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Do we have some data on serum marker correlation with symptoms?

heyitsme
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heyitsme Apprentice
heyitsme
Posted

Personally for example TTG IgA has zero correlation with my symptoms. It's been negative for a long time (even despite eating tiny amounts of gluten, which I know isin't the case for everyone) yet I have still persisting, debilitating symptom (specifically brain fog - and let's just assume it's because of celiac. I'm tired of people suggesting alternative explanations when I'm not even asking for it). We also know that a lot of people need to take "gluten challenge" for their antibodies to be elevated. I guess vast majority actually from what I read. So TTG IgA need proper amount of gluten, but occurence of symptoms does not. The correlation is weak, if any. So I wonder about other serum markers, specifically anti DGP gliadin IgG, which seems to still be positive in my case. Or others. Is there any research on that? Do you have any experiences?

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Scott Adams Grand Master
Scott Adams
Posted

Currently this is in the research phase, but zonulin levels may one day be a way to measure a gluten reaction:

 

Scott Adams Grand Master
Scott Adams
Posted

Another marker in the research stage is cytokine levels.

 

 

heyitsme Apprentice
heyitsme
Posted
  • Author

@Scott Adams Yes, I recently found some article on that: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697360/

There is nice table with all of the markers and cytokines are also there. I found the lab that checks some cytokines, IL8 and IL1b among others which apparently might be useful with celiacs. Will be doing the test next week.

Scott Adams Grand Master
Scott Adams
Posted

Before doing the test you may want to ask the lab whether or not you need to eat gluten before the test is done. I'm not sure what the protocol would be for such a test.

knitty kitty Grand Master
knitty kitty
Posted

@heyitsme,

Anemia, diabetes and Thiamine deficiency will cause poor production of tTg IgA antibodies.  

Have you had a Total IgA test done?

DGP IgG antibodies are still produced with these conditions.  

Some of us are seronegative.  

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      Welcome to the forum! Keep in mind that if you quit eating gluten before all testing is done, you may have inaccurate, possibly false negative, test results.  When you stop eating gluten, your body stops making the antibodies which are measured in the blood tests.  Stopping gluten before an endoscopy may make the intestinal damage harder to detect, and a false negative biopsy may result.  As uncomfortable as it is, finish all testing before going gluten free.  
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      Here is more info about how to do a gluten challenge for a celiac disease blood panel, or for an endoscopy: and this recent study recommends 4-6 slices of wheat bread per day:    
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      Welcome to the forum, @Whyz! By "half way to being diagnosed" I assume you mean you have had the blood antibody testing done but not the gastroscopy with biopsy. Is this correct? Were the results of your blood work positive for celiac disease?
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      By trents · Posted

      Three days of no gluten is not likely to have much impact on serum antibody test results. I have more concern over exactly what test or tests were ordered. When you get the results back, please post them including the reference ranges for the tests for negative vs. positive. What country are you in? Do you have much choice in what doctors you see? Sounds like it might be a good idea to seek out another physician who knows what they are doing in this area of disease diagnosis. At any rate, you have the link I shared above outlining the various tests that can be run so that might be a resource you could share with a physician.
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