Celiac in 10 month old?

[Shannosaurus]

Hello all, new to this site!  My 10 month old son was referred to an endocrinologist as he has consistently failed to chart in both weight and height.  After discussing his symptoms with the endocrinologist (fussiness after eating, diarrhea) she suggested it could be Celiac disease.  She ordered several blood tests to which I have received results that I am not quite sure how to interpret (and of course I haven't heard back and she hasn't returned my messages).  The following abnormal test results I received:

Immunoglobulin A:  Less than 8 mg/dl

IgA TTG Antibody:  Negative (I've read this can be a false negative if he is IgA deficient?)

SGOT/AST:  93 U/L (standard 25-55)

SGPT/AST:  49 U/L (standard 13-45)

IgF-1/Somatomedin-C:  Less than 25 ng/ml (standard for age range 16 days to 1 year is 55-327)

Any insight into what these results mean would be extremely helpful and appreciated!  Also, my son has been exclusively breastfed; if he does, in fact, have Celiac disease is gluten transferred through breast milk? 

[StephanieL]

Without reference ranges for the IgA there's no telling wether the IgA or tTG are anything worth while.  I think your best bet is to wait on a call from them for interpretation. I know that's hard but really, they are the ones with all the necessary information.  

[squirmingitch]

That was not a full celiac blood panel that was done. Plus, as I understand it, at that age the DGP is more likely to be high rather than the others. Here is the full celiac blood panel:

Anti-Gliadin (AGA) IgA
Anti-Gliadin (AGA) IgG
Anti-Endomysial (EMA) IgA
Anti-Tissue Transglutaminase (tTG) IgA
Deamidated Gliadin Peptide (DGP) IgA and IgG
Total Serum IgA 

 

Also can be termed this way:

Endomysial Antibody IgA
Tissue Transglutaminase IgA 
GLIADIN IgG
GLIADIN IgA
Total Serum IgA 
Deamidated Gliadin Peptide (DGP) IgA and IgG

 

[squirmingitch]

This is a link that will explain sreun panels for infants under 2 years of age.

Open Original Shared Link

The author of that is a doctor, has celiac herself, and is a member of celiac.com. Here is a link that tells you about her:

Open Original Shared Link

 

This link will also give you information:

Open Original Shared Link

Quoting from it in part:

Celiac Disease Testing in Children Under 3

Blood tests are not always accurate in very young children. If your child is less than 3 years old, you may be advised to see a gastroenterologist instead of relying on blood tests results.

[Shannosaurus]

Thanks all for the information! Still waiting to hear back on what sort of follow up the doctor wants to do, but this information has been very helpful in the meantime.