Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Scott Adams
    Scott Adams

    Erosions in the Second Part of the Duodenum in Patients with Villous Atrophy

    Reviewed and edited by a celiac disease expert.

    Gastrointest Endosc. 2004 Jan;59(1):116-8.

    Celiac.com 06/28/2004 - This study, although small, indicates that there may be additional damage to the second part of the duodenum caused by celiac disease, and that this can also be used for a marker for diagnosing the disease:

    Celiac.com Sponsor (A12):

    Dickey W, Hughes D.

    Department of Gastroenterology, Altnagelvin Hospital, Londonderry, Northern Ireland, UK.

    BACKGROUND: There are various, well-documented, duodenal endoscopic markers caused by the villous atrophy of celiac disease. Another abnormality seen in association with villous atrophy, erosions in the second part of the duodenum, is described. To our knowledge, this finding has not been heretofore described in patients with celiac disease.

    METHODS: Five patients with celiac disease and erosions were encountered over a period of 2 years.

    OBSERVATIONS: The erosions were multiple, superficial, and present in the second part of the duodenum but not the duodenal bulb. All 5 patients had findings typical of celiac disease (iron deficiency, osteopenia/osteoporosis), and 4 had at least one other endoscopic marker: scalloped duodenal folds (3), fold loss (2), or mosaic pattern mucosa (2). These patients represented 7% of new cases of celiac disease during the same time period. This pattern of erosion was not observed in over 1200 other patients undergoing upper endoscopy during the study period.

    CONCLUSIONS: In a European population, the finding of erosions confined to the second part of the duodenum is specific for villous atrophy, although sensitivity is low. Erosions in the second part of the duodenum should be added to the list of endoscopic markers of celiac disease.



    User Feedback

    Recommended Comments

    There are no comments to display.



    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    Am J Clin Nutr 2002;75:914-921.
    Celiac.com 06/06/2002 - Results of a recent study conducted by Anneli Ivarsson and colleagues at Umea University in Sweden suggest that continuing to breast-feed infants while they are being introduced to new foods may reduce their risk of getting celiac disease. Dr. Ivarssons study suggests that the cause of celiac disease may include environmental factors, and not just be limited to genetic factors. Their study evaluated the breast-feeding habits of 627 children with celiac disease and 1,254 healthy children, and specifically looked at their responses to newly introduced foods. The results, published in the May issue of the American Journal of Clinical Nutrition, indicate that dietary patterns of infants may have a strong influence on the bodys...


    Roy Jamron
    Celiac.com 04/10/2006 - This study looks at innate immune response to gliadin. The innate immune system responds to gliadin inducing zonulin release and increasing intestinal permeability and may be a factor in the onset of celiac disease, but I question if this leads ultimately to the Ag-specific adaptive immune response seen in patients with celiac disease. This innate response fails to explain why one identical twin may have celiac disease and not the other. Both of the twins as well as people not even susceptible to celiac disease would presumably have this same innate response to gliadin. I again urge celiac disease researchers to consider Open Original Shared Link as the necessary trigger for the onset of celiac disease. The presence or absence of such bacteria does indeed...


    Jefferson Adams
    Celiac.com 04/02/2009 - A recent study finds rates of celiac disease in Polish children are four times higher than estimated, and are only slightly lower than those of other northern European populations—at about 1 in 124 persons. Moreover, they found that symptoms in those diagnosed were typically absent, minimal or vague.
    To date, the only epidemiological studies of celiac disease undertaken in Poland had been carried out within limited areas and involved mainly symptomatic patients or high-risk groups. Until now, celiac was thought to affect about 1 in 400 children in the country. A team of researchers based in Poland recently set out to determine actual rates of celiac disease among Polish children.
    The research team was made up of Anna B. Szaflarska-Poplawska, Monika Parzecka, ...


    Jefferson Adams
    Increased Expression of Hypoxia Inducible Factor 1alpha in Celiac Disease
    Celiac.com 06/01/2010 - A clinical research team recently examined the increased expression of hypoxia inducible factor 1alpha in celiac disease. The team included A. Vannay, E. Sziksz, A. Prókai, G. Veres, K. Molnár, D. Nagy Szakál, A. Onódy, I. R. Korponay-Szabó, A. Szabó, T. Tulassay, A. Arató, and B. Szebeni.
    They are affiliated with the First Department of Pediatrics at Semmelweis University, and with the Department of Gastroenterology-Nephrology of Heim Pal Children's Hospital, both in Budapest, Hungary. They are also involved with the Research Group for Pediatrics and Nephrology, a joint project between the two institutions.
    The team set out to follow-up on the hypothesis that hypoxia inducible factor (HIF) 1 signaling may play a key role in maintaining the barrier function of the...


  • Recent Activity

    1. - PixieSticks replied to PixieSticks's topic in Super Sensitive People
      2

      Working in a kitchen with gluten?

    2. - BoiseNic replied to BoiseNic's topic in Dermatitis Herpetiformis
      11

      Skinesa

    3. - knitty kitty replied to Whyz's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      Feeling ill

    4. - Scott Adams replied to Brianne03's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Advantages vs. Disadvantages of having an official Celiac diagnosis

    5. - Scott Adams replied to Whyz's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      Feeling ill


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,540
    • Most Online (within 30 mins)
      7,748

    Melissarunkle
    Newest Member
    Melissarunkle
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.5k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Whyz
      6
    • Art Maltman
      6
    • JA917
      13
    • Dana Gilcrease
      5
    • GardeningForHealth
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...