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kthies2

Enterolab Results- Can You Help:)

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I got my Enterolab results in but not sure what exactly to make of them. Can you help me understand what they mean or what I should think of them? Any help is much appreciated! Here they are:

Gluten Sensitivity Stool and Gene Panel Complete

Fecal Anti-gliadin IgA 7 Units (Normal Range is less than 10 Units)

Fecal Anti-tissue Transglutaminase IgA 4 Units (Normal Range is less than 10 Units)

Quantitative Microscopic Fecal Fat Score Less than 300 Units (Normal Range is less than 300 Units)

Fecal Anti-casein (cow

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Enterolab usually sends an interpretation along with those results. What did yours say? From your results, all your tests appear to be negative. Either you have insuffient IgA which Elab tests need or you have no problems with gluten, dairy, eggs or yeast. Maybe soy sensitivity, but probably not. If you still have symptoms which influenced you to do the Elab panel of tests, you might want to consider more complete food allergy tests. ELISA (enzyme linked immunosorbent assay) offers a blood test for 100 commonly eaten foods. ELISA looks for IgG, IgE and IgA antibodies. So if you don't have enough IgA antibodies, ELISA could determine an allergy from IgE or IgG antibodies.

SUE

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Yes, you have the other celiac gene.

The main gene is HLA DQ2, and the minority have HLA DQ8, and then about 6% have half genes and 1-2% have other genes.

Genes say something about risk of developing celiac.

The DQ6 is DQ1 (confusing, but is has historical reasons, DQ5 and DQ6 have the 0101 alpha chain and are DQ1, and later they could discriminate between DQ5 and 6) and that is a gluten sensitive gene too. Some have neuro issues from gluten, and they are very sensitive to gluten.

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It is interesting that all of your IgA levels are low. You may want to ask your doctor to have a total serum IgA done to find our if you are IgA deficient. Do you still have ongoing symptoms that led you down this path?

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To all these were my results from Entero Path...seem very HIGH...

I am still trying to figure out what is the best way to be diagnosed?? My father was tested via blood and he was negative so...hopefully my mother will be tested as well..just wonder if I should be tested via blood as well...

Anyone have any thoughts??

Fecal Anti-gliadin IgA 194 Units (Normal Range

Fecal Anti-tissue Transglutaminase IgA 108 Units (Normal Range

Quantitative Microscopic Fecal Fat Score 278 Units (Normal Range

Fecal Anti-casein (cow's milk) IgA 103 Units (Normal Range

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0202

Serologic equivalent: HLA-DQ 2,2 (Subtype 2,2)

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smickey, you have both DQ2,5 plus DQ2,2 and no wonder your resutls are high.

I think you should go ahead and get the ordinary blood tests done.

nora

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It is interesting that all of your IgA levels are low. You may want to ask your doctor to have a total serum IgA done to find our if you are IgA deficient. Do you still have ongoing symptoms that led you down this path?

Yes. I've been on the "gluten challenge" diet for a few months now and just had the endoscopy done this week. Waiting for results now. I really hope for some kind of decisive answer to this mystery. I guess I'll likely try removing gluten for a few months now in any case, just to see if I feel better. Its just a difficult commitment to make without a diagnosis.

Thanks so much and any other advice or thoughts are welcome and much appreciated!

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smickey, you have both DQ2,5 plus DQ2,2 and no wonder your resutls are high.

I think you should go ahead and get the ordinary blood tests done.

nora

Is the blood test better?? I don't know much ...why do you say no wonder my results are high?? Still trying to figure this all out :)

Thanks!

Sarah

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Your risk of having celiac might be higher with both the main celiac gene (DQ2,5), and the gluten sensitive DQ2,2 gene. There are some charts that say how much the risk is increases, but I do not remember if this is the case with your constellation. But we have had several people with symptoms and DQ2,2 here.

DQ2,2 is 0202 but DQ2,5 is 0201. The 5 comes from the alpha chain, which is 0501.

In our experience, those with DQ2,5 usually get a mainstream diagnosis and get positive bloodwork and biopsies.

But those who are just terrribly gluten sensitive, have a harder time getting positive tests. even though they have more health issues, even more severe.

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Okay I am sorry to butt in, I just have a question about the genes. So if mine were this, "HLA-DQ 2,1 (Subtype 2,6)", would that be one that was hard to get a clear positive from a biopsy?? I know it's the gene linked to neruo issues and I had a stroke which my neuro thinks was from the gluten/Celiac.

It's just kind of hard when you don't have a CLEAR answer, but my GI says well I can't say you don't have Celiac either. Obviously, a stroke is pretty serious and I am having issues with possible cross contamination....but all at the same time thinking, but I am not positively Celiac?? It's easier for me to just think I am....or so others understand at least.

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