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Gluten Ataxia

T.H.

By T.H.
in Related Issues & Disorders

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T.H. Community Regular
T.H.
Posted

Open Original Shared Link

You have to scroll down to 'current projects' and click to expand "The role of transglutaminases in immune mediated neurological diseases - Dr. Marios Hadjivassiliou

Some interesting tidbits:

- Antibodies against TG6 are present in those with gluten ataxia, but antibodies against TG2 are typically present for those with Celiac Disease only. "Antibodies to TG6 can therefore serve as an additional marker for gluten sensitivity that is of particular value in patients with neurological dysfunction."

- Basically a one case footnote at the end had some interesting implications.

"Post mortem analysis of brain tissue from a single patient with gluten ataxia revealed cerebellar IgA deposits that contained TG6. TG6 is not present at these sites in normal brain suggesting that perivascular TG6 accumulation is linked to the inflammatory response. This is reminiscent of the perivascular IgA deposits in the dermis in dermatitis herpetiformis and suggests that antigen presenting cells may hold the key to understanding extraintestinal manifestation of gluten sensitivity."

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