Gene Test Results Question

[GFSFVegan]

Can anyone help us figure out which genes we have? Where does the DQx come from??

My husbands gene results look like this:

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0202

Serologic equivalent: HLA-DQ 2,2 (Subtype 2,2)

My gene results look like this:

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0503

Serologic equivalent: HLA-DQ 3,1 (Subtype 7,5)

Thanks !!!

Jenn

[Mother of Jibril]

When people say they have DQx, they're usually talking about the subtype. Your husband has one of the main celiac genes, DQ2.5 (HLA-DQB1*0201). You have DQ7 and DQ5, which can also cause all kinds of problems... DQ5 (one of the DQ1 subtypes) is associated with neurological reactions to gluten (MS, vertigo, ataxia, depression, etc...). DQ7 is associated with gluten intolerance, casein intolerance, thyroid disorders, lupus, grass and pollen allergies, sinusitis and gingivitis.

It seems like a lot of people with DQ7 don't produce enough stomach acid and/or digestive enzymes, which allows bacteria like candida to get out of control... causing a leaky gut, multiple sensitivities to food and environmental allergens, and all kinds of autoimmune disorders.

Wikipedia is actually a good place to start learning about the DQ genetics...

Open Original Shared Link

[GFSFVegan]

Thank you for your help & the link. That certainly does explain a lot!!! Amazing to think they've matched symptoms down to the gene level.....

When people say they have DQx, they're usually talking about the subtype. Your husband has one of the main celiac genes, DQ2.5 (HLA-DQB1*0201). You have DQ7 and DQ5, which can also cause all kinds of problems... DQ5 (one of the DQ1 subtypes) is associated with neurological reactions to gluten (MS, vertigo, ataxia, depression, etc...). DQ7 is associated with gluten intolerance, casein intolerance, thyroid disorders, lupus, grass and pollen allergies, sinusitis and gingivitis.

It seems like a lot of people with DQ7 don't produce enough stomach acid and/or digestive enzymes, which allows bacteria like candida to get out of control... causing a leaky gut, multiple sensitivities to food and environmental allergens, and all kinds of autoimmune disorders.

Wikipedia is actually a good place to start learning about the DQ genetics...

Open Original Shared Link

[Mother of Jibril]

Genetics is really revolutionizing medicine! I know a lot of people are worried about getting these things tagged as "pre-existing conditions" on their health insurance, but frankly... IMO this is the best way to figure out what kind of preventative care you need.