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About P.d

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  1. GFinDC. thank you so much for your reply. I think you're right, a gluten free diet may be a good thing to try.
  2. So, i am new here! I am European,. I live in Portugal. I started having daily diarrhea when i was 18 years old (I am 28 now), it all started one day, after breakfast and 10 years later i still have to deal with it every day.. My main symptoms are diarrhea and flatulence.. but over the years i started having some other symptoms and complications like.. An ultrasound showed that my gallblader is not working (non-functional).. for the past 4/5 years my Thyroid-stimulating hormone (TSH) has been very high (Triple the max value) suggesting hypothyroidism (Never been "officialy" diagnosed with it) and an ultrasound showed 2 nodules on my thyroid I fell very tired all the time.. my knee makes noises and hurts So i eard of celiac disease (Not well known in Portugal) and i decided to get tested These were the results: HLA-DQ2 -- Negative HLA-DQ8 -- Positive Immunoglobulin A (IgA) -- 313 mg/dl reference value 70 - 400 Anti-Gliadin IgA -- 3 U/ml reference value < 8 Anti-Gliadin IgG -- 3 U/ml reference value < 8 Endomysial antibody (EMA) Result -- Negative Title -- <1/10 reference value <1/10 Anti-transglutaminase IgA -- 6 U/ml reference value < 10 Anti-Reticulin IgA Result -- Negative Title -- <1/10 reference value <1/10 So, it suggests i don't have celiac disease... But i tested positive for the HLA-DQ8 gene.. I know that up to 40% of people test positive for this genes. But in my case, i have the genetic predisposition and i have all the symptoms Is it possible that it is a false negative? Should i get tested again?? Thanks for your help