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Found 5 results

  1. Hi there, Thanks for taking the time to read this. I am so very confused, so thought I’d ask for help to see if anyone can understand my ANA results. I am currently under investigation for celiac and for ulcerative colitis. I had some bloods done last month and only through deciding to do a private referral (I am in the UK) have I found out there there are some abnormalities in my antinuclear antibodies. I asked my doctors for a print out of all my bloods. I have lower white blood cells, my ESR is very slightly raised. These are my ANA results: ENA ANTIBODIES - (SJM) • Ro antibody level - negative • La antibody level - negative • RNP antibody level - weak positive • Sm antibody level - negative • Jo-1 antibody level - negative • Scl 70 antibody level - negative DNA binding autoantibodies (SJM) - negative • Complement - third component - C3 - 1.39g/l (range 0.55-1.20) HEP2 ANA - (SJM) - Cytoplasmic Does anyone understand what this means? Do I ignore it? Why does it not say ANA negative or positive, but says cytoplasmic instead? Why is there no titre? I am no doctor so I have no idea, but I’d really like your opinion. Something has obviously been picked my from the lovely doctor I saw privately. I also have Raynauds Thanks so much for your help.
  2. Thought I would go over what I have been on and done to treat my UC and see if it benefits anyone else. I was diagnosed almost exactly a year ago in February 2017. UC in different people has different flare triggers seemingly most common are Gluten, Diary, Soy. Some cases are Caffeine, Coffee, chocolate, Glucose, Fructose, Sucralose, Carbs. For me the 3 top ones, with sugars and carbs, and certain spices...coffee, caffeine, and chocolate seem fine....SUGAR was the worst causing not just bloody stools but moderate amounts of fruits or added sugars would cause distention. Before diagnosis I thought for years I had bad gut bacteria due to the swelling, gas, and bloody stools. I was originally put on Delzicol for it, but after losing my insurance and the prescriptions costing $680 I had to give it up. I turned to dropping all grains, sugars, starchy veggies, and using Marshmallow Powder (1tsp) twice a day. Recently after getting sick with a cold I started Thayers Slippery Elm Lozenges to deal with the sore throat and found that having 3-4 of them a day worked wonders with my UC....was more apparent when I tried getting off them and had a rebound flare that was really bad til I started them back up. And I drink 8oz of Aloe Vera Inner Fillet in a tea twice daily. SO 300-600mg of Thayers Slippery elm dosed out thought the day 1 tsp marshmallow root powder or 3 capsules from Natures Way twice a day 8oz Aloe Vera Inner Fillet twice a day with diet has kept it under control almost as good as the RX stuff I was on.....well the RX allowed me to have Mexican spices without flares which...now will flare me if I do not watch it.....I had to give up salsa. (Grew up in a mexican family....so this hit home) Love to see how others manage it and what others might have as triggers for their flares and the symptoms
  3. Celiac.com 05/16/2018 - Galectins are a family of animal lectins marked by their affinity for N-acetyllactosamine-enriched glycoconjugates. Galectins control several immune cell processes and influence both innate and adaptive immune responses. A team of researchers recently set out to assess the role of galectins, particularly galectin-1 (Gal-1), in the treatment of celiac disease. The research team included Victoria Sundblad, Amado A. Quintar, Luciano G. Morosi, Sonia I. Niveloni, Ana Cabanne, Edgardo Smecuol, Eduardo Mauriño, Karina V. Mariño, Julio C. Bai, Cristina A. Maldonado, and Gabriel A. Rabinovich. The researchers examined the role of galectins in intestinal inflammation, particularly in Crohn’s disease, ulcerative colitis, and celiac disease patients, as well as in murine models resembling these inflammatory conditions. Maintaining the fine balance between host immunity and tolerance promotes gut homeostasis, and helps to prevent inflammation. To gain insight into the role of Gal-1 in celiac patients, the team demonstrated an increase in Gal-1 expression following a gluten-free diet along with an increase in the frequency of Foxp3+ cells. The resolution of the inflammatory response may promote the recovery process, leading to a reversal of gut damage and a regeneration of villi. Among other things, the team’s findings support the use of Gal-1 agonists to treat severe mucosal inflammation. In addition, Gal-1 may serve as a potential biomarker to follow the progression of celiac disease treatment. Gut inflammation may be governed by a coordinated network of galectins and their glycosylated ligands, triggering either anti-inflammatory or pro-inflammatory responses. That network may influence the interplay between intestinal epithelial cells and the highly specialized gut immune system in physiologic and pathologic settings. The team’s results demonstrate that the anti-inflammatory and tolerogenic response associated with gluten-free diet in celiac patients is matched by a substantial up-regulation of Gal-1. This suggests a major role of this lectin in favoring resolution of inflammation and restoration of mucosal homeostasis. This data highlights the regulated expression of galectin-1 (Gal-1), a proto-type member of the galectin family, during intestinal inflammation in untreated and treated celiac patients. Further study of this area could lead to better understanding of the mechanisms behind celiac disease, and potentially to a treatment of the disease. Source: Front. Immunol., 01 March 2018. The researchers in this study are variously affiliated with the Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; the Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina; the Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina; the Laboratorio de Glicómica Funcional y Molecular, Instituto de Biología y Medicina Experimental (IBYME), Consejo de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; the Sección Intestino Delgado, Departamento de Medicina, Hospital de Gastroenterología Dr. C. Bonorino Udaondo, Buenos Aires, Argentina; the Unidad de Patología, Hospital de Gastroenterología, Bonorino Udaondo, Buenos Aires, Argentina; the Instituto de Investigaciones, Universidad del Salvador, Buenos Aires, Argentina; and the Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
  4. Let my start by giving a brief summary of what I’ve been diagnosed with. Just over the past year I’ve been diagnosed with Celiac, EOE, lactose intolerance, soy allergy, tree nut allergy. Most recently diagnosed with Ulcerative Colitis. The Colitis came 8 months after having found out I had celiac. I have never had problems with gluten in my life. Dairy was something I had to eliminate because of the excrutiating stomach pains I would get from it. But I can have gluten any day and not have a problem. I was diagnosed with a biopsy and followed by bloodwork. But who’s to say that dairy wasn’t the cause? I just feel like the GI was very quick to jump on the diagnoses without fully understanding my medical history, prescriptions I’ve took in the past ie long term antibiotic use, accutance, and 7 years of constant NSAID use.
  5. Hi lovely people, I have been a member of this forum for a while now, but I have never really introduced myself!! I have had symptoms of various kinds nearly all my life, but I thought that this just how I am! Being constantly tired, etc is part of my personality. I am in Scotland and here the knowledge about celiac is not much better as in many places and I find myself in a most ridiculous situation as I still don't know whether I am officially celiac or not! Here the system works in that one sees a different person every time one goes to the GI specialist and even at times one has to go to the GP to get blood results, have a chat, etc.... In my case there seems to be a discrepancy of opinion... As I had been gluten free for two months prior to this diagnosis journey- I was told to go on a gluten challenge, there was also disagreement as to how long, depending on who I saw.... But I settled for 8 weeks and went for my endoscopy appointment bare being able to stand on my feet as I had a terrible reaction to gluten-I also get DH and I had an enormous concentration of blisters around my mouth and inside... And a small concentration at the back of my legs.... Th endoscopist was very alarmed at my general state! Together with the nurses , he saw mild scallopings in my intestine and said: your symptoms together with what I've seen I am confident that you have celiac- they also did a blood test and took biopsies. Of course, both were negative! I asked which blod test they had performed and I found out that they had done only one, the TTG IgA which sees whether you produce antibodies or not... My GP was adamant, negative blood test no celiac, but if you feel better you can go gluten-free- just cut out wheat, you can still eat barley, etc.... Lol Letter back from GI specialist, negative biopsy - no evidence of celiac... E funny thing is that I've been a patient for 20 years in the same department as I have ulcerative colitis- it is a well know fact that individuals with certain autoimmune diseases do not produce these IgA antibodies and Erefore it is not surprising my blood was negative as I am deficient ... Signs of deficiency: constant mucosal infections: sinusitis, colds, bladder, etc... Nobody ever looks at your records carefully ... As also the type of colitis I have has been linked to celiac. Nobody ever asks any questions- my grannie had RA and horrendous digestion, my uncle has DH and RA..... How can they make a negative diagnosis based on one single, test without looking at everything else - or what happened to the other three tests? I was told by my endoscopist to go gluten-free ASAP!! And now I have been gluten-free for 2 months, so when I confront my GI in April are they going to tell me to go on another challenge? I would be very interested to hear from other fellow people who have both ulcerative colitis and celiac? Thanks so much
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