Do You Have Celiac Disease and Have Questions Or Need Help?
Join Celiac.com's forum / message board and get your questions answered! Our forum has nearly 1 MILLION POSTS, and over 62,000 MEMBERS just waiting to help you with any questions about celiac disease and the gluten-free diet. We'll see you there!
Follow / Share
|Get Email Alerts|
- Safe Gluten-Free Food List (Safe Ingredients)
- Unsafe Gluten-Free Food List (Unsafe Ingredients)
- Gluten-Free Alcoholic Beverages
- Celiac Disease Symptoms
- The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free
- Interpretation of Celiac Disease Blood Test Results
- Is Buckwheat Flour Really Gluten-Free?
Rod-Shaped Bacteria May Trigger Celiac Disease
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
Celiac.com 06/08/2004 – To determine what triggers celiac disease, researchers recently used an electron microscope to look at the jejunal biopsies of several groups of children: A group with untreated celiac disease, one with treated celiac disease, another with challenged celiac disease, and a healthy control group. The researchers discovered rod-shaped bacteria attached to the small intestinal epithelium in both the treated and untreated celiac-disease groups, but not in the healthy control group.
The researchers conclude: "Unique carbohydrate structures of the glycocalyx/mucous layer are likely discriminating features of celiac disease patients. These glycosylation differences could facilitate bacterial adhesion. Ectopic production of MUC2, HD-5, and lysozyme in active celiac disease is compatible with goblet and Paneth cell metaplasia induced by high interferon-gamma production by intraepithelial lymphocytes."
The idea that bacteria may be involved in the pathogenesis of celiac disease is a hypothesis that was also proposed by Roy S. Jamron in an article that originally appeared in the Spring 2004 edition of Celiac.coms Scott-Free Newsletter, which is further supported by this research.
Celiac.com welcomes your comments below (registration is NOT required).
Rod-shaped Bacteria in Proximal Small Intestine Tied to Celiac Disease in Children
Research indicates that rod-shaped bacteria, of the species Clostridium, Prevotella, and Actinomyces, in the proximal small intestine may contribute to some cases of celiac disease in children.... [READ MORE]