Physical Location of tTG Enzymes

[Russ H]

Coeliac disease is an autoimmune disease where as part of its immune response to gluten, the body makes antibodies against itself - particularly against the enzymes tTG2 in classical coeliac disease, tTG3 in dermatitis herpetiformis, and tTG6 in gluten ataxia and neurological manifestations. The expression of these enzymes varies in different of the body as detailed below. (There is not much for the tTG6 enzyme yet).

 

tTG2

https://www.ncbi.nlm.nih.gov/gene/7052#gene-expression

 

tTG3

https://www.ncbi.nlm.nih.gov/gene/7053#gene-expression

 

tTG6

https://www.ncbi.nlm.nih.gov/gene/343641#gene-expression

[Scott Adams]

Interesting links, thank you!

[Russ H]

This paper suggests that the immune response to tTG3 and tTG6 likely starts with antibodies to tTG2 that are cross-reactive, which then diversify by 'epitope spreading' to create distinct antibodies to tTG3 and tTG6. However, it states that direct gluten induced autoimmunity to tTG3 (and tTG6) cannot be excluded.

https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13449