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Official Test Results

IChaseFrisbees

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IChaseFrisbees Explorer
IChaseFrisbees
Posted

Hey everybody, when I was first getting tested for my various intestinal issues I did a stool test through enterolab that came back with...I think it was IGA of 24, and that's how I got on the whole gluten-free diet. So a month ago, about 3 or so months gluten free I finally got the gene testing done through Prometheus, and here were my results:

DQ2-, DQ8-.

According to the little chart, I have a <.01x chance of having Celiac. Can anyone attest to the accuracy of this test, the accuracy of that interpretation and tell me once and for all if I have Celiac, don't have Celiac or it's still a possibility??

Thank you so much for any help.

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ravenwoodglass Mentor
ravenwoodglass
Posted

Gene testing is in it's infancy and while it can be a part of the diagnostic picture it is far from conclusive. There are 7 other genes associated with celiac but most are not recognized as celiac genes in the US. There are firmly diagnosed celiacs that do not have either of those two genes. I am one of them. In the US my celiac gene would have given me a diagnosis of RA not celiac. I am someone who was really glad to be firmly diagnosed before I had gene testing done.

nora-n Rookie
nora-n
Posted

You could ask them WHAT genes you have.

You could have ordered the gene test through enterolab, it si actually done by the American Red Cross. They always give you exactly which beta chain you have.

Thing is, that 6% of celiac have just half a gene, and those are not reported on such a + or - test.

For DQ2, the half gene is the 05* alpha chain, and that would probably show up as DQ7 on the Enterolab test, and as a 05* alpha gene on the Prometheus test see thread https://www.celiac.com/gluten-free/index.php?showtopic=54018 where someone tested positive for half a gene.

Usually they do not test for it.

I am negative too. Trying to get a better test.

IChaseFrisbees Explorer
IChaseFrisbees
Posted
  • Author
You could ask them WHAT genes you have.

You could have ordered the gene test through enterolab, it si actually done by the American Red Cross. They always give you exactly which beta chain you have.

Thing is, that 6% of celiac have just half a gene, and those are not reported on such a + or - test.

For DQ2, the half gene is the 05* alpha chain, and that would probably show up as DQ7 on the Enterolab test, and as a 05* alpha gene on the Prometheus test see thread https://www.celiac.com/gluten-free/index.php?showtopic=54018 where someone tested positive for half a gene.

Usually they do not test for it.

I am negative too. Trying to get a better test.

Hmm, I stupidly left my results at home and now I'm back at school, but according to the test those are my genes, the DQ2- and DQ8-. Is that just saying I don't have the DQ2 or DQ8, or is DQ2- a different gene than DQ2?

and @ Ravenwood, the test had 8 genes on it, along with their individual likelihood of causing Celiac, are you saying there are 7 more than the 8? I'll be able to post exactly what the 8 were this weekend when I get the results from my parent's house.

The way my doctor described Celiac is that not everyone who has the gene has Celiac, but everyone who has Celiac has the gene, is that correct? So if I don't have the gene it's impossible for me to have Celiac, right?

Yet I have DQ2- and DQ8-...Are those segments of the DQ2 and 8 gene?

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