New Test For Non-Responsive Celiac Disease

[GottaSki]

New -- DGP antibody array, rather than the commonly used DGP antibody titer may be helpful to those with Non-Responsive Celiac Disease that completely adhere to the gluten-free diet

 

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[powerofpositivethinking]

thanks for posting, Lisa!  I read this study the other week and liked this part:  "One possible explanation of the persistence of antibodies against dGP despite complete removal of gluten from the diet is the presence of T-cell clones that have evolved antigen independence and continue to stimulate dGP antibody-secreting plasma cells.^[24] This phenomenon has been previously described, and pools of memory T- and B-cells can be maintained at constant levels for years even in the absence of the eliciting antigen.^[45,46] In addition, plasma cells can continuously secrete antibody even after the disappearance of memory cells.^[47] Further studies will be necessary to confirm the presence of dGP-specific memory B-cells or plasma cells in NRCD patients. Therefore, the mechanism responsible for the persistence of anti-dGP IgG antibodies remains to be elucidated."

 

Since I was being so strict with the diet, and not eating out hardly at all until recently, I was upset my levels didn't fall faster.  That paragraph made me feel better   

 

New -- DGP antibody array, rather than the commonly used DGP antibody titer may be helpful to those with Non-Responsive Celiac Disease that completely adhere to the gluten-free diet

 

Open Original Shared Link

[GottaSki]

Since I was being so strict with the diet, and not eating out hardly at all until recently, I was upset my levels didn't fall faster.  That paragraph made me feel better   

 

Which makes me glad I posted it

 

I'm just thankful more tests are being developed...I certainly could have used this one three or four years ago.  Also encouraged by the three day challenge blood test on the horizon