"Why Are Dietary Interventions Still Not Mainstream?
While there is greater knowledge of the effects of pharmaceutical therapies for arthritis, there is less knowledge of the effects of many nutrients. And even though there is evidence that physician discussions of diet make a positive influence on patient dietary selections, these conversations are not common in clinical practice. There is a global deficiency of nutrition education in physician training, including the use of nutrients to m
I found this article about a study using high doses of Niacin to treat Glioblastoma.
Glioblastoma is an aggressive brain cancer.
My mother died from Glioblastoma.
Can a Common Vitamin Fight the Most Aggressive Brain Cancer?
https://scitechdaily.com/can-a-common-vitamin-fight-the-most-aggressive-brain-cancer/
And...
A phase I-II study of niacin in patients with newly diagnosed glioblastoma: safety and interim phase II analysis
https://link.springer.com/artic
I've been researching Celiac disease and Thiamine deficiency for a long time. Recently I found information that shows a relationship between the lack of Thiamine and Celiac Disease pathogenesis. What do you think?
Thiamine is used in the mitochondria to produce energy (ATP) in the body for cells use as they go about their various functions. Various chemical reactions take place as the glucose moves through the transport chain in the mitochondria. Oxygen is needed at the end of the trans
Thiamine deficiency causes hypoxia. Hypoxia-Inducible Factor 1α binds to thiamine transporter SLC19A3 and activates it to increase thiamine uptake. HIF-1α signaling also triggers the release of inflammatory cytokines and inflammatory cells proliferation. HIF-1a affects genes in the nucleus, entering through micro-pores. Hypoxia and high levels of HIF-1a are found in many autoimmune diseases and cancer.
"HIF-1α shows its functions through translocating into the nucleus, dimerizing with H
Thiamine and Autoimmune Diseases
Human Leukocyte Antigens are coded for in our DNA. They act like street signs on cells so the body knows that they are "Self". Tissue typing in organ transplantation looks for donors with "Self" street signs similar to the recipient's in order to prevent rejection of the transplanted organ.
The HLA DQ genes code for immune cells. Some immune cells are encoded to recognize certain protein strings when that protein string attaches to the receptor on
People with diabetes may have genetic variations that cause their thiamine transporters to not absorb thiamine as well. This functional thiamine deficiency can cause inflammation and diabetes. Thiamine is needed to down regulate the inflammatory cytokines.
Genetic Variants of the Human Thiamine Transporter (SLC19A3, THTR2)—Potential Relevance in Metabolic Diseases
https://pmc.ncbi.nlm.nih.gov/articles/PMC11988879/
Thiamine, gastrointestinal beriberi and acetylcholine sign
Bovine milk caseins and transglutaminase-treated cereal prolamins are differentially recognized by IgA of celiac disease patients according to their age
https://pubmed.ncbi.nlm.nih.gov/19290628/
Gliadin and Casein Metabolism: Synthesis of Gliadomorphin and Casomorphin and Their Biological Consequences
https://www.researchgate.net/publication/397908713_Gliadin_and_Casein_Metabolism_Synthesis_of_Gliadomorphin_and_Casomorphin_and_Their_Biological_Consequences
Effec
My health declined when I was taking an SSRI. I learned that certain drugs can cause Thiamine deficiency. SSRI's are one of those drugs. Depression is a symptom of Thiamine deficiency. It's also a symptom of Vitamin D deficiency.
I was eating the Standard American Diet at the time, which is a diet that causes High Calorie Malnutrition. Consuming large amounts of carbohydrates without a corresponding increase in Thiamine causes a Thiamine deficiency. For every extra 1000 calories an ad
Yes, I do have Celiac disease. I had symptoms since infancy, but they were explained away as character flaws. I was told my stomach aches were faked to avoid going to school and other responsibilities, or to spoil family fun, and that my Dermatitis Herpetiformis was caused by being dirty and not bathing properly.
I wasn't diagnosed with Celiac until midlife. My various health problems for which I sought medical attention were treated as separate entities. No medical professional looked
Exposure to gluten (and casein in those sensitive to it) can cause an increased immune response and inflammation for months afterwards.
The immune cells that make tTg IgA antibodies which are triggered today are going to live for about two years. During that time, inflammation is heightened. Those immune cells only replicate when triggered. If those immune cells don't get triggered again for about two years, they die without leaving any descendents programmed to trigger on gluten and cas
I like Life Extension Bioactive Complete B Complex. It contains the easily activated forms of B vitamins needed by people with the MTHFR genetic variation often found with Celiac disease.
Avoid B Complex vitamins if they contain Thiamine Mononitrate if possible. (Read the ingredients listing.) Thiamine Mononitrate is the "shelf-stable" form of B 1 that the body can't utilize. B vitamins breakdown when exposed to heat and light, and over time. So "shelf-stable" forms won't breakdown s
Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements
https://pubmed.ncbi.nlm.nih.gov/10919966/
The effects of endurance training and thiamine supplementation on anti-fatigue during exercise
https://pmc.ncbi.nlm.nih.gov/articles/PMC4241913/
Effects of thiamine supplementation on exercise-induced fatigue
https://pubmed.ncbi.nlm.nih.gov/8815395/
Exploring the Relationship between Micronutrients and Athletic Performance: A Comprehensive Scie
Thiamine, gastrointestinal beriberi and acetylcholine signaling
https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/#ref3
https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/#ref3
From Section 3:
"In conclusion, TD limited to the gastrointestinal system may be an overlooked and underdiagnosed cause of the increasingly common gastrointestinal disorders encountered in modern medical settings. Left unattended, it may progress to wet or dry beriberi, most often observed as Wernicke e
Below are links to studies showing that vitamins in the B Complex help relieve anxiety and depression.
References:
Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey
https://pubmed.ncbi.nlm.nih.gov/33848753/
The Role of Vitamins and Minerals in Psychiatry
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/
Thiamine and benfotiamine: Focus on their therapeutic potential
References:
Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398893/
Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681258/
Gluten-free diet intervention reduces thiamine intake in two weeks, increases glycaemic response and decreases body weight in four weeks, with no long
Interesting Reading about vitamins needed for bone health
Nutritional Aspects of Bone Health and Fracture Healing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804294/
And...
There is a significantly inverse relationship between dietary riboflavin intake and prevalence of osteoporosis in women but not in men: Results from the TCLSIH cohort study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941537/
And...
Nutrients and Dietary Patterns Related to Osteopo
I developed vitamin and mineral deficiencies before my diagnosis.
Thiamine deficiency made me have a voracious appetite at some times and at other times, I had no appetite at all. Thiamine affects the satiety center in the brain that tells you to eat more or you've had enough.
Thiamine deficiency also causes nausea. I would wake up ravenous, but have nausea so bad I didn't want to eat. Nausea sometimes occurred after eating. My food just sat there and didn't seem to move. Gast
According to recent research, updates to the gluten challenge are being implemented.
Recommended intake of gluten should be increased to 10 grams of gluten per day for at least two weeks. Or longer.
While three grams of gluten will begin the immune response, ten grams of gluten is needed to get antibody levels up to where they can be measured in antibody tests and changes can be seen in the small intestine.
Keep in mind that there are different amounts of gluten in different kin
I found these neat articles.
B cells defined by immunoglobulin isotypes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985177/
And...
Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1
https://pubmed.ncbi.nlm.nih.gov/26411688/
And...
Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478888/
A
I went through very similar symptoms, being misdiagnosed and told it was all in my head for most of my life. It's not all in our head. It's what's NOT in doctors' heads. Doctors don't think of vitamin deficiencies as causes of symptoms like we have. Doctors are trained to prescribe pharmaceuticals in medical institutions funded by pharmaceutical companies.
I've experienced the limbs falling asleep.....
Vitamin B12 deficiency neuropathy; a rare diagnosis in young adults: a case re
https://www.frontiersin.org/articles/10.3389/fnut.2019.00048/full
Previously, we examined B cell immunometabolism in the intestine. In the intestine, naïve immunoglobulin (Ig) M+ B cells differentiate into IgA+ B cells in Peyer's patches (PPs) by class switching, and then IgA+ B cells differentiate into IgA-producing plasma cells in the intestinal lamina propria (20). Naïve B cells in PPs preferentially use a vitamin B1-dependent TCA cycle for the generation of ATP. However, once the B cell
Supplementing with the eight essential B vitamins can help stop gluten cravings.
Wheat products are required by law to be enriched with vitamins and minerals lost in processing. In other words, wheat products have vitamins added to them.
Celiac Disease damages the small intestine where the B vitamins are normally absorbed. We often do not get enough B Complex vitamins while we are healing because of the damage done by Celiac and because the gluten free diet can be deficient in these
Interesting articles about Thiamine
Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/#idm140604396876032title
Shoshin Beriberi in Critically-Ill patients: case series
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443551/
Wernicke's encephalopathy because of pancreatitis in a young boy.
https://www.ncbi.nlm.nih.gov/pubmed/21091939
https://onlinelibr
I found this site linked below, written by a pathologist for doctors doing vitamin deficiency testing.
Open Original Shared Link
Points of interest include:
Patient should not be taking supplements at time of testing. Ideally, supplements should be discontinued three to six weeks before testing for vitamin deficiencies. There are exceptions. Most B vitamins can not be stored in the body longer than three weeks. Supplementing with vitamins will skew the tests for deficiencies
