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paisleydaisy

Do you understand the genetics? DQ 2.2

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Hi all! 

This forum is so great! I'm learning a lot. And I've got a question for you if you understand genetics.
I'm relatively sciencey, have a 3 year old we're investigating (as he has relative and had symptoms as a baby), know all about DQ2.5 etc. and that research shows if you have DQ2.5/DQ2.2 you're at only a slightly lower risk than double 2.5 & that there are 3 'snps'  that make up DQ 2.2 but because when we got him gene tested, it wasn't a thing, I'm trying to decode them myself & don't know 
-whether you need the 3 risk alleles on those 3 snps or just 1 or 2 (because he has 2). 

If that makes sense? 
Maybe nobody will know but giving it a shot. ha. It doesn't realllly matter but now I'm curious. 

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Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8):


Don't know if this article will help, but thought I'd share...

"Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807782/#!po=19.5652

It rather reads like alphabet soup!

😸

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Ha. Thanks! It does but I like alphabet soup! It seems that 2.2 is related indeed but I'm just not sure (because DQ 2.2 is something coming from 3 snps not 1, as per the others) what defines it (as in the 1 allele or many). 
I also don't know does everybody have it and just different alleles? 
I thought I understood genetics and I don't. ha. I thought blood results saying no DQ8 meant you didn't even have it in you at all but I think, now, that it's there (because the snp exists) but the allele is not the risky one. 
Or do some people not have it at all, some have risky alleles, some not? 
SO INTERESTED. And confused. 

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