Enterolab Strikes Again- Twice!

[Veronica2]

Today we just got Enterolab fecal anti-gliaden IgA gluten-sensitivity results for two of our daughters.

We had them tested because I was positive last summer (12, normal is <10) and my husband's also came back positive; a 13. I am the only family member who had symptoms.

One daughter had a result of 30 Units (Normal Range <10 Units), and the other 14.

My question is:

Does ANYONE know of anyone who has had this test come back negative? I'm really getting suspicious! It seems so random. I guess the best way to find out definitively is to get genetic testing of some sort, but we will have to wait until we have the money (it's not covered by our insurance).

For now, we've chosen the cheapest $99 test they offer, which is the stool sensitivity test. I am just having doubts that it's accurate!

Thanks for any advice.

[Lisa]

According to my understanding, testing for the HLA-DQ can tell you that you MIGHT at sometime develop a variety of autoimmune diseases, such as Celiac. Although it can be a piece of the puzzle.

If you do not carry the HLA-DQ genes, you cannot develop Celiac.

Do your children have symptoms? You may have mentioned it, but I can't recall.

Genetic testing for celiac disease:

Celiac disease is a multigenic disorder associated with HLA-DQ2 (DQA1*05/DQB1*02) or DQ8 (DQA1*0301/DQB1*0302). HLA DQ2 is expressed in the majority (>90%) of those with celiac disease and DQ8 in about 8%. The expression of these HLA-DQ2 or DQ8 molecules is necessary but not sufficient to develop celiac disease and accounts for only about 50% of the genetic component of the disease. Studies in sibling (sib recurrence risk for celiac disease of 10%) [42] and of identical twins (concordance of 70%) [43] suggest that the contribution of HLA genes in celiac disease is less than 50%. The determination of the presence of HLA DQ2 or DQ8 is now available commercially. The role in the diagnosis of celiac disease is however limited because of the low specificity of the test for celiac disease. These HLA types are present in about 30% of the normal population. Their absence is useful in excluding celiac disease. The role in assessment of the presence of HLA DQ2 or is: 1. In the presence of an equivocal biopsy, 2. When someone is already on the diet, 3. To determine which family members should be screened for celiac disease.

[MaryJones2]

Does ANYONE know of anyone who has had this test come back negative?

Yes, there are several members here who tested negative through Enterolab. I personally think there is value in Enterolab. I also think there are ways to arrive at a diagnosis using other testing methods so it's really about what works for you and your family (and your wallet).

[lonewolf]

My son tested negative.