years after suffering 30+ years. Remission is possible! From Pellagra! Epigenetics has been discovered as the cause for Pellagra being diagnosed as Non-Celiac Gluten Sensitivity (NCGS) or Celiac disease when Heartburn/Gerd then IBS etc. and NCGS in time grows up to become your Celiac Diagnosis. Learn how Lifestyle (STRESS) is a risk factor for Celiac Disease. see this article entitled ‘Lifestyle is a Risk Factor for Celiac Disease”. https://www.sciencedaily.com/releases/2015/11/151102100302.htm Quoting an article that appears on Celiac.com https://www.celiac.com/articles/24166/1/Could-Changing-Gut-Bacteria-Prevent-Celiac-Disease/Page1.html “According to Dr. Decker Butzner, a Calgary-based pediatric gastroenterologist, there are another triggering factor which we’ve never understood…[t]here is an environmental trigger.“ i,e. STRESS Have you been stressed of late? Stress is said to kill you well it also maims you. NCGS is that maiming of people who have eaten wheat without resetting their stress clock. Find out how you can reset your stress clock (my words). Also see this very well article on pregnancy. https://www.verywell.com/can-pregnancy-trigger-celiac-disease-562302 where they say quoting First Comes Baby, Then Comes Symptoms "Most women are diagnosed with celiac disease after at least one pregnancy — in fact, a comprehensive Italian study published in 2010 on the reproductive effects of celiac found that 85.7% of women received their celiac diagnosis following their first pregnancy." WE also know stress is a trigger for Celiac disease. https://www.celiac.com/articles/23506/1/Stress-Common-Before-Celiac-Diagnosis/Page1.html Join his friends who no longer suffer from heartburn, gas, constipation, diarrhea, IBS , UC, Chron’s and Ulcer’s etc. of NCGS/GERD. You too can be in remission in as little as six months if you follow this ground breaking discovery hidden in medical text books now brought to light about how to manage digestive stress from Pellagra. When he (God being his help) rediscovered Pellagra as a disease of TODAY now often Diagnosed as Celiac disease instead of one conquered 75+ years ago as the doctors teach. A brief history: over 4+ years ago after being able to eat gluten again after being Gluten Free for 4 years and suffering 30+ years before I received a diagnosis as Celiac disease I begun to realize I had low stomach acid instead. So now I speak about it freely and blog about it regularly with only modest success and why I participate on celiac.com to Educate those still suffering unnecessarily to help explain how Pellagra is often confused for many GI issues up to and including Celiac Disease in time – usually 10 years or more. *** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your diet or your prescribed medical regimen. After 4 years of research and 5+ years of GI symptom remission I am convinced more than ever that 90+ percent of the most common GERD/Gluten issues are related to sub-clinical presentation of Pellagra unrecognized in a clinical setting. So much so that I tell those who will listen. As I am fond of saying Learn from my mistakes. Honey is like knowledge sticky and sweet when good news comes. “This posterboy blog is just that storehouse of knowledge learned from life experiences. The blog’s author has been stung so you don’t have to be. No man is so dumb as the man who won’t learn from other people’s mistakes. Take as much honey (knowledge) as you can from my mistakes so bad health will not sting your quality of life. Feel free to ladle and dollop your life with the sweet stickiness of the truth found here. For honey like truth stick to you once in contact and you can’t just wash it away.” This posterboy blog is about my struggle to reach people yet only about 10 percent believe and are helped when they read these things though 95+ percent are helped when they treat their Pellagra symptoms with Niacinamide taking it 3 times/daily for 4 to 6 months. Education (this blog) is about raising the conversion rate so people don’t have to suffer any longer. I will go on telling those who will listen. How can they hear if no one tells’ them? Romans 10:14 (I speak as a man) Tell others about this blog post if you decide to try Niacinamide for yourself and see If it helps you. It will help others/them too most likely! At least it helps most of my friends that will/have believe/believed and tried it for themselves. Take the Niacinamide and get/be better in 6 months (begin BURPING) (w/o bloating I might add) for the first time in years IF EVER from Pellagra undiagnosed. No one seems to believe (or at least not many) becoming deficient in (a) vitamin or vitamin(s)/minerals will/can make us sick. What a novel concept. You would not think I would need to write a blog post to tell people that! Maybe it is not true in your case. But you won’t know if you don’t try it. All I know it has been true in my life! and Hundreds’ and hundreds’ of my friends. Thanks bee to God who helped me to see these things. 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” Tell someone (share) is all I ask tell others is all I ask –when you are BURPING for the first time in years or (EVER) – tell a friend about this blog post “is all I ask” but don’t let the chain break with you. There a lot of fellow sufferers’ who still need help. I always say the number one mistake people make with Niacinamide is not taking it long enough (3 to 6 months 3/day in divided doses) but now I am going to amend that. The number one mistake people make with GI problems is the mistake of not taking the Vitamin in the first place. The 2nd biggest mistake is they don’t take it long enough! If you want to try and educate your doctor/friends and think he/she/they will listen tell them how Niacinamide helped you or some fellow who says it helped him but I was too scared to try it. Maybe they will listen to your better than they will/do me. *** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. But mine has taken Niacinamide and his digestive/GI problems are in remission. And his difficult to help/treat patients who don’t respond to “popular” medicine’s like Linzess etc. are better for IBS-C. And have stopped the medicine because their symptoms are in remission. He has even given Niacinamide to his sister to help her Chrons symptoms’ though research bears this out people don’t (Heck doctors don’t even) well understand the connection. See this article entitled “Pellagra as the presenting manifestation of Crohn's disease.” https://www.ncbi.nlm.nih.gov/pubmed/7060914 (***Note: this is an update. I saw my doctor recently and he admitted as such. But I could see it in his eyes (and hear it in his voice) because it did not fit his paradigm (world view of Vitamins/medicine) he spoke only of her Chron’s being in remission. It never occurs too him that her co-morbid Pellagra is better and it (Pellagra) could be being misdiagnosed as Chron’s instead (and won’t/wouldn’t) even if I brought him the research.) But Vitamin(s)/Minerals especially Niacinamide and Magnesium don’t get the attention they deserve because Vitamins’ don’t have a USP today in this genetic age we now live in. They (drugs) are popular because they have drug companies who have the money to advertise them. I do not. I do not have a Unique Selling Position (USP). Nor do Vitamins these days! And I say too you too. Put your Pellagra symptoms into remission too! (Your Celiac diagnosis can remain your primary disease diagnosis) as the doctor's wonder why your (Pellagra misdiagnosed) symptom's are in remission. No body profits if you get better in 6 months or a year and you no longer need the Vitamin! We don’t’ get sick from being low in “a Medicine” to quote the frustrated pharmacist but a Vitamin. I usually end up giving Niacinamide away and often they (friends) give it back instead much like a Johnny Appleseed character. Such is the fear of Vitamins these days. See also the posterboy blog post on celiac.com why this is so. . . entitled it is time for a Vitamin Reformation; Why all the hate for Vitamin’s these days. 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. I am just trying to help those who still haven’t heard yet Pellagra is being diagnosed as Celiac disease today and your Pellagra undiagnosed/mistakeningly diagnosed as Celiac can be in remission from a Vitamin deficiency. If we follow most normal paths’ for adoption it will take another 20 years (a generation) for the medical community to accept Pellagra as the proper diagnosis. ****Note: I am only reporting what medical journals have concluded. It is just not well understood today one disease is being diagnosed as the other because it can take a generation for this knowledge to filter down to the clinical level. How do we know this??? Or can we? The International Journal of Celiac disease notes this association/connection. http://pubs.sciepub.com/ijcd/3/1/6/ Not only did/does the Journal of Celiac cite common symptom’s 58 percent of the time in Celiac and Pellagra but they also cite that Pellagra has been described in a Celiac Disease diagnosis. Now if the symptoms’ are similar it is easy to confuse one disease for the other and if not well understood they might be considered “exceptional” or, i.e., not well understood and discounted as the cause. I would argue that it should be the other way around if the majority (58 Percent) of the time Pellagra symptoms are described in a Celiac diagnosis it stands to reason that medical science is identifying the wrong disease. The math doesn’t add up. 58% is the Majority (primary/parent) disease and as such should be treated first. Pellagra has 3 faces that often confuse doctors today but 75 years ago they were able to diagnose this disease with only 3 symptoms the D’s of Pellagra. Dementia’s, Digestive Disorder and Dermatitis issues. Are You starting to see a pattern here? If it starts with a D then Pellagra a Niacinamide deficiency is involved. Quoting the Celiac Posterboy “These D’s a Celiac patient encounters are not the sign of several different diseases but one parent disease Pellagra with many children.” I could go on and on and on . .. but there is no need for that. I need to stop for now. Either you will believe and be helped or go on suffering needlessly if indeed Pellagra is the parent disease and GERD, IBS, UC, Chrons, NCGS and Celiac disease it‘s unruly children. 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” ****Again this is not medical advice but it is too easy, simple and cheap not to try and see if it works for you . . . I have found it works for others. Remember Occams’ Razor. . . The Simple answer is a Vitamin. But convincing people of that fact has not been simple or easy. I can’t convince you either way. You will have to decide for yourself . . . I only know it help’s those (of my friends) who have tried it for themselves. Praise bee to God and I want other’s still suffering from Pellagra disease if the research is to be believed being diagnosed as Celiac disease to be the next to be helped Praise bee to God! But I know now you will have to discover it for yourself. I stand as your witness. I tried! Posterboy by the Grace of God, 2 Timothy 2:7 As always, “Consider what I say; and the Lord give thee understanding in all things” this included. **** I will update this blog post in a month to 6 weeks with Part 2 about how you can test these things for yourself (if I am not recovering (God forbid) from a medical procedure) depending on how and if my CT scan shows any blockage that might require a stent to be implanted like my brother had to have done. . . Otherwise I wish you all who read this posterboy blog post God speed! And good GI health soon! Praise bee to God if you are encouraged enough from this post to try the Niacinamide 3/day for 6 months for yourself.- 2 comments
-
- celiac
- celiac posterboy
- (and 13 more)
-
Why did I call this post “Time for a Vitamin Reformation”? I see this a lot. So I wanted to write more about it. I share/write these posterboy blog post’s so that others might not have to suffer the same things’ I have. As always I hope you find it helpful to learn how/what someone else did to help their own selves in this journey/road we all walk/or have walked on as a Celiac Disease/NCGS patient. I know this post is way too long (again) as usual but I had a lot of ground to cover. So hang on if you can and will and if you have an interest in learning how I became the posterboy for Celiac and Pellagra. Learn from my mistakes! Quoting the Celiac and now Pellagra Posterboy “No man is so dumb as the man/woman who won’t learn from other people’s mistakes.” I have made too many (mistakes) to count. Take as much honey (knowledge) as you can from my mistakes so bad (lack of knowledge) health will not sting your quality of life. Is it any wonder God’s promised’ land was described as a land flowing with milk and honey? Where knowledge (truth) flows there is health of mind and body. Truth of the right diagnosis can free us from the error of a wrong diagnosis. SADLY! Few listen. But some (Pellagrins’) who have received a Celiac diagnosis co-morbid have heard (listened to) the good news that Pellagra is reversible (when it is mimicking Celiac disease in a clinical setting) and have gotten better. Don’t be the Last! Tell others! So again Why did I call this post “Time for a Vitamin Reformation”? Most people (in the US anyway if you are reading this in some other country) are aware of the Protestant Reformation but most people are not as aware of the Catholic Reformation. Where basically the Catholic’s got smart? If you will and said all these Protestant’s are writing books (fresh off the invention of Gutenberg’s printing press (the internet of their day)) and the Catholic church said let us start printing our own books about how great the Catholic church is plus some minor changes essentially stopped the reformation in it’s tracks. And today there is still 1 Billion (with a Bee Catholics in this world. (I am not against either by the way) this is only by the way of illustration. I had recently wrote a blog post about this why Supplementation wins the War but I wanted to take another stab at it again. And even though I will have only used Vitamin(s) in this post. I want it to be clear this is for Vitamins and Minerals . . . like Iron, Magnesium, Calcium etc. It is just easier to type/write colloquially to use Vitamins to stand in for both Vitamins and Minerals together. See any of my comments or Ennis_Tx’s about Magnesium taken as Magnesium Citrate or Magnesium Glycinate. And why it is easy for the Protestant’s to claim a victory of sorts (there are Protestants still right) it is a pyrrhic victory at best because according to answers.com Catholics outnumber Protestant’s 2 to 1. https://answers.yahoo.com/question/index?qid=20070213184757AAHuhGz If you don’t still don’t believe me visit some of the old Cathedral’s of Europe you guessed it nearly all of them are Catholic Cathedral’s. Back to our point about Vitamins needing a Reformation. Such is the reign of Genetics today we blame it (our Genes) for everything today. Yet new research indicates maybe less than 1/3 of cancer’s day has anything to with Genetics at all. http://www.foxnews.com/health/2015/01/02/study-concludes-that-many-cancers-caused-by-bad-luck-in-cell-division.html Why this research is old it highlights my point that lifestyle (nutrition/vitamins etc) can and do help prevent Cancer today even in this GENETIC age we live in. http://www.cbsnews.com/news/lifestyle-changes-can-prevent-40-of-cancers-study/ To quote them from cbsnews “”We didn’t expect to find that eating fruit and vegetables (VItamin rich foods my words) would prove to be so important in protecting men against cancer,” Parkin said in the statement. … “This adds to the now overwhelmingly strong evidence that our cancer risk is affected by our lifestyles,” Dr Rachel Thompson, deputy head of science for the World Cancer Research Fund, told The Guardian. “ We hope this study helps to raise awareness of the fact that cancer (sickness) is not simply a question of fate (it’s in our genes my words) and that people can make changes today that can reduce their risk of developing cancer in the future.” My point is we need to be saying. Nutrition (Vitamins’ make us healthy) and not let Genetics get all the credit these day’s this includes our GI health too! I believe. It is actually probably more true too realize/say the balance is 50/50 because stress/environment effect both our health and yes even Genes. I think of it in these terms. A Vitamin is a substance we need in a “Min”ium” amount without which we become sick. I understand completely there is a lot of confusion about this topic. I will provide you some of the sources that lead/helped me come to my conclusions. Dr Prousky’s research is what I based my conclusion’s on and helped me to realize my Celiac Disease with/where he concluded “Niacin treats digestive problems” could also be confused for Low Stomach Acid. http://www.yourhealthbase.com/database/a124b.htm This is the link to the abstract. I realized this was going to be a future post when I saw Ennis_Tx muse about this question in a previous thread. Digestion is a north south process and it begins to make much more sense when you begin to understand the stomach protects your Small Intestine and if your defense are low (low stomach acid) when it is commonly thought to be high invading proteins like lactose, soy, and gluten etc. get through. http://divinehealthfromtheinsideout.com/2012/03/digestion-101/ Try a low carb (i.e. and also gluten free) diet for about a month and see if you flare ups don’t improve I think you will find your trigger is gluten and carbs. If so this will work but you will have to come to this conclusion on your own. It took me 3 years of study to understand these things God being my help. 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. If you are now taking an acid reducer/proton pump inhibitor (I can’t lie) there will be a transition period. They all have a wall effect (burning when stopped) that often lock people in to using them for years and years when they were only intended to be used for 6 weeks or less to let ulcer’s heal. Actually on the OTC kind people usually buy without a prescription. It is even less than that. Only 14 days is recommended. . . . not 14 months ++ as is so often the case for people when they begin an acid reducer. See the FDA box warning. https://www.fda.gov/drugs/drugsafety/ucm245011.htm It will take courage and conviction on your part to take a Vitamin when all you hear these days’ that the “average” person doesn’t need a Vitamin. (see link below about why all the hate for Celiac’ drug/medicine treatment?/ trials?) by Jefferson Adams which inspired my title. https://www.celiac.com/articles/24099/1/Why-All-the-Hate-for-Celiac-Disease-Drug-Treatments/Page1.html Or put another way why ‘all the hate” for Vitamins? these days” instead of “Time for a Vitamin Reformation” (though I believe it is. .. I am also convenienced) it will take another generation to realize Pellagra is now being diagnosed as Celiac disease today instead. It takes a generation to make a change unless there is Education. This posterboy blog post is about that education process/the things I have learned from studying this subject myself. Do not change any of your supplementation/medical regime unless you have consulted with a doctor. . . but I found it helped me. The ignorance of this fact that Pellagra can occur with/in/as part of a Celiac diagnosis is so strong that so much so the “average joe” won’t take a Vitamin for their health? Well an IBS/NGCS patient/ Celiac Patient is not the average patient. They are known to develop malabsorption syndromes and B Vitamins are known to help celiac patient’s why wouldn’t you at least try a B-Vitamin or B-Complex to see if could help your GI symptom’s. https://www.celiac.com/articles/21783/1/B-Vitamins-Beneficial-for-Celiacs-on-Gluten-Free-Diet/Page1.html (though this study does not include the effects of full spectrum B-complex) it would have been nice if it did. I ask again “Who’s Afraid of a B Vitamin” See my earlier posterboy blog post about this topic Or to ask it rhetorically why all the hate for Vitamins these day (reader)? Or you (reader) afraid of a Vitamin? Or have you been too (reader) taught to hate Vitamins? And it isn’t just Niacinamide by the way (which is the focus of this post) it is most B-Vitamins. See this article about how B-1 Thiamine can help reverse Kidney Damage in Type 2 Diabetes http://news.bbc.co.uk/2/hi/health/7796073.stm Entitled “Thiamine ‘reverses Kidney Damage’ in Type 2 Diabetes” As usual this research is almost 10 years old and doctor’s clinical practices have not caught on to this fact proven by research. Instead the standard reply is “you don’t need Vitamins” or at least the average person does not. People who have TD2 or Celiac disease should not be considered the average person. Let me say at this point. Why is this not on the front page of every newspaper in the US and the UK and the world. Here we have a Vitamin that reversed Kidney Damage but no one is talking about it. What is not considered or well understood that these same vitamins that can help these patients – a deficiency in these same vitamins can also cause these same symptom’s. http://glutenfreeworks.com/blog/2010/06/23/niacin-vitamin-b3-deficiency-in-celiac-disease/ Now back to Niacinamide for a few minutes. What if had a Vitamin that was known to treat GI problems? We do but clinical practice has not yet again caught up with the research. That is why Prousky’s research is so ground breaking and misunderstood because the same vitamin (commonly misunderstood) associated with these problems has been proven to help the same problems it (Vitamin B3) has been thought to cause … though not commonly (well) understood Niacin treats digestive problems. http://www.yourhealthbase.com/database/a124b.htm *****I must say at this point this is not medical advice only my experience with Niacinmaide See my previous posterboy blog post about how the average clinical delay is 17 years in implementing new research into doctor’s protocols’/treatment regimens. This clinical gap is a devastating delay. And also I want to make this disclaimer. The default (thought) here is you are not taking Niacin or any version of B-3 (in its many forms) or have either not taken it for Cholesterol management previously or are now taking it for your GI problems. If you are now taking Niacinamide/Niacin etc. this post does/is not directed at you (or other Vitamins/Minerals) for that matter . . . like Magnesium or Iron etc. Also see my posterblog post about how supplementing can help you fight a two front war. Any Vitamin or Mineral can be taken to excess . . . contributing to a worsening of your conditon.. . including Niacinamide, Iron, Calcium etc. This comment/thread is directed to those who have not yet considered supplementation previously. And with the intent you will only take this for a cycle of time. Say 4 to 6months for most people or 6 to 12 months max for the most severe forms of this disease. See this link where it explains how “up to 12 months” B-Vitamins helps improved/improves moods for those who are depressed. https://www.ncbi.nlm.nih.gov/pubmed/7477807 Reader, Do some of the research of I have listed here and if you still feel the same way. I get it. I have been on that same journey. But this is not as uncommon or unplausible as it might sound. The “House TV” show/medical drama noted this fact in their episode on Celiac Disease. Google House season 2 episode 22 on Celiac disease entilted “Forever” and you will find articles about it and probably a link to watch it. I think it would be enlightening to see how these two diseases are entangled like Siamese twins. When digestion works properly the God given burp is produced (not soda’s) but you burp like a healthy child at 6 months of age so too will an adult when they take Niacinamide (the nonflushing form of Vitamin B-3) for 6 months 2/day (especially if you are not taking PPIs currently). Your results might be different but you won’t know unless you try it. When I began my journey I was/became known as the posterboy for Celiac disease. What it has turned into unexpectedly is me being/becoming the posterboy for Pellagra too! It (Pellagra in Celiac’s) is not as rare as people think it is today especially 2ndary Pellagra caused by your original Celiac diagnosis since Vitamin absorption is frequently compromised in Celiac’s. I always have to say. **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. But I have found (and my friends have found) if you take it (Niacinamide) like an antibiotic (UNTIL BURPING) then 95% of your GI stress will be in remission. And I don’t mean twenty minutes after you have eaten but 2+ hours later when burping has replaced burping and bloating that start’s almost as soon as you take you first bite. Or burping that occurs with drinking soda or a carbonated drink. Again I say 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” I hope this is helpful. Posterboy by the Grace of God, That is all for now until the next post. (Whenever that is) but the intent of this/theses post’s is “Too Educate” and anyone of my posterboy blog posts could help you without the need to read all my posterboy blog posts??? So I am sorry if I run a little long some times. . . but people need to know if this is the only blog post they read. . . Pellagra in Celiac’s can be successfully treated with supplementation or AKA a Vitamin Reformation (in the way we think) about GI problems according to Prousky who almost 17 years ago proved Niacinamide can help those with low stomach acid misdiagnosed. Will you listen? and take the Niacinamide Challenge taking it until you are burping 2 hours after you finish a meal. This usually takes 3 to 4 months taken it 3/day or morning and evening and (one hour before) bedtime (if it is not convenient to bring to work) works well for most people. This tends to be one 300 count bottle for most people. Though a smaller amount might work I want you to have a positive experience and thus recommend conservatively a 3 month to 4 month cycle – the amount your body can typically store in your liver – thus helping to reset your body’s stress clock (my words). This schedule works well for Magnesium as well. . . and usually it (Magnesium Citrate/Glycinate) causes restful dreaming in the first month of taking it. The power to change is in your hand for “To Educate is to Free” As always remember **** This is not medical advice and should not be considered such. Results may vary. Always consult your doctor before making any changes to your medical regimen. But I have found (and friends have found) if you take it (Niacinamide) like an antibiotic (UNTIL BURPING) then 95% of your GI stress will be in remission. It is time for a Vitamin Reformation (a change in the way we think about Vitamins – a shift in our paradigm) praise bee to God! Back to when in the 20th century they understood Vitamins make us healthy! They even gave Nobel Prizes for discovering these substances called Vitamin(s) and rightly so! If this is the case for you – you the reader also have/had developed 2ndary Pellagra due to your primary diagnosis of Celiac disease. See my earlier posterboy blog post where I talked about my experience of developing Pellagra 2ndarly to my Celiac diagnosis. All those who have ears to hear may they listen! Feel free to read all my posterboy blog post’s if this pique’s your curiosity/interest but there is only so much in a/one blog post than can be explained but it really Is not necessary or visit the website/blog in my profile where I have told the same story hundreds of time that ONE fellow sufferer like myself may/might be helped by the same wisdom, I found God being my help, when I learned Pellagra and Celiac disease are Siamese twins and separating one (supplementing one to death) will kill the other (cause the other to go into remission). Also see my posterboy blog post of how I supplemented Pellagra to death/into remission. Noted above (earlier) in this post but provided here again for easy reference. And I believe you can too! Praise bee to God! 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them (fellow sufferer) which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” Posterboy by the Grace of God, 2 Timothy 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. As always it is in this spirit of truth that I share so that others like my-self might not have to suffer the same things I did.
-
- celiac
- celiac poster boy
- (and 16 more)
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8-M):
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8-M):