See who reacted to this (25740) - Will Commercially Available Gluten Digestive Enzymes Allow Those with Celiac Disease to Eat Wheat Crust Pizza? (+Video)

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1. marnie51
  September 11
2. Scott Adams
  September 10
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About Me
Scott Adams was diagnosed with celiac disease in 1994. Faced with a critical lack of resources, he dedicated himself to becoming an expert on the condition to achieve his own recovery.

In 1995, he founded Celiac.com with a clear mission: to ensure no one would have to navigate celiac disease alone. The site has since grown into one of the oldest and most trusted patient-focused resources for celiac disease and the gluten-free lifestyle.

His work to advance awareness and support includes:

Founding Celiac.com in 1995.

Founding in 2002, and publishing the Journal of Gluten Sensitivity.

Co-authoring with Dr. Ron Hoggan the book Cereal Killers.

Founding The Gluten-Free Mall in 1998, which he later sold in 2014.

Today, Celiac.com remains his primary focus. To ensure unbiased information, the site does not sell products and is 100% advertiser supported.
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AN-PEP Digestive Enzymes Degrade Gluten Better Than Most Other Digestive Enzymes
Celiac.com 06/22/2015 - Currently available digestive enzymes do not fully degrade gluten, and are thus of questionable use for people with celiac disease or gluten intolerance, say a team of researchers. Prior research had shown that post-proline cutting enzyme effectively degrade the immunogenic gluten peptides. Several existing digestive enzyme supplements claim to promote gluten degradation.
The research team set out to assess the degradation of immunogenic gluten epitopes by currently available digestive enzymes. The team included G. Janssen, C. Christis, Y. Kooy-Winkelaar, L. Edens, D. Smith, P. van Veelen, and F. Koning. They are variously affiliated with the Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands, DSM...

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AN-PEP Enzyme Digests Gluten in Healthy Volunteers, So What?
Celiac.com 10/23/2015 - Just as I finished writing about the failure of current commercial enzymes to effectively degrade gluten, an interesting study on another enzyme suggests that there may be help on the horizon, at least for people without celiac disease.
According to the latest press release, in lab conditions, aspergillus niger prolyl endoprotease (AN-PEP) efficiently degrades gluten molecules into non-immunogenic peptides. But so what?
If AN-PEP is to be effective in people with celiac disease or gluten-sensitivity, which would seem to be the whole point of an anti-gluten enzyme, it must effectively digest gluten in "non-healthy" subjects.
A team of researchers recently set out to assess AN-PEP on gluten degradation in a low and high calorie meal in healthy...

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AN-PEP Shows Promise in Breaking Down Gluten in Stomach
Celiac.com 06/26/2017 - Designed to reduce or eliminate symptoms of gluten contamination in gluten-sensitive individuals, the product known as AN-PEP, marketed in the U.S. as Tolerase G, is a prolyl endoprotease enzyme, derived from Aspergillus niger, that has shown promise in breaking down gluten proteins.
The latest news comes in the form of a small study that shows the enzyme to be effective in the stomach itself, where harshly acidic conditions render many enzymes ineffective.
Speaking to an audience at Digestive Disease Week (DDW) 2017, lead investigator Julia König, PhD, of Sweden's Örebro University, said that the enzyme was special, because…[t]here are a lot of enzymes on the market, but this functions in the stomach where the pH is acidic. Often enzymes don't work in thi...

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AN-PEP Successfully Degrades Gluten in Rye Sourdough Products
Celiac.com 09/24/2018 - A team of researchers recently set out to investigate the degradation of gluten in rye sourdough products by means of a proline-specific peptidase.
The research team included Theresa Walter, Herbert Wieser, and Peter Koehler, with the Deutsche Forschungsanstalt für Lebensmittelchemie, Leibniz Institut in Freising, Germany.
Their team monitored gluten content of rye sourdough during fermentation using competitive ELISA based on the R5 antibody. The team noted a decrease in gluten over time, but found that even prolonged fermentation did not bring gluten levels below 20 ppm requirement for gluten-free foods.
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Recent Activity
1. 2 hours ago - Wheatwacked replied to Jillian83's topic in Coping with Celiac Disease
  7
  Celiac and dermatitis herpetiformis has taken Me from Me
  
  Have faith, you will survive. I get mine from Pipingrock.com. 500 capsules of 10,000 IU for $22. That is almost two years worth for me. 250 caps 5000 IU for $6.69 if you only take 5,000 a day. It's like half the price of Walmart.
  
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2. 12 hours ago - Wheatwacked replied to Riley.'s topic in Related Issues & Disorders
  5
  
  Outgrow celiac?
  
  Testing can't alone be trusted. Else why would it take so many years of testing and retesting and misdiagnosis to finally be told, yes you have Celiac Disease. As to what to eat, I like pre 1950 style food. Before the advent of TV dinners. Fresh food is better for you, and cooking from scratch is cheaper. Watch Rachel Ray's 30 Minute Meals for how...
3. 16 hours ago - Scott Adams replied to Jillian83's topic in Coping with Celiac Disease
  7
  Celiac and dermatitis herpetiformis has taken Me from Me
  
  If you have DH you will likely also want to avoid iodine, which is common in seafoods and dairy products, as it can exacerbate symptoms in some people. This article may also be helpful as it offers various ways to relieve the itch--thanks for the tip about Dupixent, and I've added it to the article:
  
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4. 16 hours ago - Scott Adams replied to tiffanygosci's topic in Coping with Celiac Disease
  14
  
  New Celiac Mama in My 30s
  
  I just want to clarify that what I posted is a category of research summaries we've done over the years, and nearly each one shows that there is definitely a connection to celiac disease and migraine headaches. The latest study said: "the study did indicate some potential causal associations between celiac disease and migraine with or without aura, as well...
5. 19 hours ago - SusanJ replied to Jillian83's topic in Coping with Celiac Disease
  7
  Celiac and dermatitis herpetiformis has taken Me from Me
  
  Two months ago, I started taking Dupixent for dermatitis herpetiformis and it has completely cleared it up. I can't believe it! I have had a terrible painful, intensely itchy rash for over a year despite going fully gluten-free. See if your doctor will prescribe Dupixent. It can be expensive but I am getting it free. When the dermatitis herpetiformis was...
  
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