Borderline Negative Enterolab Test

[fedora]

Has anyone else had this outcome with their kids?

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Antigliadin IgA 9 (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA 6 Units (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score 288 Units (Normal Range <300 Units)

Fecal anti-casein (cow's milk) IgA antibody 6 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0501

HLA-DQB1 Molecular analysis, Allele 2 0602

Serologic equivalent: HLA-DQ 1,1 (Subtype 5,6)

Interpretation of Fecal Antigliadin IgA: Intestinal antigliadin IgA antibody was below the upper limit of normal, and hence there is no direct evidence of active gluten sensitivity from this test. However, because 1 in 500 people cannot make IgA at all, and rarely, and some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have a syndrome or symptoms known to be associated with gluten sensitivity, a gluten-free diet may help you despite a negative test. If you have no syndrome or symptoms associated with gluten sensitivity, you can follow a gluten-containing healthy diet and retest in 3-5 years; or you may opt to go gluten-free as a purely preventive measure.

Any advice. she does has symptoms and is willing to try a diet/challenge or gluten lite diet.

she is seven.

[holiday16]

If you have low IGA levels you can come back with a borderline negative result. The results for me and my son were borderline for being positive and our IGA levels are both on the lower end. My mother was borderline negative and she's been doing the diet for about 1 1/2 years and she really has not noticed a difference, but she was not symptomatic before anyway. When I called Enterolab they basically recommended what they said below and they also said they had to make the cutoff somewhere, but it's not really that black and white. If she's symptomatic it makes sense to do the diet and see what the response is.

[gfpaperdoll]

oh, my double DQ1 granddaughter was negative - parents were happy - she is 10 now, gained a bunch of weight all at once & lost all the enamel on all her teeth...

have you read the thread on here about the new findings on that DQ1 gene - 0501?

very interesting, I know two people with that gene...

[fedora]

gfpaperdoll,

she got the DQ5 gene from me. I also have the DQ2.2 gene also though. I definately have severe mood symptoms from gluten. That is her biggest symptom.

Someone on here with refractory sprue has double DQ5.

I had her IGA levels checked about a month or so ago. They told me they were in the normal range, but I am rechecking the results myself today. Can they be low without being totally absent. Quest did not consider them low enough to check her IgG levels. Of course they did not run all the IgA blood tests either. ugh.

[holiday16]

gfpaperdoll,

she got the DQ5 gene from me. I also have the DQ2.2 gene also though. I definately have severe mood symptoms from gluten. That is her biggest symptom.

Someone on here with refractory sprue has double DQ5.

I had her IGA levels checked about a month or so ago. They told me they were in the normal range, but I am rechecking the results myself today. Can they be low without being totally absent. Quest did not consider them low enough to check her IgG levels. Of course they did not run all the IgA blood tests either. ugh.

My IGA levels were low, but not by that much. I think mine were in the 70's and my sons were in the 80's. I was told my sons were normal, but that test was actually ordered through his cardiologist and when they called they gave me the numbers because they weren't really sure what they were looking at if that makes sense.

Both of us were low positive with Enterolab with a 10 and 11. We both had negative bloodwork (although the full panel was not done) my sons scope was negative, but the GI put him on the diet and so far it's been pretty obvious it's an issue. We've had to lower his miralax since starting the diet which is a good sign the diet is working. I react terribly to gluten as well.

If your dd's numbers were on the low end for IGA I'd say the Enterolab values are as good as positive in that case. BTW, I also have a DQ5 and my one daughter is a double DQ5 and we both react to gluten. Her numbers were higher than mine and she did have a positive TTG and Casein as well plus elevelated fecal fat. Oh, and my son that scored only an 11 with Enterolab had an elevated fecal fat of around 1200.

[fedora]

I got a copy of my dd total Iga levels. They are 57 out of a range of 41 to 368. That is not deficient, but seems low. I don't know really since she is seven though. Any opinions or information are welcome. Thanks.