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Showing results for tags 'type ii'.
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Is there a Type I and Type II Celiac Disease IF so what is your Type: What the Diabetic Model can tell us about Celiac Disease Subtypes? ****these opinions are my own and are not an endorsement by Celiac.com….these are only my conclusions after years of research. I am sharing to generate thought, feedback, opinions, progress on the topic and change if they make sense to you. I would say there are two types of Celiac disease based on all the available research I have read. Think Type I and Type II like diabetes. I share/post this for your feedback, education, careful thought, insight and opinion(s). Maybe it will spur your thinking! This Model of a "Type I" and "Type II" Celiac disease explains best what is happening IMO! These type of grand break though ideas deserve to be shared on Celiac.com.....I suspect it will be another 10 or 15 years (IF then) that this "Working Hypothesis" will be confirmed with more studies proving IT is a "Working Theory"....I just hope some intrepid medical who might read this will be courageous enough to do a a thorough study on this topic confirming my many years of research as the Lord has been my help! I only ask that you be Berean in your thought! as you read this Posterboy blog post and Consider what I say.... Acts 17:10, 11 10 And the brethren immediately sent away Paul and Silas by night unto Berea: who coming thither went into the synagogue of the Jews. 11 These were more noble than those in Thessalonica, in that they received the word with all readiness of mind, and searched the scriptures (research) daily, whether those things were so. Type I happens as a kid (refractory often)... and Type II happens as an adult (often triggered by PPIs or Stress) see below... and why kid's don't get better (probably)....the age you get these deficiencies effects your bodies response.... triggered, in part, by congenital Vitamin deficiencies in children IMO. I concluded this based on research I recently discovered about how Riboflavin aka Vitamin B2 can affect Villi formation in children…… and why it was first diagnosed in Children in IMO. See these links on Riboflavin....I will summarize....if you get low Riboflavin, Thiamine etc. as a kid...you villi won't recover but if it happens as an adult you can recover from PPIs (low stomach acid) triggered Celiac disease. Here is the research on Riboflavin and Thiamine and Niacin and how they work together to regulate our immune system. https://pubmed.ncbi.nlm.nih.gov/7857908/ https://www.ncbi.nlm.nih.gov/pubmed/8785207 https://www.sciencedirect.com/science/article/pii/S0278691510002474 thiamine and riboflavin together https://www.sciencedirect.com/science/article/abs/pii/S1734114016302729 thiamine, riboflavin and niacin together completely down regulated inflammation/toxicity... https://www.ncbi.nlm.nih.gov/pubmed/30903555 If this Posterboy blog post doesn’t make sense to you? It will have to be someone else to rediscover this again in 15 to 20+ years... I have tried to educate the best I could! Too Educate is Too Free!!!! I have tried to share how supplementing with B-Vitamins helped my GI problems, but it seems/seemed to be a “bridge to far” for some…. May this Posterboy blog post....help you "bridge" over the connection between Genetics and Environment IE....Epigenetics...(STRESS) To discovery this I haven't cared what the truth is....I have just wanted it as it is! Truth Frees us from Error! I only know that...... Magnesium, Thiamine, Riboflavin and Niacin(amide) changed my life! ****note this comments that follows are notes to myself that quickly summarize these points (written previously) as cliff notes version of the above...(this I wrote for you as a summary for myself) "Low stomach acid triggered by stress and we lock in with antacids.. Then being low in stomach aid makes you low in Magnesium in 6 months.. Being low in Magnesium makes thiamine unavailable to the body When thiamine is low – you get low in Riboflavin after a month.. And villi begin swelling --- affecting absorption of other nutrients.. Then because riboflavin is a cofactor for Niacin synthesis via the Kyneurine pathway…. and you develop perfuse Skin Lesions diagnosed as DH… When low in meat and dairy (or take mitochondria toxic medicine) you develop pellagra when you can’t synthesize niacin from low tryptophan and riboflavin levels…" This has recently been confirmed in IMO by the discovery that Tryptophan can be used as Therapeutic in the treatment of Celiacs… https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx Otherwise you rest/settle on just having (PSP) aka Pellagra Sine Pellagra (think thyroid problems) Or Pellagra without Skin Involvements… https://pubmed.ncbi.nlm.nih.gov/3809170/ If this is triggered by infantile Beri Beri or more probably a Riboflavin deficiency your Villi might never recover... SIDS has been linked to a thiamine deficiency in kids. Heck even in old age Beri Beri will cause blindness due to glaucoma...and 80pct of WE (brain version of Beri Beri) is not diagnosed until autopsy upon death... https://www.ncbi.nlm.nih.gov/pubmed/485004 Here is link https://academic.oup.com/ajcn/article/77/6/1352/4689829 focus on the riboflavin and gastrointestinal development paragraph... quoting from that paragraph (read it all) it very informative... "Recent work has shown that even when riboflavin is supplied to tissues intraperitoneally, the absence of riboflavin from the lumen of the gastrointestinal tract from the time of weaning leads to a disruption of normal gastrointestinal development in rats." Meaning in young children probably 2 or 3 years or young never (maybe up to 5 years of age estimate only) (fully) develop Villi if their mother was also low in Riboflavin.... cleft palates develop this way....Riboflavin deficiencies in new born baby's.....Vitamin deficiencies passed from mother to baby.... The below link was recently rediscovered by me even though it is almost 10 years people don't know its role in regulating our immune system our helping keep our GI tract healthy Here is Riboflavin’s role in protecting against the Heatshock protein in SIBO https://www.sciencedirect.com/science/article/pii/S0278691510002474 Entitled "Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25" in SIBO. This also probably happening in Celiac disease as well…..we can surmise if it helps one of the GI disease’s that mimic Celiac disease….it could help Celiac disease as well. See this old forgotten article about how SIBO is common in Celiac disease. Entitled Bacterial Overgrowth of Small Intestine aka SIBO Common in Treated Celiac Disease https://www.celiac.com/celiac-disease/bacterial-overgrowth-of-small-intestine-common-in-treated-celiac-disease-r791/ Note: a couple things here….this Is not suspected Celiac disease but “Treated Celiac Disease”….. SIBO is common in treated Celiac disease….meaning these were people eating a gluten free diet already…. And as I often site and say in my Posterboy blog post this research 10 or 15+ years old…. And yet people (doctor’s/clinician’s) are not aware of these connections/associations…. I set out to confirm my diagnosis and it took me approx. 4+ years to realize I had Low/NO stomach acid going un/misdiagnosed. I have continued studying since then….and I am convinced now more than ever 10 to 12+ years later that Low/NO stomach acid could help Celiac’s….. But we have a “Long Tail” Memory…..and can’t seem to move onto another possible diagnosis like Low/NO stomach acid despite what the research seems to say! I am not the first to discover, study or conclude this… This was studied 30+ years ago....but through much study and the grace of God I have rediscovered it..... will it be another 10 or 15 years before it is accepted??? I hope and pray not! But I honestly don't have much hope.... That people will read it and believe it.....it has been lost for 30+ years for a reason.....nobody believes it! See this research entitled Gastric morphology and function in dermatitis herpetiformis and in C(o)eliac disease. https://pubmed.ncbi.nlm.nih.gov/3992169/ quoting “Antrum-sparing chronic atrophic gastritis was present in 92% of the achlorhydric patients, and hypergastrinaemia and serum parietal cell antibodies were found in most of them. The prevalence of chronic gastritis of the body and of the antrum increased with age.” Note again: this was not in NCGS patients….but diagnosed Celiac and DH patients…. Surely Low/NO stomach acid is the trigger for Celiac disease. IF this is so we would see the same thing in PPIs users… And WE do….recent research confirmed this analysis….among PPIs users….for those who used them for a year or more Low Stomach Acid (from PPIs Acid reducers) were found to be the trigger (CAUSE) of their Celiac diagnosis! See this article about it on Celiac.com entitled “Do Proton Pump Inhibitors Increase Risk of Celiac Disease” https://www.celiac.com/celiac-disease/do-proton-pump-inhibitors-increase-risk-of-celiac-disease-r2860/ They summarize it very well…. Quoting “The data clearly show that patients who use anti-secretory medications are at much greater risk for developing celiac disease following the use of these medicines. The fact that this connection persisted even after the team excluded prescriptions for anti-secretory medicines in the year preceding the celiac disease diagnosis suggests a causal relationship.” See also this thread started by Knitty Kitty https://www.celiac.com/forums/topic/117685-atrophy-associated-with-ppis-nsaids-and-ssris/ Back to the main point of this Posterboy blog post….Low stomach is triggerable and reversible a “Type II” Celiac disease. A congenital Celiac disease diagnosed as a kid…could not be reversed (in most people)…. and why it was originally diagnosed as a “Type I” genetic disease once Celiac antibodies were discovered IMHO. I don’t believe it fair to someone who at 40 or 50 started taking PPIs to then tell them…you now have a genetic disease…. No, it was triggered by your PPIs usage….and is reversible like most EPI (Environmentally) genetic triggered diseases are…. B-Vitamins are the very definition of Epigenetics….you got low in Vitamins….and you got a disease from the deficiency…. This might not show up for years….until the Doctor’s recognize as a deficiency…..hence a “Type II” diagnosis! I have written a couple other Posterboy blog posts that might help you. An “Open Letter” Part 1 and Part 2 that explains how these things are connected if you think it would help you to read some more on these connections. I didn’t understand it at the beginning of my journey, but I hope it will help start you on your journey back to heath as it did me! It has been a long journey for me….but It can be short(er) for you….because you know the way back….I have shown you how I got back! https://www.celiac.com/blogs/entry/2167-open-letter-part-1-to-fellow-gi-sufferers-etc-like-ibs-uc-and-other-gi-diseases-like-infant-heartburn-gerd-that-grows-into-in-time-to-ibs-uc-chrons-and-ncgs-as-a-teenager-or-celiac-disease-in-time-as-an-adult-look-beyond-to-the-parent-disease/ https://www.celiac.com/blogs/entry/2515-open-letter-to-the-many-gi-sufferers-part-2-still-suffering-look-beyond-these-symptom%E2%80%99s-to-the-parent-disease-pellagra-with-these-many-unruly-children-like-ibs-gerd-uc-etc-up-to-and-including-ncgs-and-celiac-disease-in-time-i-believe-part-2/ Just trying to help those still suffering (I believe) unnecessarily. Who think there is only one Type of Celiac disease? 2 Corinthians (KJV) 1:3,4 3) “Blessed be God, even the Father of our Lord Jesus Christ, the Father of mercies, and the God of all comfort; 4) who comforteth us in all our tribulation, that we may be able to comfort them which are in any trouble, by the comfort wherewith we ourselves are comforted of God.” I hope this is helpful but it is not medical advice. 2 Timothy 2:7 As always, “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the Grace of God, ADDENDUM: I am adding this Posterboy blog post from an earlier blog post maybe it will help you…. https://www.celiac.com/blogs/entry/2103-why-and-how-pellagra-is-often-confused-with-celiac-disease-andor-other-gidigestive-problems-the-science-of-pellagra-a-hidden-epidemic-in-the-21st-century-presentingrevealing-as-ncgs-andor-possbily-celiac-disease/ At the time not many people read it…..but maybe this time more people will read and understand it! The presenting symptom of DH in Celiac disease is confirmation that the Kynurenine Pathway has broken down and who have developed the 3rd "D" of Pellagra…. Let’s hope the doctors realize this before the 4th "D" symptom DEATH occurs! Since 80 percent of Wernicke Encephalopathy better known as the mental/brain symptom of Beri Beri is diagnosed on autopsy I have my doubts they will notice the Pellagra Co-morbid in 58% (Majority) of Celiac noted no less than by the IJCD (see Posterboy blog post link above) and why I continued to emphasis this in my Posterboy blog posts….. because the IJCD noted the same thing! I only ask that you believe you own research (prophets)…..and agree with them that Beri Beri, Pellagra Sine Pellagra, and Pellagra is happening in Celiac’s. https://www.celiac.com/celiac-disease/how-low-thiamine-can-thin-villi-old-research-rediscovered-and-its-clinical-significance-in-celiac-disease-r5100/:~:text=Beriberi%20is%20is%20caused%20by%20low%20thiamine%20(B1).,dietary%20thiamin%20deficiency%20on%20intestinal%20functions%20in%20rats.” At what rate only more tests/studies can prove. I ask that others in the Celiac community that might read this…. Do these studies….so that future doctors are aware of these connections/associations. I just know we can't wait another 10 or 15 years before this trickles down to the clinical (Medical) level when current (today's) research shows that Tryptophan can be used as a Therapeutic for Celiac disease.....IMHO confirming this theory! https://www.celiac.com/celiac-disease/tryptophan-in-turkey-meat-can-speed-gut-healing-in-celiac-disease-r5338/ Isn't that we ALL want to speed our healing! This is happening in other auto-immune diseases too/also because we only have ONE immune system! With many difference (faces)….IE symptom’s….. Note: Pellagra is found in Lupus too! https://www.celiac.com/blogs/entry/2709-the-lupus-inflammation-model-for-sickness-beginning-with-b-vitamin-deficiencies-in-celiacs-and-other-inflammation-triggered-diseases%E2%80%A6/ I must stop for now, or this will be way too long again!
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A Breath Test for Celiac Disease? Yes Please!
Jefferson Adams posted an article in Diagnosis, Testing & Treatment
Celiac.com 05/20/2019 - A stuffy and obscure-sounding scientific paper has more than a few people excited about a breakthrough breath test to help manage diabetes, celiac disease and other conditions. Celiac is one of the most common and misdiagnosed disease. The process of getting a proper diagnosis can be long and convoluted. In part, that's because people with celiac disease may have few or no symptoms. In fact, these days, most people diagnosed with celiac disease report few or no symptoms. In fact, it's not at all uncommon for a person with celiac disease to suffer for up to 10 years before getting a proper celiac diagnosis. In diabetes, glucagon increases blood glucose levels. In diabetes treatment, DPP-4 inhibitors are used to reduce glucagon and blood glucose levels. According to Wikipedia, they do this by increasing levels of incretin, GLP-1 and GIP, "which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels." The excitement arrises because a team of scientists has developed a selective, non-invasive breath test that could be used to diagnose and treat celiac disease and Type-II diabetes. The development team set out to develop a selective, non-invasive, stable-isotope 13C-breath test that can detect dipeptidyl peptidase-4 inhibitors (DPP4i), a class of orally available, small molecule inhibitors for the management of Type-II diabetes. The team included Roger Yazbeck, Simone Jaenisch, Michelle Squire, Catherine A. Abbott, Emma Parkinson-Lawrence, Douglas A. Brooks & Ross N. Butler. The team's paper carries the very weighty title: Development of a 13C Stable Isotope Assay for Dipeptidyl Peptidase-4 Enzyme Activity A New Breath Test for Dipeptidyl Peptidase Activity. If you read that title, and understood only the words "breath test," you are not alone. The title and the paper are highly scientific. The takeaway is that the test they developed could be useful in diagnosing, treating, and managing diabetes and gastrointestinal diseases, including celiac disease. The team's paper describes in detail their development process for the stable-isotope 13C-breath test for DPP4. The test could potentially help to treat and manage diabetes, celiac disease, and other conditions, including certain cancers. "Furthermore," the paper reads "the significant pool of DPP4 in the small bowel and in inflammatory conditions suggests that a DPP4 breath test could also have potential application as a non-invasive method to measure intestinal function/integrity and immune status. Certain cancers also exhibit high expression of DPP4 as exemplified by the adenocarcinoma cell line in this study and this may provide a measure of cancer activity and response to therapy." Imagine a quick non-invasive breath test that can do all that. That's exciting stuff. Among other things, it could mean better treatment, and less unnecessary suffering. We say: Yes, please! Do you find the idea of a breath test for diabetes and celiac disease an exciting prospect? Share comments below. Read more in Nature.com Scientific Reports; volume 9, Article number: 4906 (2019. Also of interest is D Detel, M Persic, & J Varljen's paper titled "Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease," and published in the Journal of Pediatric Gastroenterology and Nutrition; 45, 65–70- 10 comments
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