No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Flattened Villi is Not Always Caused by Celiac Disease

Am J Clin Pathol. 2004 Apr;121(4):546-50

Celiac.com 04/20/2004 – According to researchers at the Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI, the cause of flattened villi is not always celiac disease. The researchers studied seven patients who experienced several weeks of gluten-sensitivity and the same type of villi injury—"increased lymphoplasmacytic lamina propria inflammation, moderate to complete villous flattening, numerous crypt mitoses, and markedly increased villous intraepithelial lymphocytes (IELs)." All patients were diagnosed with gluten sensitivity, and all returned 9 to 38 weeks later questioning their diagnosis, as their symptoms had substantially or completely disappeared, and clinical improvement in these patients seemed unrelated to their ingestion of gluten. A follow up endoscopy and colonoscopy was performed on these patients 4 to 16 months later, and the results of each showed a normal mucosa.

Ads by Google:

According to the researchers:

"Diseases other than GS can cause marked villous flattening and increased villous IELs in adults. The cause of small bowel mucosal injury is unknown. A similar non-GS-associated clinicopathologic complex, assumed to be due to a protracted viral enteritis or slow regression of a virus-induced immune reaction, occurs in children. The temporal aspects of symptom improvement and mucosal restitution in these 7 patients are similar to acute self-limited colitis. An overly exuberant immune response to an infectious agent is possible."

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Thanks, I appreciate the insight. I will just play it safe and stop eating that type of granola bar. If you have any other advice or comments I would love to hear it. Thanks so much!

Some of that brand are gluten-free , but they will say they are. Some of their bars are not gluten-free because they do not use gluten-free oats. If you are eating non- gluten-free oats or products made with them, there is a possibility that some are actually gluten-free and som...

I know. this will be my first celiac diagnosed halloween. ever where I go I see kit kats which were my favorite. I plan to get some m&m for myself. I still hear from people that 1 won't hurt you, but they don't understand .

Hey, I have a sensitivity to gluten, and I have been gluten free for a while. Today I started having a terrible cramp that I?ve learned I only get when I have had something with gluten in it. Recently I?ve eaten a nature valley whole grain granola bar, I wasn?t sure when I began eating them ...

Thank you! I?ll Get retested.