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RCDII Alters Normally Diverse and Plastic Innate IEL Compartment
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams
Innate IEL compartment loses differentiation potential in patients with RCDII. Photo: CC--Joe Dyer
Celiac.com 08/16/2016 - Celiac disease changes the composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment, specifically, the composition and function of duodenal intraepithelial T cells.
The intestinal tract is also home to four types of CD3-negative intraepithelial lymphocytes (IELs) with largely unknown function: CD56(-)CD127(-); CD56(-)CD127(+); CD56(+)CD127(-) and CD56(+)CD127(+).
A team of researchers wanted to gain insight into the potential function of these innate IELs in health and disease. Specifically, they wanted to assess how the composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in celiac disease.
The research team included F Schmitz, Y Kooy-Winkelaar, AS Wiekmeijer, MH Brugman, ML Mearin, C Mulder, S Chuva de Sousa Lopes, CL Mummery, FJ Staal, J van Bergen, F Koning. They are variously affiliated with the Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands, the Department of Immunohematology and Blood Transfusion at Leiden University Medical Center in Leiden, The Netherlands, the Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands, the Department of Gastroenterology at the Free University Medical Center, Amsterdam, The Netherlands, and with the Department of Anatomy and Embryology at Leiden University Medical Center in Leiden, The Netherlands.
For their study, the team measured the phenotypes, relative abundance and differentiation potential of these innate IEL subsets in duodenal biopsies from controls and patients with celiac disease or patients with refractory celiac disease type II (RCDII).
Hierarchical clustering analysis of the expression of 15 natural killer and T cell surface markers showed that innate IELs differed markedly from innate peripheral blood lymphocytes and divided innate IEL subsets into two main branches: a CD127(-) branch expressing high levels of interleukin (IL) 2/15Rβ but no IL-21R, and a CD127(+) branch with the opposite phenotype. While celiac disease was characterized by the contraction of all four innate IEL subsets, a selective expansion of CD56(-)CD127(-) and CD56(-)CD127(+) innate IEL was detected in RCDII.
In vitro, in the presence of IL-15, CD56(-)CD127(-) IEL from controls and patients with celiac disease differentiated into functional natural killer and T cells, the latter largely dependent on notch-signaling. This did not occur in patients with RCDII. Furthermore, compared with non-celiac controls, CD56(-)CD127(-) IEL from patients with celiac disease expressed more intracellular CD3ε and CD3γ and gave more pronounced T cell differentiation.
RCDII changes the normally diverse and plastic innate IEL compartment, and encourages a loss of differentiation potential.
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