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Celiac.com 08/18/2022 - There's been some evidence that diets low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), and other ingredients, can help improve symptoms of irritable bowel syndrome. In many cases, diet can trigger or worsen symptoms of IBS. Many IBS patients try restrictive diets to relieve their symptoms, but there's no good information on which diets might be effective, and advisable. A team of researchers recently conducted a systematic review and network meta-analysis of randomized-controlled trials (RCTs) reviewing the efficacy of food restriction diets in IBS. The research team included Seung Jung Yu, Hong Sub Lee, Hyeon Jeong Gung, Ju Seok Kim, Ki Bae Kim, Yong Hwan Kwon, Jae Hak Kim, Hoon Sup Koo, Hyun-Deok Shin, Sam Ryong Jee, Han Byul Lee, Jeehyoung Kim, and Hye-Won Park. To get good data for their systematic review and network meta-analysis, the research team searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Clinicaltrials.gov databases until July 21, 2021, to retrieve RCTs assessing the efficacy of restriction diets in adults with IBS. They then had two independent reviewers conduct the eligibility assessment and data abstraction. For the study, the team included RCTs that compared a restriction diet with a control diet, and assessed any improvements in global IBS symptoms. In all, the team found nearly two thousand citations. After full-text screening, they found fourteen RCTs that were eligible for the systematic review and network meta-analysis. Diet Low in FODMAPs, Starch, and Sucrose Works Best The team's analysis showed that a starch- and sucrose-reduced diet and a diet with low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) showed significantly better results than a usual diet. Symptom flare-ups in patients on a gluten-free diet were also significantly lower than in those on high-gluten diets. These findings showed that a diet low in FODMAPs, starch, and sucrose works best to reduce IBS symptoms. There are more studies to conduct to prove the benefits of these dietary restrictions on IBS symptoms, but these findings are definitely interesting for anyone suffering from IBS. Read the full article from the Korean Journal of Gastroenterology The researchers in this study are variously affiliated with the IBS Research Study Group of the Korean Society of Neurogastroenterology and Motility Department of Internal Medicine, Inje University Busan Paik Hospital, Busan; Department of Internal Medicine, Soonchunhyang University Hospital Bucheon, Bucheon; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju; Department of Internal Medicine, Kyungpook National University Hospital, Daegu; Department of Internal Medicine, Dongguk University College of Medicine, Goyang; Department of Internal Medicine, Konyang University Hospital, Daejeon; Department of Internal Medicine, Dankook University Hospital, Cheonan; Department of Public Health, Ajou University Graduate School of Public Health, Suwon; Department of Orthopedic Surgery, Seoul Sacred Heart General Hospital, Seoul; Inje University Medical Library, Busan, Korea.

Celiac.com 08/18/2014 - A team of researchers recently set out to better understand the effects of gluten-free diets on obesity. The research team included F.L. Soares, R. Matoso de Oliveira, L.G. Teixeira, Z. Menezes, S.S. Pereira, A.C. Alves, N.V. Batista, A.M. de Faria, D.C. Cara, A.V. Ferreira, and J.I. Alvarez-Leite. They are affiliated with the Departamento de Alimentos, Faculdade de Farmácia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais in Belo Horizonte, Brazil. Specifically, the team wanted to determine whether a gluten-free diet can prevent the expansion of adipose tissue, and its consequences. For their study, the team fed C57BL/6 mice a high-fat diet containing either 4.5% gluten (Control) or no gluten (gluten-free). They noted body weight and adiposity gains, leukocyte rolling and adhesion, macrophage infiltration and cytokine production in adipose tissue. The team measured blood lipid profiles, glycaemia, insulin resistance and adipokines. They also assessed the expression of the PPAR-α and γ, lipoprotein lipase (LPL), hormone sensitive lipase (HSL), carnitine palmitoyl acyltransferase-1 (CPT-1), insulin receptor, GLUT-4 and adipokines in epidydimal fat. Gluten-free animals showed less body weight and adipose gain, with no changes in food intake or lipid excretion. These results were associated with up-regulation of PPAR-α, LPL, HSL and CPT-1, which are related to lipolysis and fatty acid oxidation. The team also saw improved glucose regulation, and pro-inflammatory profile-related over-expression of PPAR-γ. Intravital microscopy revealed a lower number of adhered cells in the adipose tissue microvasculature. The over-expression of PPAR-γ is related to the increase of adiponectin and GLUT-4. The results of this study suggest that gluten-free diets can be helpful in reducing fat gain, inflammation and insulin resistance. They suggest that a gluten-free diet should be tested as a way of preventing the development of obesity and metabolic disorders. Source: Open Original Shared Link