No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Can High Definition Endoscopy Increase Celiac Disease Detection?

Celiac.com 05/02/2016 - Even with endoscopies, physicians can still miss some cases of celiac disease. A team of researchers recently set out to determine if I-Scan, or virtual chromo-endoscopy, could improve sensitivity of endoscopy to detect markers of villous atrophy in patients with celiac disease.

Photo: CC---truthout.orgThe research team included Hugo A. Penny, Peter D. Mooney, Mitchell Burden, Nisha Patel, Alexander J. Johnston, Simon H. Wong, Julian Teare, and David S. Sanders. They are variously affiliated with Royal Hallamshire Hospital in Sheffield, UK, and with St Mary's Hospital in London, UK.

For their study, the team assessed patients from two UK hospitals in 3 groups.

  • For Group 1, they used standard high definition, white light endoscopy (WLE).
  • For Group 2, they used WLE plus I-Scan.
  • For Group 3, they used a non-high definition control group.

They recruited an initial group of 758 patients. That group was 62% female, with an average age of 52. They recorded the presence of endoscopic markers, and took at least 4 duodenal biopsies from all patients. They also made concurrent blood tests, and compared observations with patient histology. The patient breakdown was as follows: Group 1: 230; Group 2: 228; Group 3: 300.

Ads by Google:

The team made 135 new diagnoses of celiac disease, with 21 cases in Group 1, 24 in Group 2, and 89 in Group 3. The sensitivity for detection of endoscopic markers of villous atrophy was significantly higher in both Group 1 at 85.7% and Group 2 at 75%, compared to non-high definition controls at 41.6%.

There was no significant difference between high definition only and I-Scan groups.

In non-high definition endoscopy, they found that missed diagnosis was mainly due to lesser degrees of villous atrophy (p = 0.019) and low tTG titre (p = 0.007).

From their data, the team concluded that high definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
aims
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
09 May 2016 1:33:12 PM PDT
I would like to have read what Iscan actually is in this article. Doing a search for it brings up many different answers.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I have problems with corn so I have to be aware of that when shopping for spices and gluten-free baking products as Raven pointed out. I use Badia which states certified gluten-free As for encouragement drink lots of water and rest. A nice soak in tub sometimes is soothing. I hope it pa...

Nov 18, 2015 >.< yeah it was older, Checked some newer testing others have done and found the more recent ones under 5ppm.....so perhaps they got their act together. I still am that old dog recalling being hit and growling at them about it.

Yes, I've seen these and believe that these were taken during the time period that GM had an issue with a contaminated truck, and this caused them to issue a recall on batches made at a plant. If I am correct about this, that was years ago, and they have corrected that issue. What is the link for...

Granbia is wholesale only, GFHarvest you can order and they ship anywhere sales under http://www.glutenfreeoats.com/gluten-free-oatmeal/ Ok it is rare...1/5 boxes seems to be a maybe..... Lab: Bia Diagnostics (www.biadiagnostics.com) Sample ...

Oh, and how much do Granbia and GFHarvest cost, and how available are these cereals?