Thiamine and Autoimmune Diseases
Human Leukocyte Antigens are coded for in our DNA. They act like street signs on cells so the body knows that they are "Self". Tissue typing in organ transplantation looks for donors with "Self" street signs similar to the recipient's in order to prevent rejection of the transplanted organ.
The HLA DQ genes code for immune cells. Some immune cells are encoded to recognize certain protein strings when that protein string attaches to the receptor on
I've been researching Celiac disease and Thiamine deficiency for a long time. Recently I found information that shows a relationship between the lack of Thiamine and Celiac Disease pathogenesis. What do you think?
Thiamine is used in the mitochondria to produce energy (ATP) in the body for cells use as they go about their various functions. Various chemical reactions take place as the glucose moves through the transport chain in the mitochondria. Oxygen is needed at the end of the trans
Thiamine deficiency causes hypoxia. Hypoxia-Inducible Factor 1α binds to thiamine transporter SLC19A3 and activates it to increase thiamine uptake. HIF-1α signaling also triggers the release of inflammatory cytokines and inflammatory cells proliferation. HIF-1a affects genes in the nucleus, entering through micro-pores. Hypoxia and high levels of HIF-1a are found in many autoimmune diseases and cancer.
"HIF-1α shows its functions through translocating into the nucleus, dimerizing with H
