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Elevated Ttg


kannne

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kannne Explorer

What can cause elevated TTG besides celiac?


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ocdsgirl Newbie

What can cause elevated TTG besides celiac?

I could be wrong about this because I am still learning, but I think Crohn's can sometimes cause elevations. My son had elevated tTg levels, and they are doing an upper and lower scope to look for both of these things. He is not too happy about this!

kannne Explorer

But she don't have any other symptoms like stomach pain ++ :unsure:

The gastroscopy did not show a clear celiac gut. It was like it was celiac some places and some places not.

ocdsgirl Newbie

But she don't have any other symptoms like stomach pain ++ :unsure:

The gastroscopy did not show a clear celiac gut. It was like it was celiac some places and some places not.

I'm not going to say my son has never had stomach pain before, but it is not his defining symptom, either. He originally was being looked at for a possibly arthritic to. They did an ANA panel, and that was raised, then among all the tests they happened to do aceliac screen as well, and that came back positive, too. His ANA was high for IBD (among a bunch of ther ofther junk, too- that's why they're looking at a few things).

I know it's weird, and frustrating when you don't have a clear answer.

Roda Rising Star

But she don't have any other symptoms like stomach pain ++ :unsure:

The gastroscopy did not show a clear celiac gut. It was like it was celiac some places and some places not.

Celiac damage (blunted villi) can be patchy like you describe.

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    • trents
      Yes, it does. And joint pain is another celiac symptom that is now well-recognized. 
    • ThomasA55
      Does my iron loss sound like celiac to you?
    • trents
      Being as how you are largely asymptomatic, I would certainly advise undertaking a gluten challenge in order to get formal testing for celiac disease. We have many forum participants who become violently ill when they undertake a gluten challenge and they therefore can't carry through with it. That doesn't seem to be the case with you. The reason I think it is important for you to get tested is that many or most people who don't have a formal diagnosis find it difficult to be consistent with the gluten-free diet. They find ways to rationalize that their symptoms are due to something other than celiac disease . . . especially when it becomes socially limiting.  The other factor here is by being inconsistent with the gluten free diet, assuming you do have celiac disease, you are likely causing slow, incremental damage to your gut, even though you are largely asymptomatic. It can take years for that damage to get to the point where it results in spinoff health problems. Concerning genetic testing, it can't be used for diagnosis, at least not definitively. Somewhere between 30 and 40% of the general population will have one or both of the two genes known to be associated with the development of active celiac disease. Yet, only about 1% of the general population will develop active celiac disease. But the genetic testing can be used as a rule out for celiac disease if you don't have either gene. But even so, that doesn't eliminate the possibility of having NCGS (Non Celiac Gluten Sensitivity).
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    • trents
      Welcome to the celiac.com community, @ThomasA55! Before I give my opinion on your question about whether or not you should undergo a gluten challenge, I would like to know how you react when you get a good dose of gluten? Are you largely asymptomatic or do you experience significant illness such as nausea and diarrhea? You mentioned intermittent joint pain before you began experimenting with a low gluten diet. Anything else?
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