Ibuprofen (aka Motrin or Advil) and ulcers

[Posterboy]

To All,

To Whomever might read this.....good luck on your continued journey!

I recently came across this article on how Ibuprofen and other NSAIDs can cause Ulcers and I though it might of interest to others and want to share in the hope that it might help some one else.

https://www.washingtonpost.com/lifestyle/wellness/perforated-ulcer-ibuprofen-dingell/2021/05/26/93f18ff8-bcc0-11eb-b26e-53663e6be6ff_story.html

quoting from the article...

"Soon, Dingell said she was regularly downing 800 mg morning and night, which continued long after the initial surgery. By around March, Dingell said her doctors started to raise concerns about how much ibuprofen she was taking.

“The doctors warned me,” she said. “They told me that taking it for this long, they wanted to watch me closely, and I thought I was invincible.”

Ibuprofen and other pain relievers such as naproxen, or Aleve, reduce your body’s ability to make a layer of mucus that protects the lining of your stomach from gastric acid, said Christian Stevoff, clinical practice director in the division of gastroenterology at Northwestern University’s Feinberg School of Medicine."

I always wondered how NSAIDs could cause ulcers and this article explains it well!

Quoting again...

“We think if we’re taking over-the-counter medicines and we’re not feeling anything, we’re okay,” said Dingell, who had been using high doses of Motrin to help with lingering pain from surgery earlier this year. “I didn’t know I had an ulcer,” she added. “I had no stomach pain before this.”

Taking pain relievers such as Advil, Motrin, Aleve or aspirin, also known as nonsteroidal anti-inflammatory drugs (NSAIDs), is one of the most common causes of ulcers, experts say. But “there’s a real education gap” among members of the public about the potentially serious side effects of these medications, said Kyle Staller, director of the Gastrointestinal Motility Laboratory at Massachusetts General Hospital.

“Just because something’s available over the counter doesn’t mean it’s safe to be used by everyone for any amount of time,” Staller said. Though NSAIDs are “wonderful medications for the relief of pain,” he said, (but) it’s important to remember how powerful they are."

.....

When taken for too long they (NSAIDs) indeed can cause ulcers by reducing the Mucus that protects our stomachs...

I hope this  is helpful but it is not medical advice.

Posterboy

[Wheatwacked]

Not to mention liver damage from the NSAIDS, excluding aspirin. My analgesic of choice has always been Alka Selzer because it works fast, has bicarbonate to reduce stomach upset and protects the stomach. And for some reason it makes me hungry, which as an anorexic is good. For long term anti-inflammitory I was on Prednisone (30mg a day pre GFD, 10 mg post) for 8 1/2 years and aside from being the least expensive, it worked the best and if I ever need to I would choose it again. I think that either the 840 mg Phosphatidy Choline (RDA 1200 mg) or the 1000 mg Pantothenic Acid (vitamin B5) that I recently started, is what has allowed me to discontinue the prednisone and not need the Tramodol the doctor prescribed to replace the prednisone. Just the occasional Alka Selzer or 200 mg Advil is now working for me.

[Posterboy]

Wheatwacked,

Because my time is limited these days.....I will try and be quick (try is the operative word here)...

If i remember correctly.....you had converted from a low absorbed Magnesium form to the higher absorbed forms (Magnesium Glycinate and/or Citrate)....

I would propose that since you are  now absorbing your Magnesium better....it is helping with your pain issues...

Epsom Salts are FAMOUS for PAIN management because they are absorbed through the skin helping reduce pain from Arthritis.....etc.

This article explains can and SHOULD be used in Pain management.

https://www.ncbi.nlm.nih.gov/books/NBK507245/

quoting from the article where much is of the research is 20+ years old and still doctor's don't know the "Role of Magnesium in Pain Management"

Quoting

Mechanism of magnesium as an analgesic adjuvant

Although magnesium has no direct analgesic effect, it inhibits calcium ions entering cells by blocking NMDA receptors, which causes an antinociceptive effect (reduction in Pain). Furthermore, this antinociceptive effect is related to its prevention of central sensitization caused by peripheral tissue injury (Woolf and Thompson, 1991). Central sensitization is the result of the enhancement of neuronal properties in nociceptive pathways of the central nervous system, and is triggered by repetitive nociceptive afferent inputs, which manifests as a prolonged reduction in the pain threshold. Central sensitization produces pain hypersensitivity, such as wind-up or long-term potentiation of pain, that is, it causes pain even when peripheral stimuli are not intense and continues to cause pain after the initiating stimuli have disappeared (Latremoliere and Woolf, 2009; Woolf, 1983; Woolf and Salter, 2000)."

I believe the Magnesium is working!

I had early onset arthritis pain....when I was younger and taking Magnesium reversed it!

NOW I know why!

I hope this is helpful but it is not medical advice.

Posterboy

[Wheatwacked]

Yes. I started drinking 2 ounces Flavored Magnesium Citrate (10 oz bottle) in 10 oz of ice water, tastes like lemonade. It has indeed made a big difference in my feet. My feet are not burning cold and numb feeling. This nothing else works on, not prednisone, not tramadol, not NSAIDs. I continue with that daily, regardless. Somedays are good. Some nights at 1 am my feet are hot whereas last year they were burning cold. I consider that progress.

The prednisone handles the Weekend Warrior inflamation pain that would never subside. But when I resumed my long list of vitamins and minerals, that pain is lessened not as well as the prednisone but tolerable. I have to give it time. I ran the totals and my normal unless I monitor it almost every day is that I don't eat enough, so need the supplements. It's not my choices of food but my quantity at this point. In theory if I continue to exceed 100% RDA of all, I will continue to improve. I'll see in time. From the Tramodol I learned with out the supplements I have pain that Tramodol works on but also inflamation pain that requires an antiinflamatory Aspirin, NSAID; or the prednisone does it all and makes me feel more positive and has less scary side effects. 

[Posterboy]

Wheatwacked,

You would probably want to do this in a step wise format....

Being very specific of what you are taking when....but I used to have paresthesia (Pins and Needles) that taking Thiamine as Benfotiamine (the fat soluble form) found in most diabetic sections helped get rid of...

I was low in Thiamine....but the doctor's at the time couldn't put the symptom's together.

I was diagnosed with Pernicious Anemia at the time...

I took a FABB tablet for 2 years (FABB stood for B-6, B12 and Folic Acid)....but until I took my missing nutrient/Vitamin.....in this case Benfotiamine my nerve endings wouldn't heal.

I think you should take some Benfotiamine (always with meals when you do take it) to see if your poor circulation issues don't continue to improve.

It usually takes about 3 months on a B-Vitamin to make a sustained difference.

Here is a nice article about how being low in Thiamine can cause Neuropathies in Diabetics....being attributed to the diabetes and not the Thiamine deficiency....

I knew was the Thiamine deficiency because my condition improved with supplementation!

https://www.naturalmedicinejournal.com/journal/2018-11/thiamine-deficiency-and-diabetic-polyneuropathy

And I think yours might too if you willing to take the Benfotiamine or other Fat Soluble Vitamin B1.

Here is a nice article from the Hormones Matter website that explains why the Fat Soluble B1s are the better absorbed forms and do the most good....

Unlike the forms found in most multivitamins....

https://www.hormonesmatter.com/navigating-thiamine-supplements/

And IF and when it helps you....report back here....so others can read about your experience.

Doctor's need to "Awaken" to role Thiamine aka Vitamin B1 plays in autonomic conditions.

https://awaken.com/2021/02/the-overlooked-vitamin-that-improves-autoimmune-disease-and-autonomic-dysfunction/

Then their patients would feel much better sooner! But then they wouldn't need the doctor anymore?

I hope this is helpful but it is not medical advise.

Posterboy,