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anabananakins

Interpreting Genetic Test Results

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Hi all. When I got the results from my genetic test I just skipped through to the conclusion since the numbers made no sense to me. But I know there are people here who are good at explaining them, so if anyone gets a chance I'd be really grateful.

The report (hoping the formatting works, I'm trying to keep it as laid out in the original) says:

===========================================

Methodology: HLA-DR and HLA-DQ genotyping by PCR-Sequence Specific Priming

HLA-DR ................12, 15

____DRB1.............12, 15

HLA-DQ ..................6,7

____HLA-DQA1 .......01, 05

____HLA-DQB1 .......0301/4/9/10/13/14/16,06

Conclusion: No genotype susceptibility for coeliac disease. The DQ2 and DQ8 antigens associated with increased risk of coeliac disease were not identified in this patient. In the absence of these antigens, coeliac disease is extremely unlikely.

============================================

Any thoughts?

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Hi all. When I got the results from my genetic test I just skipped through to the conclusion since the numbers made no sense to me. But I know there are people here who are good at explaining them, so if anyone gets a chance I'd be really grateful.

The report (hoping the formatting works, I'm trying to keep it as laid out in the original) says:

===========================================

Methodology: HLA-DR and HLA-DQ genotyping by PCR-Sequence Specific Priming

HLA-DR ................12, 15

____DRB1.............12, 15

HLA-DQ ..................6,7

____HLA-DQA1 .......01, 05

____HLA-DQB1 .......0301/4/9/10/13/14/16,06

Conclusion: No genotype susceptibility for coeliac disease. The DQ2 and DQ8 antigens associated with increased risk of coeliac disease were not identified in this patient. In the absence of these antigens, coeliac disease is extremely unlikely.

============================================

Any thoughts?

well i dont know enough about genetics yet to know what the HLA-DR is associated with- you could google it to see what it is predisposed for (but dont worry yourself- having a certain gene doesnt mean u will have the disease).

and it looks like u have a DQ 6 and a DQ 7... they're not the "classic" Celiac genes.. but that doesnt mean you could not have Celiac or Gluten Intolerance. i know many research centers and universities in America say it is virtually impossible to have Celiac without a DQ2 or DQ8, but they ARE diagnosing Celiacs in Europe with additional DQ genes. and they're are plenty of members on here with different DQ genes that are COMPLETELY gluten intolerant- and possibly Celiac. so, basically, imho, i would say you are gluten sensitive at least- and you should listen to your body and try the diet.

whoa, didnt mean to blab so long :/


1986- Elevated Speckled ANA/no Lupus.negative Sjorgens

2008- AntiGliadin IGA/IGg~ Negative,TTG IGA/IGg~ Weak Positive, Endomysial Antibody~ Positive, IGA Deficient.

no biopsy (insurance denied)

6/2010- Enterolab Gene Test:

HLA-DQB1 Allele 1 0302

HLA-DQB1 Allele 2 0302

HLADQ 3,3 (subtype 8,8)

7/2010- 100% Gluten Free

8/2010- DH

10/2010-Hypothyroid dx-> 12/2010 Hashimoto's dx + 1/11- Graves dx :(

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I am soooo glad I was firmly diagnosed celiac before any gene testing was done. I would be dead by now if I had continued eating gluten. Gene testing is a relatively new science and we are learning more every day. There are many more genes associated with celiac than just the two they look for. Don't let those results convince you to go back on gluten if the diet is helping you.


Courage does not always roar, sometimes courage is the quiet voice at the end of the day saying

"I will try again tommorrow" (Mary Anne Radmacher)

Diagnosed by Allergist with elimination diet and diagnosis confirmed by GI in 2002

Misdiagnoses for 15 years were IBS-D, ataxia, migraines, anxiety, depression, fibromyalgia, parathesias, arthritis, livedo reticularis, hairloss, premature menopause, osteoporosis, kidney damage, diverticulosis, prediabetes and ulcers, dermatitis herpeformis

All bold resoved or went into remission in time with proper diagnosis of Celiac November 2002

 Gene Test Aug 2007

HLA-DQB1 Molecular analysis, Allele 1 0303

HLA-DQB1 Molecular analysis, Allele 2 0303

Serologic equivalent: HLA-DQ 3,3 (Subtype 9,9)

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Thanks to both of you for the replies (and sorry I didn't say so before, posted then had no internet access for over a week!)

Interesting about the other DQ results. I'm very strictly gluten free and I won't go back to eating gluten again, but I find it all very interesting and I'm curious in particular about the neurological manifestations of gluten intolerance. There's so much to learn, it's a shame I'm not scientifically inclined enough to go off and study it for real :-)

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