Thiamine Thiamine Thiamine

Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398893/

Hiding in Plain Sight: Modern Thiamine Deficiency

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/

Thiamine and benfotiamine: Focus on their therapeutic potential

https://pubmed.ncbi.nlm.nih.gov/38034619/

Thiamine and benfotiamine: Focus on their therapeutic potential

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10682628/

More information....

Damage to the small intestine (villus atrophy) results in malabsorption of essential vitamins and minerals.  B vitamins cannot be made by the human body.  We must get sufficient B vitamins from our diet every day because B vitamins cannot be stored.  Unfortunately, the gluten free diet can be low in essential nutrients, especially if gluten containing products (which are required by U.S. law to be enriched and fortified with vitamins and minerals) are replaced with gluten free facsimile foods (not required to be enriched and fortified at all).  

Taking B Complex supplements boosts the availability and absorption of these essential vitamins.  

Discuss the benefits of supplementing with your Nutritionist or dietician, as well as your doctor.  Unfortunately, many doctors are not as well educated about the importance of vitamins as we would wish.  As a microbiologist, I understood how important these essential vitamins are to cellular function and health.  

Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet

https://pubmed.ncbi.nlm.nih.gov/19154566/

...Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet

https://pubmed.ncbi.nlm.nih.gov/34445038/

And...Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

https://pubmed.ncbi.nlm.nih.gov/33912967/

... Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey

https://pubmed.ncbi.nlm.nih.gov/33848753/

Thiamine Vitamin B 1 has been shown to alleviate depression and promote intestinal healing.  

...Thiamine and benfotiamine: Focus on their therapeutic potential

https://pubmed.ncbi.nlm.nih.gov/38034619/

...Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/

And...Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial

https://pubmed.ncbi.nlm.nih.gov/26984349/

And...Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults

https://pubmed.ncbi.nlm.nih.gov/23173173/

Riboflavin Vitamin B 2 helps....

Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060244/

Pyridoxine Vitamin B 6 helps...

Vitamin B6: A new approach to lowering anxiety, and depression?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577631/

And Folate Vitamin B 9....

Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490031/

And Vitamin B 12 Cobalamine....

Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression

https://pubmed.ncbi.nlm.nih.gov/33251075/

And Niacin Vitamin B 3....

Dietary niacin intake in relation to depression among adults: a population-based study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506255/

....Diagnostic value of niacin skin blunting response in adolescent patients with depression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634130/

....Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode

https://pubmed.ncbi.nlm.nih.gov/23380314/

I found taking Tryptophan, a form of Niacin Vitamin B 3, more effective than any SSRI.  Tryptophan is used by our bodies to make more Serotonin. 

Serotonin is normally made in the intestines, but inflammation due to Celiac disease can reduce its production.  With less serotonin being made, depression results.  SSRIs prevent serotonin from being reabsorbed, so more serotonin is available. 

However, Tryptophan is used to easily make more Serotonin.  With more serotonin available, there's no need for a SSRI. 

Do NOT take Tryptophan while taking an SSRI, which can result in Serotonin Syndrome (too much serotonin that can result in physical and mental symptoms).  

Demystifying serotonin syndrome (or serotonin toxicity)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184959/

My doctors had prescribed a plethora of pharmaceuticals which resulted in me developing Serotonin Syndrome.  Easily corrected by stopping the pharmaceuticals.  I just take Tryptophan since without problems.  

And Vitamin D helps, too...

Is Vitamin D Important in Anxiety or Depression? What Is the Truth?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468237/

All of these vitamins help heal the digestive system and lower inflammation.  

More research articles on Malnutrition in Celiac Disease

Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398893/

Nutritional Status and Metabolism in Celiac Disease: Narrative Review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419423/

The Gluten-Free Diet for Celiac Disease: Critical Insights to Better Understand Clinical Outcomes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537989/

Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920475/

Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681258/

Knowledge of Medical Students and Medical Professionals Regarding Nutritional Deficiencies in Patients with Celiac Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224609/

Doctors are required to take twenty hours of nutritional education while in medical schools for seven years.  Mostly vitamin deficiency diseases are thought to be in the past or in starving countries.  So doctors do not recognize vitamin deficiency disease symptoms in the early stages.  Celiac Disease causes vitamin deficiencies because the lining of the small intestine is damaged and unable to absorb nutrients.  We're starving for nutrients, those vitamins our bodies cannot make, and minerals, too.  We may be consuming sufficient calories, but without a sufficient amount of those vitamins, our bodies cannot process the carbohydrates, proteins and fats from our diet and turn them into energy and building blocks for cell repair and for our bodies' health.  Instead, our bodies can store those extra calories as fat to burn for energy, or start burning muscle.  This is High Calorie Malnutrition.  A diet high in carbohydrates requires an additional .5 mg (minimum) of Thiamine B1 to process those carbohydrates.  Benfotiamine, a form of Thiamine, has been shown to promote healing in the intestines. 

Vitamins are needed to decrease Inflammation and regulate the immune system.  Vitamins are needed for cell repair and replacement, so our villi can grow back and absorb nutrients properly for us.  

Gluten containing foods are required to be enriched with vitamins and minerals lost during processing.  Gluten Free facsimile foods are Not required to be enriched with vitamins and minerals.  The Gluten Free diet can be low in the B vitamins.  Talk to your doctor and nutritionist about supplementing with vitamins and minerals while healing.  

Yes, unfortunately many doctors are not clear on proper testing protocol for Celiac Disease, much less the treatment.

If we remove gluten from our diet, the antibodies our bodies produce against gluten go down.  

I went gluten free on my own.  My doctors had laughed at me when I suggested testing for Celiac Disease.  Later, to get a proper diagnosis, I couldn't finish the gluten challenge because my body reacted so extremely.  Symptoms get way worse with reintroduction. 

A gluten challenge requires 10 grams (4-6 slices of bread, pizza, etc.) to provoke sufficient antibody production so that the antibodies get into the bloodstream.  Less than 10 grams will make one sick (the antibodies stay in the gut wreaking havoc), but won't elicit sufficient antigluten antibodies in the bloodstream. 

I ended up getting diagnosed by DNA testing and improvement on a gluten free diet.  Celiac Disease is genetic.  Having Celiac genes doesn't mean you have active Celiac Disease, just the potential to develop it.  Your genes don't change, so no gluten challenge required.  Improvement on a gluten free diet points to active Celiac genes.

If you remove gluten from your diet, you also remove a big source of B vitamins since wheat/gluten containing products are required to be enriched with vitamins lost in processing.  Malabsorption of essential nutrients due to damaged intestines caused by Celiac Disease and reduced sources of vitamins and minerals results in malnutrition, aka vitamin deficiencies.  There's eight B vitamins, each of which are needed for proper nerve and muscle function.  Being low in these vitamins can cause the symptoms you and I have experienced.  

Most B vitamins can be stored for a month, but Thiamine B1 can become depleted in as little as three days to three weeks.  Thiamine is needed to produce energy for the cells to function.  So nerve cells misfire, muscle cells misfire, and the brain, where all these messages get sent, is affected.  MRIs showing brain damage caused by Thiamine deficiency is most frequently found postmortem, though changes may be seen before then, and damage is reversible is possible, IF recognized and treated properly and promptly.  My doctors didn't recognize my symptoms of nutritional deficiencies, but having studied microbiology and nutrition at university, I did, as far fetched as it sounded.  I took over-the-counter vitamins and had symptom improvement within an hour.  

Look at this study where people (not diagnosed with Celiac Disease nor malabsorption problems) became deficient in Thiamine quickly.  They had no long-term problems because they did Not continue the Gluten free diet like we have to do.

Gluten-free diet intervention reduces thiamine intake in two weeks, increases glycaemic response and decreases body weight in four weeks, with no long term nutritional deficiencies

https://pubmed.ncbi.nlm.nih.gov/34583628/

More Interesting Reading:

Nutritional Deficiencies in Celiac Disease: Current Perspectives

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703793/

Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet

https://pubmed.ncbi.nlm.nih.gov/19154566/

Thiamine deficiency disorders: a clinical perspective

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/

Insufficiency of B vitamins with its possible clinical implications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417807/

B Vitamins: Functions and Uses in Medicine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662251/

Hiding in Plain Sight: Modern Thiamine Deficiency

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533683/