Antibody level numbers ?

[DJFL77I]

If someone has a TTG IGA of 10... and another person has 600....

what's the difference?

Does antibody level numbers correlate to immune response strength?

Lower number =  weaker immune response happening and less damage being done?

[cristiana]

Hello glutendasher

I'm not very scientific or good at explaining things but does this link help?

https://nationalceliac.org/celiac-disease-questions/i-just-had-a-blood-test-and-my-igg-is-6-it-says-weak-positive-what-does-that-mean-to-me/#:~:text=A person with celiac disease,reason is typically gluten exposure.

From my own experience, I can tell you that in the UK most labs cut off at tTG levels at 100.  My were above 100 and took a long time to come down.   I would have loved to have known what my actual levels were as I was very unwell and I think perhaps they were stratospheric and that is why I took a while to get down to 14, my best "score" so far!  

Consultants use it as a measuring tool to see if you are responding to the gluten free diet and the direction of travel is important.  It should be going down as you recover.  If it goes up again, the usual explanation is gluten exposure.

I hope this is some help. but I'm sure others will chime in.

C.

[DJFL77I]

mine was also over 100 at diagnosis.. then 13...  5 months after

[RMJ]

Different labs use different units of measure for celiac antibodies, so part of a difference could be that rather than a real difference.

The way the tests work, within a lab, a higher value should mean more antibodies.  However, the level of antibodies does not necessarily correlate with the degree of damage in the intestines or with symptoms.