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Are Enterolab Tests Ever Negative?


Lori2

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Lori2 Contributor

I was just wondering if anyone has ever had a negative test from Enterolab.


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Gardening Apprentice

I will let you know - expecting results for three family members this Thursday. My daughter and I just received negative results on the celiac panel (this is the second time for me), so I am interested to get the Enterolab results.

But I also think it's possible that we don't have celiac, but shouldn't eat gluten for other reasons.

ravenwoodglass Mentor

Yes, there have been some on the board, in particular folks that are celiac and used Enterolab to test other family members. Do keep in mind that most of the folks that do the testing are having issues so it is not IMHO that the number of positive tests would outnumber the amount of negative ones. Do keep in mind that they do not diagnosed celiac, they simply tell you if your body is forming antibodies to the substances tested for.

Lori2 Contributor

Since my blood tests were negative but the Enterolab test was positive, I have been considering having other family members tested at E-L. But then I got to wondering if their test was so sensitive that they found everyone positive, it wouldn't be worth spending the money.

One of my daughters has a canker sore problem. Her physician finally sent her to Mayo Clinic for evaluation. Her problem is caused by iron malabsorbtion. I would really like to have her tested for gluten sensitivity.

Skylark Collaborator

Enterolab has their tests set to have a very high sensitivity. This has the associated issues with high false positive rates. It's on their website, buried in the "lectures" section.

Korwyn Explorer

My wife tested right on the line for gluten and tTG, but positive for Dairy through Enterolab. Which actually matched up with another (non-Enterolab) workup for food intolerances.

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    • trents
      Yes, it does. And joint pain is another celiac symptom that is now well-recognized. 
    • ThomasA55
      Does my iron loss sound like celiac to you?
    • trents
      Being as how you are largely asymptomatic, I would certainly advise undertaking a gluten challenge in order to get formal testing for celiac disease. We have many forum participants who become violently ill when they undertake a gluten challenge and they therefore can't carry through with it. That doesn't seem to be the case with you. The reason I think it is important for you to get tested is that many or most people who don't have a formal diagnosis find it difficult to be consistent with the gluten-free diet. They find ways to rationalize that their symptoms are due to something other than celiac disease . . . especially when it becomes socially limiting.  The other factor here is by being inconsistent with the gluten free diet, assuming you do have celiac disease, you are likely causing slow, incremental damage to your gut, even though you are largely asymptomatic. It can take years for that damage to get to the point where it results in spinoff health problems. Concerning genetic testing, it can't be used for diagnosis, at least not definitively. Somewhere between 30 and 40% of the general population will have one or both of the two genes known to be associated with the development of active celiac disease. Yet, only about 1% of the general population will develop active celiac disease. But the genetic testing can be used as a rule out for celiac disease if you don't have either gene. But even so, that doesn't eliminate the possibility of having NCGS (Non Celiac Gluten Sensitivity).
    • ThomasA55
    • trents
      Welcome to the celiac.com community, @ThomasA55! Before I give my opinion on your question about whether or not you should undergo a gluten challenge, I would like to know how you react when you get a good dose of gluten? Are you largely asymptomatic or do you experience significant illness such as nausea and diarrhea? You mentioned intermittent joint pain before you began experimenting with a low gluten diet. Anything else?
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