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Gene test

Shireen32
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Shireen32 Rookie
Shireen32
Posted

Hi 

I have done my research and am just confused right now . If a person does not have the HLA DQ 2.5 , HLA DQ8 , or HLA DQ2.2 gene does this mean they do not have celiac disease and it’s impossible for them to have it right ? Can some one confirm and kindly let me know .

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McNish Apprentice
McNish
Posted
On 12/17/2023 at 12:24 PM, Shireen32 said:

Hi 

I have done my research and am just confused right now . If a person does not have the HLA DQ 2.5 , HLA DQ8 , or HLA DQ2.2 gene does this mean they do not have celiac disease and it’s impossible for them to have it right ? Can some one confirm and kindly let me know .

Hi! 

A person can develop Celiac without any of those genes but it's very rare.   There are other genes that can be associated with gluten sensitivity.   This article may help. 

https://www.verywellhealth.com/gluten-sensitivity-genes-562967

Scott Adams Grand Master
Scott Adams
Posted

Researchers have not found all genetic markers associated with celiac disease, so it's possible you have a more rare variant. 

Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.

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