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I would like to hear from Celiacs with Chronic Kidney Disease. Recently there has been more research of a correlation between the two. I was recently diagnosed. I have been able to find a little information on a combined renal and gluten free diet. What I have not discovered yet is the comparison of gluten free flours and wheat flour in terms of phosphorus content levels. Here is a synopsis of my sudden diagnosis. I hope it helps someone else, as well as finding someone to support me. About a year ago the night sweats unrelated to menopause started, I began to notice an extremely dry mouth (worse than ever before) and as time went on I had a constant bad taste in my mouth. Additionally I noticed my blood pressure levels became erratic. I reported all of this to my three specialists and one primary doctor, the last of which was doing a CBC every three months. In September my primary care referred me to a nephrologist due to abnormal creatinine levels in my blood, although my urine had no negative test results. Days after I met the nephrologist he put me in the hospital with a diagnosis of Stage 5 (End Stage) Renal Failure. When I left a week later they had gotten it down to Stage 4. Since then I've had a kidney biopsy. My kidneys are permanently damaged due to scarring with 50% functioning. There is no known reason for this. Tests prior to January of 2013 showed no creatinine disfunction. My nephrologist told me there is growing research showing a correlation between Chronic Kidney Disease and Celiac Disease. Given my situation, I suggest you have your creatinine levels tested and GFR calculated. Request that you be followed carefully and frequently if your creatinine is lower than 95. 11 months ago mine was 90 and my physician did not note it until it dropped to 40. I don't know if he or I had known this sooner my kidney disease perhaps would not be at Stage 4 now. This means I must go on dialysis and will need a transplant eventually.
Celiac.com 09/19/2011 - Rates of end-stage renal disease are rising globally, and even though doctors often see elevated levels of celiac disease autoantibodies in renal disease, they do not yet fully understand the role of biopsy-verified celiac disease as a risk factor for end-stage renal disease. To gain a gleaner picture of possible connections, a team of researchers based in Sweden conducted a study of end-stage renal disease in individuals with celiac disease. The research team included A. Welander, K. G. Prütz, M. Fored, J. F. Ludvigsson. They are affiliated with the Department of Medicine at the Karolinska Institutet of the Karolinska University Hospital in Stockholm, Sweden. To identify individuals for their population-based prospective cohort study, the team used small-intestinal biopsy reports. They found data on 29,050 individuals with celiac disease (Marsh III) obtained between July 1969 and February 2008 in Sweden's 28 pathology departments. The team defined end-stage renal disease as the need for renal dialysis or renal transplant in accordance with the international classification of disease and procedure codes in Swedish patient registers. They used Cox regression to compare the risk of end-stage renal disease in individuals with celiac disease against the risk for age- and sex-matched reference individuals. They found that, on follow-up, 90 individuals with celiac disease had developed end-stage renal disease, compared with a projected number of 31. This means that people with celiac disease face an end-stage renal disease risk estimate of 2.87 (95% CI 2.22 to 3.71, p<0.001). Adjusting for diabetes mellitus lowered that risk estimate only slightly, to 2.52 (95% CI 1.92 to 3.31). When the team excluded people with prior urinary/renal disorders, the risk estimate for end-stage renal disease in people with celiac disease was 2.47 (95% CI 1.80 to 3.40). However, once the team restricted the outcome measure to end-stage renal confirmed by independent data from the Swedish Renal Registry (SRR), the overall risk estimate increased to 3.20 (95% CI 2.39 to 4.28). The results of this study show that people with biopsy-verified celiac disease face a higher risk of developing end-stage renal disease. Source: Gut. 2011 Aug 3.
Celiac.com 07/10/2007 - This study demonstrates that people with celiac disease face an elevated risk of glomerulonephritis. Multiple studies have shown higher levels of celiac disease auto-antibodies in patients with renal disease; and certain renal disease will improve on a low-antigenic diet that is gluten-free. Not much is understood about the risk of severe renal disease such as renal failure in individuals with celiac disease. In a general population based cohort study, a team of researchers set out to assess the individuals with celiac disease for any form of glomerulonephritis (acute, chronic and non- specified), chronic glomerulonephritis and renal replacement therapy including dialysis treatment and kidney transplantation. The research team was made up of Anders Ekbom, Michael Fored, Jonas F. Ludvigsson, Johnny Ludvigsson, Nders ekbom, Ola Ole, & Scott M. Montgomery. They looked at data from 14,336 patients who were diagnosed with celiac disease between 1964 and 2003. Patients were chosen from the Swedish Hospital Discharge Registry. They established a control group of 69,875 individuals matched for age, calendar year, sex and county. Higher Risk of Glomerulonephritis for Celiac Patients The results showed that patients with celiac disease face an increased risk of developing chronic renal disease, and may also be at a face a slightly higher risk for any form of glomerulonephritis. Nephrology Dialysis Transplantation 2006 21(7):1809-1815 health writer who lives in San Francisco and is a frequent author of articles for Celiac.com.