Blood Results

[BeHappy]

One of my daughters are diagnosed with celiac so I tested my other kids too just to be sure. I have a copy of the bloodwork results although the Dr said it was negative I wanted to doublecheck with you guys (since I have no idea what the levels mean)

iga - kid(7 yrs old) 1 - 189 tissue transglutam less than three (for all kids)

Kid 2(5yrs old)- 54

Kid 3(6yrs old)- 97

There are a whole list of other tests if you need any other level that I haven't listed....

Thanks!

[mushroom]

Yes, it would be very helpful to see what other tests were run besides the ttg, and their results and ranges.

[ravenwoodglass]

Yea we really need to see the exact names of the tests done and the lab ranges as well as the results to be able to tell you anything.

[BeHappy]

ok here we go.

cs pnl+hdl, tibc w\ fer rfx glucose - 85 reference range- 63-139 mg\dL

sodium- 139 reference range- 135-146 mmol\L

Potassium- 3.5 (L) reference range-3.8-5.1 mmol\L

chloride- 102 reference range-98-110 mmol\L

carbon dioxide- 20(L) reference range- 21-33 mmol\L

Urea nitrogen 10 reference range- 7-20 mg\dL

creatinine 0.31 reference range-0.29-0.68 mg\dL

uric acid- .5 reference range-2.0-5.1 mg\dL

phosphorus- 5.4 reference range-3.0-6.0 mg\dL

calcium- 10.0 reference range-8.9-10. mg\dL

cholesterol, total- 12 reference range-125-170 mg\dL

HDL cholesterol 58 reference range-37-75 mg\dL

Cholesterol\HDL ratio 2. reference range-<=5.0

LDL CHOL, calculated 7 reference range-<110mg\dL

Triglycerides- 48 reference range- 33-115mg\dL

protien, total- 7.0 reference range-6.3-8.2 g\dL

Albumin- .7 reference range-3.6-5.1g\dL

globulin, calculated- 2.3 reference range-2.0-3.8g\dL

A\G ratio- 2.0 reference range-1.0-2.1

bilirubin, total- 0.7 reference range-0.2-0.8mg\dL

Bilirubin direct- 0.2 reference range-<=0.2mg\dL

Alkaline phosphatase- 195 reference range- 96-297U\L

GGT- 12 reference range- 3-22 U\L

AST- 43(H)reference range-20-39U\L

ALT- 27(H) reference range-8-24U\L

LD- 257 reference range-135-345 U\L

Iron, total- 52 reference range- 27-164 mcg\dL

TIBC- 368 reference range-271-448 mcg\dL

transferrin saturation- 14 reference range-8-45%

TSH, 3rd generation- 1.16 reference range-.50-4.30 mIU\L

ferritin- 28 reference range-10-143 ng\mL

cbc (Includes diff plt)

WBC- 11.0 reference range-5.0-16.0 Thous\mcL

RBC- 4.01 reference range-3.90-5.50 Mill\mcL

hemoglobin- 11.8 reference range-11.5-14.0 g\dL

hematocrit- 34.7 reference range-34.0-2.0%

MCV- 86.5 reference range-73.0- 87.0 fL

MCH- 29. reference range-24.0-30.0pg

MCHC- 34.0 reference range-31.0-36.0 g\dL

RDW- 13.4 reference range-11.0- 15.0%

Platelet count- 254 reference range-140-400 Thous\mcL

MPV 8.9 reference range-7.5-11.5fL

total neutrophils%- 58.8 reference range-35-65%

total lymphocytes %- 33.2 reference range-25-65%

monocytes %- 5.5 reference range-0-10%

eosinophils %- 2.1 reference range-0-6%

basophils % - 0.4 reference range-0-2%

neutrophils, absolute- 6468 reference range-1500-8500 cells\mcL

lymphocytes,absoute- 3652 reference range-2000-8000 cells\mcL

monocytes, absolute- 605 reference range-200-900 cells\mcL

eosinophils, absolute- 231 reference range-15-600 cells\mcL

basophils,absolute- 4 reference range- 0-250 cells\mcL

ESR, Westergren- 5 reference range- 0-20mm\hr

IGA, Serum- 54 reference range-33-235mg\dL

Tissue Transglutam AB IGA <3 reference range-<5U\mL

Vitamin D, 25-OH, LC\MS\MS

Vitamin D 25-OH total- 19(L) reference range-30-100 ng\mL

Vitamin D 25-OH, D3- 19 reference range-ng\mL

Vitamin D 25-OH, D2 <4 reference range-ng\mL

[mushroom]

From the blood work you posted these are the specific test findings that stand out to me in relation to celiac/gluten intolerance:

transferrin saturation- 14 reference range-8-45%

TSH, 3rd generation- 1.16 reference range-.50-4.30 mIU\L

ferritin- 28 reference range-10-143 ng\mL

IGA, Serum- 54 reference range-33-235mg\dL

Tissue Transglutam AB IGA <3 reference range-<5U\mL

Vitamin D 25-OH total- 19(L) reference range-30-100 ng\mL

Potassium- 3.5 (L) reference range-3.8-5.1 mmol\L

You also have slightly low carbon dioxide for some reason.

This tests mean from my interpretation that you are not low in iron, your thyroid is probably functioning normally, you are very low in Vitamin D and at risk of osteoporosis if not supplemented radically and pretty quickly, and you are low in potassium as are many of us, in fact low enough that you should take potassium supplements right away.

The only two tests you had specific for celiac are the total serum IGA, which although within normal limits is on the low side, and means you do not produce a lot of antibodies in general, and the tissue transglutaminase IGA which was negative, but could be explained by the fact that you do not produce many antibodies.

Three tests that could and probably for you should be done are the tissue transglutaminase IGG, the endomysial antibodies (EMA, and demaidated gliadin peptid (DGP). This last one, in particular, is very specific for celiac disease. Can you get your doctor to run these other tests for you?

[ravenwoodglass]

The only two tests you had specific for celiac are the total serum IGA, which although within normal limits is on the low side, and means you do not produce a lot of antibodies in general, and the tissue transglutaminase IGA which was negative, but could be explained by the fact that you do not produce many antibodies.

Three tests that could and probably for you should be done are the tissue transglutaminase IGG, the endomysial antibodies (EMA, and demaidated gliadin peptid (DGP). This last one, in particular, is very specific for celiac disease. Can you get your doctor to run these other tests for you?

Do ask your doctor for the tests she mentioned. Those are the celiac panel and your doctor only did one of the needed tests. Do keep in mind that we can still be celiac even if the celiac panel is negative.

[BeHappy]

These results were for my 5 years old daughter. Does that make a difference at all? Her pediatrician did the test. I guess I can ask the gastro for referals to gets the right bloodwork done for the rest of the kids.

[Skylark]

The problem with the celiac tests is that with her relatively low IgA, they could be false negative. The celiac IgA tests lose sensitivity when there isn't much IgA around and frankly they aren't that great to start with. That's why Shroomie is suggesting the IgG versions. Her recommendations are very good, especially the deamidated gliadin peptide IgG. It's a new test and is very sensitive. Also, low IgA is a risk factor for celiac.

Something is going on for sure with the metabolic acidosis (low CO2) and elevated liver enzymes (AST and ALT). Liver enzymes can be elevated in celiac disease too, and they usually fall back to normal on the gluten-free diet. I agree that the low D, low potassium, and low-normal iron suggest some malabsorption. I don't agree that she has thyroid issues. Anything below 2.0 with the TSH is usually fine.

You might give her some bananas, orange juice, or potatoes to see if you can get her potassium up a little with potassium-rich foods. If you live somewhere it isn't too cold, sunlight should help the vitamin D even if she isn't absorbing it very well from food.

I think that kiddo needs a trial on the gluten-free diet once the doctor is done with the testing.