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Dr. Gunn

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  1. Dr. Gunn
    Before putting yourself through the disruption of a gluten challenge, you might want to check and see if you carry the celiac risk genes DQ2 and/or DQ8. If you don't carry the genes your celiac disease risk is below 1%. If you do have the genes, a gluten challenge followed by antibody testing would be the next steps for a proper medical diagnosis.
  2. Dr. Gunn
    As has been pointed out previously, it is not unusual to have mixed tTG and EMA results with active celiac disease. While awaiting your biopsy appointment you could request celiac genetic risk testing. If you don't carry the HLA-DQ2 and/or DQ8 genes, your lifetime risk for celiac disease is < 1%. The celiac risk genes are present in close to 100% of celiac...
  3. Dr. Gunn
    Just saw this post from earlier in the year. Agree with Scott your positive serology and clinical response to a gluten free diet point to a positive celiac disease diagnosis. Genetic testing can help you confirm the diagnosis without the need for a gluten challenge or biopsy. Increasing studies (mostly from Europe) support a protocol for celiac disease diagnosis...
  4. Dr. Gunn
    Exactly! Negative genetics can rule out celiac disease with close to 100% certainty. It takes tTg antibody testing and biopsy confirm the diagnosis in a genetically susceptible individual.
  5. Dr. Gunn
    Have you had celiac genetic risk testing? A celiac genetic test is accurate with or without gluten in your diet. If you don't carry the celiac risk genes you can effectively rule out celiac disease for life.
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