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What Does A Anti-Gliadin Result Of "Negative", But >0, Mean?


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I looked at my blood test results again and became puzzled. The test result page says results less than twenty are negative, twenty to thirty a weak positive, and above thirty positive. What supports this breakdown?

I understand that there is no generally accepted test for gluten sensitivity. Some doctors think gluten sensitivity does not exist, others go by a positive anti-gliadin blood test, some accept a positive stool test, and some rely on dietary elimination and reintroduction. Others rely on a combination of factors, which may or may not include the blood test. With that being the case, it's difficult to understand the negative/positive in blood tests results as equalling a gluten sensitivity yes/no. So the negative positive must mean something else.

I've also learned that many lab tests with a "normal range" are not based on health, but on all tests given by the lab in a period of time, after dropping of the top and bottom 5% (or some similar algorythym). Is the anti-gliadin test result range determined similarly?


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    • trents
      Yes, it does. And joint pain is another celiac symptom that is now well-recognized. 
    • ThomasA55
      Does my iron loss sound like celiac to you?
    • trents
      Being as how you are largely asymptomatic, I would certainly advise undertaking a gluten challenge in order to get formal testing for celiac disease. We have many forum participants who become violently ill when they undertake a gluten challenge and they therefore can't carry through with it. That doesn't seem to be the case with you. The reason I think it is important for you to get tested is that many or most people who don't have a formal diagnosis find it difficult to be consistent with the gluten-free diet. They find ways to rationalize that their symptoms are due to something other than celiac disease . . . especially when it becomes socially limiting.  The other factor here is by being inconsistent with the gluten free diet, assuming you do have celiac disease, you are likely causing slow, incremental damage to your gut, even though you are largely asymptomatic. It can take years for that damage to get to the point where it results in spinoff health problems. Concerning genetic testing, it can't be used for diagnosis, at least not definitively. Somewhere between 30 and 40% of the general population will have one or both of the two genes known to be associated with the development of active celiac disease. Yet, only about 1% of the general population will develop active celiac disease. But the genetic testing can be used as a rule out for celiac disease if you don't have either gene. But even so, that doesn't eliminate the possibility of having NCGS (Non Celiac Gluten Sensitivity).
    • ThomasA55
    • trents
      Welcome to the celiac.com community, @ThomasA55! Before I give my opinion on your question about whether or not you should undergo a gluten challenge, I would like to know how you react when you get a good dose of gluten? Are you largely asymptomatic or do you experience significant illness such as nausea and diarrhea? You mentioned intermittent joint pain before you began experimenting with a low gluten diet. Anything else?
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