Celiac.com 11/23/2016 - Researchers know that kids with celiac disease have fully responded to a gluten-free diet when symptoms resolve and serology returns to normal.
A team of researchers recently set out to assess the rate of normalization of the TTG and EMA for children on a gluten-free diet after diagnosis. The researchers included Dominica Gidrewicz, Cynthia L Trevenen, Martha Lyon, and J Decker Butzner.
After initiated a gluten-free diet in 228 newly diagnosed children with biopsy-proven celiac disease, the team obtained and recorded celiac serologies over a 3.5 year period.
The team categorized patients based on serology (Group A, TTG >= 10 x upper limit of normal (ULN) and EMA >= 1:80; Group B, TTG >= 10 x ULN and EMA and EMA <= 1:40; and Group C, TTG <...

Celiac.com 08/11/2020 - Research shows that people with celiac disease have an altered gut microbiota, compared with healthy control subjects. A team of researchers recently set out to evaluate the composition of the microbiota of children at celiac onset, and the connection between bacterial abundances and symptoms.
The research team included Anna Rita Di Biase, Giovanni Marasco, Federico Ravaioli, Elton Dajti, Luigi Colecchia, Beatrice Righi, Virginia D'Amico, Davide Festi, Lorenzo Iughetti, and Antonio Colecchia. They are variously affiliated with the Pediatric Unit, Modena University Hospital, Modena, Italy; the Department of Medical and Surgical Sciences, University of Bologna, Italy; and the Gastroenterology Unit of University Hospital Borgo Trento in Verona, Italy.
Celiac p...

Celiac.com 04/10/2021 - It was gratifying to learn, from a recent post to the Celiac Listserv, that some celiac-savvy medical practitioners are now ordering bone density testing as soon as a patient’s serology indicates celiac disease. This emerging standard of care is well rooted in the medical and scientific literature and constitutes a reasonable and appropriate strategy for the effective care and treatment of celiac disease patients. Investigators have been recommending this approach for more than a decade(1,2) and these recommendations are particularly important given the more recent data that showing a dramatic fracture rate among celiac patients that is seven times that of controls(3,4).
Although the sensitivity of endomysium (EMA) and tissue transglutaminase (tTG) may be o...

Celiac.com 10/23/2023 - A recent study conducted by a team of US investigators is shedding light on the use of European thresholds for diagnosing celiac disease in North America. This study seeks to determine how often biopsies are performed on children who are considered at high risk for celiac disease based on common diagnostic tests, yet meet the criteria for non-biopsy diagnoses according to European standards.
Dr. Denis Chang, the study's lead author, discussed the trial's design and its implications for celiac disease diagnostics in North America during an interview with HCPLive at the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) 2023 Annual Meeting in San Diego.
Celiac disease is an autoimmune disorder that affects the...