Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Looking For Reviews On Signet Diagnostic Corporation's Mrt Test.

Dada2hapas

Recommended Posts

Dada2hapas Rookie
Dada2hapas
Posted

Just looking for input with LEAP. How does their immune response blood test work? Effective? Thanks. -D

Signet Diagnostic Corporation

3555 Fiscal Court Suites 8 & 9

Riviera Beach, FL 33404

Ph. 888-669-5327

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

Well, LEAP made the "dubious" list at Quackwatch.

Open Original Shared Link

Another abstract with a similar conclusion. The author notes that information on mediator release testing is only found on consumer sites.

Open Original Shared Link

There are a lot of scams right now with diagnostic tests, to the point that FDA is looking hard at companies like this. The other big scam allergy test is IgG4.

Dada2hapas Rookie
Dada2hapas
Posted
  • Author

Well, LEAP made the "dubious" list at Quackwatch.

Open Original Shared Link

Another abstract with a similar conclusion. The author notes that information on mediator release testing is only found on consumer sites.

Open Original Shared Link

There are a lot of scams right now with diagnostic tests, to the point that FDA is looking hard at companies like this. The other big scam allergy test is IgG4.

:) Thanks, I was aware of the paper on PubMed. Their philosophy seems to be different than mainstream medicine, but I wonder if part of the poor review is because their MRT test is proprietary. I don't know how their lab test is performed. Maybe useful to hear from folks who may have used it to their benefit, or even otherwise. LEAP claims to have helped thousands of patients successfully. Dr. Scot Lewey (who wrote pretty informative articles on celiac disease and celiac disease testing available here on celiac.com) seems to recommend it for his patients. However, there doesn't seem to be much consumer input available. Interesting.

Open Original Shared Link

http://www.celiac.co...ewey/Page1.html

Open Original Shared Link

Skylark Collaborator
Skylark
Posted

I'm so suspicious of testing services that refuse to establish (or at least provide) sensitivity and specificity measures for their tests.

You do realize allergists say the gold standard for food allergies is elimination, right? None of these tests "diagnose" food allergies or sensitivities. They can only guide what foods might be problematic if you're not willing to do lamb/rice/pears.

I personally think MRT, IgG4, Enterolab, and other consumer "diagnostic" services are creative ways to separate consumers from their $$ because Western medicine has people confused and overly attached to diagnostic test results.

Dada2hapas Rookie
Dada2hapas
Posted
  • Author

I'm so suspicious of testing services that refuse to establish (or at least provide) sensitivity and specificity measures for their tests.

You do realize allergists say the gold standard for food allergies is elimination, right? None of these tests "diagnose" food allergies or sensitivities. They can only guide what foods might be problematic if you're not willing to do lamb/rice/pears.

I personally think MRT, IgG4, Enterolab, and other consumer "diagnostic" services are creative ways to separate consumers from their $ because Western medicine has people confused and overly attached to diagnostic test results.

Lol. I don't disagree with you regarding LEAP. I just looked up their patents, interesting. Not "state of the art" as they advertise. I'm just surprised there has been so little commentary about it, controversial as it is.

  • 3 months later...
JaisonS Newbie
JaisonS
Posted

Lol. I don't disagree with you regarding LEAP. I just looked up their patents, interesting. Not "state of the art" as they advertise. I'm just surprised there has been so little commentary about it, controversial as it is.

A word of caution ; I spent hours researching The owner of the website QUACKWATCH ; Do it on Google and you will find that he is a physician whom license is revoked and tied big-time to large pharmaceutical industry with a lot of suspicion about his income and whom supporting his website since he is out of business . His business is to discredit everything that gives answer to disease other than mainstream medicine that is hooked on giving lifetime drugs. Do not take my word for it checj it out yourselves. Signet MRT follows strict testing procedures and is used by Functional Medicine , Anti-Aging medicine all over the US and abroad ( ask someone who used it ) ; also used by metabolic typing . Do your homework . research and get well informed. A lot of websites are out-there to discredit money making drug companies and their allied health care providers. I do not do forums a lot but happened to see this part . Good luck .

  • 1 month later...
MiDoc Newbie
MiDoc
Posted

Well, LEAP made the "dubious" list at Quackwatch.

Another abstract with a similar conclusion. The author notes that information on mediator release testing is only found on consumer sites.

There are a lot of scams right now with diagnostic tests, to the point that FDA is looking hard at companies like this. The other big scam allergy test is IgG4.

Yeah, that quackwatch guy, Open Original Shared Link, is no more reliable as a source of information than Glenn Beck. In one case that Open Original Shared Link and the "Open Original Shared Link" tried to file against an alternative health company, the judge found Open Original Shared Link to be "biased and unworthy of credibility".

I haven't tried the LEAP test with any patients, but have used a combined IgE/IgG4 with a lot of people and it usually helps find things that people feel better when they don't eat, so the idea that it is necessarily "a scam" isn't supported by my experience. However, it is not diagnostic for celiac disease.

In my experience, no test is 100%. An elimination diet with careful re-challenging after 2w off all common allergens is the best bet for finding food sensitivities. The blood tests give a short-cut so people can do a smaller challenge.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Skylark Collaborator
Skylark
Posted

Interesting. Your experience directly contradicts this peer-reviewed evaluation of IgG4.

Open Original Shared Link

"In conclusion, food-specific IgG4 does not indicate (imminent) food allergy or intolerance, but rather a physiological response of the immune system after exposition to food components. Therefore, testing of IgG4 to foods is considered as irrelevant for the laboratory work-up of food allergy or intolerance and should not be performed in case of food-related complaints."

As for Quackwatch, have you actually read the website? It's common sense stuff, largely based on peer-reviewed research and not all written by Barrett. Try this classic one on homeopathy. It's a wonderful read. Open Original Shared Link

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. trents
      - trents replied to ThomasA55's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Iron loss and potential celiac.

      Being as how you are largely asymptomatic, I would certainly advise undertaking a gluten challenge in order to get formal testing for celiac disease. We have many forum participants who become violently ill when they undertake a gluten challenge and they therefore can't carry through with it. That doesn't seem to be the case with you. The reason I think it...
    2. ThomasA55
      - ThomasA55 replied to ThomasA55's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Iron loss and potential celiac.

    3. trents
      - trents replied to ThomasA55's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Iron loss and potential celiac.

      Welcome to the celiac.com community, @ThomasA55! Before I give my opinion on your question about whether or not you should undergo a gluten challenge, I would like to know how you react when you get a good dose of gluten? Are you largely asymptomatic or do you experience significant illness such as nausea and diarrhea? You mentioned intermittent joint...
    4. Joseph01
      - Joseph01 replied to bethmon's topic in Gluten-Free Foods, Products, Shopping & Medications
      14

      We Keep Getting Glutened With Vegetable Oil

      This is way past due for your post. I have Celiac and have been recovering for more than a year. Doing well. Used Essential oil to day to fry some chicken. Read the label all good. Then ate some chicken. Here comes the gluten reaction. I haven't had a gluten reaction since year. I am angry. I have been so careful with this crap and don't wan't any...
    5. ThomasA55
      - ThomasA55 posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Iron loss and potential celiac.

      Hey everyone. I'm a young adult who had very high iron in 2024. 64% saturation 160 ferritin. In 2025 I had far lower iron. 26% saturation and 130 ferritin. I know this is still in range but it seems to be a large drop. That combined with the fact that I developed some intermittent joint pain between the two years makes me wonder if I could be celiac. My dietary...
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,086
    • Most Online (within 30 mins)
      10,442
    Joseph01
    Newest Member
    Joseph01
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • trents
      Iron loss and potential celiac.

      By trents · Posted

      Being as how you are largely asymptomatic, I would certainly advise undertaking a gluten challenge in order to get formal testing for celiac disease. We have many forum participants who become violently ill when they undertake a gluten challenge and they therefore can't carry through with it. That doesn't seem to be the case with you. The reason I think it is important for you to get tested is that many or most people who don't have a formal diagnosis find it difficult to be consistent with the gluten-free diet. They find ways to rationalize that their symptoms are due to something other than celiac disease . . . especially when it becomes socially limiting.  The other factor here is by being inconsistent with the gluten free diet, assuming you do have celiac disease, you are likely causing slow, incremental damage to your gut, even though you are largely asymptomatic. It can take years for that damage to get to the point where it results in spinoff health problems. Concerning genetic testing, it can't be used for diagnosis, at least not definitively. Somewhere between 30 and 40% of the general population will have one or both of the two genes known to be associated with the development of active celiac disease. Yet, only about 1% of the general population will develop active celiac disease. But the genetic testing can be used as a rule out for celiac disease if you don't have either gene. But even so, that doesn't eliminate the possibility of having NCGS (Non Celiac Gluten Sensitivity).
    • ThomasA55
      Iron loss and potential celiac.

      By ThomasA55 · Posted

    • trents
      Iron loss and potential celiac.

      By trents · Posted

      Welcome to the celiac.com community, @ThomasA55! Before I give my opinion on your question about whether or not you should undergo a gluten challenge, I would like to know how you react when you get a good dose of gluten? Are you largely asymptomatic or do you experience significant illness such as nausea and diarrhea? You mentioned intermittent joint pain before you began experimenting with a low gluten diet. Anything else?
    • Joseph01
      We Keep Getting Glutened With Vegetable Oil

      By Joseph01 · Posted

      This is way past due for your post.  I have Celiac and have been recovering for more than a year.  Doing well.  Used Essential oil to day to fry some chicken.  Read the label all good.  Then ate some chicken.  Here comes the gluten reaction.  I haven't had a gluten reaction since year.  I am angry.   I have been so careful with this crap and don't wan't any set backs!!!!! Good luck to you with your post.   Celiac is HELL!
    • ThomasA55
      Iron loss and potential celiac.

      By ThomasA55 · Posted

      Hey everyone. I'm a young adult who had very high iron in 2024. 64% saturation 160 ferritin. In 2025 I had far lower iron. 26% saturation and 130 ferritin. I know this is still in range but it seems to be a large drop. That combined with the fact that I developed some intermittent joint pain between the two years makes me wonder if I could be celiac. My dietary intake of iron was pretty steady (mostly in the form of red meat). I did carnivore (therby eliminating gluten) for a bit after the second test and felt improvements in my joints and digestion. I still consume gluten occasionally socially, for religious reasons, and through cross contamination/food sharing. For these reasons, I would need to know if I had it, because although my lifestyle is low gluten its not at the strict level it should be if it turned out I was celiac. I will get a gene test first and hope I don't have DQ2.5,DQ2.2, or DQ8, but if I had any combination of those do you guys think I need proper screening through a gluten challenge / blood test? Other context. From 2024-2025, my b12 stayed about the same in the mid 600s folate went up slightly, but I heard it takes longer for celiac to affect the absorption of these. ANA negative, CRP low, ESR low.  I don't know how much noise exists around the saturation and ferritin, but it caught my eye and Celiac seemed like a possibility. I'm under no illusion that it is probable that I have celiac, only that it may be worth screening given my overall profile.   
×
×
  • Create New...