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Detroit Style Pizza Co. Introduces Flavorful Gluten-Free Pizza - Houston Chronicle

Scott Adams

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Scott Adams
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Houston Chronicle

People with celiac disease and gluten sensitivity can finally enjoy a great-tasting gluten-free pizza plus breadsticks at Detroit Style Pizza Co.'s two metro-Detroit locations and nationwide via mail order Detroit Style Pizza Co. introduces another ...

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    • knitty kitty
      calcium malabsorption that does not resolve with supplementation

      By knitty kitty · Posted

      @Allias, Do you have low magnesium levels?   "The serum levels of parathyroid hormone and magnesium depend on each other in a complex manner. The secretion of parathyroid hormone by the parathyroid is physiologically controlled by the serum calcium level, but magnesium can exert similar effects. While low levels of magnesium stimulate parathyroid hormone secretion, very low serum concentrations induce a paradoxical block. This block leads to clinically relevant hypocalcemia in severely hypomagnesiemic patients. The mechanism of this effect has recently been traced to an activation of the alpha-subunits of heterotrimeric G-proteins. This activation mimicks activation of the calcium sensing receptor and thus causes inhibition of parathyroid hormone secretion. In addition to the effects of magnesium on parathyroid hormone secretion, parathyroid hormone in turn regulates magnesium homeostasis by modulating renal magnesium reabsorption. The distal convoluted tubule is of crucial importance for parathyroid hormone-regulated magnesium homeostasis." Magnesium and the parathyroid https://pubmed.ncbi.nlm.nih.gov/12105390/  
    • Wheatwacked
      Problems

      By Wheatwacked · Posted

      I'm guessing it was Manic Depression. I was depressed for 30 years.  It did not go away until I increased vitamin D3 to 10,000 IU (250 mcg) a day.  Three days after going from 8000 IU to 10,000 IU a great dark cloud lifted. Unless you are deficient in Calcium intake from food, don't supplement with calcium.  A high Parathyroid Hormone PTH blood test would indicate insufficient vitamin D causing calcium absorption problems..  High intakes of calcium can be associated with coronary artery calcification. In one study, calcium and vitamin D supplementation accelerated vascular calcification. Thousands of studies of vitamin D supplementation without Calcium have shown that vitamin D is safe even as much as 20,000 IU a day. Vitamin D Is Not as Toxic as Was Once Thought That is confusing. Many gluten processed foods are fortified with vitamins that you no longer get with gluten-free foods.  Doctors don't recognize this as Knitty Kitty mentions. Sorry for the loss of your friend.   I see a pattern where a person with low vitamin D has a stressful situation, mentally or physically like Covid or a cold even allows the immune system to get out of control.  Low vitamin D is common in Celiac Disease.  You seem to fit the pattern. Low choline (eggs and meat) can cause problems digesting fat and Low Thiamine can cause gastrointestinal beriberi.  Iodine deficiency is a growing concern.  Low B12 can be the cause of anemial is you are vegan.
    • Wheatwacked
      calcium malabsorption that does not resolve with supplementation

      By Wheatwacked · Posted

      high levels of parathyroid hormone (PTH) can indicate a vitamin D deficiency. The "normal level" of 25(OH) D is 80 ng/ml (200 nmol/L). That is the level our body sets as it's normal limit when we don't limit sunshine.  For some people like me it takes 10,000 IU a day to maintain that.  Lack of enough sun and malabsorption of vitamin D orally.  
    • Allias
      calcium malabsorption that does not resolve with supplementation

      By Allias · Posted

      No, all this is related to calcium. Why would I then have a low ionized calcium level and a high PTH (hormone that controls the balance of blood calcium)? Your thiamine story doesn't hold up.
    • knitty kitty
      calcium malabsorption that does not resolve with supplementation

      By knitty kitty · Posted

      Welcome to the forum, @Allias, For the growth and maintenance of bones, more vitamins and minerals are needed than those you are taking.   Bones need calcium, as well as magnesium and iron, but also trace elements like zinc, copper, selenium, manganese, and boron.   Bones need vitamins like Vitamin D and Folate (not synthetic Folic Acid which the body doesn't utilize well), but bones also need Vitamin A,  Vitamin K, Cobalamine B12, Pyridoxine B6, Riboflavin B2, Choline B4, and Thiamine B1.   High PTH and high alkaline phosphatase (ALP) levels may indicate a deficiency in Thiamine B1.  The enzyme Alkaline phosphotase combines with Thiamine to make Adenosine Triphosphate (ATP), the "energy coinage" used in the body which is required to build bones or perform any body function.  Increased levels of ALP and PTH are produced when there's not sufficient Thiamine to meet the demands.  Bones, the liver, the thyroid and the gastrointestinal tract can all make ALP when there's a shortage of Thiamine in each of those organs.  The gastrointestinal tract makes ALP when increased thiamine absorption is required.  Thiamine is needed to attach to calcium so it can be absorbed.   Thiamine deficiency disorders include muscle spasms in muscles like the neck muscles, and neuropathy.   What is your Vitamin D level? Do talk to your doctor and nutritionist about supplementing with essential nutrients while recovering.   References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914453/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352179/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/ https://pubmed.ncbi.nlm.nih.gov/4003329/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568373/ https://pubmed.ncbi.nlm.nih.gov/36428888/ https://pubmed.ncbi.nlm.nih.gov/1156856/ https://pubmed.ncbi.nlm.nih.gov/38034619/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398819/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/
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