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Showing results for tags 'thiamine deficiency'.
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Thiamine Use by Doctors in Hospital and Interesting articles about Thiamine Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/#idm140604396876032title Shoshin Beriberi in Critically-Ill patients: case series https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443551/ Wernicke's encephalopathy because of pancreatitis in a young boy. https://www.ncbi.nlm.nih.gov/pubmed/21091939 https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-3768.2010.02033.x Thiamine and Heart Failure https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543258/ Thiamin deficiency and heart failure: the current knowledge and gaps in literature. https://www.ncbi.nlm.nih.gov/pubmed/24811895 And a different follow-up article... Thiamine supplementation for the treatment of heart failure: a review of the literature. https://www.ncbi.nlm.nih.gov/pubmed/23910704 Thiamine and Hashimoto's thyroiditis: a report of three cases. https://www.ncbi.nlm.nih.gov/pubmed/24351023 Thiamine deficiency and beriberi features in a patient with hyperemesis gravidarum.(Morning Sickness) https://www.ncbi.nlm.nih.gov/pubmed/15979284 Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study. https://www.ncbi.nlm.nih.gov/pubmed/23379830 High-dose thiamine improves fatigue after stroke: a report of three cases. (All normal levels in tests) https://www.ncbi.nlm.nih.gov/pubmed/25192035 Acute Bilateral Deafness as the First Symptom of Wernicke Encephalopathy http://www.ajnr.org/content/33/3/E44 Achlorhydria is associated with thiamine deficiency in the setting of bacterial overgrowth. https://emedicine.medscape.com/article/170066-medication Elevated Lactate Secondary to Gastrointestinal Beriberi https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699997/ Nonalcoholic Thiamine-Related Encephalopathy (Wernicke-Korsakoff Syndrome) Among Inpatients With Cancer: A Series of 18 Cases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979979/ Thiamin. Fact Sheet for Health Professionals https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/ And..... Neurological manifestations, diagnosis, and treatment of celiac disease: A comprehensive review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829244/ ?
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To All, Knitty Kitty started a thread on Thiamine, Thiamine, Thiamine, once upon a time, so now is the time to start a thread on Magnesium as a resource for others who don't have the time to do the research and wonder if taking Magnesium might help them! Maybe it will be helpful to others as Knitty Kitty's thread on Thiamine deficiency. I will start with one on IBS and Magnesium Deficiency. Entitled "Magnesium and inflammatory bowel disease" aka IBS quoting there entire abstract because it is instructive. Abstract "Mg deficiency is a frequent complication of inflammatory bowel disease (IBD) demonstrated in 13-88% of patients. Decreased oral intake, malabsorption and increased intestinal losses are the major causes of Mg deficiency. The complications of Mg deficiency include: cramps, bone pain, delirium, acute crises of tetany, fatigue, depression, cardiac abnormalities, urolithiasis, impaired healing and colonic motility disorders. Serum Mg is an insensitive index of Mg status in IBD. Twenty-four-hour urinary excretion of Mg is a sensitive index and should be monitored periodically. Parenteral Mg requirements in patients with IBD are at least 120 mg/day or more depending upon fecal or stomal losses. Oral requirements may be as great as 700 mg/day depending on the severity of malabsorption." Or simply stated up to almost 90% of IBS patients are or could be low in Magnesium. This youtube webinar that summarizes a lot of Magnesium links to allergies in about a 30 minute video. https://www.youtube.com/watch?v=NYeuSw86bzk This one for anyone who has asthma entitled "Role of magnesium in regulation of lung function" https://pubmed.ncbi.nlm.nih.gov/8509592/ This one entitled "Magnesium (Deficiency) in Infectious Diseases in Older People" https://pubmed.ncbi.nlm.nih.gov/33435521/ This one entitled "Possible roles of magnesium on the immune system" https://www.nature.com/articles/1601689 This is enough to get this thread started I/you/we can always add more research latter. I always said the Lord being my help......I was lucky I found Magnesium early and I still believe that! I hope this is helpful but it is not medical advice. Posterboy by the grace of God,
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- beri beri
- celiac disease
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08/10/2021 - The human thiamine transporter-2 (hTHTR-2) plays a key role in the intestinal absorption of thiamine (vitamin B1). Recent studies with membrane transporters of other nutrients/substrates have shown that associated proteins affect different aspects of cell physiology and cell biology. Researchers currently have no good information on the protein(s) that interact with hTHTR-2 in intestinal epithelial cells, and how those proteins may influence cell function and/or cell biology. A team of researchers recently set out to identify protein partner(s) that interacts with hTHTR-2 in human intestinal cells and determine the physiological/biological consequence of that interaction. The research team included Veedamali S. Subramanian, Svetlana M. Nabokina, and Hamid M. Said. They are affiliated with the Departments of Medicine, Physiology and Biophysics, University of California in Irvine, CA; and the Department of Veterans Affairs Medical Center in Long Beach, CA. Their team used the yeast split-ubiquitin two-hybrid approach to screen a human intestinal cDNA library. They followed with GST-pull-down and cellular co-localization approaches to confirm the interaction between hTHTR-2 and the associated protein(s). They used 3H-thiamine uptake assays to assess the effect of such an interaction on hTHTR-2 function. Their assessment showed that the human TransMembrane 4 SuperFamily 4 (TM4SF4) is a potential inter-actor with hTHTR-2. To confirm the interaction, they used in vitro GST-pull-down assay, live-cell confocal imaging of HuTu-80 cells co-expressing hTHTR-2-GFP and mCherry-TM4SF4 (the latter of which showed a substantial overlap of these two proteins in intracellular vesicles and at the cell membrane). They found that co-expression of hTHTR-2 with TM4SF4 in HuTu-80 cells triggered a sharp rise in thiamine uptake. Conversely, silencing TM4SF4 with gene-specific siRNA led to a sharp decrease in thiamine uptake. The team's results offer the first proof that the accessory protein TM4SF4 interacts with hTHTR-2 and influences the physiological function of the thiamine transporter. This finding could help researchers to better understand how certain proteins influence cell function and/or cell biology. Read more in Dig Dis Sci. 2014 Mar; 59(3): 583–590.Published online 2013 Nov 27.
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- absorbtion vitamins
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To Wheatwacked and To Whom Ever Might Read This, This is mainly for @Wheatwacked but @knitty kitty might also like this thread... I recently came across this research that shows Refeeding Syndrome being treated with Thiamine......responds to Thiamine replacement therapy even when Refeeding Syndrome aka RFS does not respond to Potassium supplementation. This confirms my earlier analysis of how Refeeding Syndrome in Celiacs can be a sign of a Thiamine deficiency. It should also be noted treatment of Refeeding Syndrome can also be treated with Magnesium......taking either Magnesium or Thiamine has been shown to help Refeeding Syndrome. Here is my earlier Posterboy blog post on this topic that explains how and why Refeeding Syndrome can happen in Celiacs... Should this happen to you.....you usually are diagnosed as being in a "Celiac Crisis" but really you have developed Refeeding Syndrome and it can treated with either Magnesium or Thiamine supplementation. Here is a recent article about it... Entitled "Refeeding syndrome in adults with celiac crisis: a case report" https://pubmed.ncbi.nlm.nih.gov/29382373/ Here is another article about it....where thiamine replacement therapy treated an electrolyte in-balance treating Refeeding Syndrome aka RFS. Entitled "Acute thiamine deficiency and refeeding syndrome:........" Which is to say Wheatwacked taking Benfotiamine or another Fat Soluble B-1 like Allithiamine or Lipothiamine should help your remaining electrolyte issues.... Here is a nice article explaining the main Fat Soluble Thiamine aka Vitamin B1 supplements and how they can help you. https://www.hormonesmatter.com/navigating-thiamine-supplements/ I hope this is helpful but it is not medical advice. Posterboy,
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- beri beri
- celiac disease
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To All, I came across some research on Lactose intolerance as trigger for a Celiac diagnosis in a Gluten Free eating person recently. And it got me thinking could the approx. 40 Percent of Celiac's patient not responding to a gluten free diet really be Lactose Intolerance instead. Here is the article on Refractory Celiac disease in those Celiac's patients whose disease is not well controlled on a gluten free diet. Then I found this research that shows Lactose (really Casein probably) can be the trigger for a Celiac diagnosis in someone who is Lactose Intolerant. See this thread where I note certain connections in Celiac disease that people have not put 2 + 2 together (yet) to notice these connections. Here is the Abstract on this topic entitled "[Anti-tissue transglutaminase antibodies not related to gluten intake]" from Cows Milk Protein...Instead. https://pubmed.ncbi.nlm.nih.gov/29555204/ From the linked thread on Refractory Celiac disease.....so I won't have to type it all again... I will quote the full abstract for those who might be following this. Abstract "Introduction: Anti-tissue transglutaminase antibodies (tTG) have high specificity for coeliac disease (celiac disease). However, positive anti-tTG antibodies have been described in non-coeliac patients. Aim To assess positive anti-tTG antibodies not related to gluten intake. Patients and methods: Retrospective review and follow up conducted on patients with suspected celiac disease (increase anti-tTG levels and gastrointestinal symptoms) but with atypical serology results, positive anti-tTG with gluten free diet and a decrease in anti-tTG levels despite gluten intake. Results: A total of 9 cases were reviewed in which 5 cases had Marsh 3 involvement in the initial biopsy, and were diagnosed with celiac disease (Group A). They began a gluten free diet and also a cow's milk protein (CMP) free diet because of their nutritional status. When CMP was re-introduced, anti-tTG increased, and returned to normal after the CMP was withdrawn again. The other 4 patients had a normal initial biopsy (Group B). Gluten was not removed from their diet, but they started a CMP free diet because a non IgE mediated CMP allergy was suspected. Symptoms disappeared, and anti-tTG was normal after CMP free diet with gluten intake. All the patients had susceptibility haplotype HLA DQ2/DQ8. Conclusions: CMP ingestion after an exclusion diet can induce an increase in anti-tTG in some coeliac subjects. CMP can produce this immune response if there were no gluten transgressions. This response has also been observed in non-IgE mediated CMP allergy patients with the susceptibility haplotype HLA DQ2/DQ8." IF you know it wasn't the gluten then Milk/Dairy is the next logical thing to removed from your diet! And there should be more awareness of this connection and why I started this thread so people can reference it in the future. Often 44% is quoted as the percent a first degree relative might have of going on to develop Celiac disease when one relative has it.... This possibility of Casein Protein also triggering a Celiac diagnosis explains this figure/connection nicely! We also know becoming low in Thiamine can trigger thin our villi and trigger a Lactose Intolerance in the process . It is an Elegant Theory! I would love to hear other's people's insights and opinion's on this exciting research. IF this is true then It (removing Dairy/Lactose/Caseins from their diet) could really help those Refractory Celiac disease still suffering from an unknown cause such as removing Dairy (Casein) from their diet to see if their Refractory Celiac disease doesn't THEN get better. The above research PROVES IT is happening. And 40 Percent is a common rate for whic Lactose Intolerance occurs, at least in part, in certain ethnicity's??? Is this also happen in Celiac patients at a similar rate the Doctor's haven't figured this out yet??? I hope this is helpful but it is not medical advice. Posterboy,
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- casein
- cows milk protein
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How Low B Vitamins can Trigger a Celiac diagnosis and be Mistaken for a Genetic Disease To Whomever May Read This, (Thank you for taking the time to read it and I hope it helps you the way it did me! and if it does tell others....is all I ask)....because I know there are many more fellow sufferers still looking for answers... (because many/most B-Vitamin deficiencies up to 80 percent of the time (especially a Thiamine Deficiency) is going undiagnosed or misdiagnosed in other diseases)....and probably a Riboflavin Deficiency too because they occur together.... Read the blog post and you will see what I mean.... Note: this Posterboy blog post will have 2 portions…. A high level summary and an Appendix/Addendum list of available resources that support these suppositions… Depending on whether you have read the other Posterboy blog post(s) will determine how you want to read this one…. If this is your first then read it all…IF you have read other Posterboy blog posts…then just jump to the Appendix where the references/additional resources are….and all the dirty details... The Posterboy blog post starts now…entitled "How Low B Vitamins can Trigger a Celiac diagnosis and be Mistaken for a Genetic Disease" For a while now (10 to 12+ years now)…..I have been studying B-Vitamins to see what role if any they (B-Vitamins) might have in regulating our Immune System and if they could be the trigger for my GI problems or could have been mistaken for my Celiac disease diagnosis…. Note: I did not say my Celiac disease….but my diagnosis as a Celiac….see Appendix for other possible triggers. I had written two previous articles/Posterboy blog posts one about Thiamine (Beri Beri) aka Vitamin B1 and one about Niacin (Pellagra) aka Vitamin B3. Provided here for easy reference.....if you want to go back and read them sometime... Both play a critical role in our immune system and down regulate inflammation pathways in the body… This Posterboy blog post/article unites the two into an "Elegant Theory" of how and why these occur together in Celiac disease. I had previously done an unpublished article/blog post on Riboflavin….which I might share in the future (but probably not at this point) This Posterboy blog post will serve as the argument (thesis) that Riboflavin deficiency is common in Celiac’s going commonly undiagnosed/misdiagnosed….much like the other B-Vitamin deficiencies of Thiamine (B1) and Niacin (B3) in Celiac’s. I have now found that it is a cascade of all three of these B-Vitamins and maybe 4 (beyond the scope of this blog post Vitamin B6)….. B1, B2, B3 work synergistically together to control inflammation in the body. I found first that Pellagra could be common in Celiac’s going undiagnosed/misdiagnosed…. Then I found that Beri Beri might also be the reason for Celiac’s thin Villi…. SO I had to write about it/that too!.....but no ONE Vitamin/Mineral answered all the questions…. So that made me think I could be wrong about the Pellagra question (in part) at least… IF there is NO SKIN issues IE DH with your Celiac diagnosis then you have NOT YET developed Pellagra…. but more appropriately Pellagra Sine Pellagra…..or Pellagra without skin issues…. And brings me to the point of my current Posterboy blog post. I believe that most Celiac’s have developed Pellagra Sine Pellagra. Now granted they developed Beri Beri FIRST….because B-Vitamin deficiencies NEVER happen alone…. It (Celiac disease) is a sequalae (aftermath) of B-Vitamin deficiencies…and possibly some Minerals like Magnesium and Zinc and Copper etc….(Again beyond the scope of this post) See this Posterboy blog post to see how nutrients (IE Vitamin and Mineral Deficiencies), Genetics and your Environment (STRESS) interact…. To produce disease… So how did I arrive at Pellagra Sine Pellagra instead of Pellagra or Beri Beri (only)…. Because you definitely develop Beri Beri (FIRST)…..why not continue on the Pellagra tack… There is a couple of distinguishing features between the two most notably the level of SKIN involvement…. Pellagra is a very VISUAL disease…..IF you don’t have DH or other Skin problems then you have not yet developed Clinical Pellagra…. But Pellagra Sine Pellagra a Riboflavin deficiency has all the same symptoms of Pellagra without the pervasive skin issues… Make no mistake about it….I had already developed Beri Beri first (horrible fatigue) and Peripheral Neuropathy etc…. They typically occur together…..because as noted earlier B-Vitamin deficiencies don’t occur alone… ONE will affect the others… And why I landed on B2 (Riboflavin) instead of B3 (Niacin)…. The 2nd clue was the pervasive Iron deficiency issues most Celiac’s develop. Is Notable that Iron Deficient Anemia aka IDA is very common in Celiac’s… And people have forgotten how Riboflavin aka Vitamin B2 plays an important role in Iron deficient anemia… https://pubmed.ncbi.nlm.nih.gov/31318024/ Riboflavin deficiency individuals often have fertility problems as well… I too had these same problems that got better after Riboflavin supplementation… Riboflavin again aka Vitamin B2 can cause people to have Hypothyroid problems…..which again was me three…. got better after Riboflavin supplementation… Reason number 4) Anxiety can be the first sign of a Riboflavin deficiency check that one off too! Reason number 5) Riboflavin is the trigger for a Homocysteine problem…..commonly diagnosed as MTHFR Gene defect…. https://chrismasterjohnphd.com/blog/2019/02/26/mthfr-just-riboflavin-deficiency/ Check, Check, Check, Check, Check….I had all the signs of a Riboflavin deficiency and the doctor’s missed them ALL! Not to mention the hallmark angular cheilitis (Leaky Lips) for years…..and the doctor could only recommend for/to me was to stop leaking my lips sooooooo much! ALL this symptom’s and more got better after supplementing with Riboflavin…. SO that is why I know Pellagra Sine Pellagra happened to me and is also happening in other Celiac’s going undiagnosed/Misdiagnosed. The Iron Deficient Anemia…..can be treated (in many if not most cases) with either/by treating your Low Stomach Acid or by taking Riboflavin and/or Copper. See this research entitled “Is achlorhydria (No Stomach Acid) an (independent) cause of iron deficiency anemia” https://pubmed.ncbi.nlm.nih.gov/25994564/ The answer was a resounding yes! So, I had developed low/NO stomach acid as the trigger for my Celiac/NCGS diagnosis… AND just what another intrepid research discovered/studied 35+ years ago and was promptly forgot and never believed….the more things change…the more they stay the same! See this research entitled “Gastric morphology and function in dermatitis herpetiformis (DH) and in Celiac disease” https://www.ncbi.nlm.nih.gov/pubmed/3992169 That should be the end of the discussion…..but It won't be....while their patients suffer...they will do more studies about it! Quoting the whole abstract for emphasis! Abstract “Gastric acid secretory capacity was evaluated in 116 patients with dermatitis herpetiformis by means of the pentagastrin test. Endoscopic gastric mucosal biopsy specimens were obtained from both the body and the antrum in 90 of them. Forty-eight patients (41%) had a maximal acid output less than 10 mmol/h, and 30 of them (26%) were achlorhydric. T he frequency of achlorhydria increased with age, and 27 out of 58 patients (47%) more than 50 years old were achlorhydric. Antrum-sparing chronic atrophic gastritis was present in 92% of the achlorhydric patients, and hypergastrinaemia and serum parietal cell antibodies were found in most of them. The prevalence of chronic gastritis of the body and of the antrum increased with age. There was no correlation between atrophic gastritis or achlorhydria and small-intestinal villous atrophy, the results of the D-xylose test, and blood folate and serum zinc determinations. The transferrin saturation index was lower in patients with achlorhydria. The frequency of achlorhydria was significantly higher in patients with dermatitis herpetiformis than in 69 patients with celiac disease.” Note: 90+ percent of Celiac’s have NO stomach acid (at all)….this is not counting the percent of Celiac’s where just Low in Stomach acid….mind you This was not in NCGS but a study of Celiac’s who were already diagnosed as Celiac’s…. But EVEN this is not enough to get some people to believe!!!! The research is out there…..this is a Classic example of Co-Morbidity….IE a Sequelae of one condition triggering the other! The aftermath of B-Vitamin and Mineral deficiencies of Zinc, Magnesium, B1 (Thiamine), B2 (Riboflavin), B3 (Niacin) and possibly Copper is being diagnosed as NCGS and/or as Celiac disease diagnosis IMHO! It is my hope by sharing this old research rediscovered that at least ONE other person will believe me (YOU) and be helped! Use a Celiac disease diagnosis as the way back. . . . not the end of the road for your health but the beginning of your way back to health! As the I have the Lord being my help! As I am fond of saying “To Educate is to truly free!” Where there is a free exchange of knowledge there is health and peace for one’s soul and body! So, what can I do NOW about this know that I know B-Vitamins might help my Celiac diagnosis? There is “No Formula” but this is the best advice I can offer you. Take a B-Complex AND a Benfotiamine (Fat Soluble B-1) or other Fat Soluble B-1s like AlliThiamine or Lipothiamine (harder to find) AND a Magnesium Citrate (with meals) or Magnesium Glycinate (anytime) 2x to 3x a day (with meals) for 3 to 6 months. (IF you are not taking an acid reducer like a PPI or H2 Blocker (better of the two kind with less long term side effects) ) you will begin to burp continuously even up to 2 hours after you have finished your meal….. and between meals with the smallest snack… producing the biggest BURPS you have had in years, and years. Don’t stop for at least 6 months….don’t stop taking them when you begin burping (again without bloating/gas distension) BUT continue for 6 months till BURPING without these other symptom’s and a regular movement will become your new normal. You are now again digesting proteins in your diet triggering a food allergy. What I didn’t know at the time was that Pellagra is a “Capstone” diagnosis and not the “Cornerstone” disease. Pellagra is definitely happening in Celiac’s because Tryptophan has been shown the ability to be a therapeutic for Celiac’s. See this research about it… https://www.eurekalert.org/pub_releases/2020-10/aaft-tri101920.php Here is another article about the same research indicating Tryptophan as Therapeutic treatment for Celiac’s… https://www.news-medical.net/news/20201023/Intestinal-microbiota-offers-new-prospects-for-treating-celiac-disease.aspx Confirming that when you develop “Leaky Gut Syndrome(s)” you have developed Pellagra. But Pellagra does not happen alone and is not the trigger….it is the combination of multiple B-Vitamin deficiencies beginning with Low Thiamine (B1), then Low B2 (Riboflavin) and finally Low Niacin (B3) aka Niacinamide presenting as DH in Celiac’s… I did not develop Pellagra but Sine Pellagra instead! Note: as to not overpower the reader (you) with too much information see addendum/appendix for more reference’s resource where you can read to your Heart’s content (as much) or as little as you need to help you understand these “Lost Connections” explaining how the Chicken came before the Egg (Diagnosis). First you develop Low B-Vitamin deficiencies (IE Thiamine deficiency or undiagnosed Beri Beri) THEN your Villi Thin and THEN you develop Pellagra Sine Pellagra a Riboflavin deficiency leading (in time) finally to a/your Celiac diagnosis! Also Note: SIBO and Cows Milk Protein IE Casein (not Lactose as is commonly believed) might also be a problem for you. See the Appendix for more details. 2 Timothy 2: 7 “Consider what I say; and the Lord give thee understanding in all things” this included. I hope this is helpful but it is not medical advice. Posterboy by the Grace of God, ADDENDUM/Appendix Resources Thiamine the Overlooked Vitamin That Improves Autoimmune Disease And Autonomic Dysfunction https://awaken.com/2021/02/the-overlooked-vitamin-that-improves-autoimmune-disease-and-autonomic-dysfunction/ The issues/symptoms of a Thiamine deficiency hide in other diseases…. It is only suspected (tested) for in diseases with high clinical suspicion such as Alcoholics and Anorexic’s etc…. Also here is a nice overview of how to recognize a Thiamine deficiency… https://healthprep.com/articles/fitness-nutrition/guide-symptoms-thiamine-deficiency/#:~:text=Weight loss may occur in a thiamine deficiency,individuals called AMP-activated protein kinase (AMPK) becomes impaired. Here is the best thread on a Thiamine deficiency and its many presentations/faces/symptoms on Celiac.com for more resources on Beri Beri in GI diseases like Celiac disease and IBS etc. Recently Celiac.com wrote an article linking AnitGAD antibodies to Celiac disease. So that set me out to see if there was a link between Gluten Ataxia and AntiGAD antibodies…. And it turns out AntiGAD antibodies are diagnostic confirmation of a Thiamine deficiency in Celiac’s manifesting themselves as Gluten Ataxia… See this research that explains the connection… entilted “Wernicke's encephalopathy: an excitotoxicity hypothesis” https://pubmed.ncbi.nlm.nih.gov/9346467/ This confirms exactly what is happening in other GI diseases like UC and Chrons. See this research entitled "Wernicke Encephalopathy in Crohn's disease and Ulcerative Colitis" https://www.sciencedirect.com/science/article/pii/S0899900721000447 AS if often the case in WE the treatment is too little too late….let's not let the same thing apply/happen to Celiac disease patients too! IF the research on UC and Chrons’ is to be believed Low Thiamine level’s can be a predictor of disease severity and recovery. NOW a similar study needs to be done to confirm my many years of research proving once and for all…. A Thiamine deficiency is the trigger for Thin Villi! Note: The Hormones Matter website is the best Thiamine resource on the web….and EON Health is a close second. Zonulin a Marker for Niacin deficiency Links/Resources https://alobar.livejournal.com/2930798.html#%2F2930798.html Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine: Trp enhanced tight junction protein ZO-1… https://www.researchgate.net/publication/312962348_Dietary_Tryptophan_Enhanced_the_Expression_of_Tight_Junction_Protein_ZO-1_in_Intestine_Trp_enhanced_tight_junction_protein_ZO-1 Dietary l-tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model https://pubmed.ncbi.nlm.nih.gov/30977499/ Intestinal permeability IE Leaky Gut and oxidative stress in patients with alcoholic pellagra (reversed with Niacinamide) https://pubmed.ncbi.nlm.nih.gov/16713031/ Which is what the latest research confirms Tryptophan can be used in Celiac’s to heal Villi https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx Does Going Gluten Free Provide Relief or All Celiacs? The answer is NO! https://medicalxpress.com/news/2021-02-gluten-free-diets-cure-all-celiac-disease.html And why I recommended B-Vitamins as an adjunct treatment for Co-Morbidities that happen in Celiac’s. This a complimentary approach. See this Posterboy blog post that discusses the B-Vitamins that might help treat a Celiac diagnosis About 40 pct of Celiacs are NOT helped when they go gluten free. This is about what else someone can do that is still triggering Villi blunting when eating gluten fee is not enough to heal your Villi??? Three or four of the most common triggers (IMO) for continued GI inflammation (Issues) in IMO are Milk (Cows’ Milk Protein) aka CMP in the literature. See this great Celiac.com article about how Milk in peoples diet can also trigger Villi Blunting… A reaction to Cows Milk Protein (Casein) can happen in up to 40 percent of Celiac’s… See this nice study on the issue of Caseins’ also triggering an Immune response in Celiac’s Entitled “IgA anti-gliadin antibody immunoreactivity to food proteins IE Cows Milk Proteins” https://www.tandfonline.com/doi/full/10.1080/09540100400003204 You can just read the abstract and not surprising it is 15+ years old and only recently Celiac.com did an article on it….. people can’t wait another 15 years for the medical community to pick up on this connection and why I am writing this blog post NOW! 2) SIBO can happen in the Majority of Celiac’s Note: This study is about SIBO happening in Celiac’s already treated with a gluten free diet. Almost 2/3 of Celiac’s symptoms got better after treating their underlying causes for a Celiac diagnosis such as SIBO in this study. 3) B-Vitamins that become low when one has SIBO You will find this a common theme…..after treating Celiac disease…..continued symptoms continued until the underlying cause(s) like SIBO, Cows Milk, Low/NO stomach acid or Medicines keep triggering Villi blunting… I can only tell you it helped me to treat my underlying cause’s like Low Stomach Acid and my B-Vitamin deficiencies going undiagnosed as part of Celiac disease diagnosis. See this new research that verify this fact from 2020 just a year old…from Chicago University https://medicalxpress.com/news/2020-02-mouse-celiac-disease-treatments.html Where they note quoting “Even while maintaining a strict gluten-free diet, 40% of celiac disease patients still show signs of inflammation and villous atrophy, or damage to the villi, the small, finger-like protrusions in the small intestine that help absorb nutrients. Therefore, treatments that can reverse or prevent the disease are greatly needed to improve quality of life for people with celiac.” Tryptophan can do that. So can B1 (Thiamine), B2 (Riboflavin) and B3 (Niacin) if you can believe the latest research on this topic. Some of it is 15 or 20 years old now….and doctors are not aware of this groundbreaking research. 4) Low/NO Stomach Acid See this research discovered 30+ years ago entitled “Gastric morphology and function in dermatitis herpetiformis (DH) and in Celiac disease” https://www.ncbi.nlm.nih.gov/pubmed/3992169 Celiac’s are suffering now and can’t wait another 10 or 15 years before they rediscover this research on their own! I wrote a Posterboy blog post about this too about how Low/NO Stomach acid could be the trigger for a subsequent Non Celiac Gluten Sensitivity diagnosis aka NCGS ….but few people seemed to understand it… Recently PPIs use has shown to trigger a Celiac diagnosis…..and yet nonchalantly this research is minimized…. among other medicines that can also trigger Villi Blunting (Atrophy) with use… See this Celiac.com thread about it…how PPIs, NSAIDS and SSRIs use were found to be associated with Villi Atrophy and subsequent Celiac diagnosis. See also this thread about how some Blood Pressure Medicine might blunt your Villi…. Back to the discussion at hand….how Zonulin can be a biological marker for a Niacin deficiency… This is important because Niacin is used in Stomach Acid production…. Zonulin as a marker for a (Low) Niacin levels aka Deficiency confirms IMHO a metabolic trigger for Pellagra going undiagnosed in Celiac disease. The IJCD noted this association of Pellagra in Celiac’s in 2015…..where they noted the majority or 58 percent approximately of Celiac’s would be Co-Morbid with their Celiac disease. It just nobody has followed up on these associations…..because you can’t see Pellagra in people until Skin Rashes develop….. by then DH has been diagnosed as a symptom of Celiac disease and by then you are too late! Doctors can’t see how these two diseases are connected but researchers can……. and fellow sufferers who have suffered at the hands of Doctor’s ignorance of the 4 Ds of Pellagra…. They get a D+ on recognizing Pellagra, Beri and Beri and Pellagra Sine Pellagra in Celiac disease today! IT is no one’s fault….IT is the process. There are not good B-Vitamin tests to determine the status of B-Vitamin deficiencies in Celiac’s and other GI patients. The FIRST good study about this is the link I noted above that confirmed the SEVERITY of the Thiamine deficiency IE Beri Beri predicted the SEVERITY of UC and Chron’s patients! Provided here again for easy reference… See this research entitled "Wernicke Encephalopathy in Crohn's disease and Ulcerative Colitis" https://www.sciencedirect.com/science/article/pii/S0899900721000447 Why would we not think it would be the same for Celiac disease! And IF the research is to be believed low Zonulin levels are an indicator of Low Niacin levels aka Pellagra in it’s most severe presentation of perfuse Skin Lesions….being diagnosed as DH today! ETA: Found only this month (week) while writing this article/blog post Very recent research Circa 2021 also confirmed that eating gluten free alone does not heal all Celiac’s making supplementation with B-Vitamins (IMHO) and Magnesium, in part, an essential treatment for those suffering from inflammation not due to gluten! See this research entitled “Do gluten-free diets provide a cure-all for celiac disease” and the answer is unequivocally NO… In a subset of Celiac’s. https://medicalxpress.com/news/2021-02-gluten-free-diets-cure-all-celiac-disease.html Quoting their conclusion(s) A significant number of patients previously thought to be well-treated by a gluten-free diet may in fact require additional interventions to fully curb their gut inflammation. Don’t be surprised if takes another 10 or 15+ years of “more study” to confirm these findings! Each generation much pass on their knowledge to the next….or it soon becomes lost again… This is my humble attempt to pass on that knowledge. To quote Isaac Newton “I do not know what I may appear to the world, but to myself I seem to have been only like a boy playing on the seashore, and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me.” — Isaac Newton I did this first for myself…..with the hope that it might help others someday. 3 Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God. It is my sincerest hope that I was able to throw a few “Starfish” back. But I fear I have not helped enough! http://www.starrbrite.com/starfish.html The Starfish Story Original Story by: Loren Eisley "One day a man was walking along the beach when he noticed a boy picking something up and gently throwing it into the ocean. Approaching the boy, he asked, What are you doing? The youth replied, Throwing starfish back into the ocean. The surf is up and the tide is going out. If I don’t throw them back, they’ll die. Son, the man said, don’t you realize there are miles and miles of beach and hundreds of starfish? You can’t make a difference! After listening politely, the boy bent down, picked up another starfish, and threw it back into the surf. Then, smiling at the man, he said I made a difference for that one!" Part 4 Additional Resources Is COVID 19 primarily a GI disease first See this research entitled “Severe COVID19 Is Fueled by Disrupted Gut Barrier Integrity” https://www.medrxiv.org/content/10.1101/2020.11.13.20231209v1.full Is “Leaky Gut Syndrome” a sign of Vitamin/Mineral deficiency See this research entitled “Regulation of the intestinal barrier by nutrients (Nutrition): The role of tight junctions” https://onlinelibrary.wiley.com/doi/10.1111/asj.13357 And this one entitled Intestinal permeability and oxidative stress in patients with alcoholic pellagra https://pubmed.ncbi.nlm.nih.gov/16713031/ See also the is Live Journal article about how Zonulin can be a “Marker for Niacin Issues”….IE is Zonulin a sign of Pellagra going undiagnosed or Misdiagnosed as Celiac disease today! https://alobar.livejournal.com/2930798.html#/2930798.html I can also recommend this blog post on Zinc deficiency by Blue Sky
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- beri beri
- low stomach acid
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Unintentional weight loss is a classic symptom of Thiamine deficiency. Muscle wasting is a classic symptom of Thiamine deficiency. Your body needs thiamine to turn carbohydrates into energy. Without enough thiamine, your body burns fat and muscle as energy sources because this route doesn't require thiamine. Please read this article....and the informative comments after it.... https://www.hormonesmatter.com/connecting-symptom-dots-discovering-thiamine-deficiency/ Celiac Disease causes malabsorption which results in malnutrition. Your damaged intestines are not absorbing enough Thiamine. When you're thiamine deficient, Thiamine transporters on your body's cells quit working. In order to get them working again, you have to take high doses of thiamine. The muscle wasting and weight loss happened to me. I lost sixty pounds in six weeks after a Celiac Crisis. Luckily I found the hormones matter web site and began high dose thiamine. Here's a few articles to which you might relate.... https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/ http://www.hormonesmatter.com/thiamine-deficiency-causes-problems/ https://www.hormonesmatter.com/gastrointestinal-disease-thiamine/ https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/ "Levels of thiamin in the blood are not reliable indicators of thiamin status. Thiamin status is often measured indirectly by assaying the activity of the transketolase enzyme, which depends on TDP, in erythrocyte hemolysates in the presence and absence of added TDP [3]. The result, known as the “TDP effect,” reflects the extent of unsaturation of transketolase with TDP. The result is typically 0%–15% in healthy people, 15%–25% in those with marginal deficiency, and higher than 25% in people with deficiency. Another commonly used measure of thiamin status is urinary thiamin excretion, which provides data on dietary intakes but not tissue stores [5]. For adults, excretion of less than 100 mcg/day thiamin in urine suggests insufficient thiamin intake, and less than 40 mcg/day indicates an extremely low intake [6]." How was your thiamine level tested? High dose thiamine means 500 mg of thiamine a day or above. Some take 500 mg three times a day for several days, then a maintenance dose is set. Thiamine has no upper limit. It is safe. It is water soluble, any excess is flushed out in urine. At most, you may get nauseous. If so back down the amount. The RDA's are minimums to prevent illness, most set in World War II. This article is in reference to Wernicke's Encephalopathy, but it proves high dose thiamine is effective and safe. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354137/ My Celiac Crisis happened before my Celiac Disease diagnosis. My doctors couldn't figure out what was wrong with me. They said I was a hypochondriac and wrote me off. Doctors don't recognize (or even think about the possibility of) vitamin deficiencies. Thank my lucky stars I had a university degree and figured it out for myself. The IBS, anxiety and sleep issues are all early signs of thiamine deficiency. I know this one. I lived through it. 500 mg for three days and there will be a difference! I'm currently taking LifeExtension Benfotiamine with thiamine 100mg capsules (fat soluble form of thiamine) which helps my diabetes. Once or twice a day. And I currently take Now B-1, 100mg tablets, one with every meal. I've tried several fat soluble forms of thiamine like Benfotimine and these two others... I have tried Ecological Formulas Allithiamine 50 mg capsules. This one is derived from garlic and works well. (But kind of pricey.) I've tried Cardiovascular Research, Ltd Lipothiamine, 50 mg tablets, another fat soluble one. I really like this one. All are gluten free, casein free. I took Ecological Formulas Allithiamine (tetrahydrofurfuryl disulfide) but found it's really strong...and I take it on alternate days instead of the Benfotiamine. https://pubmed.ncbi.nlm.nih.gov/15328496/ I took just the Now B-1 100mg as the high dose thiamine because I was sceptical, too. I took up to ten a day and my brain came back on. After three days I could cut back, and I experimented with the other fat soluble ones. I had read the fat soluble forms cross the blood brain barrier and I didn't need such high doses. Every one is different. You have to find what works for you. Hope this helps! site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy.× Post Diagnosis, Recovery & Treatment of Celiac Disease All Activity Mark site read Celiac.com Sponsor (A1-m): You've found your Celiac Tribe! Join our like-minded, private community and share your story, get encouragement and connect with others. 💬 Sign In Sign Up Join eNewsletter Sign in with Facebook Weight Loss/Muscle Wasting on gluten-free Diet By Kate333, July 5, 2020 in Post Diagnosis, Recovery & Treatment of Celiac Disease PREV 1 NEXT Page 1 of 2 Kate333 26 Posted July 5, 2020 Did anyone here suffer noticeable weight loss either BEFORE or esp. AFTER your celiac disease diagnosis and beginning gluten-free diet? That has become a BIG issue for me, despite being strictly gluten-free for 6 months. Yesterday, I had 2 small sirloin steaks, potatoes and veggies yet STILL LOST a pound! I am really struggling with this and esp. the muscle wasting/hunger...I know I have become rather obsessed with diet (paranoia about G exposure, esp. CC, almost makes scared to eat most foods). 😡 I used to LOVE eating before celiac disease and IBS/SIBO? ...now it's just a damn "chore". I am afraid this problem has given me serious anorexia. I look like a skeleton compared to my body pre-celiac disease diagnosis.....yet feel so helpless to prevent hunger/muscle wasting...😪.Do I have to wait until my gut heals BEFORE I can regain/normalize weight?? Thanks for any comments... Celiac.com Sponsor (A11-m): knitty kitty 221 Posted July 6, 2020 Kate333, Unintentional weight loss is a classic symptom of Thiamine deficiency. Muscle wasting is a classic symptom of Thiamine deficiency. Your body needs thiamine to turn carbohydrates into energy. Without enough thiamine, your body burns fat and muscle as energy sources because this route doesn't require thiamine. Please read this article....and the informative comments after it.... https://www.hormonesmatter.com/connecting-symptom-dots-discovering-thiamine-deficiency/ Celiac Disease causes malabsorption which results in malnutrition. Your damaged intestines are not absorbing enough Thiamine. When you're thiamine deficient, Thiamine transporters on your body's cells quit working. In order to get them working again, you have to take high doses of thiamine. The muscle wasting and weight loss happened to me. I lost sixty pounds in six weeks after a Celiac Crisis. Luckily I found the hormones matter web site and began high dose thiamine. Here's a few articles to which you might relate.... https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/ http://www.hormonesmatter.com/thiamine-deficiency-causes-problems/ https://www.hormonesmatter.com/gastrointestinal-disease-thiamine/ 1 Kate333 26 Posted July 6, 2020 Thanks KK for reading/commenting/posting these article links! I know TD is a popular issue of discussion among holistic med community folks...However, my labs all show normal vit./mineral levels--including all the "B"s. I also have really IBS/stress/sleep issues, esp. bad since this pandemic/quarantine began...EVERYDAY loose BMs no matter what the heck I eat😖. I suspect these factors are big issues in my continued weight/muscle loss. Kate333 26 Posted July 6, 2020 KK...I also forgot to mention that I take both daily multivitamin and B complex supplements. B complex pill includes 3 mg. of B1 and I also try to eat foods high in Bs every day. What triggered your "CC"?? Did you experience that rapid weight loss (and digestion issues) BEFORE you were dx with celiac disease? And how long did it take for you to regain that weight? I am glad you are so much better! knitty kitty 221 Posted July 6, 2020 https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/ "Levels of thiamin in the blood are not reliable indicators of thiamin status. Thiamin status is often measured indirectly by assaying the activity of the transketolase enzyme, which depends on TDP, in erythrocyte hemolysates in the presence and absence of added TDP [3]. The result, known as the “TDP effect,” reflects the extent of unsaturation of transketolase with TDP. The result is typically 0%–15% in healthy people, 15%–25% in those with marginal deficiency, and higher than 25% in people with deficiency. Another commonly used measure of thiamin status is urinary thiamin excretion, which provides data on dietary intakes but not tissue stores [5]. For adults, excretion of less than 100 mcg/day thiamin in urine suggests insufficient thiamin intake, and less than 40 mcg/day indicates an extremely low intake [6]." How was your thiamine level tested? Celiac.com Sponsor (A10-m): knitty kitty 221 Posted July 6, 2020 High dose thiamine means 500 mg of thiamine a day or above. Some take 500 mg three times a day for several days, then a maintenance dose is set. Thiamine has no upper limit. It is safe. It is water soluble, any excess is flushed out in urine. At most, you may get nauseous. If so back down the amount. The RDA's are minimums to prevent illness, most set in World War II. This article is in reference to Wernicke's Encephalopathy, but it proves high dose thiamine is effective and safe. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354137/ My Celiac Crisis happened before my Celiac Disease diagnosis. My doctors couldn't figure out what was wrong with me. They said I was a hypochondriac and wrote me off. Doctors don't recognize (or even think about the possibility of) vitamin deficiencies. Thank my lucky stars I had a university degree and figured it out for myself. The IBS, anxiety and sleep issues are all early signs of thiamine deficiency. I know this one. I lived through it. 500 mg for three days and there will be a difference! 1 Posterboy 222 Posted July 6, 2020 Kat333, If you are losing weight you should consider SIBO or Refeeding Syndrome presenting as a Celiac Crisis.... Here is a study about it....entitled "Refeeding syndrome in adults with celiac crisis: a case report" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791168/ You might also have Low Albumin levels....I did and the doctor's didn't know I had developed Refeeding Syndrome because it is often diagnosed as something else instead. I wrote a Posterboy blog post about how and why Refeeding Syndrome aka (RFS) happens in Celiac......maybe it will help you. If you have low BMI, and weight loss....you are definitely at risk for Refeeding Syndrome aka RFS. See table 1 from above link on Refeeding Syndrome Presenting as a Celiac Crisis .... Taking Magnesium Glycinate and Benfotiamine (fat soluble) B-1 with meals can help your Refeeding Syndrome. I would also take an Enzymic B-Vitamin since all the B's works synergistically. A Thiamine deficiency has also been show to be low/common in SIBO.....so it (Thiamine) should help either the SIBO or Refeeding Syndrome condition....when taken with a Magnesium Glycinate. https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo I hope this is helpful but it is not medical advice. 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God, 1 Kate333 26 Posted July 6, 2020 Hi again KK. Thanks for your great words of reassurance, wisdom, and experience. I will definitely give that higher B1 dose a try, esp. knowing small risk of damage due to overdose (as can happen with other vitamins). Did you really notice an improvement after ONLY 3 days on B1?! Awesome! Could you pls. share the gluten-free brand name you take? Did you need Dr. script for such a high dose? Is sublingual dissolvable better absorbed than pills? I don't know if I've ever had a "classic CC crisis" but, last year (June) I had sudden sharp spike in BP/heartburn and the worst severe headache (I never even had those before in my life!) after bad phone conversations with first a screaming, cursing client and then a screaming boss. Those symptoms were so severe I literally ended up in the ER, fearing a stroke, heart attack. Luckily that wasn't the case. Doc. said extreme stress/panic attack (well...hello??). I went home, promptly quit the (toxic, stressful, draining) job I had endured far too long to save my sanity/health. I thought a nice, long work break (I never took "real" vacations before) would make me feel better, but still terrible, inexplicable fatigue/anxiety/insomnia.. Then a few months after I quit toxic job, my bowels decided to revolt after another/different big stress in my life. That's when primary care doc thought to do a TTG blood test which came back with elevated G antibodies at level 224. I got EGD/SI biopsies afterward which was showed no small intestine damage, negative for C sprue, but mild gut gastritis. I began gluten-free diet in Dec./Jan. and, encouragingly, my next G antibody test (March 2020) showed my G numbers had signif. dropped to 73. However, my June 2020 test showed slight increase (81)...I was disappointed, expecting/hoping G antibody numbers to have fallen to near "normal" levels. But I realize that can take some time to happen and I should just be patient, count my blessings (progress after only 6 months on gluten-free diet). I can so relate to being tagged by some docs as "hypochondriac". 😉 I'm a lifelong HSP (highly sensitive person), very prone to anxiety/depression, and anx. DOES affect the ENTIRE body so definitely a link between physical/mental symptoms. (All the more reason for docs to ROUTINELY test for celiac disease/vitamin def the same way they do for cholesterol and thyroid.) I keep wishing they had tested me for celiac disease in childhood...It is a real downer knowing I have been unknowingly damaging my gut for DECADES before docs even thought to check for celiac disease. IMO ALL babies should be genetically tested for celiac disease after birth and retested for G antibodies before kindergarten. Would probably spare so much lifelong misery... Kate333 26 Posted July 6, 2020 If you are losing weight you should consider SIBO or Refeeding Syndrome presenting as a Celiac Crisis.... Here is a study about it....entitled "Refeeding syndrome in adults with celiac crisis: a case report" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791168/ Thanks for the comments, PB. But, good God no! I am NOWHERE as sick as the person discussed in that study report. 😱 My BMI is in the "normal" range (although I wish it were a bit higher). Also, I got blood tests recently which showed ALL vitamins/minerals and organ function tests are well within normal range. My only symptoms are daily loose stools/sometimes constipation...constant fatigue, poor sleep. Occasionally foot/leg cramps at night and "pins/needles". I am just going to try a trial of extra vitamin B and MH counseling...I think most of my digestive issues are primarily related to IBS/anxiety/fear of eating/G exposure. Possibly some SIBO mixed in there..but trials of Rifaximin followed by probiotics have not provided long term bowel change relief. CV pandemic certainly doesn't help anxiety which can manifest in gut (aka our "2nd brain"). I probably should learn better sleep habits and spend time away from this blog, obsessing about my symptoms/illness...😉 knitty kitty 221 Posted July 6, 2020 I'm currently taking LifeExtension Benfotiamine with thiamine 100mg capsules (fat soluble form of thiamine) which helps my diabetes. Once or twice a day. And I currently take Now B-1, 100mg tablets, one with every meal. I've tried several fat soluble forms of thiamine like Benfotimine and these two others... I have tried Ecological Formulas Allithiamine 50 mg capsules. This one is derived from garlic and works well. (But kind of pricey.) I've tried Cardiovascular Research, Ltd Lipothiamine, 50 mg tablets, another fat soluble one. I really like this one. All are gluten free, casein free. I took Ecological Formulas Allithiamine (tetrahydrofurfuryl disulfide) but found it's really strong...and I take it on alternate days instead of the Benfotiamine. https://pubmed.ncbi.nlm.nih.gov/15328496/ I took just the Now B-1 100mg as the high dose thiamine because I was sceptical, too. I took up to ten a day and my brain came back on. After three days I could cut back, and I experimented with the other fat soluble ones. I had read the fat soluble forms cross the blood brain barrier and I didn't need such high doses. Every one is different. You have to find what works for you. Hope this helps! knitty kitty 221 Posted July 6, 2020 Wanted to add.... Thiamine needs magnesium to work best, so I take Doctor's Best High Absorption Magnesium. Years ago, I read this book... Niacin, the Real Story... by Dr. Hoffer and it really helped. I had returned to normal niacin intake, but I felt something missing after correcting my thiamine, so started taking Niacin as described in Dr. Hoffer's book. With the thiamine and niacin together, I feel so much better! Niacin likes to work with Vitamin C. I take Doctor's Best Vitamin C with Q-C. Niacin and Thiamine work together. Now I've got both corrected, I feel so much better. Hope this helps! P.S. Thiamine deficiency and SIBO https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo Sorry, so much information I wanted to impart. The difference I felt was within hours of taking that first 500 mg dose of thiamine. Took another 500 mg at lunch. I kept feeling better and better. I realized I could take 300 mg or 400 mg with each meal and get the same effect. Three or four days later, I didn't feel an improvement as obvious as when I took the first few doses, so I dropped to 200 - 300 mg with each meal and now I'm down to 100 mg with two meals and one benfotiamine. If I get stressed or am very active, I can always take an extra. I can tell when I need more. I know I've had enough when my pee smells like I've eaten a ton of asparagus. (There's lots of thiamine in asparagus which causes that sulfur smell.) Thiamine is water soluble and is excreted in urine. Same way with the niacin, high doses at first, improvement within hours. Improvement for days, hit a plateau, taper back slowly to maintenance dose. It's in that book. I felt like the lights in my head came back on. I'd been living in a clammy basement, and all of a sudden, the lights switched on and continued to get brighter. It was almost as if I could feel brain cells firing and connecting with other brain cells again. My anxiety dissipated. I felt competent, confident and calm again. The pain and fatigue left. I had tons of energy. When I was deficient, I didn't notice how much my brain function had declined. With the high dose thiamine and niacin, I see the improvement and am shocked at the difference. I'm aghast when I think of the years struggling with physical health problems, anxiety, depression, PTSD, mental illness problems that are all easily remedied with a five dollar bottle of vitamins in the correct dosage. I'm horrified to think that the medical professionals ignore this simple solution and prefer prescription medications from which they can make a profit. I still have a lot of hostility about how I was written off by the medical profession and lost everything, so I can't go into further detail, but it wounds me deeply when I realize how pervasive their attitude is that vitamins aren't that important, just eat healthy. You can't eat enough food to make up for a deficiency when you can't absorb and utilize what you eat because of deficiencies. Paraphrasing Dr. Hoffer, you're sick because you're vitamin deficient, not because you're medication deficient. If you give the body what it needs to function properly, it will correct itself. As for me, I'm taking thiamine and niacin. I think doctors and especially gastroenterologists should be taught about vitamins and deficiency diseases. I learned about them in the premed courses I took at university. Why couldn't they? Because Big Pharma is in control of many medical schools and training hospitals. Vitamins usually can't be patented, so Big Pharma can't make money off prescribing them. But they can make money off of synthetic drugs. So that's where they focus their attention, development and training. I had "band-aid" prescription drugs thrown at me by the dozens. My health deteriorated all the more the faster they threw pills at me. The known side effects of some of the medications I had been prescribed are vitamin deficiencies. My doctors never warned me about this, they never took preventative actions, never prescribed prophylactic vitamins to counteract these known side effects. Nothing. One doctor did check my Vitamin D level only after he ascertained that my insurance would cover it. And to shut me up. He knew he could prescribe Vitamin D 2, a synthetic form of Vitamin D made by Big Pharma. Vitamin D 2 is about useless (not a biologically active form). But he refused to check for any other deficiencies. My gastroenterologist did not recognize the niacin deficiency disease, Pellagra, when I went to an appointment with three out of the four D's. (Diarrhea, Dermatitis, Dementia and Death). I had Casal's necklace which was mistaken for syphilis. And despite a negative on the syphilis test, no other explanation was given me by that office. Not even for the unrelenting diarrhea. Just advised to keep taking my prescriptions. Thank my lucky stars, I knew the four D's of Pellagra. It was on a test at university. It clicked. I recognized it. I started supplementing. Amazon Next Day Delivery saved my life. 😼 I found Dr. Holder's book about Niacin. If you read that, you can see how his revelations about Niacin was squeezed out by Big Pharma, too. I researched and refreshed what had I learned at university about vitamins and Celiac Disease. I quit taking all those medications. I started supplementing. My health improved. I got a different doctor who told me my vitamin levels were fine and I could stop supplementing. He promptly prescribed several medications that he said without which I risked serious consequences. My health disintegrated again. He promptly took me off the prescription medications. And I resumed supplementing. And my health continues to improve. So, yes, highly skeptical of Big Pharma and the medical profession. All those supplements I listed are available on Amazon.com without a prescription. Much of the information is now available for free on the internet or for minimal costs (certainly less than tuition). Knowledge is power. I hope the supplements work as dramatically for you as they did for me. Please keep me posted on your results. Please bear in mind, I am not a medical professional. You may want to discuss your supplementation with your doctor. Here's the links to the book about Niacin and the vitamins..... Dr. Holder's book on Niacin.... https://www.amazon.com/Niacin-Story-Wonderful-Healing-Properties/dp/1591202752/ref=mp_s_a_1_3?dchild=1&keywords=niacin+dr.+hoffer&qid=1594125580&sr=8-3
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To All, This is the thread I said I would start.... This analysis/opinion will turn on the neurotransmitter Acetylcholine. While it is well known Acetylcholine effects our CNS....it is less well know that Acetylcholine also performs the same function for the Parasympathetic Nervous System. https://en.wikipedia.org/wiki/File:1503_Connections_of_the_Parasympathetic_Nervous_System.jpg When we get low in Thiamine and subsequently Acetylcholine we lose the ability to control our bowels because our Vagus nerve in essence short circuits....and our body no longer can control it's organs connected to the Vagus Nerve leading to bowel problems associated with Celiac disease. IE a Vagus Nerve disorder develops once we get low in Thiamine..... Here is a nice over of how a Vagus nerve disorder can trigger issues with our Parasympathetic Nervous System. https://www.md-health.com/Vagus-Nerve.html I hope this is helpful but it is not medical advise. Posterboy,
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- acetylcholine
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To All, I recently came across this new research that show Environmental Toxins can increase the risks of Celiac disease in Children? Could this also be happening in Adults? https://medicalxpress.com/news/2020-09-highly-fluorinated-chemicals-diabetes-coeliac.html Have they found an Environmental trigger for Celiac disease and if so what can people do about it if anything? I know Celiac.com will write a more exhaustive article about it soon.....I just wanted to get it out there for people to comment on and provide feedback too! I hope this is helpful but it is not medical advise. Posterboy,
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A Case for Thiamine Supplemenation in Celiacs IF only for a Season in Time
Posterboy posted a blog entry in Posterboy's Blog
A Case for Thiamine Supplementation in Celiac’s IF only for a Season in Time I have been doing Posterboy blog posts every so often now for a while now to share my experience with supplementation. I have settled on the fact that many of the existing GI issues can triggered by existing nutritional deficiencies. ((I think most people must think I still take Niacinamide or Thiamine or a B-complex.....I do not now take any of these things. I only took them for a Season in Time and the reason for the name of this Posterboy blog post. For many taking an Enzymic B-Complex with Benfotiamine (preferably with Magnesium Glycinate or Magnesium Citrate with meals) for 3 to 6 months when taken with meals will be enough, for some 6 months or longer might be needed..... you decide the Season and the times that is best for you!)) See this research entitled “Nutritional inadequacies of the gluten free diet in both recently diagnosed and long term patients with celiac disease” https://pubmed.ncbi.nlm.nih.gov/23198728/ As I often note….. research is 5 or 10 years old (for whatever topic it is)…in this case that Thiamine is not only Low at diagnosis of a Celiac diagnosis…continuing to eat a gluten free diet without supplementation will make you even LOWER in Thiamine. This is not a case of the “Chicken or the Egg”….. a Thiamine deficiency comes FIRST….then you develop GI problems IMHO. This leads to an impaired Vagus Nerve response…. https://www.md-health.com/Vagus-Nerve.html I once thought this was a Niacin deficiency (and in part it still can be) but it begins with a Thiamine Deficiency first (beyond the scope of this Posterboy blog post)…..when one develops the skin condition of DH in/with their Celiac diagnosis…. the Celiac has gone onto to develop a Niacin deficiency. I never developed full blown Pellagra (beyond limited skin involvement) I did not develop symptom’s beyond Pellagra Sine Pellagra aka as a Riboflavin deficiency as noted by horrid Angular Cheiliitis (Leaky Lips)…. After extensive PMing back and forth with EnnisTx (I don’t think I ever told him) I realized….I had gotten the wrong diagnosis…. so from then I adjusted/iterated the model. I changed my opinions/mind about my conclusions…..and realized I had been wrong…. So that sent me back to the drawing board(s) so to speak…..if it wasn’t Pellagra what was it…. And I will skim over this portion because it is only an intermediate step in the process as noted above I had developed not Pellagra but Pellagra Sine Pellagra a Riboflavin deficiency. See this research entitled “Kynurenine pathway metabolites in humans: disease and healthy States” Here is the abstract to keep it on the lighter side…. https://pubmed.ncbi.nlm.nih.gov/22084578/ Once the Kynurenine Pathway breaks down…essentially your immune system goes haywire… Here is the more technical answer via their conclusion on the Kynurenine Pathway and disease states… “Conclusion The kynurenine pathway is an effective mechanism in modulating the immune response and in inducing immune tolerance. This is achieved by accelerating the degradation of tryptophan and the generation of kynurenines. The metabolites of the pathway, with their different inherent properties, can also synergize or antagonize the effects of one another. By measuring the levels of tryptophan, kynurenines and the K/T ratio under various pathological conditions, the degree of immune activation and the relationship between the kynurenine pathway and disease states may be gleaned. However, much research is still needed to fully understand the complex interaction between tryptophan, IDO and kynurenines among themselves and within the CNS and in the periphery. With the seemingly prevalent involvement of the kynurenine pathway in a wide range of different diseases and disorders, the knowledge gained from research focusing on the kynurenine pathway may be translated into designing novel and more effective treatment strategies.” I did not set out to learn this….but only set out for the truth of the matter. But from there I was able to back track and find out the trigger for this cascade… It was not B3 or B2 (not really) but B1….(Or lack thereof) that was the real trigger… I have been counting down B-Vitamins all this time….you might say I have been counting down to One! The combination of these B-Vitamins (B1, B2, B3) had been shown to down regulate inflammation in the body. See where this was recently studied in the mouse model for health entitled “Vitamin B combination (of B1, B2, B3) reduces fluconazole toxicity in Wistar rats” https://pubmed.ncbi.nlm.nih.gov/30903555/ And while they each work to down regulate inflammation…..together they are dynamite! But what was the Spark??? That creates the BOOM! Thiamine is the Spark for Energy! According to Lonsdale it (Thiamine) is the “Spark of Life”…. http://europepmc.org/article/MED/22116701 Stress requires energy and we absolutely can NOT make energy without Thiamine. The Thiamine deficiency came First…..It is not a “Chicken AND the Egg” scenario. One interesting new study that illustrates this point and I will try and wrap up this Posterboy blog post at least for a Season of Time. Let’s go back to the B1, B2, B3 issue of picking which one is the Spark for the Autoimmune BOOM triggered by inflammation..... Sepsis is a condition in the body that is triggered by unchecked infection often….and what down regulates inflammation in the body??? Answer B-Vitamins at least in part…..we know B1, B2, and B3 work synergistically to down regulate inflammation in the body thereby controlling first inflammation and thus Sepsis. How can we know it is B1 instead of B3…because new research bears this fact out! See this Sciencedirect article about Thiamine and Sepsis and how unchecked inflammation can be a sign of a Thiamine deficiency not the other way around … https://www.sciencedirect.com/topics/nursing-and-health-professions/thiamine-deficiency quoting Effect of Sepsis on Intestinal Thiamine Uptake Thiamine deficiency is prevalent in patients with sepsis.15–17 This appears to be mediated in part via an effect of sepsis on intestinal thiamine uptake37 given recently reported observations of a significant inhibition in intestinal thiamine uptake in rat model of sepsis where the degree of inhibition was shown to correlate with the severity of sepsis. The degree of the Thiamine Deficiency correlated with the degree of the Sepsis! Again, the Thiamine deficiency came First…..It is not a “Chicken AND the Egg” scenario. To quote Ecclesiastes 3 (read it all if you get chance) it is so well known the first few verses can be quoted (or commonly known). And it is often quoted at major life events such as death and at marriages or when one gets sick…..this too can pass! But if you want energy during these emotional times you can’t pass by Thiamine! Ecclesiastes 3:1 “To everything there is a season, and a time to every purpose under the heaven:” It is time for a “Season of Thiamine” to fight off the stress and inflammation your GI tract is now experiencing because your body is low in Thiamine…… before medically diagnosable Beri Beri develops from unchecked inflammation in the body! There will be time of Joy! Of Celebration that you found out what was causing your “Chronic” Fatigue that the doctors couldn’t diagnose! Because they didn’t know the cause of the unchecked inflammation https://www.msn.com/en-us/health/other/chronic-fatigue-syndrome-may-be-due-to-an-overactive-immune-system-study-shows/ar-BBR5ba3 I had similar things happen to me….before Sepsis develops someone in a Celiac Crisis will develop Refeeding Syndrome….. presenting itself as “Electrolyte Abnormalities” See my Posterboy blog post how I was a Posterboy for a Thiamine deficiency post and the doctor’s were misdiagnosing it! If this is the right diagnosis you would expect patterns to emerge in the research and when we look we see we/they do! 2 out of 3 Celiac’s who do not respond to a gluten free diet get (feel) better when they are treated for SIBO or unchecked inflammation from an overgrowth of bacteria! And a Thiamine Deficiency is known to be common in a SIBO diagnosis. It Turns out the Bacteria need Thiamine for their Spark of Life too! Draining your in the process leading to your Fatigue! And new research is emerging that Toxic Shock (this is no longer an hypothesis) but a working Theory that “Thiamine (vitamin B1) (can be used) in septic shock: a targeted therapy” which IMO is being triggered by gluten in Celiac’s when you First get low in Thiamine presenting as a Celiac Crisis or being Misdianosed as Refeeding Syndrome or SIBO in IMO. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024754/ I must stop before this blog post gets too long again…… I truly hope it helps someone else! It is time for a Season of health! I share that it might help the next person…..so they won’t have to suffer without the doctor’s help the way I did! I hope this is helpful but it is not medical advise. 2 Corinthians 1:3, 4 3 Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4 Who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God. 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the grace of God, ADDENDUM IF you have a spare hour of your time this youtube link about how a Thiamine Deficiency can lead to Vagus Nerve disorders is worth your time! Entitled “Is Thiamine Deficiency Destroying Your Digestive Health? Why B1 Is ESSENTIAL For Gut Function” Or if you prefer to reading to video this is a nice article that shows the Thiamine Deficiency in a SIBO Patient connection… and remember in 2 out of 3 Celiac’s who do not get better eating a gluten free diet feel better after treating their SIBO Or is it more appropriately treating their Thiamine Deficiency??? A Season of Thiamine (or a B-complex) can tell you if it was the "Chicken or the Egg". What have you got to loose but Time! It is time for a Season of Health! https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo -
To All. Is Refeeding Syndrome being misdiagnosed as Celiac Disease today? Refeeding Syndrome happens among the severely malnourished and having Celiac disease is a risk for a Refeeding Syndrome leading to a Celiac Crisis aka Celiac diagnosis. See this research entitled “Celiac Crisis: an unusual presentation of gluten-sensitive enteropathy” where the Symptoms of Refeeding Syndrome (Electrolyte Imbalances) is being diagnosed as “Celiac Crisis” instead…. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066267/ Refeeding Syndrome is missed in 50 percent of patients and there have been many studies showing Refeeding Syndrome (RFS) being diagnosed as Celiac Crisis instead…. Quoting from the above study about this phenomenon in Celiacs... “PubMed articles published between September 1990 and April 2018, were searched using the uniterm “celiac crisis” in patients older than 18 years; 31 reported cases were gathered (Table 1). The mean age was 52 years ranging from 23 to 83 years and a gender predominance was found among females (1.81:1). Interestingly, amid the 31 cases, only 3 had the diagnosis of Celiac Disease before the crisis. ” So in these studies these Electrolyte Anomalies aka Refeeding Syndrome where ultimately diagnosed as Celiac disease instead of RFS….of which there is a readily medically treatable regimen with good clinical/patient outcomes. See this Medical New Today article to see if you are experiencing what is known as Refeeding Syndrome many times diagnosed as a Celiac Crisis instead... https://www.medicalnewstoday.com/articles/322120 I only know it happened in my case.....and your case might be similar....low Potassium is often an early sign of Refeeding Syndrome.... IN these cases the Electrolyte abnormalities showed up before the Celiac diagnosis as it did in my case too! It is not as a rare as people/doctor's believe it is .....in only two years time the case studies on the this topic for Refeeding Syndrome (Connection/Association) as a a trigger for Celiac disease has gone up 50+ Percent because doctors are now more aware and are looking for it more! See this very recent 2020 Case Study article that bears this out...entitled "Life-threatening onset of celiac disease: a case report and literature review" https://pubmed.ncbi.nlm.nih.gov/32381744/ where they note: "The present case highlights that celiac disease may manifest quite abruptly with a severe malabsorption syndrome, that is, electrolyte abnormalities".. .IE Refeeding Syndrome....commonly known/diagnosed as a "Celiac Crisis" instead today I believe... Comparing the number of studies of Refeeding Syndrome in Celiac's went from only 31 to almost 50 studies in under two years time... It is time doctor's became more aware of these connections so Celiac's can be helped sooner in those who have developed a Thiamine deficiency (commonly found in Refeeding Syndrome) as the triggering cause of a Celiac Crisis! You will probably also have a Magnesium deficiency presenting as Low Potassium and Chronic Fatigue.....I know I did in my case! Because as the Medical News Today article pointed out.....Low Potassium is a symptom of Low Magnesium levels...quoting from the above Medical News Today article... Refeeding syndrome can also lead to a lack of magnesium. Hypomagnesemia is the name for dangerously low levels of magnesium. Signs and symptoms of hypomagnesemia include: low potassium levels, or hypokalemia ......weakness.... and fatigue. And in my case terrible "Charlie Horses" aka Muscle Spasms that got better after taking Magnesium Citrate with meals. I hope this helps at least one other person....I share because I have suffered these same symptom's going undiagnosed in/with my Celiac diagnosis and if I am right being the Posterboy for Celiac disease and this research is right being Misdiagnosed as a Celiac Crisis instead today! I hope it helps the next person....I only know it helped me! I hope this is helpful but it is not medical advise. 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God,
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To All, AuntiE's question....triggered this thread post....I had found it earlier but got busy with life.... I thought there was a research section once before either way it is a related problem Celiac's sometimes develops.... To not spam the other thread....I created a new topic about it... Cornell University has established that Sulfites can interfer with the Thiamine content of food....so the "Red" meat we eat (especially those using food preservatives like Sulfites to artificially make them "bright" red And like the color of which we like to see....maybe not be as good for as we think... http://thiamine.dnr.cornell.edu/Thiamine_causes.html quoting from their article .... "Various physical and chemical conditions can cause the breakdown of thiamine. Conditions of high pH, elevated temperatures, and the presence of sulfites (Figure 2), which are used as preservatives of meat products, are common causes of thiamine loss. Sulfiting agents used for food preservation include bisulfites, sulfites, metabisulfites, and sulfur dioxide.".... "These preservatives serve to prevent the oxidation of oxymyoglobin to metmyoglobin in meat, which causes its discoloration from red to brown upon exposure to air..... As, as well as in other foods recognized as a source of thiamine, is prohibited.4 Aside from causing allergic reactions in sensitive people, sulfites cleave thiamine at its methylene bridge (Figure 2), causing its destruction. Foods and beverages that contain high concentrations of polyphenolic compounds can also cause thiamine deficiency. Polyphenolic compounds are plant extracts including tannins and catechins (Figure 3), that are commonly found in coffee and tea." It is me again.....This can explain why people who eat a lot meat (and fish can do it too naturally) in their diet without knowing it... Combine these seemingly harmless foods with high CARB meals and you on can quickly become low in Thiamine without even knowing it... And if you get low enough in Thiamine...it can thin your Villi .....leading in time to food sensitivities.... I have had friends who say they can only organic "meats" and this explains why....or could at least explain part of the reason... I hope this is helpful but it is not medical advise. Posterboy,
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