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Showing results for tags 'relief'.
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Celiac.com 02/05/2024 - Celiac disease is a condition triggered by gluten consumption in susceptible individuals, and which has long posed challenges for those affected. However, a new study has illuminated a potential guardian in the microbial world that could shield against the gut disruptions caused by gluten. The study team included Tina Tran, Stefania Senger, Mariella Baldassarre, Rachel A. Brosnan, Fernanda Cristofori, Marco Crocco, Stefania De Santis, Luca Elli, Christina S. Faherty, Ruggero Francavilla, Isabella Goodchild-Michelman, Victoria A. Kenyon, Maureen M. Leonard, Rosiane S. Lima, Federica Malerba, Monica Montuori, Annalisa Morelli, Lorenzo Norsa, Tiziana Passaro, Pasqua Piemontese, James C. Reed, Naire Sansotta, Francesco Valitutti, Ali R. Zomorrodi, and the CDGEMM Team. Their novel research focuses on Bacteroides vulgatus, a bacterial species known for its anti-inflammatory properties, and its impact on maintaining the integrity of the human celiac gut. Researchers Single Out Bacteroides Vulgatus' Protective Effect The study, conducted by a dedicated team of researchers, initially observed a decreased presence of microbial species with potential anti-inflammatory properties in individuals developing celiac disease compared to those who did not. This led the researchers to hone in on Bacteroides vulgatus, aiming to establish its protective role and understand how its byproducts could counteract gluten-induced changes in human gut epithelial functions. To delve into this, the researchers identified, isolated, cultivated, and sequenced a unique strain, named 20220303-A2, of B. vulgatus found exclusively in control subjects. Using a human gut organoid system developed from pre-celiac patients, they closely monitored the epithelial phenotype and innate immune cytokines under various conditions: baseline, after exposure to gliadin (a component of gluten), and after exposure to both gliadin and B. vulgatus cell-free supernatant (CFS). The results were striking. After gliadin exposure, there were noticeable increases in epithelial cell death, epithelial monolayer permeability, and the secretion of pro-inflammatory cytokines—typical hallmarks associated with celiac disease. However, when the organoids were exposed to B. vulgatus 20220303-A2 CFS, these adverse effects were significantly mitigated. Remarkably, the protective effects were linked to epigenetic reprogramming of the treated organoids, suggesting a sophisticated mechanism at play. The study underscores the significance of gut microbiota in the context of celiac disease, emphasizing that alterations in microbial composition may precede the onset of the condition in genetically susceptible individuals. The dysbiosis observed in these individuals is characterized by a decline in protective bacterial strains, such as B. vulgatus. In summary, this research not only identifies a unique strain of Bacteroides vulgatus with potential protective properties, but also sheds light on the intricate mechanisms by which it shields the gut epithelium from the disruptions from gluten. Exactly what, if any new avenues for understanding and, potentially, managing celiac disease, are opened by this research, remains to be seen. Exactly what hope this may offer for those navigating the complexities of a gluten-free lifestyle, also remains unclear. Stay tuned for more on this, and related, celiac disease and gluten-free developments. Read more in Nature
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Celiac.com 02/16/2024 - In addition to the humanitarian crisis resulting from the Israeli invasion of the Gaza Strip, a separate humanitarian crisis has unfolded among Israeli hostages in Gaza, who have gone without essential medical treatment for over 100 days. The situation has raised serious concerns about the health and well-being of these individuals, many of whom are grappling with chronic illnesses. Reports from Maariv highlight the severity of the conditions, with some individuals suspected to have succumbed to infectious diseases amid the harsh living conditions in the strip. In a significant development, talks between Israel and Qatar have included plans to transfer life-saving medicine to address the health issues faced by the Israeli hostages. This collaborative effort is a response to the urgent need for medical intervention and aims to provide much-needed drugs to those in captivity, including those with inflammatory bowel disease and endocrine disease. The critical medical support includes a range of medications targeting various health conditions prevalent among the hostages. Some of the key medications expected to be transferred include: Celiac Disease and Asthma Several individuals among the hostages, including 21-year-old Omer Shem Tov from Herzliya, suffers from asthma. Omer, who has been using inhalers since childhood, also battles celiac disease, which brings symptoms such as anemia, weakness, and severe stomach pains. Crucial medications for asthma, such as Ventolin inhalers and corticosteroids like Felixotide, are vital for managing acute attacks with oral or intravenous steroids. It's unclear, but very doubtful, that Shem Tov has had access to gluten-free food, which is crucial in treating his celiac disease. Diabetes Diabetes is another significant health concern among hostages in Hamas captivity, requiring medication through pills and insulin injections. Without proper treatment, these patients face elevated blood sugar levels, increasing the risk of heart attacks, blindness, and amputation. The planned medical support includes oral drugs like metformin and insulin injections to regulate blood sugar levels. Additionally, glucose meters for self-monitoring are expected to be provided. Nearsightedness Many hostages are dealing with myopia, exacerbating their vision problems due to poor lighting conditions in captivity. Estimates suggest that glasses will be provided based on the degree of nearsightedness or farsightedness and the specific lens prescription, known as "diopter." Cardiovascular Diseases Hypertension, a prevalent chronic disease, affects some older hostages. Interruption in drug treatment can lead to life-threatening increases in blood pressure. Israel plans to deliver blood pressure medications, including "beta blockers," "calcium blockers," or "angiotensin inhibitors." Additionally, some patients may receive aspirin to reduce the risk of heart attack and stroke, along with cholesterol-lowering drugs from the "statins" group. Inflammatory Bowel Diseases Omer Vankert, a 22-year-old from Gadera, suffers from ulcerative colitis, a type of inflammatory bowel disease. The expected medical support includes the transfer of the Rafcel drug, crucial for preventing serious digestive system disorders such as abdominal pain, fluid loss, bleeding, and anemia. Endocrine Diseases Some hostages with chronic illnesses also face hormonal system disorders, like 42-year-old Hanan Yablonka from Tel Aviv, who has hypothyroidism and Addison's disease. The medications "Altroxin" and corticosteroids are vital to preventing life-threatening dysfunction in the thyroid and adrenal glands. As the international community closely watches these developments, the delivery of these medications is seen as a crucial step in addressing the medical crisis faced by the hostages in Gaza. The collaboration between Israel and Qatar provides hope for improved health outcomes for those in captivity. The humanitarian effort emphasizes the importance of prioritizing the health and well-being of individuals, even in challenging geopolitical situations. Read more in the JPOST
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Celiac.com 01/16/2020 - So, I've been thinking about this for a while. There are stages to the diagnosis of Celiac disease just like there are stages to grief or healing from alcoholism. Here's how I see it. The First Stage is Relief Relief that I finally have a name to go with all of the crazy symptoms that have been happening. Relief that this beast finally has a name. Now I know what has been causing the diarrhea and/or constipation, constant fatigue, and brain fog. Even the doctors know that I'm not crazy now - I was really sick. Ha, ha, sweet revenge. I kept telling them I was sick, but they wouldn't listen. Relief that now there is an enemy to fight and that enemy is gluten!! The Second Stage is Panic Panic in OMG what the heck am I going to eat. All of my go to foods - spaghetti, pizza, beer, and sandwiches are all gone. Holy cow!! What about Christmas stuffing and Thanksgiving pumpkin pie? What on earth am I going to eat? What about vacations? We can't travel because I won't be able to eat anything. We can't leave the house. I will be trapped for the rest of my sorry, sad gluten-less life. AAAAGGGGHHHH The Third Stage is Overboard Now, I've figured out what I can eat and I'm going to be hyper vigilant about being gluten free. Nothing can ever be in the vicinity of my gluten free food. People eating at the same table as me cannot possibly have bread on the table otherwise I might get sick. I cannot possibly go to a gluten filled bakery. I will die, literally die! I'm also going to tell everyone I'm gluten free and have celiac and cannot possibly ever come to their house because I will die, literally die! I have to take a bottle of water to a restaurant because I cannot trust them to wash the dishes. If someone had a gluten drink in that glass and they washed it, how can I be sure they got the gluten off. What if they washed it with gluten items? OMG, I will die, literally die if I drink from that glass. I will bring my own bottled water to the restaurant and just sit quietly while you enjoy your plates of gluten filled poison. The Fourth Stage is Acceptance I've got this awful disease. I'm going to do the very best I can at a gluten free diet. I will make mistakes, but it will be ok. For the most part, I'm healthy and I have a good grasp of what to do in most social situations. I know where I can eat safely and can cook safely. I no longer have to look up every single item I'm buying at the grocery store because I've looked it up 100 times before. I know the item is safe. I'm confident in my ability to order a gluten free meal at a restaurant and be okay. I know to say that I have a gluten allergy or celiac disease and it is not a choice. I know not to order fried chicken and expect the kitchen to be able to provide me gluten free fried chicken unless it is explicitly marked. I know for the most part this disease sucks. I know what my body can handle and what it can't. I never purposefully ingest gluten but realize we live in a gluten covered world and I will get glutened. I can calmly and rationally get through the temporary pain to get to the other side. I know that the double edged sword of the gluten free fad diet is temporary. I am grateful that the diet has brought awareness to the disease, but deeply saddened that the need for gluten free food has been cheapened by the fad dieters. I am grateful for spring with the gluten free bonanza of Passover and Aldi in May. The last stage is Hope. Hope that there is a cure around the corner. Hope that our Celiac children don't have to endure the lack of treatment for Celiac. Hope that we will have a way shortly to alleviate the symptoms of a minor and maybe major glutening and trust that we aren't doing long term damage to our systems. Or even, the ability to eat freely again without worrying about every morsel of food we put in our mouths. Hope that another generation doesn't have to endure the long and painful process of being diagnosed with Celiac. When the doctors dismiss every symptom as depression or IBS without really looking at me as a whole. The Really, Final Stage is the "GOOP" Stage This is where I mistakenly believe, like Gwyneth Paltrow, I invented Celiac disease. This is a little tongue in cheek! I hope everyone can get to the Hope stage of this disease and not get stuck along the way.
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Celiac.com Article:The Five Stages of Celiac Disease
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Celiac.com 04/16/2019 - A team of researchers from the Celiac Center at Beth Israel Deaconess Medical Center highlighted the potential of an enteric-release, oral budesonide as a treatment for acute reactions to gluten exposure in patients with celiac disease. The research team included Amelie Therrien, MD MSc, Jocelyn A. Silvester, MD PhD, Daniel A. Leffler, MD MSc, Ciaran P. Kelly, MD. They are variously affiliated with the Celiac Center, Department of Medicine and Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston USA; the Celiac Research Program, Harvard Medical School, Boston USA; the Division of Gastroenterology, Hepatology and Nutrition, Boston Children Hospital, Boston USA; the Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; and with Takeda Pharmaceutical International Co, Cambridge, USA. Celiac Center physician, Ciaran Kelly, MD, and colleagues wrote that inadvertent exposure to gluten is still common even though patients specifically try to avoid it. Researchers report on a group of consecutive celiac patients with acute gluten exposure, who were treated with enteric-related budesonide. The group included 12 patients with biopsy-confirmed celiac disease, and one patient with potential celiac disease — defined as normal duodenal histology, elevated tissue transglutaminase antibodies, HLADQ2.5 or DG8 positivity and clinical response to a gluten-free diet. Researchers measured patient-reported clinical response to budesonide, defined in terms of symptom severity and duration as “substantial,” “partial,” or, simply “response." The patients started budesonide therapy as soon as possible after gluten exposure and symptom onset. All patients reported a clinical response to the drug, with eight patients reporting "substantial" improvement of GI symptoms. The team makes clear that they do not "advocate steroid use for uncomplicated [celiac disease]." The team notes that they selected patients for the budesonide trial based on severe, debilitating gluten reactions, due to intermittent accidental gluten exposure" despite following a [gluten-free diet],” the team wrote. Though the study lacks objective endpoints and includes varying treatments, budesonide can help to relieve serious symptoms of gluten exposures in celiac patients, justifying both this, and future, clinical trials, according to Dr. Alex Young. As a disclosure, Dr. Kelley notes that he served as a scientific advisory to Cour Pharmaceuticals, Glutenostics, Innovate, ImmunogenX, and Takeda. He also acts as a principal investigator on research grants on celiac disease supported by Aptalis and Takeda. Please see the full study for all other authors’ relevant financial disclosures. Clin Gastroenterol Hepatol 2019. doi:10.1016/j.cgh.2019.03.029.
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Celiac.com 11/27/2017 - For centuries, physicians have used cannabis to treat numerous disorders. Modern research shows that various cannabis compounds can alleviate symptoms from numerous conditions, including neurological disorders, cancer, rheumatism, epilepsy, sexual disorders, pain, among others. Many people with celiac disease suffer from neuropathy, which causes nerve pain, among other symptoms. Neuropathy can be difficult to treat. Nerve pain is a debilitating symptom that can significantly impair a patient's quality of life. Could a new cannabis patch change that? Some researchers think so. One California-based company, Cannabis Science, is developing an innovative new medicinal patch specifically designed to treat nerve pain. In addition to celiac related neuropathy, the patch could be helpful in treating nerve pain from many illnesses including fibromyalgia, diabetes, and multiple sclerosis. The National Institute of Health estimates that over 5 million Americans suffer from fibromyalgia, which has no known cure, and is difficult to treat. With diabetes on the rise in the U.S., diabetic nerve pain is also on the rise. When placed on the patient's skin, the patch developed by Cannabis Science delivers a measured dose of high potency cannabidiol (CBD) extract. CBD is the second major cannabinoid in marijuana after THC, but CBD has no psychoactive effects, so it won't get people high. When the patch is applied, the CBD is first absorbed into the blood, then moves to the central nervous system, where it delivers pain relief. Numerous studies have documented CBD's “anti-inflammatory and pain-relieving properties. More recent studies have shown that CBD provides relief from many kinds of pain. In addition to nerve pain, CBD has been shown to relieve inflammatory pain. Some studies have shown CBD to be more effective than current medication in treating inflammatory pain, such as pain from arthritis. As researchers home in on the pain-relieving properties of cannabis, look for more treatments to be developed, including treatments that may helpful for peopl with celiac disease. Read more: cannatech.news
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Soooooo, how many of you realized that Sodium Starch Glycolate (a common filler in EVERYTHING) is considered gluten and toxic to those of us who have severe Celiac? I learned the hard way..... After being bitten by what they think was a deer tick (had a round bullseye rash) I was put on what was supposed to be a gluten free drug. I was SICKER after taking the drug...dawned on me I had better research the filler ingredients. Turns out to those very sensitive, SODIUM STARCH GLYCOLATE is in the same family as gluten and cannot be tolerated. Now.....go to www.glutenfreedrugs.com and they list SO many drugs that indeed CONTAIN this hidden gluten! I have been getting sick and not understanding why.....now I know. Please let everyone know about this hidden substance that should be included in the GLUTEN TOXIC SUBSTANCES that make us so very sick
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