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CD57 / NK Levels in Celiac Question

deezer
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deezer Apprentice
deezer
Posted

Does anyone have any information about CD57 NK cells in Celiac patients?    I am trying to understand if my levels are normal and if there is anything I should do or can do to correct.
I had a low lab test (CD8-CD57+ Lymphs 1.4% (ref 2.0-17.0), 15 Abs (ref 60-360)) and am concerned about my ability to fight disease and cancer with these readings.   A doctor told me that I have Lyme disease because of these results.  However, I have no other symptoms or lab results to support the diagnosis of Lyme disease and I doubt the diagnosis. 

I am aware that in other autoimmune diseases, such as Sjogren's syndrome,  that CD57 levels can be reduced( ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856678/) , but I have not heard anything about this in relation to Celiac disease.  Would be interested in any information you can share.

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cyclinglady Grand Master
cyclinglady
Posted

I know nothing about this subject and I am not a doctor, but I found this interesting while drinking my morning coffee.  

If you are unsure about your doctor’s diagnosis of Lyme disease, I would suggest getting a second opinion from a clinician who has some Lyme disease expertise.  

What made you go to the doctor when he/she ordered this test?  Is your celiac disease in remission?  When was the last time you had your antibodies checked or had a follow-up endoscopy?  

 

  

RMJ Mentor
RMJ
Posted

In this paper they conclude that CD57 cells do not appear to have a role in celiac disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222270/

deezer Apprentice
deezer
Posted
  • Author
20 hours ago, RMJ said:

In this paper they conclude that CD57 cells do not appear to have a role in celiac disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222270/

That's interesting, but I believe they are not looking at serum CD57 levels - they are looking at levels in intraepithelial lymphocytes (IELs), lamina propria (LP) lymphocytes, and glands.

In the study I linked above, they look at serum CD57 levels and find them to be low in several autoimmune diseases.  Unfortunately, they did not review Celiac disease.

  • 3 years later...
T burd Enthusiast
T burd
Posted

Hey my Abs.CD8-CD57+ Lymphs were a little low also. The main thing that’s going on with me is increasingly more joint inflammation. I am 42 and I probably last got bit by a tick when I was under 19. The first time I was four. And I can’t recall how many times there were so many. I never thought that I got sick from any of those,  sometimes the sickness doesn’t come on for several weeks. I’m just wondering if you ended up having symptoms and if you figured out that it is truly lyme. 

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