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DebW

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  1. Thanks so much to everyone who replied -- I have some info from other listservs and sources, too, and I'll post it here when I put together the summary. (So watch for those links, GTP. ) The double DQ1 combo is actually quite interesting... To Confused, I'm next for the genetic testing. We know I have at least one gene for gluten sensitivity since my son was double gened, and that's no shock at all. I have a whole laundry list of chronic and severe symptoms that disappeared when I stopped eating gluten. We'll eventually get everyone tested, but we figure that if I show up as double-gened as well, then we'll know all our children are, too. (Since my husband has the double, too.) My daughters both had intense symptoms which cleared in the absence of gluten as well. To Hathor, my husband's going to go gluten-free anyway. Since he's double-gened, he doesn't want to take the risk, and frankly, since we have a gluten-free household already, and he was only eating gluten occasionally at work, this is not a major change for him -- just a little more dedication. He hasn't noticed a lot of symptoms, but that's primarily because he was looking at gastro symptoms and not the neurological ones. Now that he's considering that angle, he's realized that he had started to automatically avoid all carbs on days he wanted to be particularly alert to avoid the "brain fog" and he has some peripheral neuropathy issues as well. Nantzie, thanks so much for sharing your symptoms and experience with this type -- it helped us a lot ! Now that we're understanding that the gastro angle is only one manifestation, this is becoming much clearer. Cheers, Deb
  2. We did genetic testing on my husband and son through Enterolab, and now that I have the results, I'm thrown as to the difference between celiac/gluten intolerance/gluten sensitivity. (Is there even a difference between the last two?) I know celiac disease involves damage to the intestine, but can gluten intolerance do the same? What ARE the manifestations of gluten intolerance, and what would happen if someone who was double-gened gluten sensitive continued consuming gluten? Here are the results: Husband: Gluten Sensitivity Gene Test HLA-DQB1 Molecular analysis, Allele 1 0502 HLA-DQB1 Molecular analysis, Allele 2 06xx Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6) Son: Gluten Sensitivity Gene Test HLA-DQB1 Molecular analysis, Allele 1 0301 HLA-DQB1 Molecular analysis, Allele 2 0502 Serologic equivalent: HLA-DQ 3,1 (Subtype 7,5) Both had this message: Interpretation Of HLA-DQ Testing: Although you do not possess the main genes predisposing to celiac sprue (HLA-DQ2 or HLA-DQ8), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (DQ1 or DQ3 not subtype 8). Having two copies of a gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe. We all eat gluten-free at home, but my husband consumes gluten at work. (The rest of us are entirely gluten-free.) My son had symptoms which improved on the gluten-free diet. My husband had no symptoms. The more I read about this, the more confused I am. Some articles seem to indicate that gluten sensitivity to celiac disease is a progression of sorts, while others seem to draw a clear line between the two, with gluten intolerance being rather vaguely defined. Any light you could shed on this would be most appreciated! Thanks! Deb
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