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knitty kitty

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Latest Celiac Disease News & Research:

Blog Entries posted by knitty kitty

  1. knitty kitty

    Cocoa Powder and SCFAs

    By knitty kitty,


    My Journey
    I'm not a big fan of inulin in chicory root.  I found it a bit rough on my digestive system.  Members of the alum family (onions, leeks, garlic) were studied for the thiamine forms they contain which led to Benfotiamine and Thiamine TTFD, but there's limitations to the amount of garlic one can eat.  Those sulfur burps!  LoL.  But thiamine does help influence the kinds of bacteria that grow in the intestinal tract and the production of Short Chain Fatty Acids that the brain ...
  2. knitty kitty
    Neutrophils and neutrophil extracellular traps in diabetes mellitus and its complications: Mechanisms and therapeutic implications
    https://pmc.ncbi.nlm.nih.gov/articles/PMC13098529/
    Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity
    https://pubmed.ncbi.nlm.nih.gov/38654733/
    Decreased Neutrophils Are Associated With Reduced Risk of Type 2 Diabetes Incidence: Results From the CORDIOPREV Study
    https...
  3. knitty kitty

    Why Are Dietary Interventions Still Not Mainstream?

    By knitty kitty,


    Nutrition and Gluten free diet
    "Why Are Dietary Interventions Still Not Mainstream?
    While there is greater knowledge of the effects of pharmaceutical therapies for arthritis, there is less knowledge of the effects of many nutrients. And even though there is evidence that physician discussions of diet make a positive influence on patient dietary selections, these conversations are not common in clinical practice. There is a global deficiency of nutrition education in physician training, including...
  4. knitty kitty

    Gastrointestinal Beriberi

    By knitty kitty,


    Gastrointestinal Beriberi
    Thiamine, gastrointestinal beriberi and acetylcholine signaling
    https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/#ref3
    https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/#ref3
    From Section 3:
    "In conclusion, TD limited to the gastrointestinal system may be an overlooked and underdiagnosed cause of the increasingly common gastrointestinal disorders encountered in modern medical settings. Left unattended, it may progress to wet or dry beriberi...
  5. knitty kitty
    I found this article about a study using high doses of Niacin to treat Glioblastoma. 
    Glioblastoma is an aggressive brain cancer.
    My mother died from Glioblastoma.  
    Can a Common Vitamin Fight the Most Aggressive Brain Cancer?
    https://scitechdaily.com/can-a-common-vitamin-fight-the-most-aggressive-brain-cancer/
     And...
    A phase I-II study of niacin in patients with newly diagnosed glioblastoma: safety and interim phase II analysis
    ...
  6. knitty kitty

    Is Thiamine Deficiency the Beginning of Celiac Disease?

    By knitty kitty,


    Thiamine and Autoimmune Diseases
    I've been researching Celiac disease and Thiamine deficiency for a long time.  Recently I found information that shows a relationship between the lack of Thiamine and Celiac Disease pathogenesis.  What do you think?
    Thiamine is used in the mitochondria to produce energy (ATP) in the body for cells use as they go about their various functions.  Various chemical reactions take place as the glucose moves through the transport chain in the mitochondria.  Oxygen is needed at ...
  7. knitty kitty

    Thiamine Deficiency, Hypoxia, and Autoimmune Disease

    By knitty kitty,


    Thiamine and Autoimmune Diseases
    Thiamine deficiency causes hypoxia.  Hypoxia-Inducible Factor 1α binds to thiamine transporter SLC19A3 and activates it to increase thiamine uptake.  HIF-1α signaling also triggers the release of inflammatory cytokines and inflammatory cells proliferation.  HIF-1a affects genes in the nucleus, entering through micro-pores.  Hypoxia and high levels of HIF-1a are found in many autoimmune diseases and cancer.
    "HIF-1α shows its functions through translocating into the ...
  8. knitty kitty

    Thiamine and Autoimmune Diseases

    By knitty kitty,


    Thiamine and Autoimmune Diseases
    Thiamine and Autoimmune Diseases
    Human Leukocyte Antigens are coded for in our DNA.  They act like street signs on cells so the body knows that they are "Self".   Tissue typing in organ transplantation looks for donors with "Self" street signs similar to the recipient's in order to prevent rejection of the transplanted organ.  
    The HLA DQ genes code for immune cells.  Some immune cells are encoded to recognize certain protein strings when that protein strin...
  9. knitty kitty

    Thiamine and Diabetes

    By knitty kitty,


    Research Links
    People with diabetes may have genetic variations that cause their thiamine transporters to not absorb thiamine as well.  This functional thiamine deficiency can cause inflammation and diabetes.  Thiamine is needed to down regulate the inflammatory cytokines.
     
    Genetic Variants of the Human Thiamine Transporter (SLC19A3, THTR2)—Potential Relevance in Metabolic Diseases
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11988879/
    Thiamine, gastrointestinal beri...
  10. knitty kitty

    Dairy and Celiac: studies

    By knitty kitty,


    Nutrition and Gluten free diet
    Bovine milk caseins and transglutaminase-treated cereal prolamins are differentially recognized by IgA of celiac disease patients according to their age
    https://pubmed.ncbi.nlm.nih.gov/19290628/
     
    Gliadin and Casein Metabolism: Synthesis of Gliadomorphin and Casomorphin and Their Biological Consequences
    https://www.researchgate.net/publication/397908713_Gliadin_and_Casein_Metabolism_Synthesis_of_Gliadomorphin_and_Casomorphin_and_Their_Biological_C...
  11. knitty kitty

    My Story Chapter Two

    By knitty kitty,


    My Journey
    My health declined when I was taking an SSRI.  I learned that certain drugs can cause Thiamine deficiency.  SSRI's are one of those drugs.  Depression is a symptom of Thiamine deficiency.  It's also a symptom of Vitamin D deficiency.
    I was eating the Standard American Diet at the time, which is a diet that causes High Calorie Malnutrition.  Consuming large amounts of carbohydrates without a corresponding increase in Thiamine causes a Thiamine deficiency.  For every ex...
  12. knitty kitty

    My Story

    By knitty kitty,


    My Journey
    Yes, I do have Celiac disease.  I had symptoms since infancy, but they were explained away as character flaws.  I was told my stomach aches were faked to avoid going to school and other responsibilities, or to spoil family fun, and that my Dermatitis Herpetiformis was caused by being dirty and not bathing properly. 
    I wasn't diagnosed with Celiac until midlife. My various health problems for which I sought medical attention were treated as separate entities.  No med...
  13. knitty kitty

    About Celiac Remission

    By knitty kitty,


    Nutrition and Gluten free diet
    Exposure to gluten (and casein in those sensitive to it) can cause an increased immune response and inflammation for months afterwards. 
    The immune cells that make tTg IgA antibodies which are triggered today are going to live for about two years. During that time, inflammation is heightened.  Those immune cells only replicate when triggered.  If those immune cells don't get triggered again for about two years, they die without leaving any descendents programmed to ...
  14. knitty kitty

    Vitamins I Take

    By knitty kitty,


    Nutrition and Gluten free diet
    I like Life Extension Bioactive Complete B Complex.  It contains the easily activated forms of B vitamins needed by people with the MTHFR genetic variation often found with Celiac disease.  
    Avoid B Complex vitamins if they contain Thiamine Mononitrate if possible.  (Read the ingredients listing.)  Thiamine Mononitrate is the "shelf-stable" form of B 1 that the body can't utilize.  B vitamins breakdown when exposed to heat and light, and over time.  So "shelf-stable...
  15. knitty kitty

    Nutrition and Gluten free diet

    By knitty kitty,


    Nutrition and Gluten free diet
    Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements
    https://pubmed.ncbi.nlm.nih.gov/10919966/
    The effects of endurance training and thiamine supplementation on anti-fatigue during exercise
    https://pmc.ncbi.nlm.nih.gov/articles/PMC4241913/
    Effects of thiamine supplementation on exercise-induced fatigue
    https://pubmed.ncbi.nlm.nih.gov/8815395/
    Exploring the Relationship between Micronutrients and A...
  16. knitty kitty

    Nutritional deficiencies on Gluten free diet References

    By knitty kitty,


    My Vitamin Deficiencies
    References:
    Nutritional Imbalances in Adult Celiac Patients Following a Gluten-Free Diet
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398893/
    Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681258/
    Gluten-free diet intervention reduces thiamine intake in two weeks, increases glycaemic response and decreases body...
  17. knitty kitty

    Antibody production and Thiamine

    By knitty kitty,


    Thiamine and IgA production
    I found these neat articles.
    B cells defined by immunoglobulin isotypes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985177/
    And...
    Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B1
    https://pubmed.ncbi.nlm.nih.gov/26411688/
    And...
    Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
    https://www.ncbi...
  18. knitty kitty

    Thiamine Deficiency Disorders

    By knitty kitty,


    My Vitamin Deficiencies
    I developed vitamin and mineral deficiencies before my diagnosis.  
    Thiamine deficiency made me have a voracious appetite at some times and at other times, I had no appetite at all.  Thiamine affects the satiety center in the brain that tells you to eat more or you've had enough.  
    Thiamine deficiency also causes nausea.  I would wake up ravenous, but have nausea so bad I didn't want to eat.  Nausea sometimes occurred after eating.  My food just sat there and ...
  19. knitty kitty

    Gluten Challenge Revised

    By knitty kitty,


    Gluten Challenge
    According to recent research, updates to the gluten challenge are being implemented.

    Recommended intake of gluten should be increased to 10 grams of gluten per day for at least two weeks. Or longer.

    While three grams of gluten will begin the immune response, ten grams of gluten is needed to get antibody levels up to where they can be measured in antibody tests and changes can be seen in the small intestine.  

    Keep in mind that there are dif...
  20. knitty kitty

    Vitamins for Anxiety, Depression and Mental Health

    By knitty kitty,


    Vitamins for Anxiety
    Below are links to studies showing that vitamins in the B Complex help relieve anxiety and depression.  
    References:
    Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey
    https://pubmed.ncbi.nlm.nih.gov/33848753/
    The Role of Vitamins and Minerals in Psychiatry
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046018/
    Thiamine and benfotiamine: F...
  21. knitty kitty

    Interesting Articles about Thiamine

    By knitty kitty,


    My Vitamin Deficiencies
    Interesting articles about Thiamine
    Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/#idm140604396876032title
     
    Shoshin Beriberi in Critically-Ill patients: case series
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443551/
     
    Wernicke's encephalopathy because of pancreatitis in a young boy.
    https://www.ncbi.nlm.ni...
  22. knitty kitty

    More info about Vitamin Deficiencies

    By knitty kitty,


    My Vitamin Deficiencies
    I went through very similar symptoms, being misdiagnosed and told it was all in my head for most of my life.  It's not all in our head.  It's what's NOT in doctors' heads.  Doctors don't think of vitamin deficiencies as causes of symptoms like we have.  Doctors are trained to prescribe pharmaceuticals in medical institutions funded by pharmaceutical companies.  
    I've experienced the limbs falling asleep.....
    Vitamin B12 deficiency neuropathy; a rare diagnosis in yo...
  23. knitty kitty

    Bone health, Osteoporosis and Vitamins

    By knitty kitty,


    Bone Health and Osteoporosis
    Interesting Reading about vitamins needed for bone health
     
    Nutritional Aspects of Bone Health and Fracture Healing
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804294/
    And...
    There is a significantly inverse relationship between dietary riboflavin intake and prevalence of osteoporosis in women but not in men: Results from the TCLSIH cohort study
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941537/
    And...
    Nutrients ...
  24. knitty kitty

    Thiamine and Decreased IgA production

    By knitty kitty,


    Thiamine and IgA production
    https://www.frontiersin.org/articles/10.3389/fnut.2019.00048/full
    Previously, we examined B cell immunometabolism in the intestine. In the intestine, naïve immunoglobulin (Ig) M+ B cells differentiate into IgA+ B cells in Peyer's patches (PPs) by class switching, and then IgA+ B cells differentiate into IgA-producing plasma cells in the intestinal lamina propria (20). Naïve B cells in PPs preferentially use a vitamin B1-dependent TCA cycle for the generation of ATP....
  25. knitty kitty
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